PT94846A - Processo de preparacao de 11,15-diacilesterprostaglandinas redutoras da pressao intra-ocular e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de 11,15-diacilesterprostaglandinas redutoras da pressao intra-ocular e de composicoes farmaceuticas que os contem Download PDF

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Publication number
PT94846A
PT94846A PT94846A PT9484690A PT94846A PT 94846 A PT94846 A PT 94846A PT 94846 A PT94846 A PT 94846A PT 9484690 A PT9484690 A PT 9484690A PT 94846 A PT94846 A PT 94846A
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PT
Portugal
Prior art keywords
compound
groups
formula
process according
bonds
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Application number
PT94846A
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English (en)
Portuguese (pt)
Inventor
Ming Fai Chan
David Frederick Woodward
Original Assignee
Allergan Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Allergan Pharma filed Critical Allergan Pharma
Publication of PT94846A publication Critical patent/PT94846A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT94846A 1989-07-27 1990-07-27 Processo de preparacao de 11,15-diacilesterprostaglandinas redutoras da pressao intra-ocular e de composicoes farmaceuticas que os contem PT94846A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/385,645 US4994274A (en) 1989-07-27 1989-07-27 Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using

Publications (1)

Publication Number Publication Date
PT94846A true PT94846A (pt) 1991-03-20

Family

ID=23522284

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94846A PT94846A (pt) 1989-07-27 1990-07-27 Processo de preparacao de 11,15-diacilesterprostaglandinas redutoras da pressao intra-ocular e de composicoes farmaceuticas que os contem

Country Status (14)

Country Link
US (1) US4994274A (oth)
EP (1) EP0410786A1 (oth)
JP (1) JPH0358929A (oth)
KR (1) KR910002448A (oth)
CN (1) CN1048980A (oth)
AU (1) AU641412B2 (oth)
CA (1) CA2020252A1 (oth)
HU (1) HU207847B (oth)
IE (1) IE902723A1 (oth)
IL (1) IL94907A0 (oth)
PH (1) PH26580A (oth)
PT (1) PT94846A (oth)
TW (1) TW197418B (oth)
ZA (1) ZA905230B (oth)

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US5312842A (en) * 1992-10-30 1994-05-17 Allergan, Inc. Cyclopentane heptenylsulfinylalkyl and heptanylsulfinylalkyl-2-aliphatic or aryl aliphatic derivatives
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
US5387608A (en) * 1993-08-17 1995-02-07 Allergan, Inc. Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl sulfonamidomethyl and derivatives thereof as therapeutic agents
US5476872A (en) * 1993-10-18 1995-12-19 Allergan, Inc. 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
US5741812A (en) * 1993-12-28 1998-04-21 Allergan Thromboxane ligands without blood clotting side effects
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US5416106A (en) * 1993-12-28 1995-05-16 Allergan, Inc. 7-[carboxyalkyl or alkenyl]-6-[alkyl or alkenyl]3-oxo-2,4-dioxobicyclo-[3.2.1] octane and derivatives thereof
US6462077B1 (en) 1993-12-28 2002-10-08 Allergan, Inc. Thromboxane ligands without blood clotting side effects
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US5741810A (en) 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
US5658897A (en) * 1996-04-08 1997-08-19 Allergan Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents
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US5877211A (en) * 1997-11-21 1999-03-02 Allergan EP2 receptor agonists as neuroprotective agents for the eye
US6248783B1 (en) 2000-09-20 2001-06-19 Allergan Sales, Inc. Cyclopentane 1-hydroxy alkyl or alkenyl-2-one or 2-hydroxy derivatives as therapeutic agents
US6291522B1 (en) 2000-09-27 2001-09-18 Allergan Sales, Inc. Cyclopentane heptan(ENE)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents
US6376533B1 (en) 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6586462B2 (en) 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6531504B2 (en) 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
US6476064B1 (en) 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents
US7872045B2 (en) * 2001-06-14 2011-01-18 Allergan, Inc. Combination therapy for glaucoma treatment
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ES2246419T3 (es) 2001-11-05 2006-02-16 Allergan, Inc. Analogos de omega-cicloalquil-17-heteroaril-prostaglandina e2 como agonistas del receptor ep-2.
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6875787B2 (en) 2003-02-11 2005-04-05 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
AU2004211936B2 (en) * 2003-02-11 2008-09-11 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
US7855226B2 (en) 2003-02-11 2010-12-21 Allergan, Inc. Treatment of inflammatory bowel disease
US6734206B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6734201B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
US7326716B2 (en) * 2003-06-06 2008-02-05 Allergan, Inc. Treatment of inflammatory bowel disease
US6977260B2 (en) * 2004-01-22 2005-12-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US6747037B1 (en) 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
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US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US7015243B2 (en) 2003-08-28 2006-03-21 Allergan, Inc. Cyclohexyl prostaglandin analogs as EP4-receptor agonists
US7235586B2 (en) * 2003-09-09 2007-06-26 Allergan, Inc. Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents
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US7169807B2 (en) * 2004-04-09 2007-01-30 Allergan, Inc. 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7326698B2 (en) * 2004-07-02 2008-02-05 Allergan, Inc. Prostaglandin analogs
US7183310B2 (en) * 2004-08-10 2007-02-27 Allergan, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
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US7906552B2 (en) * 2004-08-10 2011-03-15 Allergan, Inc. Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
WO2010102078A1 (en) 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
KR20110008263A (ko) * 2008-04-24 2011-01-26 알러간, 인코포레이티드 치료제로서의 치환된 감마 락탐
US20110136872A1 (en) * 2009-12-09 2011-06-09 Burk Robert M Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
MX2012007397A (es) 2009-12-22 2012-08-15 Allergan Inc Composiciones y metodos para reducir la presion intraocular.
JP6014033B2 (ja) 2010-07-29 2016-10-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 防腐剤無添加ビマトプロストおよびチモロール溶液
US9061034B2 (en) 2010-07-29 2015-06-23 Allergan, Inc. Preservative free bimatoprost and timolol solutions
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Also Published As

Publication number Publication date
EP0410786A1 (en) 1991-01-30
US4994274A (en) 1991-02-19
KR910002448A (ko) 1991-02-25
PH26580A (en) 1992-08-19
TW197418B (oth) 1993-01-01
IE902723A1 (en) 1991-02-27
HU207847B (en) 1993-06-28
CA2020252A1 (en) 1991-01-28
HU904670D0 (en) 1991-01-28
ZA905230B (en) 1991-03-27
AU641412B2 (en) 1993-09-23
IL94907A0 (en) 1991-04-15
AU5979290A (en) 1991-01-31
CN1048980A (zh) 1991-02-06
JPH0358929A (ja) 1991-03-14
HUT54499A (en) 1991-03-28

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Effective date: 19901024

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Effective date: 19961126