PT3044223T - Derivados de 2,3-di-hidro-1h-inden-1-ona como antagonistas do recetor órfão gama relacionado com o ácido retinoico (ror gama) para o tratamento de esclerose múltipla - Google Patents
Derivados de 2,3-di-hidro-1h-inden-1-ona como antagonistas do recetor órfão gama relacionado com o ácido retinoico (ror gama) para o tratamento de esclerose múltiplaInfo
- Publication number
- PT3044223T PT3044223T PT148448921T PT14844892T PT3044223T PT 3044223 T PT3044223 T PT 3044223T PT 148448921 T PT148448921 T PT 148448921T PT 14844892 T PT14844892 T PT 14844892T PT 3044223 T PT3044223 T PT 3044223T
- Authority
- PT
- Portugal
- Prior art keywords
- inden
- dihydro
- substituted
- multiple sclerosis
- receptor antagonists
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201361876099P | 2013-09-10 | 2013-09-10 |
Publications (1)
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PT3044223T true PT3044223T (pt) | 2020-05-06 |
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PT148448921T PT3044223T (pt) | 2013-09-10 | 2014-08-28 | Derivados de 2,3-di-hidro-1h-inden-1-ona como antagonistas do recetor órfão gama relacionado com o ácido retinoico (ror gama) para o tratamento de esclerose múltipla |
Country Status (16)
Country | Link |
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US (4) | US9359315B2 (pt) |
EP (2) | EP3680237A1 (pt) |
JP (2) | JP6437560B2 (pt) |
AU (1) | AU2014318178B2 (pt) |
CA (1) | CA2916419C (pt) |
CY (1) | CY1123133T1 (pt) |
DK (1) | DK3044223T3 (pt) |
ES (1) | ES2788660T3 (pt) |
HR (1) | HRP20200686T1 (pt) |
HU (1) | HUE051458T2 (pt) |
LT (1) | LT3044223T (pt) |
PL (1) | PL3044223T3 (pt) |
PT (1) | PT3044223T (pt) |
RS (1) | RS60342B1 (pt) |
SI (1) | SI3044223T1 (pt) |
WO (1) | WO2015038350A2 (pt) |
Families Citing this family (5)
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US9359315B2 (en) * | 2013-09-10 | 2016-06-07 | Arrien Pharmaceuticals Llc | Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis |
UY37507A (es) | 2016-12-05 | 2018-06-29 | Lead Pharma Holding Bv | Moduladores de ror gamma (ror¿) |
US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
CN113710239A (zh) * | 2019-02-20 | 2021-11-26 | 加利福尼亚大学董事会 | 视黄酸受体相关孤儿受体γ(RORγ)依赖性癌症的治疗 |
WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
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FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
JP2777159B2 (ja) * | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | 環状アミン誘導体を含有する医薬 |
DE4439822A1 (de) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
DE69924467T2 (de) | 1998-01-16 | 2006-02-16 | Eisai Co., Ltd. | Verfahren zur herstellung von donepezilderivaten |
EP1257264B1 (en) * | 2000-02-14 | 2011-09-14 | Merck Sharp & Dohme Corp. | Estrogen receptor modulators |
PT1311272E (pt) * | 2000-03-03 | 2007-02-28 | Eisai R&D Man Co Ltd | Novos métodos utilizando inibidores de colinesterase |
JPWO2003061658A1 (ja) * | 2002-01-22 | 2005-05-19 | エーザイ株式会社 | インダノン誘導体を含有するシグマ受容体結合剤 |
JP2008518959A (ja) * | 2004-11-01 | 2008-06-05 | メルク エンド カムパニー インコーポレーテッド | 1,5−二置換−2−ヒドロキシ−ジバテトラエン−6−オンの合成 |
AR051597A1 (es) | 2004-11-01 | 2007-01-24 | Merck & Co Inc | Moduladores de los receptores de estrogeno |
HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
WO2008057309A2 (en) * | 2006-11-02 | 2008-05-15 | Merck & Co., Inc. | Estrogen receptor modulators |
WO2012158784A2 (en) * | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
US9359315B2 (en) * | 2013-09-10 | 2016-06-07 | Arrien Pharmaceuticals Llc | Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis |
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2014
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- 2014-08-28 SI SI201431560T patent/SI3044223T1/sl unknown
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- 2014-08-28 PL PL14844892T patent/PL3044223T3/pl unknown
- 2014-08-28 WO PCT/US2014/053227 patent/WO2015038350A2/en active Application Filing
- 2014-08-28 RS RS20200523A patent/RS60342B1/sr unknown
- 2014-08-28 DK DK14844892.1T patent/DK3044223T3/da active
- 2014-08-28 EP EP14844892.1A patent/EP3044223B1/en active Active
- 2014-08-28 LT LTEP14844892.1T patent/LT3044223T/lt unknown
- 2014-08-28 PT PT148448921T patent/PT3044223T/pt unknown
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2016
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2018
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2019
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US20190209574A1 (en) | 2019-07-11 |
LT3044223T (lt) | 2020-07-10 |
HUE051458T2 (hu) | 2021-03-01 |
US9359315B2 (en) | 2016-06-07 |
US10172866B2 (en) | 2019-01-08 |
WO2015038350A2 (en) | 2015-03-19 |
JP2018184408A (ja) | 2018-11-22 |
JP2016531146A (ja) | 2016-10-06 |
RS60342B1 (sr) | 2020-07-31 |
WO2015038350A3 (en) | 2015-05-28 |
PL3044223T3 (pl) | 2020-09-21 |
JP6437560B2 (ja) | 2018-12-12 |
EP3680237A1 (en) | 2020-07-15 |
CY1123133T1 (el) | 2021-10-29 |
ES2788660T3 (es) | 2020-10-22 |
CA2916419C (en) | 2019-06-18 |
US10682358B2 (en) | 2020-06-16 |
US20160213627A1 (en) | 2016-07-28 |
US20150072980A1 (en) | 2015-03-12 |
US20160213676A1 (en) | 2016-07-28 |
AU2014318178B2 (en) | 2016-09-08 |
DK3044223T3 (da) | 2020-05-04 |
EP3044223A4 (en) | 2017-04-26 |
AU2014318178A1 (en) | 2015-03-19 |
JP6574289B2 (ja) | 2019-09-11 |
HRP20200686T1 (hr) | 2020-10-02 |
CA2916419A1 (en) | 2015-03-19 |
AU2014318178A8 (en) | 2016-01-14 |
US9446047B2 (en) | 2016-09-20 |
SI3044223T1 (sl) | 2020-08-31 |
EP3044223B1 (en) | 2020-04-01 |
EP3044223A2 (en) | 2016-07-20 |
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