PT3647306T - Composto de ácido tetrâmico 4-oxo-alquilado e método de preparação para o mesmo - Google Patents
Composto de ácido tetrâmico 4-oxo-alquilado e método de preparação para o mesmoInfo
- Publication number
- PT3647306T PT3647306T PT188437263T PT18843726T PT3647306T PT 3647306 T PT3647306 T PT 3647306T PT 188437263 T PT188437263 T PT 188437263T PT 18843726 T PT18843726 T PT 18843726T PT 3647306 T PT3647306 T PT 3647306T
- Authority
- PT
- Portugal
- Prior art keywords
- oxo
- preparation
- acid compound
- method therefor
- tetramic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710684334.9A CN107353239B (zh) | 2017-08-11 | 2017-08-11 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3647306T true PT3647306T (pt) | 2022-07-01 |
Family
ID=60287057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT188437263T PT3647306T (pt) | 2017-08-11 | 2018-06-20 | Composto de ácido tetrâmico 4-oxo-alquilado e método de preparação para o mesmo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11332440B2 (pt) |
| EP (1) | EP3647306B1 (pt) |
| CN (1) | CN107353239B (pt) |
| AU (1) | AU2018314472B9 (pt) |
| DK (1) | DK3647306T3 (pt) |
| ES (1) | ES2920132T3 (pt) |
| HU (1) | HUE059136T2 (pt) |
| PT (1) | PT3647306T (pt) |
| WO (1) | WO2019029274A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107353239B (zh) | 2017-08-11 | 2019-06-18 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法 |
| CN107468690B (zh) * | 2017-08-11 | 2020-01-31 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法与应用 |
| CN112409234A (zh) * | 2020-11-30 | 2021-02-26 | 北京卓凯生物技术有限公司 | 一种左旋氟吡咯酮的晶型a及其制备方法 |
| WO2024146571A1 (zh) * | 2023-01-03 | 2024-07-11 | 浙江同源康医药股份有限公司 | 用于预防和/或治疗神经退行性疾病的化合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE134610T1 (de) | 1991-08-22 | 1996-03-15 | Lonza Ag | Verfahren zur herstellung von optisch aktiven 4- amino-3-hydroxycarbonsäuren |
| GB9210393D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| DE10354629A1 (de) | 2003-11-22 | 2005-06-30 | Bayer Cropscience Ag | 2-Ethyl-4,6-dimethyl-phenyl substituierte spirocyclische Tetramsäure-Derivate |
| MXPA06005734A (es) * | 2003-11-28 | 2006-08-17 | Hoffmann La Roche | Acidos tetronico y tetramico como inhibidores de beta-secretasa. |
| EP1992614A1 (de) | 2007-05-16 | 2008-11-19 | Bayer CropScience Aktiengesellschaft | 3-(2-Alkoxy-phenyl)-substituierte Tetramate |
| RU2519948C2 (ru) | 2008-08-22 | 2014-06-20 | Бритиш Коламбиа Кэнсер Эйдженси Бранч | Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов |
| US8389443B2 (en) | 2008-12-02 | 2013-03-05 | Bayer Cropscience Ag | Geminal alkoxy/alkylspirocyclic substituted tetramate derivatives |
| CN101838260B (zh) * | 2010-03-31 | 2013-08-14 | 华南理工大学 | 二氢吡咯酮衍生物作为Caspase-3抑制剂 |
| DK2668158T3 (en) * | 2011-01-25 | 2018-10-15 | Bayer Cropscience Ag | PROCEDURE FOR PREPARING 1-H-PYRROLIDINE-2,4-DION DERIVATIVES |
| EA027136B1 (ru) * | 2012-07-02 | 2017-06-30 | Пнб Веспер Лайф Сайенс Пвт Лимитед | Новые лиганды холецистокининовых рецепторов |
| US20140371283A1 (en) * | 2013-02-12 | 2014-12-18 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| CN107056672A (zh) * | 2017-05-22 | 2017-08-18 | 北京卓凯生物技术有限公司 | 吡咯烷‑2,4‑二酮类化合物及其制备方法 |
| CN107353239B (zh) * | 2017-08-11 | 2019-06-18 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法 |
| CN107468690B (zh) | 2017-08-11 | 2020-01-31 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法与应用 |
-
2017
- 2017-08-11 CN CN201710684334.9A patent/CN107353239B/zh active Active
-
2018
- 2018-06-20 DK DK18843726.3T patent/DK3647306T3/da active
- 2018-06-20 EP EP18843726.3A patent/EP3647306B1/en active Active
- 2018-06-20 HU HUE18843726A patent/HUE059136T2/hu unknown
- 2018-06-20 PT PT188437263T patent/PT3647306T/pt unknown
- 2018-06-20 US US16/637,609 patent/US11332440B2/en active Active
- 2018-06-20 AU AU2018314472A patent/AU2018314472B9/en active Active
- 2018-06-20 ES ES18843726T patent/ES2920132T3/es active Active
- 2018-06-20 WO PCT/CN2018/091962 patent/WO2019029274A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20200181081A1 (en) | 2020-06-11 |
| AU2018314472A1 (en) | 2020-02-13 |
| US11332440B2 (en) | 2022-05-17 |
| DK3647306T3 (da) | 2022-06-27 |
| CN107353239A (zh) | 2017-11-17 |
| CN107353239B (zh) | 2019-06-18 |
| AU2018314472B9 (en) | 2020-09-17 |
| EP3647306A4 (en) | 2021-04-07 |
| EP3647306B1 (en) | 2022-04-06 |
| ES2920132T3 (es) | 2022-08-01 |
| WO2019029274A1 (zh) | 2019-02-14 |
| HUE059136T2 (hu) | 2022-10-28 |
| AU2018314472B2 (en) | 2020-08-27 |
| EP3647306A1 (en) | 2020-05-06 |
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