PT2494962E - Administração pulmonar de levodopa - Google Patents

Administração pulmonar de levodopa Download PDF

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Publication number
PT2494962E
PT2494962E PT121702377T PT12170237T PT2494962E PT 2494962 E PT2494962 E PT 2494962E PT 121702377 T PT121702377 T PT 121702377T PT 12170237 T PT12170237 T PT 12170237T PT 2494962 E PT2494962 E PT 2494962E
Authority
PT
Portugal
Prior art keywords
levodopa
pulmonary delivery
pulmonary
delivery
Prior art date
Application number
PT121702377T
Other languages
English (en)
Inventor
David J Bennett
Raymond T Bartas
Dwaine F Emerich
Blair Jackson
Original Assignee
Civitas Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Civitas Therapeutics Inc filed Critical Civitas Therapeutics Inc
Publication of PT2494962E publication Critical patent/PT2494962E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT121702377T 2002-03-20 2003-03-19 Administração pulmonar de levodopa PT2494962E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36647102P 2002-03-20 2002-03-20

Publications (1)

Publication Number Publication Date
PT2494962E true PT2494962E (pt) 2014-08-27

Family

ID=28454804

Family Applications (3)

Application Number Title Priority Date Filing Date
PT131619298T PT2630954T (pt) 2002-03-20 2003-03-19 Administração pulmonar de levodopa
PT121702377T PT2494962E (pt) 2002-03-20 2003-03-19 Administração pulmonar de levodopa
PT03714302T PT1531798E (pt) 2002-03-20 2003-03-19 Administração pulmonar de levodopa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT131619298T PT2630954T (pt) 2002-03-20 2003-03-19 Administração pulmonar de levodopa

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT03714302T PT1531798E (pt) 2002-03-20 2003-03-19 Administração pulmonar de levodopa

Country Status (13)

Country Link
US (7) US7879358B2 (pt)
EP (3) EP2494962B1 (pt)
JP (1) JP4384503B2 (pt)
AU (1) AU2003218307B8 (pt)
CA (1) CA2478980C (pt)
CY (1) CY1118517T1 (pt)
DK (2) DK2630954T3 (pt)
ES (3) ES2609482T3 (pt)
HU (1) HUE031167T2 (pt)
LT (1) LT2630954T (pt)
PT (3) PT2630954T (pt)
SI (1) SI2630954T1 (pt)
WO (1) WO2003079992A2 (pt)

