PT3825307T - Métodos para a síntese de dextrometorfano deuterado - Google Patents
Métodos para a síntese de dextrometorfano deuteradoInfo
- Publication number
- PT3825307T PT3825307T PT202037040T PT20203704T PT3825307T PT 3825307 T PT3825307 T PT 3825307T PT 202037040 T PT202037040 T PT 202037040T PT 20203704 T PT20203704 T PT 20203704T PT 3825307 T PT3825307 T PT 3825307T
- Authority
- PT
- Portugal
- Prior art keywords
- synthesis
- methods
- deuterated dextromethorphan
- dextromethorphan
- deuterated
- Prior art date
Links
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical class C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016088414 | 2016-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3825307T true PT3825307T (pt) | 2022-08-26 |
Family
ID=59351125
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT202037040T PT3825307T (pt) | 2016-07-04 | 2017-07-03 | Métodos para a síntese de dextrometorfano deuterado |
| PT177402237T PT3478664T (pt) | 2016-07-04 | 2017-07-03 | Métodos para a síntese de dextrometorfano deuterado |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177402237T PT3478664T (pt) | 2016-07-04 | 2017-07-03 | Métodos para a síntese de dextrometorfano deuterado |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10730841B2 (pt) |
| EP (4) | EP3825307B1 (pt) |
| JP (4) | JP7061079B2 (pt) |
| KR (3) | KR102720795B1 (pt) |
| CN (2) | CN115215801A (pt) |
| ES (2) | ES2840078T3 (pt) |
| PT (2) | PT3825307T (pt) |
| WO (1) | WO2018009488A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3825306T3 (pl) | 2007-05-01 | 2023-09-11 | Sun Pharmaceutical Industries, Inc. | Związki morfinanu |
| PT3825307T (pt) * | 2016-07-04 | 2022-08-26 | Avanir Pharmaceuticals Inc | Métodos para a síntese de dextrometorfano deuterado |
| TW202102219A (zh) * | 2019-03-18 | 2021-01-16 | 美商艾賓爾製藥公司 | 使用氘化右旋美沙芬(dextromethorphan)及奎尼丁(quinidine)治療精神分裂症之負面徵候之方法 |
| TWI844786B (zh) * | 2020-07-20 | 2024-06-11 | 大陸商深圳信立泰藥業股份有限公司 | 一種藥物組合物及其應用 |
| CN112358446B (zh) * | 2020-11-30 | 2022-09-20 | 天津阿尔塔科技有限公司 | 一种稳定同位素标记的盐酸曲托喹酚的合成方法 |
| CN115322150B (zh) * | 2021-05-11 | 2024-05-28 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316888A (en) | 1980-04-15 | 1982-02-23 | Nelson Research & Development Co. | Method and composition of reducing pain |
| US4446140A (en) | 1981-12-10 | 1984-05-01 | Nelson Research & Development Company | Method and composition for treating mouth pain |
| US4694010A (en) | 1985-08-16 | 1987-09-15 | New York University | Anticonvulsant compositions and method |
| US4898860A (en) | 1985-08-16 | 1990-02-06 | New York University | Anticonvulsant composition and method |
| US4806543A (en) | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5166207A (en) | 1991-06-17 | 1992-11-24 | Neurotherapeutics, Inc. | Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders |
| US5366980A (en) | 1991-06-17 | 1994-11-22 | Smith Richard A | Use of dextromethorphan and an oxidase inhibitor to treat dermatitis |
| US5206248A (en) | 1992-03-27 | 1993-04-27 | Smith Richard A | Method for reducing emotional lability |
| US5350756A (en) | 1991-06-17 | 1994-09-27 | Smith Richard A | Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan |
| US5336980A (en) | 1992-12-10 | 1994-08-09 | Leopold Kostal Gmbh & Co. | Apparatus and method for controlling a windshield wiping system |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| AU8071894A (en) | 1994-09-22 | 1996-04-09 | Jonathan M Licht | Compositions useful for the preparation of medicines for treating a variety of intractable disorders |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
| CH690817A5 (de) | 1996-09-03 | 2001-01-31 | Flachsmann Ag Emil | Verfahren zur Herstellung eines stabilen, homogenen, von Folgeprodukten freien oder nahezu freien Extraktes. |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| AU4517201A (en) | 1999-12-08 | 2001-06-18 | Vanderbilt University | Modulation of in vivo glutamine and glycine levels in the treatment of autism |
