PT84294B - Processo de preparacao de anilinas substituidas e de composicoes farmaceuticas contendo-as - Google Patents

Processo de preparacao de anilinas substituidas e de composicoes farmaceuticas contendo-as

Info

Publication number
PT84294B
PT84294B PT84294A PT8429487A PT84294B PT 84294 B PT84294 B PT 84294B PT 84294 A PT84294 A PT 84294A PT 8429487 A PT8429487 A PT 8429487A PT 84294 B PT84294 B PT 84294B
Authority
PT
Portugal
Prior art keywords
anilines
replaced
preparation
composition
pharmaceutical compositions
Prior art date
Application number
PT84294A
Other languages
English (en)
Other versions
PT84294A (en
Inventor
Harald Maschler
Original Assignee
Beecham Wuelfing Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Wuelfing Gmbh & Co Kg filed Critical Beecham Wuelfing Gmbh & Co Kg
Publication of PT84294A publication Critical patent/PT84294A/pt
Publication of PT84294B publication Critical patent/PT84294B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT84294A 1986-02-15 1987-02-13 Processo de preparacao de anilinas substituidas e de composicoes farmaceuticas contendo-as PT84294B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868603765A GB8603765D0 (en) 1986-02-15 1986-02-15 Compounds

Publications (2)

Publication Number Publication Date
PT84294A PT84294A (en) 1987-03-01
PT84294B true PT84294B (pt) 1989-09-14

Family

ID=10593121

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84294A PT84294B (pt) 1986-02-15 1987-02-13 Processo de preparacao de anilinas substituidas e de composicoes farmaceuticas contendo-as

Country Status (11)

Country Link
US (1) US5494933A (pt)
EP (1) EP0233762B1 (pt)
JP (2) JP2543690B2 (pt)
AU (1) AU6877987A (pt)
DE (1) DE3781174T2 (pt)
DK (1) DK75587A (pt)
GB (1) GB8603765D0 (pt)
HK (1) HK196796A (pt)
NZ (1) NZ219267A (pt)
PT (1) PT84294B (pt)
ZA (1) ZA871062B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
IT1229214B (it) * 1989-03-31 1991-07-25 Alfa Wassermann S P A Contrada Processo per la sintesi della n metil 3,4 dimetossifeniletilamina
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
CA2094724A1 (en) * 1990-10-25 1992-04-26 Hiromu Hara Tri(lower alkoxy) benzene derivatives
FR2691064B3 (fr) * 1992-05-14 1996-01-12 Beecham Laboratoires Nouveau medicament pour le traitement de l'arythmie.
FR2694557B1 (fr) * 1992-08-05 1994-09-23 Synthelabo Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique.
FR2710059A1 (fr) * 1993-09-13 1995-03-24 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
FR2710065B1 (fr) * 1993-09-13 1996-10-04 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
TW281667B (pt) * 1994-02-03 1996-07-21 Synthelabo
FR2715652B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de N-[3-[(2,3-dihydro-1H-inden-2-yl)alkyl-amino]propyl]-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide leur préparation et leur application en thérapeutique.
AU1949795A (en) * 1995-03-08 1996-09-23 Smithkline Beecham Laboratoires Pharmaceutiques Heterocyclycarboxamides and other compounds for the treatment of the cardiac arrhythmias
GB9513756D0 (en) * 1995-07-06 1995-09-06 Smithkline Beecham Plc Novel process & compounds
AR067584A1 (es) * 2007-07-20 2009-10-14 Hoffmann La Roche Un conjugado de un anticuerpo contra la cd4 y peptidos antifusogenicos

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670374A (en) * 1952-05-17 1954-02-23 Searle & Co N-dialkylaminoalkyl aminobenzanilides and n-aralkylaminobenzamides and their salts
GB862467A (en) * 1958-03-14 1961-03-08 American Cyanamid Co N-substituted anilides and acid addition salts thereof
US2944081A (en) * 1958-03-14 1960-07-05 American Cyanamid Co Diphenyl alkylenediamines and methods of preparing the same
FR965M (pt) * 1960-02-04 1961-11-27
US3049552A (en) * 1960-11-03 1962-08-14 Merck & Co Inc Furfuryl isocyanates
US3049562A (en) * 1961-03-09 1962-08-14 American Cyanamid Co 1-(aralkyl, lower alkylamino lower alkyl), 1-phenyl, 3, 3-dilower alkylureas
GB1004071A (en) * 1961-07-03 1965-09-08 Council Scient Ind Res Substituted ª‰-phenethylamines and a process for the production thereof
DE1170961B (de) * 1962-04-19 1964-05-27 Roehm & Haas Gmbh Verfahren zur Herstellung von N-(N'-Methyl-N'-ª‰-phenaethylamino-tert.-butyl)-propionaniliden
GB1050132A (pt) 1963-03-01
US3196172A (en) * 1963-05-20 1965-07-20 American Cyanamid Co Trifluoromethylphenylalkylenediamines
US3365453A (en) 1963-10-28 1968-01-23 Sterling Drug Inc 1-phenyl-4-lower-alkyl-2-piperazinones
GB1232787A (pt) * 1967-08-08 1971-05-19
US3528990A (en) 1967-11-14 1970-09-15 Colgate Palmolive Co 1-aminoalkyl derivatives of 2,1-benzisothiazoline
US3789073A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Adamantylalkylaminoalkyl benzamides
CH586784B5 (pt) 1970-05-16 1977-04-15 Bayer Ag
US4322434A (en) * 1979-05-04 1982-03-30 Schering Corporation N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
DE3242344A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds
DE3428526A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminoalkohole, verfahren zu deren herstellung sowie diese verbindung enthaltende arzneimittel
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
JPH0328137A (ja) * 1989-06-23 1991-02-06 Nippon Sheet Glass Co Ltd 平坦な面を有するガラス容器成形方法

Also Published As

Publication number Publication date
DK75587D0 (da) 1987-02-13
HK196796A (en) 1996-11-01
DE3781174T2 (de) 1993-02-11
PT84294A (en) 1987-03-01
JPH08268983A (ja) 1996-10-15
EP0233762A2 (en) 1987-08-26
EP0233762A3 (en) 1989-05-10
JPS62240653A (ja) 1987-10-21
AU6877987A (en) 1987-08-20
EP0233762B1 (en) 1992-08-19
US5494933A (en) 1996-02-27
DK75587A (da) 1987-08-16
JP2663258B2 (ja) 1997-10-15
NZ219267A (en) 1990-11-27
ZA871062B (en) 1988-10-26
GB8603765D0 (en) 1986-03-19
JP2543690B2 (ja) 1996-10-16
DE3781174D1 (de) 1992-09-24

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19910806