RO84094B - Procedeu pentru prepararea unor derivati de dihidropiridina - Google Patents

Procedeu pentru prepararea unor derivati de dihidropiridina

Info

Publication number
RO84094B
RO84094B RO108554A RO10855482A RO84094B RO 84094 B RO84094 B RO 84094B RO 108554 A RO108554 A RO 108554A RO 10855482 A RO10855482 A RO 10855482A RO 84094 B RO84094 B RO 84094B
Authority
RO
Romania
Prior art keywords
page
formula
preparation
description
general formula
Prior art date
Application number
RO108554A
Other languages
English (en)
Other versions
RO84094A (ro
Inventor
Stig A.I. Carlsson
Richard B. Ljung
Original Assignee
Ab Hassle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Hassle filed Critical Ab Hassle
Publication of RO84094A publication Critical patent/RO84094A/ro
Publication of RO84094B publication Critical patent/RO84094B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedeul pentru prepararea unor derivati de dihidropiridina cu formula generala I (vezi formula în pag.1 a descrierii) în care R este metil sau etil, R1 si R2 sînt diferiti si unul reprezinta ciclopropil sau metoximetil, iar celalalt reprezinta metil sau etil, R3 reprezinta unul sau doi substituenti halogen în pozitiile 2 si/sau 3 ale ciclului fenil, iar A este propil, este caracterizat prin aceea ca un compus cu formula generala II (vezi formula în pag.1 a descrierii) în care R2, R3 si A au semnificatiile de mai sus, se trateaza cu un compus cu formula generala III (vezi formula în pag.1 a descrierii) în care R si R1 au semnificatiile de mai sus, în prezenta unui alcanol inferior ca solvent, la temperatura camerei, dupa care compusul cu formula I obtinut se transforma, daca se doreste, într-o sare acceptabila fiziologic si/sau se transforma într-un stereoizomer pur al acestuia.
RO108554A 1981-09-03 1982-09-02 Procedeu pentru prepararea unor derivati de dihidropiridina RO84094B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8105230A SE8105230L (sv) 1981-09-03 1981-09-03 Nya dihydropyridiner

Publications (2)

Publication Number Publication Date
RO84094A RO84094A (ro) 1984-05-12
RO84094B true RO84094B (ro) 1984-06-30

Family

ID=20344487

Family Applications (1)

Application Number Title Priority Date Filing Date
RO108554A RO84094B (ro) 1981-09-03 1982-09-02 Procedeu pentru prepararea unor derivati de dihidropiridina

Country Status (12)

Country Link
JP (1) JPS5852286A (ro)
AU (1) AU8779982A (ro)
DD (1) DD208614A5 (ro)
DK (1) DK381682A (ro)
FI (1) FI823033A7 (ro)
GR (1) GR78053B (ro)
IL (1) IL66145A0 (ro)
NO (1) NO822506L (ro)
OA (1) OA07203A (ro)
PT (1) PT75502B (ro)
RO (1) RO84094B (ro)
SE (1) SE8105230L (ro)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR851819B (ro) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd

Also Published As

Publication number Publication date
NO822506L (no) 1983-03-04
RO84094A (ro) 1984-05-12
PT75502B (en) 1985-11-25
FI823033L (fi) 1983-03-04
PT75502A (en) 1982-10-01
DK381682A (da) 1983-03-04
DD208614A5 (de) 1984-04-04
FI823033A0 (fi) 1982-09-02
FI823033A7 (fi) 1983-03-04
JPS5852286A (ja) 1983-03-28
AU8779982A (en) 1983-03-10
GR78053B (ro) 1984-09-26
SE8105230L (sv) 1983-03-04
OA07203A (fr) 1984-04-30
IL66145A0 (en) 1982-09-30

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