RO84584B - Procedeu pentru prepararea unor derivati de benzotiofen - Google Patents

Procedeu pentru prepararea unor derivati de benzotiofen

Info

Publication number
RO84584B
RO84584B RO107118A RO10711882A RO84584B RO 84584 B RO84584 B RO 84584B RO 107118 A RO107118 A RO 107118A RO 10711882 A RO10711882 A RO 10711882A RO 84584 B RO84584 B RO 84584B
Authority
RO
Romania
Prior art keywords
benzotiofen
derivatives
preparation
benzotiofen derivatives
Prior art date
Application number
RO107118A
Other languages
English (en)
Romanian (ro)
Other versions
RO84584A (ro
Inventor
Mary Kathleen Peters
Charles David Jones
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/331,046 external-priority patent/US4380635A/en
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO84584A publication Critical patent/RO84584A/ro
Publication of RO84584B publication Critical patent/RO84584B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RO107118A 1981-04-03 1982-04-01 Procedeu pentru prepararea unor derivati de benzotiofen RO84584B (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24633381A 1981-04-03 1981-04-03
US24633581A 1981-04-03 1981-04-03
US33104581A 1981-12-16 1981-12-16
US06/331,046 US4380635A (en) 1981-04-03 1981-12-16 Synthesis of acylated benzothiophenes

Publications (2)

Publication Number Publication Date
RO84584A RO84584A (ro) 1984-07-17
RO84584B true RO84584B (ro) 1984-09-30

Family

ID=27500218

Family Applications (1)

Application Number Title Priority Date Filing Date
RO107118A RO84584B (ro) 1981-04-03 1982-04-01 Procedeu pentru prepararea unor derivati de benzotiofen

Country Status (13)

Country Link
EP (1) EP0062505B1 (en:Method)
BG (1) BG37378A3 (en:Method)
DE (1) DE3264853D1 (en:Method)
DK (1) DK151382A (en:Method)
ES (1) ES511123A0 (en:Method)
FI (1) FI821161L (en:Method)
GB (1) GB2096608B (en:Method)
GR (1) GR78364B (en:Method)
HU (1) HU191084B (en:Method)
IL (1) IL65379A0 (en:Method)
PL (1) PL130584B1 (en:Method)
PT (1) PT74693B (en:Method)
RO (1) RO84584B (en:Method)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
USRE38968E1 (en) 1992-07-28 2006-02-07 Eli Lilly And Company Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride
USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5462949A (en) * 1993-12-21 1995-10-31 Eli Lilly And Company Methods of inhibiting fertility in women
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5731436A (en) * 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
ES2163587T3 (es) * 1995-02-28 2002-02-01 Lilly Co Eli Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos.
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
CA2215902A1 (en) * 1995-04-21 1996-10-24 Charles David Jones Benzothiophenes with novel basic side chains
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
AU698076B2 (en) * 1995-06-07 1998-10-22 Eli Lilly And Company Process for the synthesis of vinyl sulfenic acid derivatives
EP0888331A4 (en) * 1996-03-19 2001-05-23 Lilly Co Eli SYNTHESIS OF 3- [4- (2-AMINOETHOXY) BENZOYL] -2-ARYL-6-HYDROXY-BENZO [b] THIOPHENES
AR013321A1 (es) * 1996-09-25 2000-12-27 Lilly Co Eli Procedimiento para preparar 2-(4-alcoxifenil)-6-alcoxi-benzo[b]tiofenos.
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
AU7261598A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and a process for preparing benzo{b}thiophenes
JP2001523253A (ja) * 1997-04-30 2001-11-20 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造のための中間体および方法
CA2287943A1 (en) * 1997-04-30 1998-11-05 Tony Yantao Zhang Processes for preparing benzothiophenes
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
AU7165398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
FI821161A7 (fi) 1982-10-04
HU191084B (en) 1987-01-28
DK151382A (da) 1982-10-04
DE3264853D1 (en) 1985-08-29
PL130584B1 (en) 1984-08-31
EP0062505B1 (en) 1985-07-24
GR78364B (en:Method) 1984-09-26
BG37378A3 (bg) 1985-05-15
EP0062505A1 (en) 1982-10-13
PT74693A (en) 1982-05-01
RO84584A (ro) 1984-07-17
PT74693B (en) 1985-01-08
ES8304116A1 (es) 1983-02-16
GB2096608A (en) 1982-10-20
GB2096608B (en) 1985-06-12
FI821161L (fi) 1982-10-04
ES511123A0 (es) 1983-02-16
FI821161A0 (fi) 1982-04-02
PL235751A1 (en:Method) 1982-11-22
IL65379A0 (en) 1982-05-31

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