ATE103598T1 - Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem. - Google Patents
Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem.Info
- Publication number
- ATE103598T1 ATE103598T1 AT89113136T AT89113136T ATE103598T1 AT E103598 T1 ATE103598 T1 AT E103598T1 AT 89113136 T AT89113136 T AT 89113136T AT 89113136 T AT89113136 T AT 89113136T AT E103598 T1 ATE103598 T1 AT E103598T1
- Authority
- AT
- Austria
- Prior art keywords
- diltiazem
- synthesis
- preparation
- intermediate products
- dimethylaminoethanol
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
- 229960004166 diltiazem Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8821479A IT1226301B (it) | 1988-07-26 | 1988-07-26 | Processo per la preparazione di intermedi per la sintesi del diltiazem. |
| EP89113136A EP0355395B1 (de) | 1988-07-26 | 1989-07-18 | Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE103598T1 true ATE103598T1 (de) | 1994-04-15 |
Family
ID=11182442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89113136T ATE103598T1 (de) | 1988-07-26 | 1989-07-18 | Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4937334A (de) |
| EP (1) | EP0355395B1 (de) |
| JP (1) | JP3101819B2 (de) |
| AT (1) | ATE103598T1 (de) |
| DE (1) | DE68914211T2 (de) |
| ES (1) | ES2061819T3 (de) |
| IT (1) | IT1226301B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1244878B (it) * | 1990-12-11 | 1994-09-12 | Lusochimica Spa | Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato |
| TW438787B (en) | 1997-02-27 | 2001-06-07 | Tanabe Seiyaku Co | Process for preparing optically active trans-3-substituted glycidic acid ester |
| FR3033701B1 (fr) | 2015-03-19 | 2021-01-15 | Univ Claude Bernard Lyon | Nouvelles compositions antivirales pour le traitement de la grippe |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| JPS5899471A (ja) * | 1981-12-07 | 1983-06-13 | Tanabe Seiyaku Co Ltd | ベンゾチアゼピン誘導体の新規製造法 |
| US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
| HU195795B (en) * | 1985-11-06 | 1988-07-28 | Richter Gedeon Vegyeszet | Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one |
-
1988
- 1988-07-26 IT IT8821479A patent/IT1226301B/it active
-
1989
- 1989-07-18 DE DE68914211T patent/DE68914211T2/de not_active Expired - Fee Related
- 1989-07-18 ES ES89113136T patent/ES2061819T3/es not_active Expired - Lifetime
- 1989-07-18 EP EP89113136A patent/EP0355395B1/de not_active Expired - Lifetime
- 1989-07-18 AT AT89113136T patent/ATE103598T1/de not_active IP Right Cessation
- 1989-07-25 US US07/384,730 patent/US4937334A/en not_active Expired - Lifetime
- 1989-07-26 JP JP01193818A patent/JP3101819B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1226301B (it) | 1990-12-27 |
| US4937334A (en) | 1990-06-26 |
| DE68914211D1 (de) | 1994-05-05 |
| DE68914211T2 (de) | 1994-07-07 |
| JPH0278673A (ja) | 1990-03-19 |
| EP0355395A1 (de) | 1990-02-28 |
| EP0355395B1 (de) | 1994-03-30 |
| ES2061819T3 (es) | 1994-12-16 |
| IT8821479A0 (it) | 1988-07-26 |
| JP3101819B2 (ja) | 2000-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |