HUP1800333A2 - GABAA A5 receptor modulátor hatású biciklusos vegyületek - Google Patents
GABAA A5 receptor modulátor hatású biciklusos vegyületekInfo
- Publication number
- HUP1800333A2 HUP1800333A2 HU1800333A HUP1800333A HUP1800333A2 HU P1800333 A2 HUP1800333 A2 HU P1800333A2 HU 1800333 A HU1800333 A HU 1800333A HU P1800333 A HUP1800333 A HU P1800333A HU P1800333 A2 HUP1800333 A2 HU P1800333A2
- Authority
- HU
- Hungary
- Prior art keywords
- gabaa
- receptor modulators
- bicyclic derivatives
- bicyclic
- derivatives
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1800333A HU231223B1 (hu) | 2018-09-28 | 2018-09-28 | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| EP19779613.9A EP3856342A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as gabaa a5 receptor modulators |
| ARP190102762A AR116549A1 (es) | 2018-09-28 | 2019-09-27 | DERIVADOS BICÍCLICOS COMO MODULADORES DEL RECEPTOR GABAA a5 |
| MX2021003670A MX2021003670A (es) | 2018-09-28 | 2019-09-27 | Derivados biciclicos como moduladores del receptor gabaa a5. |
| CN201980063431.3A CN112805063B (zh) | 2018-09-28 | 2019-09-27 | 作为gabaa a5受体调节剂的双环衍生物 |
| TW108135172A TW202035403A (zh) | 2018-09-28 | 2019-09-27 | 作為ｇａｂａａ ａ５受體調節子的雙環衍生物 |
| JP2021516369A JP7480128B2 (ja) | 2018-09-28 | 2019-09-27 | Ｇａｂａａ ａ５受容体モジュレーターとしての二環式誘導体 |
| US17/279,654 US20210386718A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as gabaa a5 receptor modulators |
| BR112021005837-0A BR112021005837A2 (pt) | 2018-09-28 | 2019-09-27 | composto, uso de um composto, método de tratamento ou de prevenção de doença, e, composição farmacêutica |
| CA3113072A CA3113072A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as gabaa a5 receptor modulators |
| PCT/IB2019/058208 WO2020065597A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as gabaa α5 receptor modulators |
| KR1020217012783A KR20210086631A (ko) | 2018-09-28 | 2019-09-27 | Gabaa α5 수용체 조절제로서의 바이사이클릭 유도체 |
| EA202190857A EA202190857A1 (ru) | 2018-09-28 | 2019-09-27 | Бициклические производные как модуляторы 5 рецепторов gabaa |
| AU2019346147A AU2019346147A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as GABAA α5 receptor modulators |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1800333A HU231223B1 (hu) | 2018-09-28 | 2018-09-28 | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP1800333A2 true HUP1800333A2 (hu) | 2020-04-28 |
| HU231223B1 HU231223B1 (hu) | 2022-01-28 |
Family
ID=89992765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1800333A HU231223B1 (hu) | 2018-09-28 | 2018-09-28 | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210386718A1 (hu) |
| EP (1) | EP3856342A1 (hu) |
| JP (1) | JP7480128B2 (hu) |
| KR (1) | KR20210086631A (hu) |
| CN (1) | CN112805063B (hu) |
| AR (1) | AR116549A1 (hu) |
| AU (1) | AU2019346147A1 (hu) |
| BR (1) | BR112021005837A2 (hu) |
| CA (1) | CA3113072A1 (hu) |
| EA (1) | EA202190857A1 (hu) |
| HU (1) | HU231223B1 (hu) |
| MX (1) | MX2021003670A (hu) |
| TW (1) | TW202035403A (hu) |
| WO (1) | WO2020065597A1 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202202495A (zh) * | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物 |
| WO2021191837A1 (en) * | 2020-03-26 | 2021-09-30 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators |
| HUP2100338A1 (hu) * | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0986562B1 (en) | 1997-05-08 | 2002-08-07 | MERCK SHARP & DOHME LTD. | Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands |
| GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
| GB0017518D0 (en) | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| JP4148672B2 (ja) | 2000-11-17 | 2008-09-10 | 武田薬品工業株式会社 | イソオキサゾール誘導体 |
