PT85506A - Process for preparing sulfonamides derived from piperazine useful as antiarrhythmic agents - Google Patents

Process for preparing sulfonamides derived from piperazine useful as antiarrhythmic agents

Info

Publication number
PT85506A
PT85506A PT85506A PT8550687A PT85506A PT 85506 A PT85506 A PT 85506A PT 85506 A PT85506 A PT 85506A PT 8550687 A PT8550687 A PT 8550687A PT 85506 A PT85506 A PT 85506A
Authority
PT
Portugal
Prior art keywords
antiarrhythmic agents
sulfonamides derived
preparing sulfonamides
piperazine
useful
Prior art date
Application number
PT85506A
Other languages
English (en)
Other versions
PT85506B (pt
Inventor
Peter Edward Cross
John Edward Glyn Kemp
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PT85506A publication Critical patent/PT85506A/pt
Publication of PT85506B publication Critical patent/PT85506B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
PT85506A 1986-08-09 1987-08-07 Processo para a preparacaode sulfonamidas derivadas da piperazina, uteis como agentes anti-arritmicos PT85506B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619472A GB8619472D0 (en) 1986-08-09 1986-08-09 Anti-arrhythmia agents

Publications (2)

Publication Number Publication Date
PT85506A true PT85506A (en) 1987-09-01
PT85506B PT85506B (pt) 1990-06-29

Family

ID=10602501

Family Applications (1)

Application Number Title Priority Date Filing Date
PT85506A PT85506B (pt) 1986-08-09 1987-08-07 Processo para a preparacaode sulfonamidas derivadas da piperazina, uteis como agentes anti-arritmicos

Country Status (11)

Country Link
US (1) US4797401A (pt)
EP (1) EP0257864B1 (pt)
JP (1) JPS6344572A (pt)
AT (1) ATE58898T1 (pt)
DE (1) DE3766570D1 (pt)
DK (1) DK169129B1 (pt)
ES (1) ES2031509T3 (pt)
GB (1) GB8619472D0 (pt)
GR (1) GR3001231T3 (pt)
IE (1) IE60030B1 (pt)
PT (1) PT85506B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
DE3933163A1 (de) * 1988-10-27 1990-05-03 Toyoda Gosei Kk Zylindrische daempfungsbuchse
US5033872A (en) * 1989-09-06 1991-07-23 Toyoda Gosei Co., Ltd. Bushing
US5051422A (en) * 1989-09-15 1991-09-24 Schering Ag 2-substituted-1(4)-aryl piperazines and the process for their preparation
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
CN110156729B (zh) * 2019-05-14 2022-12-06 浙江大学 一种苯基哌嗪类ube2f小分子抑制剂及其合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997166A (en) * 1961-07-14 1965-07-07 May & Baker Ltd N-phenylpiperazine derivatives
BE654017A (pt) * 1963-04-04 1965-04-06
ES291187A1 (es) * 1963-04-04 1964-01-16 American Cyanamid Co Un procedimiento para preparar piperazinas sustituidas
US3331845A (en) * 1963-04-04 1967-07-18 American Cyanamid Co 1-substituted-4-substituted amino alkylene piperazines
US3822266A (en) * 1968-12-24 1974-07-02 Hoffmann La Roche (3-(1-piperazinyl)-2-hydroxy-propoxy)acetanilides
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
US3764602A (en) * 1969-12-04 1973-10-09 Hoffmann La Roche 3-(4-phenyl-1 2, 6 di keto piperazinyl)-2-hydroxy-propoxy)-aniline
US3930004A (en) * 1970-11-10 1975-12-30 Pfizer Method of using phenoxypropanolpiperazine compounds to lower blood pressure
GB1361863A (en) * 1972-09-25 1974-07-30 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2515648A1 (fr) * 1981-11-03 1983-05-06 Cortial Nouvelles (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof

Also Published As

Publication number Publication date
EP0257864B1 (en) 1990-12-05
DK411687A (da) 1988-04-28
US4797401A (en) 1989-01-10
GR3001231T3 (en) 1992-07-30
DK411687D0 (da) 1987-08-07
IE872120L (en) 1988-02-09
GB8619472D0 (en) 1986-09-17
DK169129B1 (da) 1994-08-22
PT85506B (pt) 1990-06-29
ATE58898T1 (de) 1990-12-15
EP0257864A1 (en) 1988-03-02
JPS6344572A (ja) 1988-02-25
ES2031509T3 (es) 1992-12-16
JPH0567150B2 (pt) 1993-09-24
IE60030B1 (en) 1994-05-18
DE3766570D1 (de) 1991-01-17

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Legal Events

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MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040630