RO126742A0 - Toothpaste containing maiden wax - Google Patents

Abstract

The invention relates to a toothpaste composition for the hygiene of the oral cavity. According to the invention, the composition consists of 17...20% of 96% glycerol, 0.9...1.1% sodic carboxymethyl cellulose, 5...10% propylene glycol, 23...24% deionized water, 0.4...0.5% sodium bicarbonate, 40...41% calcium carbonate, 1.2...1.4% sodium lauryl sulphate, 0.2...0.3% clove essential oil, 4...5% maiden wax, 0.2...0.3% saccharine, 2.3...2.5% sodium methabisulphite.

Description

TOOTHPASTE WITH PASTURE

The present invention relates to a toothpaste with natural active principles (pasture and volatile clove oil) intended for oral hygiene, with antimicrobial, antifungal, anti-inflammatory, immunomodulatory, calming and healing action.

Various toothpastes with natural extracts used to prevent or treat various dental and gingival diseases are known: PERODONTAX, PELL-AMAR, COLGATE PROPOLIS, TOOTHPASTE WITH ALOE VERA ICE, etc.

The invention relates to a toothpaste for oral hygiene, which consists in combining 96% glycerin with sodium carboxymethylcellulose, propylene glycol, deionized water, sodium bicarbonate, calcium carbonate, sodium lauryl sulfate, volatile oil of cloves, pasture, sodium saccharin and 0,1% sodium metabisulphite solution, in a combination ratio, parts by weight of: 17. ..20: 0,9 ... 1,1: 5 ... 10:23 ... 24: 0.4 ... 0.5: 40 ... 41: 1.2 ... 1.4: 0.2 ... 0.3:

4 ... 5: 0.2 ... 0.3: 2.3 ... 2.5.

The main advantages of toothpaste according to the invention are the following:

- by combining natural principles, an effective antimicrobial and antifungal action is obtained for the hygiene of the oral cavity;

- a significant anti-inflammatory and healing effect;

- immunomodulatory effect by non-specific mechanisms;

- an obvious calming and anesthetic action from the first use;

- a feeling of freshness and a pleasant smell of breath;

- good tolerance and cleaning capacity.

This paste enriches the range of pharmaceuticals with natural active ingredients used in the treatment of dental and gingival diseases, as well as for the maintenance of oral hygiene, in that it is obtained by combining natural products, each with known effects on the human body: pasture and volatile oil. cloves.

The action of toothpaste is mainly determined by the natural principles that make up its composition:

- bee pasture or “bread” is the pollen stored in the honeycomb and covered with a layer of wax. Feed is obtained by fermenting pollen under the conditions of the bacterial microflora of the hive. Pollen goes through a series of biochemical transformations under the influence of substances added by bees, microorganisms, temperature and humidity in the hive. Mrs. Dr.

STATE OF INVENTIONS! ȘL MĂRCl | revo ce dîov ^ î of invention | / ^ 2 0 1 0 - 0 1 0 2 1 - 2 7 -10- ZOW biochemist Cristina Mateescu from the Research and Development Institute for Beekeeping claims in her articles published in specialized journals that the tonic, immunostimulatory and detoxifying properties of pollen are taken over and grazing (Rev. Medical Week, no. 82; 94; 102/2010). It even seems that the therapeutic action of the so-called bee bread is faster and more intense than the action of pollen. The therapeutic properties of the feed are due to the high content of essential amino acids, enzymes, vitamin K and simple sugars. Due to the large amount of lactic acid and antibiotic properties, the feed can be stored for a long time, without major changes, quantitative or qualitative. This product is currently receiving increased attention from researchers for the effects obtained by its application in various diseases. In the current stage of experimentation, it seems that there are sufficient premises that justify the statement of specialists that pasture is a natural bee product with great prospects for use in human health.

- volatile clove oil contains a high percentage of eugenol (along with flavones and tannin) which gives it antiseptic, antimicrobial, antiviral, anti-inflammatory, antioxidant, astringent, analgesic and anesthetic properties, which makes its use in dentistry be effective in treating diseases of the oral cavity as well as in relieving dental pain. It is known to use volatile clove oil in the preparation of DENTOCALM gingival ointment used successfully in dentistry to treat dental and gingival pain, but also to flavor chewing gums due to antiseptic properties and to remove unpleasant odors from the oral cavity. Volatile clove oil is used in some surgeries in the oral cavity (treatment of abscesses) due to its very intense antiseptic and antimicrobial effect.

The combination of the two natural principles leads to a synergistic antimicrobial, anti-inflammatory and immunomodulatory effect.

The advantage of the formula for obtaining toothpaste with pasture and volatile clove oil is that it covers the full range of problems related to ensuring effective oral hygiene while having therapeutic properties: removes dental and gingival pain, reduces gingival bleeding by the astringent effect of the clove oil that contains tannin but also by the hemostatic effect of the calcium carbonate that enters the composition of the base. Calcium carbonate gives the toothpaste and mineralizing action. Also, toothpaste has a strong anti-inflammatory action, but also healing.

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The following are several embodiments of the invention. in fig. 1-4 are presented the results of testing the antimicrobial activity of the preparation on culture media by diffusimetric method.

Example 1. The composition for 100 g of paste is as follows: 17 g 96% glycerin, 0.9 g sodium carboxymethylcellulose, 10 g propylene glycol, 23 g deionized water, 0.4 g sodium bicarbonate, 41 g calcium carbonate, 1.2 g sodium lauryl sulfate, 0. 2g volatile clove oil, 4g pasture, 0.2g sodium saccharin and 2.3g 0.1% sodium metabisulphite solution.

