PT79930B - Process for stabilizing of cinnamic aldehyde-containing flavors for dentifrice formulations with terpenes and sesquiterpenes and propylene glycol and dipropylene glycol - Google Patents

Process for stabilizing of cinnamic aldehyde-containing flavors for dentifrice formulations with terpenes and sesquiterpenes and propylene glycol and dipropylene glycol Download PDF

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Publication number
PT79930B
PT79930B PT79930A PT7993085A PT79930B PT 79930 B PT79930 B PT 79930B PT 79930 A PT79930 A PT 79930A PT 7993085 A PT7993085 A PT 7993085A PT 79930 B PT79930 B PT 79930B
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Portugal
Prior art keywords
process according
dentifrice
weight
white
cinnamic aldehyde
Prior art date
Application number
PT79930A
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Portuguese (pt)
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PT79930A (en
Inventor
Robert J Steltenkamp
Miriam L Douglass
Gerard E Natarelli
Original Assignee
Colgate Palmolive Co
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Priority claimed from US06/578,457 external-priority patent/US4562064A/en
Priority claimed from US06/578,942 external-priority patent/US4547361A/en
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of PT79930A publication Critical patent/PT79930A/en
Publication of PT79930B publication Critical patent/PT79930B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Dentifrices with stability against discolouration upon aging contain as flavouring agent cinnamic aldehyde or citral and 0.1-5% of (1) a terpene or sesquiterpene colour stabilizer with trisubstituted double bonds e.g. limonene, ocimene, caryophyllene, citrus oils, clove sesquiterpenes, myrcene, terpene derivatives, citronellyl acetate or (2) propylene glycol or dipropylene glycol in a dental vehicle of pH below 8.5 and free of oxidizing agents.

Description

Descrição Detalhada do Invento

Os exemplos seguintes são mais ilustra^ tivos da natureza do presente invento, mas ê evidente que o invento não ê limitado por eles. As composições são prepa radas de forma usual e todas as quantidades e proporções peles referidas e nas reivindicações anexas são em peso, a não ser que indicado de outra maneira.

0 ingrediente aromatizante é uma composição aromatizante contendo citral ou aldeído cinâmico, â qual se adiciona um terpeno ou sesquiterpeno (Quadros 4 a 7) ou propileno glicol ou dipropileno glicol, conforme se descreve nas experiencias que se seguem aos exemplos (Quadro 8).

1

-34Exemplo 1

Creme dentifrico

Ingredientes A B I I gl icerina 22,00 ' 22,00 monofluorofosfato de sódio 0,76 0,8 carboximetilcelulose de sódio 1 ,00 1,0 pirofosfato de tetrassódico 0,25 0,2 Ingredientes A B I T sacarina sódica 0,20 0,2 benzoato de sódio 0,50 0,5 ãgua desionizada 24,49 24,5 Di-hidrato de fosfato dicálcico 48,76 48,8 Agente aromatizante 0,84 0,8 1auri1-sulfato de sódio 1 ,20 1,2 PH 6,9-7,1 6,9-7,1

Exemplo 2

Creme dentifrico

Ingredientes A % B % glicerina 10,00 10,0 monofluorofosfato de sódio 0,76 0,8 carboximetilcelulose de sódio 1,10 1,1 benzoato de sódio 0,50 0,5 sacarina sódica 0,20 0,2 sorbitol (solução a 70%) 17,00 17,0 Ingredientes A % B % Agua desionizada 22,19 22,2 dióxido de titânio 0,40 0,4 metafosfato de sódio insolúvel 39,35 39,3 alumina hidratada 1 ,00 1,0 fosfato dicálcio anidro 5,00 5,0 agente aromatizante 1,00 1,0 lauri1-sulfato de sódio 1 ,50 1,5 6,15 pH

Exemplo 3

Creme dentifrico em gel

Ingredientes %

água desionizada 3,00

sacarina sódica 0,30

monofluorofosfato de sódio 0,76

glicerina 25,00

carboximetilcelulose de sódio 0,35

benzoato de sódio 0,50

dióxido de titânio 0,01

Ingredientes %

sorbitol (solução a 7o%) 41,53

carbowax 600 (PEG 12) 3,00

agente corante 0,20

alumino-si1icato de sódio 18,00

(silica contendo alumina combinada)

Aerogel de silica coloidal

5,50

-37-

agente aromatizante

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0,65

1,20

Exemplo 4

Pasta dentifrica

Ingredientes % gl icerina 25,00 carboximeti1 celulose de sódio 1 ,40 benzoato de sódio 0,50 sacarina sódica 0,20 monof1uorofosfato de sódio 0,76 água desionizada 35,44

dióxido de titânio

0,40

Ingredientes

óxido de alumínio 10,00

silica 24,00

agente aromatizante 1,10

lauril-sulfato de sódio 1,20

pH 6,2 + 0,5

Exemplo 5

Repete-se o Exemplo 4, com a excepção de se aumentar o lauril-sulfato de sódio para 1,5% e de se rectificar o teor de água em conformidade.

