PT78628A - Pharmaceutical composition with reduced toxicity - Google Patents

Pharmaceutical composition with reduced toxicity

Info

Publication number
PT78628A
PT78628A PT78628A PT7862884A PT78628A PT 78628 A PT78628 A PT 78628A PT 78628 A PT78628 A PT 78628A PT 7862884 A PT7862884 A PT 7862884A PT 78628 A PT78628 A PT 78628A
Authority
PT
Portugal
Prior art keywords
pharmaceutical composition
reduced toxicity
drug
preparations
toxicity
Prior art date
Application number
PT78628A
Other languages
English (en)
Other versions
PT78628B (en
Original Assignee
Liposome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24419861&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT78628(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Corp filed Critical Liposome Corp
Publication of PT78628A publication Critical patent/PT78628A/pt
Publication of PT78628B publication Critical patent/PT78628B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT78628A 1984-05-02 1984-05-22 Pharmaceutical composition with reduced toxicity PT78628B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60450384A 1984-05-02 1984-05-02

Publications (2)

Publication Number Publication Date
PT78628A true PT78628A (en) 1984-06-01
PT78628B PT78628B (en) 1986-06-18

Family

ID=24419861

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78628A PT78628B (en) 1984-05-02 1984-05-22 Pharmaceutical composition with reduced toxicity

Country Status (11)

Country Link
EP (1) EP0180581B2 (pt)
JP (1) JP2506323B2 (pt)
AT (1) ATE65912T1 (pt)
AU (1) AU3063884A (pt)
DE (1) DE3484904D1 (pt)
DK (1) DK607885A (pt)
FI (1) FI860018A0 (pt)
HK (1) HK32492A (pt)
PT (1) PT78628B (pt)
SG (1) SG18792G (pt)
WO (1) WO1985005030A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US5043107A (en) * 1986-08-21 1991-08-27 Vestar Research, Inc. Preparation small unilamellar vesicles including polyene antifungal antibiotics
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US4822777A (en) * 1987-02-27 1989-04-18 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
AU598958B2 (en) 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
CA2044663A1 (en) * 1990-07-12 1992-01-13 Makoto Tanaka Water-dispersible polyene antifungal complexes
PT100486B (pt) * 1992-05-14 1999-07-30 Ineti Inst Nac Engenh E Tecnol Aminoglucosidos lipossomais com altas eficacia de encapsulacao e actividade terapeutica, nomeadamente a netilmicina, e processo para a sua preparcao
JP2915296B2 (ja) * 1993-08-30 1999-07-05 宇野 潤 抗真菌製剤
AU1350099A (en) * 1997-12-01 1999-06-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Formulations for topical treatment of skin infections
CA2450949C (en) 2001-06-28 2009-04-28 John Samuel Methods and compositions for polyene antibiotics with reduced toxicity
CN104856931B (zh) * 2014-02-24 2019-06-18 石药集团中奇制药技术（石家庄）有限公司 一种两性霉素b纳米复合物及其制备方法
CN116473985A (zh) * 2023-03-29 2023-07-25 暨南大学 一种多烯类抗真菌药物组合物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119724A (en) * 1973-11-26 1978-10-10 Pepro Fungicidal compositions containing phosphorous acid and derivatives thereof
TR19072A (tr) * 1973-11-26 1978-05-01 Pepro Fosforlu tuerevler ihtiva eden fungisid terkipler
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4160827A (en) * 1978-02-06 1979-07-10 The Upjohn Company Metronidazole phosphate and salts
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
DE2856333C2 (de) * 1978-12-27 1983-09-22 A. Nattermann & Cie GmbH, 5000 Köln Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
GR73668B (pt) * 1978-11-21 1984-03-28 Hoffmann La Roche
GB2046092B (en) * 1979-03-05 1983-11-02 Toyama Chemical Co Ltd Pharmaceutical composition containing a lysophospholid and a phospholipid
US4287187A (en) * 1979-03-07 1981-09-01 Engelhard Minerals & Chemicals Corporation Method for treating tumors with cis-diammineplatinum(II) orthophosphate complexes
US4291023A (en) * 1979-03-07 1981-09-22 Engelhard Minerals & Chemicals Corp. Method for treating tumors using cis-diammineplatinum (II) organophosphate complexes
US4291027A (en) * 1979-03-07 1981-09-22 Engelhard Minerals & Chemicals Corp. Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes
DE2914789A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Injizierbare arzneimittel mit entzuendungshemmender wirkung
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
DE2941384A1 (de) * 1979-10-12 1981-04-23 Bayer Ag, 5090 Leverkusen Phosphono-hydroxy-essigsaeure, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2952115C2 (de) * 1979-12-22 1982-05-06 A. Nattermann & Cie GmbH, 5000 Köln Rosmarinsäure-Phospholipid-Komplex
HU184141B (en) * 1979-12-27 1984-07-30 Human Oltoanyagtermelo Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof
US4346084A (en) * 1980-02-29 1982-08-24 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lithium and choline
US4430330A (en) * 1980-02-29 1984-02-07 Massachusetts Institute Of Technology Process and composition for treating disorders by administering a phenothiazine and choline
JPS5793909A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Carcinostatic pharmaceutical having directivity to specific internal organ and its preparation
US4419348A (en) * 1981-04-27 1983-12-06 Georgetown University Anthracycline glycoside compositions, their use and preparation
US4397846A (en) * 1981-05-15 1983-08-09 Murray Weiner Storage-stable lipid vesicles and method of preparation

