RO128266A2 - Wound-healing ointment with calendula officinalis extract - Google Patents
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- RO128266A2 RO128266A2 ROA201100699A RO201100699A RO128266A2 RO 128266 A2 RO128266 A2 RO 128266A2 RO A201100699 A ROA201100699 A RO A201100699A RO 201100699 A RO201100699 A RO 201100699A RO 128266 A2 RO128266 A2 RO 128266A2
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- calendula officinalis
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- 239000002674 ointment Substances 0.000 title claims abstract description 16
- 229940002386 calendula officinalis extract Drugs 0.000 title claims description 8
- 230000029663 wound healing Effects 0.000 title abstract 2
- 240000001432 Calendula officinalis Species 0.000 claims abstract description 6
- 239000004264 Petrolatum Substances 0.000 claims abstract description 5
- 229940066842 petrolatum Drugs 0.000 claims abstract description 5
- 235000019271 petrolatum Nutrition 0.000 claims abstract description 5
- 241000208818 Helianthus Species 0.000 claims abstract description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 3
- 230000035876 healing Effects 0.000 claims description 17
- 229940031955 anhydrous lanolin Drugs 0.000 claims description 4
- 239000001993 wax Substances 0.000 claims description 4
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 claims description 2
- 235000003880 Calendula Nutrition 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 11
- 208000027418 Wounds and injury Diseases 0.000 abstract description 10
- 235000005881 Calendula officinalis Nutrition 0.000 abstract description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 abstract 1
- 208000010201 Exanthema Diseases 0.000 abstract 1
- 239000004166 Lanolin Substances 0.000 abstract 1
- 239000007766 cera flava Substances 0.000 abstract 1
- 201000005884 exanthem Diseases 0.000 abstract 1
- 229940039717 lanolin Drugs 0.000 abstract 1
- 235000019388 lanolin Nutrition 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229960005323 phenoxyethanol Drugs 0.000 abstract 1
- 206010037844 rash Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000003902 lesion Effects 0.000 description 6
- 231100000444 skin lesion Toxicity 0.000 description 5
- 206010040882 skin lesion Diseases 0.000 description 5
- 206010063560 Excessive granulation tissue Diseases 0.000 description 4
- 210000002808 connective tissue Anatomy 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 210000001126 granulation tissue Anatomy 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000003871 white petrolatum Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000009043 Chemical Burns Diseases 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010011985 Decubitus ulcer Diseases 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035778 pathophysiological process Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 241000132025 Calendula Species 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940037395 electrolytes Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000003619 fibrillary effect Effects 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000035752 proliferative phase Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000036575 thermal burns Effects 0.000 description 1
- 230000005944 tissue migration Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Prezenta invenție se referă la realizarea unui unguent cicatrizant destinat tratamentului plăgilor postoperatorii, postraumatice, arsurilor de gradul I, II și III A, a iritațiilor de scutec a nou-născuților și sugarilor și a escarelor de decubit.The present invention relates to the realization of a healing ointment for the treatment of postoperative, post-traumatic wounds, grade I, II and III A burns, diaper irritations of newborns and infants and decubitus ladders.
Unguentul cicatrizant cu extract de Calendula officinalis are în compoziția sa Helianthi oleum, parafină lichidă (ulei de parafină), Cera flava, vaselină albă (petrolatum), lanolină anhidră, extract de calendulae, euxil , butii hidroxianisol. Unguentul cicatrizant cu extract de Calendula officinalis are acțiune epitelizantă, bacteriostatică și bactericidă și intervine în stimularea procesului de cicatrizare în diferite situații de leziuni tegumentare: arsuri termice de gradul I, II și III A, arsuri chimice provocate de diferite substanțe alcaline sau acide, arsuri provocate de iradiații, leziuni traumatice postchirurgicale sau postraumatice de diferite etiologii.The healing ointment with calendula officinalis extract has in its composition Helianthi oleum, liquid paraffin (paraffin oil), yellow wax, white petroleum jelly (petrolatum), anhydrous lanolin, calendulae extract, euxil, hydroxyanisole butyl. The healing ointment with Calendula officinalis extract has epithelizing, bacteriostatic and bactericidal action and intervenes in stimulating the healing process in different skin lesions: 1st degree, 2nd and 3rd degree thermal burns, chemical burns caused by different alkaline or acidic substances, caused by irradiation, post-traumatic or post-traumatic lesions of different etiologies.