Exemplo 6

Solução para lavagens da boca

Ingredientes %

álcool etílico 15 - 30

glicerina 10 - 15

"Polysocbate" 801· 2-3

"Poloxamer" 338^ 0 - 0,5

Cloreto de benzetónio 0 - 0,075

Composição aromatizante 0,1-0,5

âgua desionizada o restante

' Uma mistura de ésteres oleato de sorbitol e anidridos de sorbitol, consistindo no monoéster condensado com aproxi madamente 20 mol de óxido de etileno.

0 polímero em cadeia de polioxietileno polioxipropileno que corresponde à fórmula

H0(CHpCHpO) (-CH-CHpO) (CH?CH?O) H , χ , y z

ch3

em que x e z = 128, e y = 54.

Os níveis de aromatizante numa solução para lavagens da boca são geralmente inferiores aos de um creme dentifrico.

Exemplo 7

Pó dentifrico

Ingredientes A % % silicato de magnésio 7,00 7,0 sacarina de sódio 0,15 0,2 agente aromatizante 2,50 2,5 fosfato dicálcico anidro 88,35 88,3 1auri1-sulfato de sódio 2,00 2,0

Os níveis de aromatizante em pós dentifricos são geralmente superiores aos dos cremes dentífricos.

-41Exemplo 8

Creme dentrifico não-aquoso

Ingredientes %

Propileno glicol 43,4

Klucel GF1 (Hercules) 1,5

Sacarina sódica 0,2

Ti02 0,4

Di-hidrato de fosfato dicálcico 50,0

peroxidifosfato 3,0

lauri1-sulfato de sódio 1,5

pH 6,4

1 Hidroxipropilcelulose - um éter de propilenoglicol de celulose

-42Exemplo 9

Creme dentifrico aquoso

Ingredientes %

propileno glicol 22,0

monofluorofosfato de sódio 0,8

carboximetilcelulose de sódio 1,0

pirofosfato tetrassódico 0,2

sacarina sódica 0,2

benzoato de sódio 0,5

di-hidrato de fosfato dicãlcico 48,8

especiaria 10 0,9

1auri1-sulfato de sódio 1,2

Ti02 1,0

H20 q.b.

Os quadros seguintes apresentam resulta dos da descoloração dos cremes dentifricos do exemplo 1. com envelhecimento a 120°F (49°C) excepto quando especificado de outra maneira, tanto não aromátocos como contendo um agente aromatizante de aldeído cinâmico (AC) per se e com terpenos e sesquiterpenos especificos incluindo uma ligação dupla tri-substituida ou propileno glicol ou dipropilenoglicol para evitar ou reduzir a descoloração provocada pelo ingrediente de aldeído cinâmico os valores b indicados nos quadros representam o amarelecimento em cremes dentifricos, medido no reflectómetro de "Colorgard" e o valor A represen ta o aumento do amarelecimento da amostra não envelhecida e não aromatizada, que é o controlo zero b.

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Os quadros 4 a 7 inclusive revelam formulações contendo uma variedade de agentes aromatizantes incluindo aldeído cinâmico e citral, que amarelece com o envelhecimento, e a redução do referido amarelecimento pela adição de limoneno e outros terpenos e sesquiterpenos, caracterizados por ligações duplas tri-substituidas. A rectificação do pH para cerca de 6 e a adição de Ti02 fazem reduzir ainda mais o amarelecimento destas formulações com aromatizantes. E evidente que a detalhada descrição anterior ê simplesmente dada como forma de ilustração e podem-se fazer variações a ela, desde que não haja um afastamento do espirito do invento. 0 "Resumo" dado anteriormente destina-se simplesmente aos investigadores técnicos e não pretende ter qualquer peso no que respeita ao âmbito do invento.