Also Published As

Publication number Publication date
DK607885D0 (da) 1985-12-30
EP0180581A1 (en) 1986-05-14
AU3063884A (en) 1985-11-28
JP2506323B2 (ja) 1996-06-12
EP0180581B2 (en) 1995-12-20
JPS61502055A (ja) 1986-09-18
DK607885A (da) 1985-12-30
ATE65912T1 (de) 1991-08-15
HK32492A (en) 1992-05-08
WO1985005030A1 (en) 1985-11-21
SG18792G (en) 1992-04-16
EP0180581B1 (en) 1991-08-07
FI860018A (fi) 1986-01-02
DE3484904D1 (de) 1991-09-12
EP0180581A4 (en) 1988-04-27
FI860018A0 (fi) 1986-01-02
PT78628B (en) 1986-06-18

Similar Documents

Publication Publication Date Title
ES8603272A1 (es) Procedimiento de producir un preparado de farmaco de toxicidad reducida
PT78628B (en) Pharmaceutical composition with reduced toxicity
SE8504945L (sv) Farmaceutiska kompositioner innehallande antracyklinglykosider
NO875299D0 (no) Insulinpreparat for ikke-paranteral administrasjon.
DE3665717D1 (en) Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions
DE3580616D1 (de) Mitomycinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
IT8467767A1 (it) Preparati farmaceutici ad attività antimicrobica e procedimento per la loro preparazione.
ES478967A1 (es) Un procedimiento para preparar compuestos de acido 3-cefem-4-carboxilico disustituido en las posiciones 3 y 7.
DE3867086D1 (de) Benzothiepino(5,4-c)pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
IE781117L (en) Medicament comprising erythromycin and metoclopramide
ATE32882T1 (de) Phenylnonatetraensaeurederivate, ihre herstellung und pharmazeutische praeparate mit diesen derivaten.
IT8722218A0 (it) Ftalazino derivati ad attivita'farmaceutica.
DE3579074D1 (de) Verminderung der toxischen wirkungen von anthrachinon-medikamenten.
ES2016052A6 (es) Procedimiento para preparar derivados de adenosinmonofosfonato (amp) ciclico y de guanosinmonofosfonato (gmp) ciclico.
ES469648A1 (es) Un procedimiento para preparar derivados de oleandomicina
IT8520514A0 (it) Composizioni di farmaci dotate di attivita' antimicrobica eprocedimento per la loro preparazione.
ATE70840T1 (de) Benzothiepino(5,4-c>pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
ATE45956T1 (de) 11 beta-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate.
IT8520150A0 (it) Nuovi derivati ad attivita'terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
FR2567755B1 (fr) Nouveau medicament anti-tumoral contenant comme ingredient actif le triacetoxy-1,8,9 anthracene
TW238246B (en) Pharmaceutical composition for reducing the renal toxicity and enhancing the effect of antitumor
ATE53214T1 (de) Glycero-3(2)-phospho-l-serinderivate und diese enthaltende pharmazeutischen praeparate.
ATE1011T1 (de) 5-fluoruracil-derivate, deren herstellung und ihre pharmazeutischen zusammensetzungen.
DE3678729D1 (de) Neue arzneimittelzubereitung mit geregelter verabreichung des aktiven mittels, und deren herstellungsverfahren.
IT8219410A0 (it) Derivati tiolici dell'eritromicina ad attivita' terapeutica, relativo procedimento di preparazione e composizioni farmaceutiche che licontengono.