O acțiune epitelizantă deosebit de eficientă s-a remarcat în cazul escarelor apărute la persoane în vârstă imobilizate la pat sau în cazul bolnavilor cronici care stau în decubitus dorsal timp îndelungat. După aplicarea unguentului cicatrizant cu extract de Calendula officinalis, chiar în cazul escarelor întinse, s-a constatat întotdeauna reparația acestora, epitelizarea survenind în decurs de câteva săptămâni. Pentru îngrijirea nou-născuților și sugarilor ce prezintă iritație de scutec, folosirea unguentului cicatrizant cu extract de Calendula officinalis, a dat întotdeauna rezultate bune datorită atât activității sale epitelizante, cât și acțiunii emoliente și calmante.A particularly effective epithelizing action was noted in the case of stairs in elderly people immobilized in bed or in chronic patients who have been in the dorsal decubitus for a long time. After applying the healing ointment with Calendula officinalis extract, even in the case of large ladders, their repair has always been found, with epithelialization occurring within a few weeks. For the care of newborns and infants with diaper irritation, the use of the healing ointment with Calendula officinalis extract has always yielded good results due to both its epithelializing activity, as well as the emollient and calming action.
Procesul de vindecare în leziunile tegumentare de diferite etiologii cuprinde trei faze: faza vasculară și inflamatorie, faza proliferați vă și faza restructurantă.The healing process in the skin lesions of different etiologies comprises three phases: the vascular and inflammatory phase, the proliferate phase and the restructuring phase.
AA
In faza vasculară și inflamatorie au loc următoarele procese:hemostaza caracterizată prin vasoconstrictție, agregare plachetară, procese de migrare tisulară și inflamație manifestată prin vasodilatație și fagocitoză.In the vascular and inflammatory phase the following processes take place: hemostasis characterized by vasoconstriction, platelet aggregation, processes of tissue migration and inflammation manifested by vasodilation and phagocytosis.
Faza proliferativă este dominată de apariția procesului de granulație, a vaselor noi de sânge și de procesul de epitelizare. Epitelizarea leziunii are loc prin două componente:epidermizarea leziunii și proliferarea țesutului conjunctiv. Epidermizarea leziunii se produce prin: a) epidermizare marginală care constă în alunecarea gradată a epidermului de la periferia plăgii către centrul acesteia și acoperirea țesutului conjunctiv de granulație; b) metaplazia diferitelor structuri din ^-2011-00699--The proliferative phase is dominated by the appearance of the granulation process, the new blood vessels and the epithelialization process. The epithelialization of the lesion occurs through two components: the epidermis of the lesion and the proliferation of the connective tissue. The epidermis of the lesion is produced by: a) marginal epidermis which consists in the gradual sliding of the epidermis from the periphery of the wound towards its center and covering the connective tissue of granulation; b) metaplasia of the different structures from ^ -2011-00699--
Π -07- 2011 derm (foliculi piloși, glande sebacee) din zona arsă care dau naștere la insule de țesut epidermic care se întinde spre periferie acoperind zona lezată.0 -07- 2011 dermis (hair follicles, sebaceous glands) from the burned area giving rise to islands of epidermal tissue that extends to the periphery covering the injured area.
