PT2614052E - Novos análogos de piperazina como antivirais de influenza de amplo espectro - Google Patents
Novos análogos de piperazina como antivirais de influenza de amplo espectro Download PDFInfo
- Publication number
- PT2614052E PT2614052E PT11758034T PT11758034T PT2614052E PT 2614052 E PT2614052 E PT 2614052E PT 11758034 T PT11758034 T PT 11758034T PT 11758034 T PT11758034 T PT 11758034T PT 2614052 E PT2614052 E PT 2614052E
- Authority
- PT
- Portugal
- Prior art keywords
- broad
- novel piperazine
- spectrum influenza
- influenza antivirals
- piperazine analogs
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- IDQFVBBBGMXQKM-UHFFFAOYSA-N CC(Nc(cc1)ccc1C(Nc(c([N+]([O-])=O)c1)cc(NCCNC(c2c(C)[o]nc2-c(cccc2)c2OC)=O)c1Cl)=O)=O Chemical compound CC(Nc(cc1)ccc1C(Nc(c([N+]([O-])=O)c1)cc(NCCNC(c2c(C)[o]nc2-c(cccc2)c2OC)=O)c1Cl)=O)=O IDQFVBBBGMXQKM-UHFFFAOYSA-N 0.000 description 1
- BETKUHJAABLBDV-UHFFFAOYSA-N CNc(cc1)ccc1C(Nc(c([N+]([O-])=O)c1)cc(NCCNC(c2c(-c(cccc3)c3OC)nn[n]2C)=O)c1Cl)=O Chemical compound CNc(cc1)ccc1C(Nc(c([N+]([O-])=O)c1)cc(NCCNC(c2c(-c(cccc3)c3OC)nn[n]2C)=O)c1Cl)=O BETKUHJAABLBDV-UHFFFAOYSA-N 0.000 description 1
- BWNHGSWIEGRMFQ-UHFFFAOYSA-N Cc1c(C(N(CC2)CCN2c(cc(c([NH+2]O)c2)NC(c(cc3)ccc3N(CCC3)C3=O)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(N(CC2)CCN2c(cc(c([NH+2]O)c2)NC(c(cc3)ccc3N(CCC3)C3=O)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 BWNHGSWIEGRMFQ-UHFFFAOYSA-N 0.000 description 1
- PBHSTAMMNXLCEZ-UHFFFAOYSA-O Cc1c(C(NCCNc(cc(c([N+](O)=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2Cl)=O)c(-c(cccc2)c2O)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+](O)=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2Cl)=O)c(-c(cccc2)c2O)n[o]1 PBHSTAMMNXLCEZ-UHFFFAOYSA-O 0.000 description 1
- ZEUPUGVMLCYCII-UHFFFAOYSA-O Cc1c(C(NCCNc(cc(c([N+](O)=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+](O)=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 ZEUPUGVMLCYCII-UHFFFAOYSA-O 0.000 description 1
- MGXPDHSTFZGLFB-UHFFFAOYSA-N Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3-[n]3ncnc3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3-[n]3ncnc3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 MGXPDHSTFZGLFB-UHFFFAOYSA-N 0.000 description 1
- RJOIPYOZYVDZII-UHFFFAOYSA-N Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2C#N)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N(C)C)=O)c2C#N)=O)c(-c(cccc2)c2OC)n[o]1 RJOIPYOZYVDZII-UHFFFAOYSA-N 0.000 description 1
- WDWUGXGKFFLNEO-UHFFFAOYSA-N Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N(C)S(C)(=O)=O)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N(C)S(C)(=O)=O)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 WDWUGXGKFFLNEO-UHFFFAOYSA-N 0.000 description 1
- AHNKQFSLNLXYSU-UHFFFAOYSA-N Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N3CCCC3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c(cc3)ccc3N3CCCC3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 AHNKQFSLNLXYSU-UHFFFAOYSA-N 0.000 description 1
- XXKLQWYYMBOJGB-UHFFFAOYSA-N Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c3ccc(CN(C)I)cc3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 Chemical compound Cc1c(C(NCCNc(cc(c([N+]([O-])=O)c2)NC(c3ccc(CN(C)I)cc3)=O)c2Cl)=O)c(-c(cccc2)c2OC)n[o]1 XXKLQWYYMBOJGB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38072810P | 2010-09-08 | 2010-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2614052E true PT2614052E (pt) | 2015-03-31 |
Family
ID=44653573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT11758034T PT2614052E (pt) | 2010-09-08 | 2011-09-06 | Novos análogos de piperazina como antivirais de influenza de amplo espectro |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8362004B2 (enExample) |
| EP (1) | EP2614052B1 (enExample) |
| JP (1) | JP5902172B2 (enExample) |
| CN (1) | CN103201268B (enExample) |
| BR (1) | BR112013005552A2 (enExample) |
| CA (1) | CA2809624A1 (enExample) |
| DK (1) | DK2614052T3 (enExample) |