Μ

1-56-

Detailed Description of the Invention

The following examples are more illustrative of the nature of the present invention, but it is clear that the invention is not limited thereto. The compositions are prepared in a customary manner and all the amounts and proportions of said skins and the appended claims are by weight, unless otherwise noted.

The flavoring ingredient is a flavoring composition containing citral or cinnamic aldehyde, to which is added a terpene or sesquiterpene (Tables 4 to 7) or propylene glycol or dipropylene glycol as described in the experiments that follow the examples (Table 8).

1

Example 1

Toothpaste

Ingredients THE B I I glicerin 22.00 ' 22.00 sodium monofluorophosphate 0.76 0.8 carboxymethylcellulose sodium 1.00 1.0 tetrasodium pyrophosphate 0.25 0.2 Ingredients THE B I T saccharin sodium 0.20 0.2 sodium benzoate 0.50 0.5 deionized water 24.49 24.5 Dicalcium phosphate dihydrate 48.76 48.8 Flavoring agent 0.84 0.8 Sodium hydrogen sulfate 1.20 1.2 PH 6.9-7.1 6.9-7.1

Example 2

Toothpaste

Ingredients THE % B % glycerin 10.00 10.0 sodium monofluorophosphate 0.76 0.8 carboxymethylcellulose sodium 1.10 1.1 sodium benzoate 0.50 0.5 saccharin sodium 0.20 0.2 sorbitol (70% solution) 17.00 17.0 Ingredients THE % B % Deionized water 22.19 22.2 titanium dioxide 0.40 0.4 insoluble sodium metaphosphate 39.35 39.3 hydrated alumina 1.00 1.0 anhydrous dicalcium phosphate 5.00 5.0 flavoring agent 1.00 1.0 sodium lauryl sulfate 1, 50 1.5 6.15 pH

Example 3

Gel toothpaste

Ingredients %

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saccharin sodium 0.30

sodium monofluorophosphate 0.76

glycerol 25.00

carboxymethylcellulose 0.35

sodium benzoate 0.50

titanium dioxide 0.01

Ingredients %

sorbitol (7% solution) 41.53

carbowax 600 (PEG 12) 3.00

coloring agent 0.20

sodium aluminum silicate 18.00

(silica containing combined alumina)

Colloidal silica airgel

5.50

-37-

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Toothpaste

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titanium dioxide

0.40

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silica 24.00

flavoring agent

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pH 6.2 + 0.5

Example 5

Example 4 is repeated except that the sodium lauryl sulfate is increased to 1.5% and the water content is rectified accordingly.

Example 6

Solution for mouth washes

Ingredients %

ethyl alcohol 15 - 30

glycerol 10-15

"Polysocbate" 80 1 · 2-3

&Quot; Poloxamer " 338

Benzethonium chloride 0 - 0.075

Flavoring composition 0.1-0.5

deionized water or the rest

A mixture of sorbitol oleate esters and sorbitol anhydrides, consisting of the monoester condensed with about 20 moles of ethylene oxide.

The polyoxyethylene polyoxypropylene chain polymer corresponding to formula

H0 (CHpCHpO) (-CH CHpO) (CH? CH? O) H, χ, yz

ch 3

where x and z = 128, and y = 54.

The levels of flavoring in a mouthwash solution are generally lower than that of a toothpaste.

Example 7

Tooth-powder

Ingredients THE % % magnesium silicate 7.00 7.0 sodium saccharin 0.15 0.2 flavoring agent 2.50 2.5 anhydrous dicalcium phosphate 88.35 88.3 Sodium hydrogen sulfate 2.00 2.0

Flavor levels in dentifrice powders are generally higher than in toothpastes.

Example 8

Non-aqueous toothpaste

Ingredients %

Propylene glycol 43.4

Klucel GF 1 (Hercules) 1.5

Saccharin Sodium 0.2

Ti0 2 0.4

Dicalcium phosphate dihydrate 50.0

peroxydiphosphate 3.0

sodium lauryl sulfate 1.5

pH 6.4

1 Hydroxypropylcellulose - a cellulose propylene glycol ether

Example 9

Aqueous dentifrice cream

Ingredients %

propylene glycol 22.0

sodium monofluorophosphate 0.8

sodium carboxymethylcellulose 1.0

tetrasodium pyrophosphate 0.2

saccharin sodium 0.2

sodium benzoate 0.5

diacetyl phosphate dihydrate 48.8

spice 10 0.9

Sodium 1α-1-sulfate

Ti0 2 1.0

H 2 0 qb

The following tables show results of discoloration of the dentifrice creams of Example 1 with aging at 120øF (49øC) except as otherwise specified, both non-aromatic and containing a cinnamic aldehyde (CA) flavoring agent per se and with specific terpenes and sesquiterpenes including a tri-substituted double bond or propylene glycol or dipropylene glycol to prevent or reduce discoloration caused by the cinnamic aldehyde ingredient, the values b indicated in the tables represent yellowing in dentifrice creams measured on the Colorgard reflectometer and the value A represents the increased yellowing of the unaged and unflavored sample, which is the zero control b.