Proliferarea țesutului conjunctiv începe cu apariția cheagurilor de sânge unde se acumulează diferite substanțe ca imunoglobuline, glucoză, electroliți, acid ascorbic, enzime precum și o bogată populație celulară cu rol în producerea de proteinoglicani, glicoproteine, proteine fibrilare și colagen; aceste elementeProliferation of connective tissue begins with the appearance of blood clots where various substances such as immunoglobulins, glucose, electrolytes, ascorbic acid, enzymes, as well as a rich cellular population, play a role in the production of proteinoglycans, glycoproteins, fibrillary proteins and collagen; these elements
A realizează matricea intercelualară. In acest timp în zona lezată are loc procesul de capilaroneogeneză care se va cupla la circulația sistemică și crează condițiile metabolice pentru multiplicarea celulară.To realize the intercellular matrix. During this time in the injured area the process of capillaryogenesis takes place which will be coupled to the systemic circulation and create the metabolic conditions for cell multiplication.
Populația celulară, matricea intercelulară și neocapilarogeneza constituie categoria histologică numită „țesut de granulație” care are rol esențial în vindecarea leziunilor tegumentare produse de agenți mecanici, termici, chimici, radiații etc.The cell population, intercellular matrix and neocapillogenesis constitute the histological category called "granulation tissue" which plays an essential role in healing the skin lesions produced by mechanical, thermal, chemical, radiation, etc.
»»
Faza restructurantă se manifestă prin creșeterea numărului de fibre de colagen, sinteza de noi fibre elastice și dezvoltarea rețelei capilare care trebuie să susțină tesutul neofformat.The restructuring phase is manifested by the increase of the number of collagen fibers, the synthesis of new elastic fibers and the development of the capillary network that must support the unformed tissue.
»»
Componentele active ale unguentului cicatrizant cu extract de Calendula officinalis intervin în procesul de vindecare a plăgilor vizând următoarele procese fiziopatologice care vizează epitelizarea leziunilor tegumentare:The active components of the healing ointment with extract of Calendula officinalis intervene in the healing process of the wounds concerning the following pathophysiological processes that aim at the epithelialization of the skin lesions:
-Cera flava și helianthi oleum au proprietăți epitelizante, emoliente, bacteriostatice și bactericide și au fost utilizate în acest scop din timpuri străvechi în medicina populară;- Wax flava and helianthi oleum have epithelizing, emollient, bacteriostatic and bactericidal properties and have been used for this purpose since ancient times in folk medicine;
-Calendula officinalis stimulează procesul de granulație și de epitelizare, având și o puternică acțiune trofică locală;-Calendula officinalis stimulates the granulation and epithelialization process, also having a strong local trophic action;
- vaselină albă (petrolatum) și lanolină anhidră au rol emolient, ocluziv și plastifiant pentru realizarea caracteristicilor reologice ale unguentului;- white petroleum jelly (petrolatum) and anhydrous lanolin have an emollient, occlusive and plasticizing role for achieving the rheological characteristics of the ointment;
-Euxil PE 9010 și butii hidroxianisolul au rol antixidant și asigură stabilitate unguentului pe timpul păstrării.-Euxil PE 9010 and the hydroxyanisole cylinders have an antioxidant role and ensure stability of the ointment during storage.
în continuare se dă un exemplu de relizare a invenției.The following is an example of an embodiment of the invention.
După divizarea, materiilor prime, se încălzesc într-un reactor uleiul de helianthus și cel de parafină. Se topesc apoi împreună vaselina albă (petrolatum), butii- hidroxi- anisol și lanolina anhidră. Separat se topește cera flava și se controlează puritatea, după care se introduce peste amestecul obținut anterior. La final se adaugă extraxtul de calendula și euxilul. Ungunetul astfel obținut se trece la divizare și ambalare.After dividing the raw materials, the helianthus and paraffin oil are heated in a reactor. The white petroleum jelly (petrolatum), butyl hydroxy anisole and anhydrous lanolin are then melted. Separately melt the wax yolk and check the purity, after which it is introduced over the mixture obtained previously. Finally add the calendula extract and the euxil. The grease thus obtained goes to the division and packing.
