PT90248A - Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1 - Google Patents

Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1

Info

Publication number
PT90248A
PT90248A PT90248A PT9024889A PT90248A PT 90248 A PT90248 A PT 90248A PT 90248 A PT90248 A PT 90248A PT 9024889 A PT9024889 A PT 9024889A PT 90248 A PT90248 A PT 90248A
Authority
PT
Portugal
Prior art keywords
oxindole
carboxamides
substituted
mammal
interleukin
Prior art date
Application number
PT90248A
Other languages
English (en)
Other versions
PT90248B (pt
Inventor
Ivan George Otterness
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT90248A publication Critical patent/PT90248A/pt
Publication of PT90248B publication Critical patent/PT90248B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
PT90248A 1988-04-13 1989-04-11 Metodo para a inibicao da interleucina-1 num mamifero PT90248B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/181,131 US4861794A (en) 1988-04-13 1988-04-13 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis

Publications (2)

Publication Number Publication Date
PT90248A true PT90248A (pt) 1989-11-10
PT90248B PT90248B (pt) 1994-11-30

Family

ID=22663029

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90248A PT90248B (pt) 1988-04-13 1989-04-11 Metodo para a inibicao da interleucina-1 num mamifero

Country Status (17)

Country Link
US (1) US4861794A (pt)
EP (1) EP0337627B1 (pt)
JP (1) JPH01305028A (pt)
KR (1) KR920002327B1 (pt)
AT (1) ATE89724T1 (pt)
AU (1) AU601325B2 (pt)
CA (1) CA1324761C (pt)
DE (1) DE68906706T2 (pt)
DK (1) DK174389A (pt)
HU (1) HU203970B (pt)
IE (1) IE63458B1 (pt)
IL (1) IL89871A (pt)
MY (1) MY103871A (pt)
NZ (1) NZ228711A (pt)
PH (1) PH25884A (pt)
PT (1) PT90248B (pt)
ZA (1) ZA892623B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
DE69221794T2 (de) * 1991-01-21 1998-03-19 Shionogi Seiyaku Kk 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
WO1992016226A1 (en) * 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) * 1985-07-16 1985-08-21 Cellena Cell Eng Ag Compositions containing melatonin/homologues
AU6898287A (en) * 1986-01-30 1987-08-25 University Of Utah, The Treatment of bone loss
US4677132A (en) * 1986-03-12 1987-06-30 American Home Products Corporation Inhibition of bone resorption by etodolac
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

Also Published As

Publication number Publication date
DE68906706T2 (de) 1993-09-16
DK174389A (da) 1989-10-16
KR890015739A (ko) 1989-11-25
AU601325B2 (en) 1990-09-06
PH25884A (en) 1991-12-02
NZ228711A (en) 1997-02-24
KR920002327B1 (ko) 1992-03-21
EP0337627A3 (en) 1991-01-02
IE63458B1 (en) 1995-04-19
AU3271189A (en) 1989-10-19
DK174389D0 (da) 1989-04-12
US4861794A (en) 1989-08-29
IE891172L (en) 1989-10-13
EP0337627A2 (en) 1989-10-18
ATE89724T1 (de) 1993-06-15
MY103871A (en) 1993-09-30
CA1324761C (en) 1993-11-30
JPH01305028A (ja) 1989-12-08
EP0337627B1 (en) 1993-05-26
IL89871A (en) 1994-11-11
PT90248B (pt) 1994-11-30
DE68906706D1 (de) 1993-07-01
ZA892623B (en) 1990-11-28
HU203970B (en) 1991-11-28
IL89871A0 (en) 1989-12-15
HUT52377A (en) 1990-07-28

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940526

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20001130