RO100033B1 - Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului - Google Patents

Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

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Publication number
RO100033B1
RO100033B1 RO135259A RO13525988A RO100033B1 RO 100033 B1 RO100033 B1 RO 100033B1 RO 135259 A RO135259 A RO 135259A RO 13525988 A RO13525988 A RO 13525988A RO 100033 B1 RO100033 B1 RO 100033B1
Authority
RO
Romania
Prior art keywords
hidroxypropoxy
terbutylamino
tiadiazole
morpholine
production method
Prior art date
Application number
RO135259A
Other languages
English (en)
Other versions
RO100033A2 (ro
Inventor
Gabriela Putina
Corina Ilie
Steliana Cilianu
Teodor Burghelea
Mariana Simina Ionescu
Rodica Caproiu
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO135259A priority Critical patent/RO100033B1/ro
Publication of RO100033A2 publication Critical patent/RO100033A2/ro
Publication of RO100033B1 publication Critical patent/RO100033B1/ro

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Inventia se refera la un procedeu de obtinere a S-(-)-3-(3-tertbutilamino-2-hidroxipropoxi)-4-(N-morfolino)-1,2,5-tiadiazolului [S-(-)Timolol baza] prin scindarea (R,S)-Timololului prin diestereoizomeri de tip monoesteri Timolol-acid (R,R(-)O,O-tartric disubstituit. Scindarea are loc în doua etape: obtinerea esterului diastereoizomer si hidroliza alacalina sau acida a acestuia. Puritatea optica 99...100%.
RO135259A 1988-09-26 1988-09-26 Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului RO100033B1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO135259A RO100033B1 (ro) 1988-09-26 1988-09-26 Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO135259A RO100033B1 (ro) 1988-09-26 1988-09-26 Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Publications (2)

Publication Number Publication Date
RO100033A2 RO100033A2 (ro) 1990-07-24
RO100033B1 true RO100033B1 (ro) 1990-10-30

Family

ID=20122524

Family Applications (1)

Application Number Title Priority Date Filing Date
RO135259A RO100033B1 (ro) 1988-09-26 1988-09-26 Procedeu de obtinere a s(-)3-(3-tertbutilamino-2-hidroxipropoxi)-4-(n-morfolino)-1, 2, 5-tiadiazolului

Country Status (1)

Country Link
RO (1) RO100033B1 (ro)

Also Published As

Publication number Publication date
RO100033A2 (ro) 1990-07-24

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