| JP2003261545A (ja) | 2001-12-28 | 2003-09-19 | Takeda Chem Ind Ltd | 神経栄養因子産生・分泌促進剤 |
| WO2007018660A2 (en) | 2005-05-16 | 2007-02-15 | Wisys Technology Foundation, Inc. | Gabaergic imidazobenzodiazepine derivatives to treat memory deficits |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| EA014720B1 (ru) | 2006-05-24 | 2011-02-28 | Эли Лилли Энд Компани | Соединения и способы модуляции fxr |
| US20100249179A1 (en) | 2007-06-13 | 2010-09-30 | Smithkline Beecham Corporation | Farnesoid X Receptor Agonists |
| KR101175859B1 (ko) | 2007-12-04 | 2012-08-24 | 에프. 호프만-라 로슈 아게 | 이속사졸로-피라진 유도체 |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| SI2227467T1 (sl) | 2007-12-04 | 2015-03-31 | F. Hoffmann-La Roche Ag | Derivati izoksazolo-piridina |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| CN102414205B (zh) | 2009-05-05 | 2014-11-05 | 弗·哈夫曼-拉罗切有限公司 | 异噁唑-吡唑衍生物 |
| EP2427457B1 (en) | 2009-05-07 | 2013-07-17 | F.Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives as gaba modulators |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| GB201016088D0 (en) | 2010-09-24 | 2010-11-10 | Phase Focus Ltd | Improvements in imaging |
| SG189248A1 (en) | 2010-11-05 | 2013-06-28 | Hoffmann La Roche | Use of active pharmaceutical compounds for the treatment of central nervous system conditions |
| US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
| ES2536667T3 (es) | 2010-11-09 | 2015-05-27 | F. Hoffmann-La Roche Ag | Derivados de triazol como ligandos de receptores Gaba |
| CN103313968A (zh) | 2010-11-15 | 2013-09-18 | Abbvie公司 | Nampt和rock抑制剂 |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| WO2014001278A1 (en) * | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| EP2877463B1 (en) | 2012-06-26 | 2018-11-07 | Saniona A/S | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CN108602811B (zh) | 2016-02-01 | 2021-11-16 | 轩竹生物科技有限公司 | Fxr受体激动剂 |
| AR110498A1 (es) | 2016-12-08 | 2019-04-03 | Hoffmann La Roche | DERIVADOS DE ISOXAZOLIL ÉTER COMO MODULADORES ALOSTÉRICOS POSITIVOS (PAM) DE RECEPTORES DE GABAA a5 |
-
2018
- 2018-09-28 HU HU1800333A patent/HU231223B1/hu unknown
-
2019
- 2019-09-27 US US17/279,654 patent/US20210386718A1/en active Pending
- 2019-09-27 AR ARP190102762A patent/AR116549A1/es unknown
- 2019-09-27 JP JP2021516369A patent/JP7480128B2/ja active Active
- 2019-09-27 BR BR112021005837-0A patent/BR112021005837A2/pt unknown
- 2019-09-27 KR KR1020217012783A patent/KR20210086631A/ko not_active Application Discontinuation
- 2019-09-27 EP EP19779613.9A patent/EP3856342A1/en active Pending
- 2019-09-27 CA CA3113072A patent/CA3113072A1/en active Pending
- 2019-09-27 TW TW108135172A patent/TW202035403A/zh unknown
- 2019-09-27 CN CN201980063431.3A patent/CN112805063B/zh active Active
- 2019-09-27 MX MX2021003670A patent/MX2021003670A/es unknown
- 2019-09-27 AU AU2019346147A patent/AU2019346147A1/en active Pending
- 2019-09-27 WO PCT/IB2019/058208 patent/WO2020065597A1/en unknown
- 2019-09-27 EA EA202190857A patent/EA202190857A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3113072A1 (en) | 2020-04-02 |
| JP2022502366A (ja) | 2022-01-11 |
| CN112805063A (zh) | 2021-05-14 |
| EP3856342A1 (en) | 2021-08-04 |
| AU2019346147A1 (en) | 2021-05-20 |
| HU231223B1 (hu) | 2022-01-28 |
| WO2020065597A1 (en) | 2020-04-02 |
| EA202190857A1 (ru) | 2021-06-23 |
| JP7480128B2 (ja) | 2024-05-09 |
| US20210386718A1 (en) | 2021-12-16 |
| BR112021005837A2 (pt) | 2021-07-27 |
| KR20210086631A (ko) | 2021-07-08 |
| TW202035403A (zh) | 2020-10-01 |
| CN112805063B (zh) | 2024-02-23 |
| MX2021003670A (es) | 2021-08-19 |
| AR116549A1 (es) | 2021-05-19 |
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