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Tables 4 to 7 inclusive disclose formulations containing a variety of flavoring agents including cinnamic aldehyde and citral yellowing with aging, and reducing said yellowing by the addition of limonene and other terpenes and sesquiterpenes, characterized by tri-substituted double bonds. Rectification of the pH to about 6 and the addition of TiO 2 further reduce the yellowing of these flavored formulations. It is evident that the foregoing detailed description is simply given as an illustration, and variations may be made thereto, so long as there is no departure from the spirit of the invention. The "Summary" given above is intended simply for the technical investigators and is not intended to carry any weight with regard to the scope of the invention.

(I.e.

1-56-

Claims (27)

REIVINDICAÇÕES 1â. - Processo para a preparação de uma formulação dentifrica tendo melhoria de estabilidade relativamente â descoloração provocada pelo envelhecimento,cq racterizado por se fazer a adição de um aromatizante de aldej_ do insaturado seleccionado a partir do grupo formado por al deido cinâmico e citral, que tem tendência para descoloração com o envelhecimento, e de cerca de 0,1-5% em peso de1 â . A process for the preparation of a dentifrice formulation having improved stability with respect to discolouration caused by aging, characterized in that an unsaturated aldehyde flavorant selected from the group consisting of cinnamic acid and citral acid is added, which has a tendency for discolouration with aging, and from about 0.1-5% by weight of (1) pelo menos um terpeno ou sesquiterpeno contendo 1ig£ ções duplas tri-substituídas, como inibidor da descoloração, ou(1) at least one terpene or sesquiterpene containing tri-substituted double bonds, as discoloration inhibitor, or (2) propileno glicol, dipropileno glicol ou suas mistu ras, a um veículo dentário isento de agentes oxidantes e te£ do um pH inferior a 8,5.(2) propylene glycol, dipropylene glycol or mixtures thereof, to a dental vehicle free of oxidizing agents and having a pH below 8.5. 2â. - Processo de acordo com a reivindicação 1, caracterizado por o inibidor de descolora ção consistir em pelo menos um terpeno ou sesquiterpeno.2 â . 5. A process according to claim 1, wherein the disintegration inhibitor consists of at least one terpene or sesquiterpene. 35. - Processo de acordo com a reivindicação 2, caracterizado por o inibidor de descolora ção ser seleccionado a partir do grupo formado por limoneno e óleos essenciais ricos em sesquiterpenos de limoneno, ocimeno, cariofileno e cravo da india, mirceno, seus derivados terpeno e suas misturas.3 5 . The process according to claim 2, wherein the decolorizing inhibitor is selected from the group consisting of limonene and essential oils rich in sesquiterpenes of limonene, ocimene, caryophyllene and clove of India, myrcene, its terpene derivatives and mixtures thereof . 4ã. - Processo de acordo com a reivindicação 1, caracterizado por o inibidor de descolora ção consistir em propileno glicol, dipropileno glicol ou suas misturas.4 ã . 5. A process as claimed in claim 1, wherein the disintegration inhibitor consists of propylene glycol, dipropylene glycol or mixtures thereof. 55. - Processo de acordo com a reivindicação 1, caracterizado por o referido aromatizante consistir em cerca de 0,1-1% em peso, da formulação.5 5 . A process according to claim 1, characterized in that said flavoring consists of about 0.1-1% by weight of the formulation. 6â. - Processo de acordo com a reivindicação 2, caracterizado por a quantidade do referido aromatizante de aldeído relativamente ao terpeno se apresentar numa proporção em peso de 1:1.6 â . 2. A process according to claim 2, wherein the amount of said aldehyde flavorant relative to terpene is in a 1: 1 weight ratio. 7â. - Processo de acordo com a7 â . - Process according to the reivindicação 4, caracterizado por o inibidor de descoloração consistir em cerca de 10-45% em peso de formulação.Claim 4, characterized in that the discoloration inhibitor consists of about 10-45% by weight formulation. 89. - Processo de acordo com a reivindicação 4, caracterizado por o veículo dentário ser um creme dentífrico anidro.8 9 . 6. A composition according to claim 4, wherein the dental carrier is an anhydrous dentifrice cream. 