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DK2630954T3 (en) * 2002-03-20 2017-01-23 Civitas Therapeutics Inc PULMONAL SUBMISSION OF LEVODOPA
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CN101171023A (zh) * 2005-03-09 2008-04-30 小野药品工业株式会社 一种粒子以及含有该粒子的制剂
ECSP077628A (es) * 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
GB2454480A (en) * 2007-11-07 2009-05-13 Vectura Group Plc Pulmonary inhalation of levodopa containing compositions in the treatment of Parkinsons disease and other central nervous system disorders
MX354829B (es) 2009-03-26 2018-03-22 Pulmatrix Operating Co Inc Formulaciones de polvo seco y metodos para el tratamiento de enfermedades pulmonares.
EP2464346A1 (en) 2010-08-30 2012-06-20 Pulmatrix, Inc. Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder
AU2011296343B2 (en) 2010-08-30 2015-12-10 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
DK2621488T3 (en) 2010-09-29 2019-03-04 Pulmatrix Operating Co Inc CATIONIC DRY POWDER
CN107096014B (zh) 2010-09-29 2022-07-15 普马特里克斯营业公司 吸入用单价金属阳离子干粉剂
CN104487075A (zh) 2012-02-29 2015-04-01 普马特里克斯公司 可吸入干粉剂
PT2908805T (pt) * 2012-10-22 2021-09-10 Civitas Therapeutics Inc Formulações de levodopa para alívio rápido da doença de parkinson
CN107982246A (zh) * 2012-10-22 2018-05-04 丝维塔斯治疗有限公司 降低左旋多巴血浆浓度的患者间可变性的方法相关申请
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
US8545878B1 (en) * 2012-11-09 2013-10-01 Civitas Therapeutics, Inc. Capsules containing high doses of levodopa for pulmonary use
US20140150787A1 (en) 2012-12-04 2014-06-05 Civitas Therapeutics, Inc. Devices and methods for puncturing a capsule to release a powdered medicament therefrom
CN105324106A (zh) 2013-04-01 2016-02-10 普马特里克斯营业公司 噻托铵干粉
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
TWI589308B (zh) * 2014-03-25 2017-07-01 林信湧 一種用於治療帕金森氏症之吸入式醫藥組成物及其備製方法
BR112016024502A8 (pt) * 2014-04-21 2021-06-29 Civitas Therapeutics Inc uso de uma dose de partículas finas (fdp) de levodopa na fabricação de um medicamento
MA40910A (fr) 2014-11-07 2017-09-12 Civitas Therapeutics Inc Poudres de rapamycine pour administration pulmonaire
EP3291872A4 (en) 2015-05-06 2019-02-13 SynAgile Corporation PHARMACEUTICAL SUSPENSIONS WITH ACTIVE SUBSTANCES, DEVICES FOR THEIR ADMINISTRATION AND METHOD FOR THEIR USE
EP3316865A4 (en) 2015-07-02 2019-01-23 Civitas Therapeutics, Inc. POWDERS CONTAINING TRIPTAN, FOR PULMONARY DELIVERY
EP3597250B1 (en) 2017-01-30 2023-02-22 GlobalMed, Inc. Heated respiratory hose assembly
EP3823607A4 (en) * 2018-07-19 2022-04-06 Impel NeuroPharma Inc. ADMINISTRATION OF LEVODOPA AND DOPA DECARBOXYLASE INHIBITOR INTO THE RESPIRATORY TRACT FOR THE TREATMENT OF PARKINSON'S DISEASE
JP2019108379A (ja) * 2019-03-05 2019-07-04 サイヴィタス セラピューティックス，インコーポレイテッド パーキンソン病の運動症状変動の迅速な緩和
US12005185B2 (en) * 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods

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Also Published As

Publication number Publication date
US20180055800A1 (en) 2018-03-01
EP1531798A4 (en) 2010-11-03
EP2630954B1 (en) 2016-10-05
ES2389156T3 (es) 2012-10-23
PT2630954T (pt) 2017-01-05
JP2006507218A (ja) 2006-03-02
WO2003079992A3 (en) 2005-03-31
US20160058727A1 (en) 2016-03-03
US9155699B2 (en) 2015-10-13
AU2003218307B8 (en) 2006-08-31
US20130164349A1 (en) 2013-06-27
AU2003218307B2 (en) 2006-07-27
ES2609482T3 (es) 2017-04-20
JP4384503B2 (ja) 2009-12-16
EP2494962B1 (en) 2014-05-14
DK1531798T3 (da) 2012-08-13
US7879358B2 (en) 2011-02-01
AU2003218307A1 (en) 2003-10-08
LT2630954T (lt) 2017-01-25
USRE43711E1 (en) 2012-10-02
CY1118517T1 (el) 2017-07-12
HUE031167T2 (hu) 2017-07-28
EP1531798B1 (en) 2012-06-06
US8586093B2 (en) 2013-11-19
US20140105983A1 (en) 2014-04-17
EP2494962A2 (en) 2012-09-05
CA2478980C (en) 2008-07-15
PT1531798E (pt) 2012-09-10
EP2630954A1 (en) 2013-08-28
ES2487816T3 (es) 2014-08-25
DK2630954T3 (en) 2017-01-23
US20110151008A1 (en) 2011-06-23
CA2478980A1 (en) 2003-10-02
SI2630954T1 (sl) 2017-02-28
US8404276B2 (en) 2013-03-26
WO2003079992A2 (en) 2003-10-02
US20040018989A1 (en) 2004-01-29
EP1531798A2 (en) 2005-05-25
EP2494962A3 (en) 2013-01-16

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