RO85311B1 - Process for obtaining a beta-adrenergic blocking agent - Google Patents

Process for obtaining a beta-adrenergic blocking agent

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Publication number
RO85311B1
RO85311B1 RO108290A RO10829082A RO85311B1 RO 85311 B1 RO85311 B1 RO 85311B1 RO 108290 A RO108290 A RO 108290A RO 10829082 A RO10829082 A RO 10829082A RO 85311 B1 RO85311 B1 RO 85311B1
Authority
RO
Romania
Prior art keywords
defined above
general formula
blocking agent
beta
obtaining
Prior art date
Application number
RO108290A
Other languages
Romanian (ro)
Inventor
W. Erhardt Paul
J. Robert Borgman
John P. O'donnell
Original Assignee
American Hospital Supply Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corporation filed Critical American Hospital Supply Corporation
Priority to RO108290A priority Critical patent/RO85311B1/en
Publication of RO85311B1 publication Critical patent/RO85311B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru obtinerea unui agent de blocare beta afrenergica avînd formula generala I: (vezi formula) în care R este alchil inferior, alchenil inferior, haloalchil inferior sau aralalchil; n este un numar între 0 si 2; Ar este un radical fenil sau naftil, alchenil inferior; R1 este alchil inferior sau aralalchil inferior conform caruia se supune reactiei un derivat de fenol cu formula generala II: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, cu epiclorhidrina, prin încalzirea reactantilor la reflux în mediul de solvent organic, în prezenta unei baze, pentru a forma un derivat de 1,2-epoxi-3-ariloxipropan, avînd formula generala III: (vezi formula) în care R, n si Ar sunt definiti ca mai înainte, care se lasa apoi sa reactioneze cu o amina avînd formula R1-NH2, în care R1 este definit ca mai înainte, încalzind reactantii la reflux, într-un solvent organic, pentru a se obtine produsul final care poate fi eventual transformat, într-o sare farmaceutic acceptabila.The invention relates to a process for the production of an afrenergic beta blocking agent having the general formula I wherein R is lower alkyl, lower alkenyl, lower haloalkyl or aralkyl; n is a number between 0 and 2; Ar is a phenyl or naphthyl radical, lower alkenyl; R 1 is lower alkyl or lower aralkyl which is reacted with a phenol derivative of the general formula II wherein R 1, n and Ar are as defined above with epichlorohydrin by heating the reactants to reflux in the solvent medium in the presence of a base, to form a 1,2-epoxy-3-aryloxypropane derivative having the general formula III wherein R 1, n and Ar are as defined above, which is then is reacted with an amine having the formula R 1 -NH 2, wherein R 1 is as defined above, by heating the reactants at reflux in an organic solvent to obtain the final product which may optionally be converted into a pharmaceutically acceptable salt.

RO108290A 1982-07-27 1982-07-27 Process for obtaining a beta-adrenergic blocking agent RO85311B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO108290A RO85311B1 (en) 1982-07-27 1982-07-27 Process for obtaining a beta-adrenergic blocking agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO108290A RO85311B1 (en) 1982-07-27 1982-07-27 Process for obtaining a beta-adrenergic blocking agent

Publications (1)

Publication Number Publication Date
RO85311B1 true RO85311B1 (en) 1984-10-30

Family

ID=40903496

Family Applications (1)

Application Number Title Priority Date Filing Date
RO108290A RO85311B1 (en) 1982-07-27 1982-07-27 Process for obtaining a beta-adrenergic blocking agent

Country Status (1)

Country Link
RO (1) RO85311B1 (en)

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