PT2906252T - Conjugados de anticorpo anti-her2 de pirrolobenzodiazepina - Google Patents

Conjugados de anticorpo anti-her2 de pirrolobenzodiazepina Download PDF

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Publication number
PT2906252T
PT2906252T PT137886917T PT13788691T PT2906252T PT 2906252 T PT2906252 T PT 2906252T PT 137886917 T PT137886917 T PT 137886917T PT 13788691 T PT13788691 T PT 13788691T PT 2906252 T PT2906252 T PT 2906252T
Authority
PT
Portugal
Prior art keywords
antibody
mmol
conjugate
cancer
drug
Prior art date
Application number
PT137886917T
Other languages
English (en)
Portuguese (pt)
Inventor
Hendrikus Cornelis Van Berkel Patricius
Wilson Howard Philip
Original Assignee
Medimmune Ltd
Adc Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd, Adc Therapeutics Sa filed Critical Medimmune Ltd
Publication of PT2906252T publication Critical patent/PT2906252T/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
PT137886917T 2012-10-12 2013-10-11 Conjugados de anticorpo anti-her2 de pirrolobenzodiazepina PT2906252T (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261712924P 2012-10-12 2012-10-12
US201261712928P 2012-10-12 2012-10-12
US201361784233P 2013-03-14 2013-03-14
US201361784270P 2013-03-14 2013-03-14
US201361784249P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
PT2906252T true PT2906252T (pt) 2017-09-19

Family

ID=49552324

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137886917T PT2906252T (pt) 2012-10-12 2013-10-11 Conjugados de anticorpo anti-her2 de pirrolobenzodiazepina

Country Status (22)

Country Link
US (1) US20150273077A1 (cg-RX-API-DMAC7.html)
EP (1) EP2906252B1 (cg-RX-API-DMAC7.html)
JP (1) JP2016502504A (cg-RX-API-DMAC7.html)
KR (1) KR20150083856A (cg-RX-API-DMAC7.html)
CN (1) CN104955485B (cg-RX-API-DMAC7.html)
AU (1) AU2013328621B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015008177A2 (cg-RX-API-DMAC7.html)
CA (1) CA2887896A1 (cg-RX-API-DMAC7.html)
CY (1) CY1119287T1 (cg-RX-API-DMAC7.html)
DK (1) DK2906252T3 (cg-RX-API-DMAC7.html)
ES (1) ES2640449T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20171264T1 (cg-RX-API-DMAC7.html)
HU (1) HUE034505T2 (cg-RX-API-DMAC7.html)
LT (1) LT2906252T (cg-RX-API-DMAC7.html)
MX (1) MX2015004423A (cg-RX-API-DMAC7.html)
PL (1) PL2906252T3 (cg-RX-API-DMAC7.html)
PT (1) PT2906252T (cg-RX-API-DMAC7.html)
RS (1) RS56222B1 (cg-RX-API-DMAC7.html)
SI (1) SI2906252T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201700444T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014057115A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201502267B (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
PL2906252T3 (pl) 2017-11-30
HRP20171264T1 (hr) 2017-10-20
EP2906252B1 (en) 2017-06-14
CN104955485B (zh) 2018-01-30
ZA201502267B (en) 2017-09-27
ES2640449T3 (es) 2017-11-03
EP2906252A1 (en) 2015-08-19
CN104955485A (zh) 2015-09-30
CY1119287T1 (el) 2018-02-14
SI2906252T1 (sl) 2017-10-30
HUE034505T2 (en) 2018-02-28
WO2014057115A1 (en) 2014-04-17
BR112015008177A2 (pt) 2017-09-19
KR20150083856A (ko) 2015-07-20
SMT201700444T1 (it) 2017-11-15
US20150273077A1 (en) 2015-10-01
MX2015004423A (es) 2015-10-29
AU2013328621A1 (en) 2015-04-23
AU2013328621B2 (en) 2016-12-01
CA2887896A1 (en) 2014-04-17
LT2906252T (lt) 2017-09-11
DK2906252T3 (en) 2017-09-11
JP2016502504A (ja) 2016-01-28
RS56222B1 (sr) 2017-11-30

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