PT965588E - Processo de preparacao de derivados de 4-fenil-1,2,3,6-tetra-hidropiridina e os produtos intermediarios utilizados no processo - Google Patents
Processo de preparacao de derivados de 4-fenil-1,2,3,6-tetra-hidropiridina e os produtos intermediarios utilizados no processoInfo
- Publication number
- PT965588E PT965588E PT99401497T PT99401497T PT965588E PT 965588 E PT965588 E PT 965588E PT 99401497 T PT99401497 T PT 99401497T PT 99401497 T PT99401497 T PT 99401497T PT 965588 E PT965588 E PT 965588E
- Authority
- PT
- Portugal
- Prior art keywords
- phenyl
- reacting
- compound
- formula
- agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9807677A FR2780056B1 (fr) | 1998-06-18 | 1998-06-18 | Nouveau procede de preparation de derives de la 4-phenyl-1-2 3,6-tetrahydropyridine et les produits imtermediaires mis en oeuvre |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT965588E true PT965588E (pt) | 2004-07-30 |
Family
ID=9527532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99401497T PT965588E (pt) | 1998-06-18 | 1999-06-17 | Processo de preparacao de derivados de 4-fenil-1,2,3,6-tetra-hidropiridina e os produtos intermediarios utilizados no processo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6136981A (pt) |
| EP (1) | EP0965588B1 (pt) |
| JP (1) | JP4538114B2 (pt) |
| AT (1) | ATE261432T1 (pt) |
| CA (1) | CA2275192C (pt) |
| DE (1) | DE69915413T2 (pt) |
| DK (1) | DK0965588T3 (pt) |
| ES (1) | ES2213991T3 (pt) |
| FR (1) | FR2780056B1 (pt) |
| HU (1) | HU225621B1 (pt) |
| PT (1) | PT965588E (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5981747B2 (ja) * | 2012-03-28 | 2016-08-31 | 東ソー・ファインケム株式会社 | アザディールス−アルダー反応用触媒、それを用いたテトラヒドロピリジン化合物の製造方法 |
| CA2982928A1 (en) | 2015-04-20 | 2016-10-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
| EP3298021B1 (en) | 2015-05-18 | 2019-05-01 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs having increased bioavailability |
| US10568887B2 (en) | 2015-08-03 | 2020-02-25 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CN110234659A (zh) | 2016-12-19 | 2019-09-13 | 特雷罗药物股份有限公司 | 用于敏感性分析的分析肽和方法 |
| US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
| KR20210099066A (ko) | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2338043A1 (fr) * | 1976-01-13 | 1977-08-12 | Delmar Chem | Derives de 4-arylpiperidine et procedes de production |
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| US6268499B1 (en) * | 1998-08-10 | 2001-07-31 | Hoffman-La Roche Inc. | Process and intermediates for preparation of substituted piperidine-epoxides |
-
1998
- 1998-06-18 FR FR9807677A patent/FR2780056B1/fr not_active Expired - Lifetime
-
1999
- 1999-06-15 CA CA002275192A patent/CA2275192C/fr not_active Expired - Lifetime
- 1999-06-16 JP JP16964099A patent/JP4538114B2/ja not_active Expired - Lifetime
- 1999-06-16 US US09/334,776 patent/US6136981A/en not_active Expired - Lifetime
- 1999-06-17 AT AT99401497T patent/ATE261432T1/de active
- 1999-06-17 EP EP99401497A patent/EP0965588B1/fr not_active Expired - Lifetime
- 1999-06-17 PT PT99401497T patent/PT965588E/pt unknown
- 1999-06-17 DE DE69915413T patent/DE69915413T2/de not_active Expired - Lifetime
- 1999-06-17 HU HU9902040A patent/HU225621B1/hu unknown
- 1999-06-17 ES ES99401497T patent/ES2213991T3/es not_active Expired - Lifetime
- 1999-06-17 DK DK99401497T patent/DK0965588T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2780056B1 (fr) | 2000-08-04 |
| ATE261432T1 (de) | 2004-03-15 |
| CA2275192C (fr) | 2008-12-30 |
| HU225621B1 (en) | 2007-05-02 |
| DE69915413D1 (de) | 2004-04-15 |
| ES2213991T3 (es) | 2004-09-01 |
| HUP9902040A2 (hu) | 2001-11-28 |
| HU9902040D0 (en) | 1999-08-30 |
| DK0965588T3 (da) | 2004-06-21 |
| CA2275192A1 (fr) | 1999-12-18 |
| DE69915413T2 (de) | 2004-08-19 |
| JP4538114B2 (ja) | 2010-09-08 |
| FR2780056A1 (fr) | 1999-12-24 |
| EP0965588B1 (fr) | 2004-03-10 |
| US6136981A (en) | 2000-10-24 |
| EP0965588A1 (fr) | 1999-12-22 |
| JP2000026418A (ja) | 2000-01-25 |
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