| US20050129783A1 (en) | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| US6780871B2 (en) | 2001-01-29 | 2004-08-24 | Albany Medical College | Methods and compositions for treating addiction disorders |
| US6583152B2 (en) | 2001-04-30 | 2003-06-24 | Dexgen Pharmaceuticals, Inc. | Composition for reducing the risk or progression of cardiovascular diseases |
| US20040087479A1 (en) | 2001-04-30 | 2004-05-06 | Sosnowski Robert E. | Composition and method for reducing the risk or progression of cardiovascular, glaucoma, tardive dyskinesia and other diseases |
| BR0209325A (pt) | 2001-05-03 | 2004-07-20 | Hoffmann La Roche | Forma de dosagem farmacêutica de mesilato de nelfinavir amorfo |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Pharmaceuticals, Inc. | Delivery of drug esters through an inhalation route |
| TWI326214B (en) | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| BRPI0516170A (pt) | 2004-09-29 | 2008-08-26 | Cordis Corp | formas de dosagens farmacêuticas estáveis e amorfas de compostos de rapamicina |
| US20070191411A1 (en) | 2004-10-07 | 2007-08-16 | Smith Richard A | Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor |
| US7114547B2 (en) | 2005-01-11 | 2006-10-03 | Sullivan Michael R | Casting ring |
| GB2471802B (en) * | 2006-05-25 | 2011-02-16 | Alpharma | Chemical process |
| CN102964302B (zh) * | 2007-05-01 | 2015-10-21 | 康塞特医药品公司 | 吗啡烷化合物 |
| AU2011256898B2 (en) * | 2007-05-01 | 2013-09-19 | Sun Pharmaceutical Industries, Inc. | Morphinan compounds |
| DK3248978T3 (da) * | 2008-09-19 | 2019-11-18 | Concert Pharmaceuticals Inc | Deutererede morphinanforbindelser |
| PL2397158T3 (pl) * | 2008-10-30 | 2016-09-30 | Skojarzone podawanie związków morfinanów oraz leków przeciwdepresyjnych w leczeniu nietrzymania afektu | |
| CN102977021A (zh) | 2012-11-29 | 2013-03-20 | 威海迪之雅医药化工开发有限公司 | 一种氢溴酸右美沙芬的制备方法 |
| CN104003936B (zh) | 2014-05-22 | 2016-05-11 | 江苏宝众宝达药业有限公司 | 一种氢溴酸右美沙芬的精制纯化方法 |
| SG10201901242PA (en) * | 2014-09-14 | 2019-03-28 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia |
| PT3825307T (pt) * | 2016-07-04 | 2022-08-26 | Avanir Pharmaceuticals Inc | Métodos para a síntese de dextrometorfano deuterado |
| CN115322150B (zh) * | 2021-05-11 | 2024-05-28 | 深圳信立泰药业股份有限公司 | 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途 |
-
2017
- 2017-07-03 PT PT202037040T patent/PT3825307T/pt unknown
- 2017-07-03 WO PCT/US2017/040623 patent/WO2018009488A1/en not_active Ceased
- 2017-07-03 CN CN202210796632.8A patent/CN115215801A/zh active Pending
- 2017-07-03 ES ES17740223T patent/ES2840078T3/es active Active
- 2017-07-03 KR KR1020237002014A patent/KR102720795B1/ko active Active
- 2017-07-03 JP JP2018568436A patent/JP7061079B2/ja active Active
- 2017-07-03 CN CN201780052018.8A patent/CN109641849B/zh active Active
- 2017-07-03 ES ES20203704T patent/ES2925277T3/es active Active
- 2017-07-03 KR KR1020197003589A patent/KR102491214B1/ko active Active
- 2017-07-03 EP EP20203704.0A patent/EP3825307B1/en active Active
- 2017-07-03 PT PT177402237T patent/PT3478664T/pt unknown
- 2017-07-03 KR KR1020247001612A patent/KR20240013845A/ko active Pending
- 2017-07-03 EP EP24151458.7A patent/EP4335500A3/en not_active Withdrawn
- 2017-07-03 US US16/312,439 patent/US10730841B2/en active Active
- 2017-07-03 EP EP17740223.7A patent/EP3478664B1/en active Active
- 2017-07-03 EP EP22181650.7A patent/EP4122919A1/en not_active Withdrawn
-
2020
- 2020-06-24 US US16/910,353 patent/US10865187B2/en active Active
- 2020-11-11 US US17/095,026 patent/US11845731B2/en active Active
-
2022
- 2022-02-04 JP JP2022016351A patent/JP7312284B2/ja active Active
-
2023
- 2023-07-07 JP JP2023112142A patent/JP2023123851A/ja active Pending
- 2023-11-08 US US18/388,041 patent/US12291505B2/en active Active
- 2023-12-26 US US18/395,979 patent/US20240124402A1/en not_active Abandoned
-
2024
- 2024-01-15 JP JP2024003725A patent/JP2024029239A/ja active Pending
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