CV-2 O 1 1 - O O 5 9 9 - Z O -07- 2011CV-2 O 1 1 - O O 5 9 9 - Z O -07- 2011
Avantajele realizării unguentului cicatrizant cu extract de Calendula officinalis sunt următoarele:The advantages of making the healing ointment with Calendula officinalis extract are the following:
1. Aplicarea imediată a ungunetului cicatrizant cu extratct de Calendula officinalis pe leziunile tegumentare produse de arsuri solare, termice, chimice, plăgi produse de traumatisme prin acțiunea diferiților factori mecanici sau fizici, produce o calmare evidentă a durerii, fapt ce contribuie la îndepărtarea panicii și stresului.1. The immediate application of the healing grease with extract of Calendula officinalis on the skin lesions produced by solar, thermal, chemical burns, wounds caused by traumas through the action of different mechanical or physical factors, produces an obvious pain relief, which contributes to the removal of panic and stress.
2. Adminsitrarea locală a diferitelor preparate cu acțiune epitelizantă, bactericidă și bacteriostatică este logic justificată de faptul că distrugerile vasculare arteriale și venoase manifestate prin tromboza extensivă împiedică difuzia diferitelor droguri în aria leziunii.2. The local administration of the various preparations with epithelializing, bactericidal and bacteriostatic action is logically justified by the fact that the arterial and venous vascular damage manifested by the extensive thrombosis prevent the diffusion of the different drugs in the area of the lesion.
3. Componentele unguentului cicatrizant cu extract de Calendula officinalis stimulează procesul de epitelizare a plăgilor prin proprietățile intrinseci ale componentelor sale.3. The components of the healing ointment with Calendula officinalis extract stimulate the process of epithelialization of the wounds by the intrinsic properties of its components.
4. Pe lângă corecția diferitelor procese fiziopatologice de la nivelul plăgii, unguentul cicatrizant cu extract de Calendula officinalis realizează transformarea plăgii dintr-o pagă deschisă, într-o plagă închisă, reducând potențialul septic al acesteia și îndeplinind rolul unui adevărat pansament aseptic ocluziv.4. In addition to the correction of the different pathophysiological processes at the wound level, the healing ointment with extract of Calendula officinalis performs the transformation of the wound from an open wound, into a closed wound, reducing its septic potential and fulfilling the role of a true aseptic bandage.
5. Ca urmare a îmbibării pansamentului cu unguent, la schimbarea acestuia, desprinderea de plagă se face cu ușurință, fără a rupe țesutul de granulație format.5. As a result of soaking the dressing with the ointment, when it is changed, the loosening of the wound is done easily, without breaking the granulation tissue formed.
6. Acest fapt previne sângerările și durerile ce se produc în mod obișnuit la scimbarea pansamentului pe de o parte, iar pe de altă, parte protejează țesutul de granulație care intervine în vindecarea leziunii și micșorează considerabil timpul de vindecare.6. This prevents the bleeding and pain that usually occur when the dressing is changed on the one hand, and on the other hand, it protects the granulation tissue that is involved in healing the lesion and considerably reduces the healing time.
7. Prin stimularea în special a țesutului epitelial în procesul de epitelizare și mai puțin țesutului de granulație care favorizează dezvoltarea țesutului conjunctiv, se previne formarea cicatricilor vicioase și inestetice.7. By stimulating especially the epithelial tissue in the epithelialization process and less the granulation tissue that favors the development of the connective tissue, the formation of vicious and unsightly scars is prevented.
8. Preparatul este ușor de realizat, iar costurile sunt relativ mici.8. The preparation is easy to make and the costs are relatively low.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201100699A RO128266B1 (en) | 2011-07-20 | 2011-07-20 | Wound-healing ointment with calendula officinalis extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201100699A RO128266B1 (en) | 2011-07-20 | 2011-07-20 | Wound-healing ointment with calendula officinalis extract |
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| Publication Number | Publication Date |
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| RO128266A2 true RO128266A2 (en) | 2013-04-30 |
| RO128266B1 RO128266B1 (en) | 2014-11-28 |
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| RO (1) | RO128266B1 (en) |
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