RO85311B1 - Process for obtaining a beta-adrenergic blocking agent - Google Patents
Process for obtaining a beta-adrenergic blocking agentInfo
- Publication number
- RO85311B1 RO85311B1 RO108290A RO10829082A RO85311B1 RO 85311 B1 RO85311 B1 RO 85311B1 RO 108290 A RO108290 A RO 108290A RO 10829082 A RO10829082 A RO 10829082A RO 85311 B1 RO85311 B1 RO 85311B1
- Authority
- RO
- Romania
- Prior art keywords
- defined above
- general formula
- blocking agent
- beta
- obtaining
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru obtinerea unui agent de blocare beta afrenergica avînd formula generala I: (vezi formula) în care R este alchil inferior, alchenil inferior, haloalchil inferior sau aralalchil; n este un numar între 0 si 2; Ar este un radical fenil sau naftil, alchenil inferior; R1 este alchil inferior sau aralalchil inferior conform caruia se supune reactiei un derivat de fenol cu formula generala II: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, cu epiclorhidrina, prin încalzirea reactantilor la reflux în mediul de solvent organic, în prezenta unei baze, pentru a forma un derivat de 1,2-epoxi-3-ariloxipropan, avînd formula generala III: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, care se lasa apoi sa reactioneze cu o amina avînd formula R1-NH2, în care R1 este definit ca mai înainte, încalzind reactantii la reflux, într-un solvent organic, pentru a se obtine produsul final care poate fi eventual transformat, într-o sare farmaceutic acceptabila.The invention relates to a process for the production of an afrenergic beta blocking agent having the general formula I wherein R is lower alkyl, lower alkenyl, lower haloalkyl or aralkyl; n is a number between 0 and 2; Ar is a phenyl or naphthyl radical, lower alkenyl; R 1 is lower alkyl or lower aralkyl which is reacted with a phenol derivative of the general formula II wherein R 1, n and Ar are as defined above with epichlorohydrin by heating the reactants to reflux in the solvent medium in the presence of a base, to form a 1,2-epoxy-3-aryloxypropane derivative having the general formula III wherein R 1, n and Ar are as defined above, which is then is reacted with an amine having the formula R 1 -NH 2, wherein R 1 is as defined above, by heating the reactants at reflux in an organic solvent to obtain the final product which may optionally be converted into a pharmaceutically acceptable salt.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RO108290A RO85311B1 (en) | 1982-07-27 | 1982-07-27 | Process for obtaining a beta-adrenergic blocking agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RO108290A RO85311B1 (en) | 1982-07-27 | 1982-07-27 | Process for obtaining a beta-adrenergic blocking agent |
Publications (1)
Publication Number | Publication Date |
---|---|
RO85311B1 true RO85311B1 (en) | 1984-10-30 |
Family
ID=40903496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO108290A RO85311B1 (en) | 1982-07-27 | 1982-07-27 | Process for obtaining a beta-adrenergic blocking agent |
Country Status (1)
Country | Link |
---|---|
RO (1) | RO85311B1 (en) |
-
1982
- 1982-07-27 RO RO108290A patent/RO85311B1/en unknown
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