RO87433B1 - Procedeu pentru prepararea unor derivati de n-piperdinil-benzamide - Google Patents
Procedeu pentru prepararea unor derivati de n-piperdinil-benzamideInfo
- Publication number
- RO87433B1 RO87433B1 RO113079A RO11307982A RO87433B1 RO 87433 B1 RO87433 B1 RO 87433B1 RO 113079 A RO113079 A RO 113079A RO 11307982 A RO11307982 A RO 11307982A RO 87433 B1 RO87433 B1 RO 87433B1
- Authority
- RO
- Romania
- Prior art keywords
- general formula
- defined above
- compound
- isomeric forms
- represents hydrogen
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 1
- 150000008041 alkali metal carbonates Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- -1 cyano, nitro, amino Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002496 iodine Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ITNXJLXLFAFOHO-UHFFFAOYSA-N n-piperidin-1-ylbenzamide Chemical class C=1C=CC=CC=1C(=O)NN1CCCCC1 ITNXJLXLFAFOHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor N-piperidinilbenzamide cu formula generala I: (vezi formula) si a formelor izomere stereochimice ale acestora, în care R1 reprezinta hidrogen, alchilinferior, alchilinferiorfenil si dialchilinferioramino, R2 reprezinta hidrogen, alchilinferior sau fenil, R3, R4 si R5 reprezinta independent unul de celalalt hidrogen, alchil inferior, alcoxi inferior, halogen, hidroxi, cian, nitro, amino, alchilinferioramino si altele constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R1, R2, R4 si R5 au semnificatiile de mai sus, se trateaza cu un compus cu formula generala III: (vezi formula) în care L are semnificatiile de mai sus si W este o grupa reactiva aleasa între un atom de halogen, o grupa alchilsulfoniloxi si o grupa alchilcarboniloxi, reactia avînd loc într-un solvent organic inert ales dintre N,N-dimetilformamida, 4-metil-2-pentanona si 2-propanona la o temperatura cuprinsa între temperatura casei si cea de reflux a amestecului de reactie, în prezenta unui acceptor de acid ales dintre un carbonat sau carbonat acid de metal alcalin si N,N-dietiletanamina, eventual în prezenta unei sari de iod, dupa care compusii cu formula I obtinuti pot fi eventual transformati în saruri de aditie acida acceptabile farmaceutic si/sau se pot izola formele izomere stereochimice ale acestora.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO113079A RO87433B1 (ro) | 1982-09-21 | 1982-09-21 | Procedeu pentru prepararea unor derivati de n-piperdinil-benzamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO113079A RO87433B1 (ro) | 1982-09-21 | 1982-09-21 | Procedeu pentru prepararea unor derivati de n-piperdinil-benzamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO87433B1 true RO87433B1 (ro) | 1985-08-31 |
Family
ID=40903964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO113079A RO87433B1 (ro) | 1982-09-21 | 1982-09-21 | Procedeu pentru prepararea unor derivati de n-piperdinil-benzamide |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO87433B1 (ro) |
-
1982
- 1982-09-21 RO RO113079A patent/RO87433B1/ro unknown
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