PT79845A - Process for preparing imidazodiazepine derivatives and of pharmaceutical compositions containing the same - Google Patents

Process for preparing imidazodiazepine derivatives and of pharmaceutical compositions containing the same

Info

Publication number
PT79845A
PT79845A PT79845A PT7984585A PT79845A PT 79845 A PT79845 A PT 79845A PT 79845 A PT79845 A PT 79845A PT 7984585 A PT7984585 A PT 7984585A PT 79845 A PT79845 A PT 79845A
Authority
PT
Portugal
Prior art keywords
signifies
image
lower alkyl
hydrogen
propenylene
Prior art date
Application number
PT79845A
Other languages
English (en)
Other versions
PT79845B (en
Inventor
Walter Hunkeler
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT79845A publication Critical patent/PT79845A/pt
Publication of PT79845B publication Critical patent/PT79845B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Lubricants (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
PT79845A 1984-01-19 1985-01-18 Process for preparing imidazodiazepine derivatives and of pharmaceutical compositions containing the same PT79845B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH22584 1984-01-19
CH314984 1984-06-29
CH512384 1984-10-26

Publications (2)

Publication Number Publication Date
PT79845A true PT79845A (en) 1985-02-01
PT79845B PT79845B (en) 1986-12-18

Family

ID=27171919

Family Applications (1)

Application Number Title Priority Date Filing Date
PT79845A PT79845B (en) 1984-01-19 1985-01-18 Process for preparing imidazodiazepine derivatives and of pharmaceutical compositions containing the same

Country Status (20)

Country Link
US (1) US4775671A (pt)
EP (1) EP0150040B1 (pt)
JP (1) JPH0657710B2 (pt)
AT (1) ATE110726T1 (pt)
AU (1) AU577079B2 (pt)
CA (1) CA1252462A (pt)
CS (2) CS249146B2 (pt)
DE (1) DE3587913D1 (pt)
DK (1) DK24585A (pt)
DO (1) DOP1985004334A (pt)
ES (2) ES8604964A1 (pt)
FI (1) FI850191L (pt)
HU (1) HU195818B (pt)
IL (1) IL74070A (pt)
MC (1) MC1640A1 (pt)
NO (1) NO850232L (pt)
NZ (1) NZ210850A (pt)
PH (1) PH21052A (pt)
PT (1) PT79845B (pt)
ZW (1) ZW985A1 (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339372C (en) * 1983-09-26 1997-08-26 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic ester
CA1259612A (en) * 1985-02-28 1989-09-19 Emilio Kyburz Imidazodiazepine derivatives
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
GB2174695A (en) * 1985-05-08 1986-11-12 Merck Sharp & Dohme Heteroanalogs of imidazobenzodiazepines
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
ATE38671T1 (de) * 1985-05-17 1988-12-15 Ferrosan As Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4771051A (en) * 1985-05-17 1988-09-13 A/S Ferrosan 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
AU594676B2 (en) * 1985-05-17 1990-03-15 Novo Nordisk A/S Oxadiazolyl imidazobenaodiazepine compound, pharmaceutical composition containing said compound, method of preparing said compound and method of treating a central nervous system ailment
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
ZA881538B (en) * 1987-03-10 1988-09-12 F. Hoffmann-La Roche & Co. Aktiengesellschaft Imidazodiazepine derivatives
FI880814A7 (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
GB8923008D0 (en) * 1989-10-12 1989-11-29 Roussel Lab Ltd Chemical compounds
GB8927928D0 (en) * 1989-12-11 1990-02-14 Roussel Lab Ltd Chemical compounds
TW201311B (pt) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5453424A (en) * 1993-11-22 1995-09-26 Merck & Co., Inc. Furanodiazepines
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
EP0730581B1 (en) * 1993-11-22 2001-10-04 Merck & Co. Inc. 3-acylaminobenzazepines
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
CA2195974C (en) * 1994-08-18 2000-12-05 David A. Claremon 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
ATE235472T1 (de) * 1995-06-07 2003-04-15 Merck & Co Inc N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepi - 3-yl)-3-amide
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
ES2312022T3 (es) * 2004-10-12 2009-02-16 F. Hoffmann-La Roche Ag Derivados de imidazo (1,5-a-triazolo (1,5-dibenzodiapeina para el tratamiento e trastornos cognitivos.
MX2007004639A (es) 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de imidazo-benzodiazepina.
KR100915469B1 (ko) 2004-10-20 2009-09-03 에프. 호프만-라 로슈 아게 할로겐 치환된 벤조다이아제핀 유도체
DE602005007265D1 (de) 2004-12-14 2008-07-10 Hoffmann La Roche Tetrazyklische imidazobenzodiazepine als gaba-rezeptormodulatoren
CA2607226A1 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
BRPI0815579A2 (pt) 2007-08-20 2015-02-18 Evotec Neurosciences Gmbh Tratamento de distúrbio do sono
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
UA110640C2 (uk) 2011-05-05 2016-01-25 Янссен Фармацевтика Нв ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1173441A (en) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
CA1185601A (en) * 1981-02-27 1985-04-16 Walter Hunkeler Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method

Also Published As

Publication number Publication date
DK24585D0 (da) 1985-01-18
FI850191A7 (fi) 1985-07-20
NZ210850A (en) 1988-10-28
AU3775485A (en) 1985-07-25
EP0150040A2 (de) 1985-07-31
CA1252462A (en) 1989-04-11
CS249146B2 (en) 1987-03-12
JPS60161989A (ja) 1985-08-23
JPH0657710B2 (ja) 1994-08-03
HUT36796A (en) 1985-10-28
ES8604964A1 (es) 1986-03-01
CS249148B2 (en) 1987-03-12
ES548399A0 (es) 1986-04-01
MC1640A1 (fr) 1986-01-09
DK24585A (da) 1985-07-20
ZW985A1 (en) 1985-08-28
IL74070A0 (en) 1985-04-30
NO850232L (no) 1985-07-22
EP0150040A3 (en) 1986-07-30
DE3587913D1 (de) 1994-10-06
ATE110726T1 (de) 1994-09-15
HU195818B (en) 1988-07-28
US4775671A (en) 1988-10-04
PT79845B (en) 1986-12-18
FI850191L (fi) 1985-07-20
ES8605791A1 (es) 1986-04-01
FI850191A0 (fi) 1985-01-16
EP0150040B1 (de) 1994-08-31
PH21052A (en) 1987-07-03
IL74070A (en) 1988-12-30
ES539663A0 (es) 1986-03-01
DOP1985004334A (es) 1990-09-13
AU577079B2 (en) 1988-09-15

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