PT3870586T - Derivados de imidazole pentacíclico fundido como moduladores da atividade do tnf - Google Patents
Derivados de imidazole pentacíclico fundido como moduladores da atividade do tnfInfo
- Publication number
- PT3870586T PT3870586T PT197900004T PT19790000T PT3870586T PT 3870586 T PT3870586 T PT 3870586T PT 197900004 T PT197900004 T PT 197900004T PT 19790000 T PT19790000 T PT 19790000T PT 3870586 T PT3870586 T PT 3870586T
- Authority
- PT
- Portugal
- Prior art keywords
- modulators
- imidazole derivatives
- tnf activity
- fused pentacyclic
- pentacyclic imidazole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18275165 | 2018-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3870586T true PT3870586T (pt) | 2023-07-19 |
Family
ID=63998674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT197900004T PT3870586T (pt) | 2018-10-24 | 2019-10-23 | Derivados de imidazole pentacíclico fundido como moduladores da atividade do tnf |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11554122B2 (pt) |
| EP (1) | EP3870586B1 (pt) |
| JP (1) | JP7429694B2 (pt) |
| CN (1) | CN113227097B (pt) |
| CA (1) | CA3117344A1 (pt) |
| ES (1) | ES2951837T3 (pt) |
| PT (1) | PT3870586T (pt) |
| WO (1) | WO2020084008A1 (pt) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014030940B1 (pt) | 2012-06-11 | 2022-09-06 | UCB Biopharma SRL | Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos |
| GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321738D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| CN107108672B (zh) * | 2014-10-03 | 2019-11-08 | Ucb生物制药私人有限公司 | 稠合的五环咪唑衍生物 |
| EA201892149A1 (ru) * | 2016-04-01 | 2019-04-30 | Юсб Байофарма Спрл | Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf |
| WO2017167993A1 (en) * | 2016-04-01 | 2017-10-05 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
| BR112018069941A2 (pt) * | 2016-04-01 | 2019-02-05 | Sanofi Sa | derivados de imidazol pentacíclicos fundidos como moduladores de atividade do tnf |
| BR112018069937A2 (pt) | 2016-04-01 | 2019-02-05 | Sanofi Sa | derivados de imidazol hexacíclicos fundidos como moduladores de atividade do tnf |
| JP7121033B2 (ja) * | 2017-03-15 | 2022-08-17 | ユーシービー バイオファルマ エスアールエル | Ｔｎｆ活性のモジュレーターとしての縮合五環式イミダゾール誘導体 |
| SG11201909245PA (en) | 2017-04-05 | 2019-11-28 | Alkahest Inc | Methods and compositions for treating aging-associated impairments using ccr3-inhibitors |
| LT3615534T (lt) * | 2017-04-25 | 2021-11-25 | UCB Biopharma SRL | Sulieti pentacikliniai imidazolo dariniai kaip tnf aktyvumo moduliatoriai |
-
2019
- 2019-10-23 WO PCT/EP2019/078922 patent/WO2020084008A1/en unknown
- 2019-10-23 JP JP2021522352A patent/JP7429694B2/ja active Active
- 2019-10-23 EP EP19790000.4A patent/EP3870586B1/en active Active
- 2019-10-23 US US17/284,950 patent/US11554122B2/en active Active
- 2019-10-23 CA CA3117344A patent/CA3117344A1/en active Pending
- 2019-10-23 ES ES19790000T patent/ES2951837T3/es active Active
- 2019-10-23 CN CN201980070050.8A patent/CN113227097B/zh active Active
- 2019-10-23 PT PT197900004T patent/PT3870586T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7429694B2 (ja) | 2024-02-08 |
| JP2022505706A (ja) | 2022-01-14 |
| ES2951837T3 (es) | 2023-10-25 |
| EP3870586B1 (en) | 2023-07-05 |
| US11554122B2 (en) | 2023-01-17 |
| US20210361668A1 (en) | 2021-11-25 |
| CN113227097A (zh) | 2021-08-06 |
| EP3870586A1 (en) | 2021-09-01 |
| WO2020084008A1 (en) | 2020-04-30 |
| CA3117344A1 (en) | 2020-04-30 |
| CN113227097B (zh) | 2023-09-08 |
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