The process for obtaining the invention consists in dispersing, in a suitable container provided with a vacuum stirring system, sodium carboxymethylcellulose is dispersed in glycerin under stirring, a part of propylene glycol is added, then deionized water in which they have been dissolved by slight heating. sodium benzoate, sodium saccharin and baking soda. Add the sodium metabisulphite solution, close the container and homogenize under vacuum at a pressure of 27 ... 29 mmHg for 10.. .25min. Prepare separately by grinding a powder composed of equal parts of pasture and calcium carbonate and then add to the toothpaste preparation container together with the rest of the calcium carbonate and homogenize under vacuum for 30 min. Finally, add the volatile clove oil and the remaining propylene glycol in which the sodium lauryl sulfate has been dispersed. Homogenize under vacuum for 5 min.

Example 2. To obtain 100 g of composition combine: 20 g 96% glycerin with 1.1 g sodium carboxymethylcellulose, 5 g propylene glycol, 24 g deionized water, 0.5 g sodium bicarbonate, 40 g calcium carbonate, 1,3 g sodium lauryl sulfate, 0 , 3g volatile clove oil, 5g pasture, 0.3g sodium saccharin and 2.5g 0.1% sodium metabisulphite solution.

The process for obtaining it is as described in Example 1.

Example 3. To obtain 100 g of composition combine: 20 g 96% glycerin with sodium carboxymethylcellulose, 5 g propylene glycol, 24 g deionized water, 0.5 g sodium bicarbonate, 40 g calcium carbonate, 1,4 g sodium lauryl sulfate, 0.3 g oil volatile cloves, 5g pasture, 0.3g sodium saccharin and 2.5g 0.1% sodium metabisulphite solution,

The process for obtaining it is as described in Example 1.

The main active components of toothpaste are pasture and volatile clove oil through their bactericidal, fungicidal, antiviral, anti-inflammatory, immunomodulatory, healing, astringent, anesthetic and analgesic action.

Baking soda acts as a teeth whitening agent, sodium metabisulfite is an antioxidant agent along with volatile clove oil. Calcium carbonate acts as an abrasive agent but also prints a <7 2 Ο 1 Ο - ο 1 ο 2 1 - 2 7 -ΙΟ- 20W hemostatic and mineralizing action, sodium lauryl is a foaming agent and sodium saccharin is a sweetener.

Characteristics of the prepared toothpaste:

- homogeneous appearance;

- yellowish-white color;

- aromatic-characteristic smell;

- sweet-burning taste;

- pH 6.8-7.4;

- viscosity (mcPs) 230-250;

- R.D.A (Radio Dentine Abrasio) 110-115.

The testing of the antimicrobial and antifungal action was done by the diffusimetric method:

As culture media were used:

- for bacteria - nutrient agar distributed in Petri dishes;

- for fungi - Sabouraud solid medium distributed in Petri dishes.

inoculum:

- for bacteria - bacterial cultures of 24 hours in nutritious broth diluted 1/100;

- for fungi - cultures of 24 hours in medium Sabouraud liquid diluted 1/100 for yeasts of the genus candida; culture for 48 hours in liquid Sabouraud medium diluted 1/100 for Cryptococcus neoformans', suspension in distilled water of Aspergillus niger spores.

Product analyzed:

- simple toothpaste (incorporation base without pasture and volatile clove oil);

- toothpaste with natural active principles.

Working technique:

The test microorganisms were seeded by microincorporation in the respective fluidized and cooled medium at 56-60 ° C. The procedure was as follows: 1 ml of inoculum was aseptically distributed in a sterile Petri dish and 15 ml of fluidized and cooled medium was poured at 56-60 ° C. The inoculum was homogenized by circular and perpendicular movements of the plate in the horizontal plane. It was expected to solidify the medium thus seeded then with a sterile glass tube having a diameter of 8 mm were cut in the medium layer wells. The samples to be analyzed were inserted into the wells with a sterile spatula. The plates were incubated at 37 ° C for bacteria and yeast for 48 hours and at 28 ° C for 5 days for the filamentous fungus Aspergillus niger.

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Interpretation of results (fig 1 .. .4):

The diameter (mm) of the areas of inhibition of microbial growth around the washers impregnated with the tested products was measured.

Diameter of test microorganism growth inhibition areas (mm)

Micro-organism Simple pasta (basic) Paste with natural active principles Staphylococcus aureus 10 28 Bacillus subtilus 18 32 Mycobacterium smegmatis 16 24 Candida albicans 0 22 Candida tropicalis 8 22 Candida pseudotropicalis 16 26 Candida krusei 16 28 Cryptococcus neoformans 18 34 Aspergillus niger 18 32

There is a strong antimicrobial and antifungal action for toothpaste with pasture and volatile clove oil. The incorporation base also has a slight antimicrobial and antifungal action due to the ingredients it contains and especially due to the foaming agent (sodium lauryl sulfate, surfactant with cleaning action). The association of the base with the natural active principles leads to a pronounced antimicrobial and antifungal effect. In addition to the preparation, it also has analgesic, anesthetic, astringent and anti-inflammatory action.

Claims (2)

Claim Toothpaste for oral hygiene, characterized by the combination of 96% glycerin with sodium carboxymethylcellulose, propylene glycol, deionized water, sodium bicarbonate, calcium carbonate, sodium lauryl sulphate, volatile clove oil, soda, sugar 0,1% sodium metabisulphite solution, in an association ratio, parts by weight of: 17 ... 20: 0,9 ... 1,1. 5 ... 10: 23 .. .24: 0,4 ... 0,5: 40 ... 41: 1,2 ... 1,4: 0,2 ... 0,3: 4 ... 5: 0, 2 ... 0.3: 2.3 .. .2.5.