9ã. - Processo de acordo com a reivindicação 4, caracterizado por o veículo dentário ser um creme dentífrico quoso.9 ã . 6. A composition according to claim 4, wherein the dental carrier is a quantilty dentifrice. 10â. - Processo de acordo com a reivindicação 1, caracterizado por o dentífrico ser um ve_í culo dentêrio com um pH de cerca de 5 a 7,5.10 â . 5. A composition according to claim 1, wherein the dentifrice is a toothpaste having a pH of about 5 to 7.5. 112. _ Processo de acordo com a reivindicação 10, caracterizado por o dentífrico ser um creme dentífrico estabilizado de côr branca.The method of claim 10, wherein the dentifrice is a white stabilized dentifrice cream. 122. _ Processo de acordo com122. Process according to a reivindicação 11, caracterizado por se adicionar ainda cer. ca de 0,5-1% em peso, de dióxido de titânio.Claim 11, characterized in that a further addition of cer. 0.5-1% by weight of titanium dioxide. 13â. _ Processo de acordo com13 â . Process according to a reivindicação 10, caracterizado por o dentífrico ser uma soluçãó para lavagem da boca de côr branca, estabilizada.Claim 10, characterized in that the dentifrice is a stabilized white mouthwash solution. 14â. - Processo de acordo com14 â . - Process according to a reivindicação 2, caracterizado por o creme dentífrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 1% de estabilizador de côr de limoneno.Claim 2, wherein the white dentifrice cream contains 1% cinnamic aldehyde flavorant and 1% limonene color stabilizer. 15a. - Processo de qcordo com15 a . - A process involving a reivindicação 2, caracterizado por o creme dentifrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 1% de estabilizador de côr de ocimeno.Claim 2, wherein the white dentifrice cream contains 1% cinnamic aldehyde flavoring and 1% oxyhemoglobin stabilizer. 16a. - Processo de acordo com16 a . - Process according to a reivindicação 2, caracterizado por o creme dentifrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 1% de estabilizador de côr de cariofileno.Claim 2, characterized in that the white dentifrice cream contains 1% cinnamic aldehyde flavor and 1% caryophyllene color stabilizer. 17a. - Processo de acordo com17 a . - Process according to a reivindicação 2, caracterizado por o creme dentifrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 1% de estabilizador de côr de acetato de citronelilo.Claim 2, characterized in that the white dentifrice cream contains 1% cinnamic aldehyde flavorant and 1% citronellyl acetate color stabilizer. 18a. - Processo de acordo com18 a . - Process according to a reivindicação 2, caracterizado por o creme dentifrico de côr branca conter 1% de aromatizante de citral e 1% de estabilizador de côr de limoneno.Claim 2, wherein the white dentifrice cream contains 1% citral flavoring and 1% limonene color stabilizer. 19a. - Processo de acordo com19 a . - Process according to a reivindicação 2, caracterizado por o creme dentifrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 1% de estabilizador de côr de limoneno e por conter adicionalmente cerca de 0,5-1%, em peso, de dioxido de sitânio.Claim 2, wherein the white dentifrice cream contains 1% cinnamic aldehyde flavoring and 1% limonene color stabilizer and in addition contains about 0.5-1% by weight of sitanium dioxide. 20a. - Processo de acordo com a reivindicação 13, caracterizado por a solução para lava gens da boca, de côr branca, conter 0,1-0,5%, em peso, de uma composição aromatizante contendo aldeído cinâmico ou citral .20 a . A process according to claim 13, wherein the white-washed solution for the mouthwash contains 0.1-0.5% by weight of a flavoring composition containing cinnamic or citral aldehyde. 21a. - Processo de acordo com21 a . - Process according to a reivindicação 2, caracterizado põr o creme dentifrico de côr branca conter 0,1-1%, em peso, de uma composição aromaU zante contendo aldeído cinâmico ou citral e contendo, adicio nalmente, cerca de 0,5-1%, em peso, de dióxido de titânio.Claim 2, characterized in that the white dentifrice cream contains 0.1-1% by weight of a cinnamic or citral aldehyde containing flavoring composition and further containing about 0.5-1% by weight , of titanium dioxide. 