| EA (1) | EA023258B1 (enExample) |
| ES (1) | ES2533068T3 (enExample) |
| HR (1) | HRP20150228T1 (enExample) |
| MX (1) | MX2013002557A (enExample) |
| PL (1) | PL2614052T3 (enExample) |
| PT (1) | PT2614052E (enExample) |
| RS (1) | RS53844B1 (enExample) |
| SI (1) | SI2614052T1 (enExample) |
| SM (1) | SMT201500068B (enExample) |
| WO (1) | WO2012033736A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101369584B1 (ko) * | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
| JP6293770B2 (ja) * | 2012-11-05 | 2018-03-14 | ナント ホールディングス アイピー，エルエルシー | ヘッジホッグシグナル伝達経路阻害剤としての環状スルホンアミド含有誘導体 |
| KR102089122B1 (ko) | 2016-08-25 | 2020-03-13 | 주식회사 엘지화학 | 디아민 화합물 및 이를 이용하여 제조된 플렉시블 소자용 기판 |
| CA3052353A1 (en) * | 2017-02-02 | 2018-08-09 | Janssen Vaccines & Prevention B.V. | Piperazine derivatives for influenza virus inhibition |
| WO2018141854A1 (en) | 2017-02-02 | 2018-08-09 | Janssen Vaccines & Prevention B.V. | Piperazine derivatives for influenza virus inhibition |
| WO2021204924A1 (en) * | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Compounds for use in the treatment of hypercytokinemia |
| WO2021204923A1 (en) * | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Antiviral agents |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| US7196080B2 (en) * | 2001-06-15 | 2007-03-27 | Astellas Pharma Inc. | Phenylpyridinecarbonylpiperazinederivative |
| AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
| WO2004078732A1 (fr) * | 2003-01-28 | 2004-09-16 | Aventis Pharma S.A. | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| US6949865B2 (en) * | 2003-01-31 | 2005-09-27 | Betabatt, Inc. | Apparatus and method for generating electrical current from the nuclear decay process of a radioactive material |
| GB0428235D0 (en) | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
| RU2012104214A (ru) * | 2009-08-05 | 2013-09-10 | Верситек Лимитед | Противовирусные соединения и способы их получения и применения |
-
2011
- 2011-09-06 JP JP2013528244A patent/JP5902172B2/ja not_active Expired - Fee Related
- 2011-09-06 PT PT11758034T patent/PT2614052E/pt unknown
- 2011-09-06 CA CA2809624A patent/CA2809624A1/en not_active Abandoned
- 2011-09-06 BR BR112013005552A patent/BR112013005552A2/pt not_active Application Discontinuation
- 2011-09-06 WO PCT/US2011/050504 patent/WO2012033736A1/en not_active Ceased
- 2011-09-06 MX MX2013002557A patent/MX2013002557A/es active IP Right Grant
- 2011-09-06 DK DK11758034.0T patent/DK2614052T3/en active
- 2011-09-06 PL PL11758034T patent/PL2614052T3/pl unknown
- 2011-09-06 HR HRP20150228AT patent/HRP20150228T1/hr unknown
- 2011-09-06 EP EP11758034.0A patent/EP2614052B1/en active Active
- 2011-09-06 US US13/225,851 patent/US8362004B2/en active Active
- 2011-09-06 RS RS20150127A patent/RS53844B1/sr unknown
- 2011-09-06 ES ES11758034.0T patent/ES2533068T3/es active Active
- 2011-09-06 EA EA201390362A patent/EA023258B1/ru not_active IP Right Cessation
- 2011-09-06 CN CN201180053649.4A patent/CN103201268B/zh not_active Expired - Fee Related
- 2011-09-06 SI SI201130411T patent/SI2614052T1/sl unknown
-
2015
- 2015-03-18 SM SM201500068T patent/SMT201500068B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103201268B (zh) | 2015-08-12 |
| HRP20150228T1 (hr) | 2015-04-10 |
| EA023258B1 (ru) | 2016-05-31 |
| ES2533068T3 (es) | 2015-04-07 |
| SMT201500068B (it) | 2015-05-05 |
| MX2013002557A (es) | 2013-05-28 |
| PL2614052T3 (pl) | 2015-06-30 |
| BR112013005552A2 (pt) | 2016-05-03 |
| US8362004B2 (en) | 2013-01-29 |
| CN103201268A (zh) | 2013-07-10 |
| EP2614052B1 (en) | 2014-12-31 |
| EP2614052A1 (en) | 2013-07-17 |
| JP5902172B2 (ja) | 2016-04-13 |
| SI2614052T1 (sl) | 2015-04-30 |
| WO2012033736A1 (en) | 2012-03-15 |
| JP2013537193A (ja) | 2013-09-30 |
| CA2809624A1 (en) | 2012-03-15 |
| US20120238539A1 (en) | 2012-09-20 |
| DK2614052T3 (en) | 2015-04-07 |
| RS53844B1 (sr) | 2015-08-31 |
| EA201390362A1 (ru) | 2013-07-30 |
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