PT89836A - Processo para a preparacao de amlodipina "r" e "s" - Google Patents

Processo para a preparacao de amlodipina "r" e "s"

Info

Publication number
PT89836A
PT89836A PT89836A PT8983689A PT89836A PT 89836 A PT89836 A PT 89836A PT 89836 A PT89836 A PT 89836A PT 8983689 A PT8983689 A PT 8983689A PT 89836 A PT89836 A PT 89836A
Authority
PT
Portugal
Prior art keywords
amlodipin
preparing
preparing amlodipin
Prior art date
Application number
PT89836A
Other languages
English (en)
Inventor
John Edmund Arrowsmith
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PT89836A publication Critical patent/PT89836A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT89836A 1988-02-27 1989-02-24 Processo para a preparacao de amlodipina "r" e "s" PT89836A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804630A GB8804630D0 (en) 1988-02-27 1988-02-27 Preparation of r-& s-amlodipine

Publications (1)

Publication Number Publication Date
PT89836A true PT89836A (pt) 1989-10-04

Family

ID=10632492

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89836A PT89836A (pt) 1988-02-27 1989-02-24 Processo para a preparacao de amlodipina "r" e "s"

Country Status (6)

Country Link
EP (1) EP0331315A3 (pt)
JP (1) JPH01254661A (pt)
DK (1) DK86889A (pt)
FI (1) FI890888A (pt)
GB (1) GB8804630D0 (pt)
PT (1) PT89836A (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233974A (en) * 1989-07-22 1991-01-23 Pfizer Ltd Dihydropyridine antiinflammatory agent
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
JPH07501547A (ja) * 1991-11-26 1995-02-16 セプラコア，インコーポレーテッド 光学的に純粋な（−）アムロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
EP1614420A3 (en) * 1992-11-25 2006-04-19 Sepracor Inc. Treatment of hypertension, angina and other disorders using (-) amlodipine
GB9317773D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
CN1100038C (zh) * 2000-02-21 2003-01-29 张喜田 氨氯地平对映体的拆分
KR100476636B1 (ko) * 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
CN1231469C (zh) 2003-12-05 2005-12-14 石家庄制药集团欧意药业有限公司 一种光学活性氨氯地平的拆分方法
US20060035940A1 (en) * 2004-03-16 2006-02-16 Sepracor Inc. (S)-Amlodipine malate
WO2006043148A1 (en) 2004-10-20 2006-04-27 Emcure Pharmaceuticals Limited Process for producing enantiomer of amlodipine in high optical purity
WO2006059886A1 (en) 2004-12-02 2006-06-08 Sk Chemicals, Co., Ltd. Optical resolution method of amlodipine
HUP0500570A3 (en) * 2005-06-08 2008-03-28 Richter Gedeon Nyrt Process for the preparation of (s)-(-)-amlodipine
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
KR100828883B1 (ko) 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
CN116332832A (zh) * 2023-03-29 2023-06-27 安徽美致诚药业有限公司 一种马来酸左旋氨氯地平无定型晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
EP0353238A1 (de) * 1987-03-27 1990-02-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue zwischenprodukte und verfahren
JPS63295560A (ja) * 1987-05-27 1988-12-01 Taisho Pharmaceut Co Ltd 光学活性１，４−ジヒドロピリジン化合物

Also Published As

Publication number Publication date
EP0331315A2 (en) 1989-09-06
FI890888A (fi) 1989-08-28
FI890888A0 (fi) 1989-02-24
DK86889A (da) 1989-08-28
DK86889D0 (da) 1989-02-24
JPH01254661A (ja) 1989-10-11
EP0331315A3 (en) 1990-08-22
GB8804630D0 (en) 1988-03-30

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Legal Events

Date Code Title Description
FC3A Refusal

Effective date: 19931011