22â. - Processo de acordo com22 â . - Process according to a reivindicação 1, caracterizado por se adicionar ao creme dentífrico cerca de 20-75%, em peso, de um agente de polimen to insolúvel na água.Claim 1, characterized in that about 20-75% by weight of a water-insoluble polymers is added to the dentifrice. 23â. - Processo de acordo com23 â . - Process according to a reivindicação 9, .caracterizado por se adicionar carca de 0,05-5% de agente tensio-activo.Claim 9, characterized in that the carotenoid is 0.05-5% surfactant. 24â. - Processo de acordo com24 â . - Process according to a reivindicação 1, caracterizado por o creme dentífrico apre sentar um teor de líquido de cerca de 20-75%, em peso, da composição.Claim 1, characterized in that the dentifrice cream has a liquid content of about 20-75% by weight of the composition. 25â. - Processo de acordo com a reivindicação 1, caracterizado por a solução para a lava gem da boca apresentar um teor de líquido de cerca de 90-98%, em peso, da composição.25 â . 2. A composition according to claim 1, wherein the solution for mouthwashing has a liquid content of about 90-98% by weight of the composition. 262. _ Processo de acordo com262. Process according to a reivindicação 4, caracterizado por o creme dentífrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 22% de propileno glicol, como inibidor de descoloração, e, adicionalmente, conter cerca de 0,5-2% em peso de dioxido de titânio.Claim 4, wherein the white dentifrice cream contains 1% cinnamic aldehyde flavorant and 22% propylene glycol as a discoloration inhibitor, and additionally contains about 0.5-2% by weight of titanium. 27â. - Processo de acordo com27 â . - Process according to a reivindicação 4, caracterizado por 0 creme dentífrico de côr branca conter 1% de aromatizante de aldeído cinâmico e 35% de dipropilenoglicol como inibidor de descoloração, e, adicionalmente, conter cerca de 0,5-1%, em peso, de dióxido de titânio.Claim 4, characterized in that the white dentifrice cream contains 1% cinnamic aldehyde flavor and 35% dipropylene glycol as a discoloration inhibitor, and additionally contains about 0.5-1% by weight of titanium. 28â. - Processo de acordo com28 â . - Process according to a reivindicação 8, caracterizado por 0 creme dentífrico anidro conter 1% de aromatizante de aldeído cinâmico e 43% deClaim 8, characterized in that the anhydrous dentifrice contains 1% cinnamic aldehyde flavor and 43% -60propilenoglicol.Propylene glycol. 29â. - Processo de acordo com a reivindicação 8, caracterizado por o creme dentifrico anidro conter 1% de aromatizante de aldeído cinâmico e 22% de propilenoglicol e 1% de dióxido de titânio.29 â . The process according to claim 8, wherein the anhydrous dentifrice cream contains 1% cinnamic aldehyde flavorant and 22% propylene glycol and 1% titanium dioxide. 30â. - Processo de acordo com a reivindicação 13, caracterizado por a solução para lava gens da boca, que ê anidra, conter 10-15% de propileno glicol e 0,1-0,5% de aldeido cinâmico.30 â . 13. A process according to claim 13, wherein the solution for mouthwash which is anhydrous contains 10-15% of propylene glycol and 0.1-0.5% of cinnamic aldehyde.
PT79930A 1984-02-09 1985-02-06 Process for stabilizing of cinnamic aldehyde-containing flavors for dentifrice formulations with terpenes and sesquiterpenes and propylene glycol and dipropylene glycol PT79930B (en)

Applications Claiming Priority (2)

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US06/578,457 US4562064A (en) 1984-02-09 1984-02-09 Stabilizing of cinnamic aldehyde-containing flavors with terpenes and sesqueterpenes
US06/578,942 US4547361A (en) 1984-02-10 1984-02-10 Stabilizing of cinnamic aldehyde-containing flavors with propylene glycol and dipropylene glycol

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CN116120159A (en) * 2023-03-03 2023-05-16 无锡江大百泰科技有限公司 Extraction method of cinnamaldehyde

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CA1254149A (en) 1989-05-16
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FR2559387A1 (en) 1985-08-16
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IT1184263B (en) 1987-10-22
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DE3502830A1 (en) 1985-08-14
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PT79930A (en) 1985-03-01
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