PT3177596T - Processo melhorado para a preparação de eslicarbazepina e acetato de eslicarbazepina - Google Patents
Processo melhorado para a preparação de eslicarbazepina e acetato de eslicarbazepinaInfo
- Publication number
- PT3177596T PT3177596T PT167057892T PT16705789T PT3177596T PT 3177596 T PT3177596 T PT 3177596T PT 167057892 T PT167057892 T PT 167057892T PT 16705789 T PT16705789 T PT 16705789T PT 3177596 T PT3177596 T PT 3177596T
- Authority
- PT
- Portugal
- Prior art keywords
- eslicarbazepine
- preparation
- improved process
- acetate
- eslicarbazepine acetate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2540/00—Compositional aspects of coordination complexes or ligands in catalyst systems
- B01J2540/30—Non-coordinating groups comprising sulfur
- B01J2540/32—Sulfonic acid groups or their salts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITVI20150064 | 2015-03-06 | ||
| EP15195474.0A EP3064490A1 (en) | 2015-03-06 | 2015-11-19 | Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3177596T true PT3177596T (pt) | 2018-07-27 |
Family
ID=52781229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT167057892T PT3177596T (pt) | 2015-03-06 | 2016-02-23 | Processo melhorado para a preparação de eslicarbazepina e acetato de eslicarbazepina |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9845293B2 (pt) |
| EP (2) | EP3064490A1 (pt) |
| CA (1) | CA2962543C (pt) |
| PT (1) | PT3177596T (pt) |
| WO (1) | WO2016142164A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107033079B (zh) * | 2016-10-17 | 2020-07-28 | 扬子江药业集团北京海燕药业有限公司 | 醋酸艾司利卡西平的制备方法 |
| CN108101740B (zh) * | 2017-12-05 | 2022-02-01 | 三峡大学 | 一种芳香炔烃一锅法直接转化成手性醇的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT101732B (pt) | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| GB0111566D0 (en) | 2001-05-11 | 2001-07-04 | Portela & Ca Sa | Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide |
| GB0223224D0 (en) | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| TW200502222A (en) | 2003-04-02 | 2005-01-16 | Novartis Ag | Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders |
| GB2401605A (en) | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
| GB2416167A (en) | 2004-07-13 | 2006-01-18 | Portela & Ca Sa | Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides |
| ITMI20042291A1 (it) | 2004-11-26 | 2005-02-26 | Farchema S R L | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB2437078A (en) | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| WO2011045648A2 (en) | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof |
| WO2011091131A2 (en) | 2010-01-23 | 2011-07-28 | Dr. Reddy's Laboratories Ltd. | Eslicarbazepine acetate and its polymorphs |
| WO2011117885A1 (en) | 2010-03-23 | 2011-09-29 | Intas Pharmaceuticals Limited | Process for preparation of enantiomers of licarbazepine |
| EP2383261B1 (en) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Process for the asymmetric hydrogenation of ketones |
| WO2011138795A2 (en) | 2010-05-03 | 2011-11-10 | Msn Laboratories Limited | Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide |
| US9217005B2 (en) | 2010-08-26 | 2015-12-22 | Takasago International Corporation | Ruthenium-diamine complexes and method for producing optically active compounds |
| WO2012121701A1 (en) | 2011-03-07 | 2012-09-13 | Watson Laboratories, Inc. | Process for the resolution of racemic (±)-10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide |
| WO2012156987A2 (en) | 2011-05-19 | 2012-11-22 | Glenmark Generics Limited | A novel process for the preparation of eslicarbazepine |
| US20150065704A1 (en) | 2011-07-13 | 2015-03-05 | Ketan Hirpara | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
-
2015
- 2015-11-19 EP EP15195474.0A patent/EP3064490A1/en not_active Withdrawn
-
2016
- 2016-02-23 WO PCT/EP2016/053706 patent/WO2016142164A1/en active Application Filing
- 2016-02-23 US US15/515,863 patent/US9845293B2/en active Active
- 2016-02-23 EP EP16705789.2A patent/EP3177596B1/en active Active
- 2016-02-23 CA CA2962543A patent/CA2962543C/en active Active
- 2016-02-23 PT PT167057892T patent/PT3177596T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2962543C (en) | 2017-07-11 |
| EP3177596A1 (en) | 2017-06-14 |
| EP3064490A1 (en) | 2016-09-07 |
| EP3177596B1 (en) | 2018-04-18 |
| WO2016142164A1 (en) | 2016-09-15 |
| CA2962543A1 (en) | 2016-09-15 |
| US20170305860A1 (en) | 2017-10-26 |
| US9845293B2 (en) | 2017-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL250744A0 (en) | A method for preparing flavociclib and its pharmaceutical preparations | |
| SI3380530T1 (sl) | Izboljšan postopek za pripravo sugamadeksa in njegovih intermediatov | |
| HK1254055A1 (zh) | 製備奧貝膽酸及其衍生物的方法 | |
| ZA201706795B (en) | Process for the preparation of dicycloplatin | |
| EP2951158A4 (en) | PROCESS FOR THE PREPARATION OF IVACAFTOR AND SOLVATES THEREOF | |
| EP3227298A4 (en) | Process for the preparation of baricitinib and an intermediate thereof | |
| HUE049170T2 (hu) | Eljárás szubsztituált cikloszerinek elõállítására | |
| IL246944B (en) | A process for the preparation of abiraterone acetate and its intermediates | |
| SI3253772T1 (sl) | Postopek za pripravo diosmina | |
| GB201709604D0 (en) | Tea solid composition and process of making the same | |
| HUP1400543A2 (hu) | Eljárás és köztitermék apixaban elõállítására | |
| PT3177596T (pt) | Processo melhorado para a preparação de eslicarbazepina e acetato de eslicarbazepina | |
| IL255819A (en) | An improved process for the preparation of sofosbuvir and intermediates | |
| IL253077A0 (en) | Process and intermediates for the preparation of Fermpanel | |
| GB2564185B (en) | Process for the preparation of derivatives of benzodioxole | |
| HUP1500647A2 (en) | Intermediate of baricitinib and process for its preparation | |
| EP3242876A4 (en) | An improved process for the preparation of lurasidone and its intermediate | |
| IL237572A0 (en) | Process and intermediates for the preparation of dastinib | |
| HK1245267A1 (zh) | 用於製備噻吩並-吲哚衍生物的不對稱方法 | |
| ZA201608823B (en) | Processes for the preparation of azd5363 and novel intermediate used therein | |
| HUP1600671A2 (en) | Industrial process for the preparation of nomegestrol acetate | |
| EP3253760A4 (en) | Process for the preparation of baricitinib and an intermediate thereof | |
| HUP1400518A2 (hu) | Eljárás tofacitinib elõállítására | |
| IL274560A (en) | A process for the preparation of raltagravir | |
| IL253175A0 (en) | A process for the preparation of ospemifene and fispemifene |