PT2467489E - Produção de biofarmacêuticos com base em baculovíru isentos de viriões baculovíricos contaminantes - Google Patents
Produção de biofarmacêuticos com base em baculovíru isentos de viriões baculovíricos contaminantes Download PDFInfo
- Publication number
- PT2467489E PT2467489E PT107430837T PT10743083T PT2467489E PT 2467489 E PT2467489 E PT 2467489E PT 107430837 T PT107430837 T PT 107430837T PT 10743083 T PT10743083 T PT 10743083T PT 2467489 E PT2467489 E PT 2467489E
- Authority
- PT
- Portugal
- Prior art keywords
- baculovirus
- based production
- biopharmaceuticals
- free
- baculoviral virions
- Prior art date
Links
- 229960000074 biopharmaceutical Drugs 0.000 title 1
- 241000701447 unidentified baculovirus Species 0.000 title 1
- 210000002845 virion Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14151—Methods of production or purification of viral material
- C12N2710/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/50—Vectors for producing vectors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305761A EP2292781A1 (en) | 2009-08-17 | 2009-08-17 | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2467489E true PT2467489E (pt) | 2015-09-04 |
Family
ID=41203903
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT107430837T PT2467489E (pt) | 2009-08-17 | 2010-08-05 | Produção de biofarmacêuticos com base em baculovíru isentos de viriões baculovíricos contaminantes |
| PT151687753T PT2933336T (pt) | 2009-08-17 | 2010-08-05 | Produção biofármacos com base em baculovírus isentos de viriões baculovíricos contaminantes |
| PT162054407T PT3187589T (pt) | 2009-08-17 | 2010-08-05 | Produção de biofarmacêuticos com base em baculovíru isentos de viriões baculovíricos contaminantes |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT151687753T PT2933336T (pt) | 2009-08-17 | 2010-08-05 | Produção biofármacos com base em baculovírus isentos de viriões baculovíricos contaminantes |
| PT162054407T PT3187589T (pt) | 2009-08-17 | 2010-08-05 | Produção de biofarmacêuticos com base em baculovíru isentos de viriões baculovíricos contaminantes |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8993317B2 (pt) |
| EP (4) | EP2292781A1 (pt) |
| CN (1) | CN102686732A (pt) |
| CA (2) | CA3050271A1 (pt) |
| DK (3) | DK3187589T3 (pt) |
| ES (3) | ES2542740T3 (pt) |
| HU (1) | HUE025056T2 (pt) |
| PL (2) | PL2467489T3 (pt) |
| PT (3) | PT2467489E (pt) |
| WO (1) | WO2011020710A2 (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2292781A1 (en) | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
| EP2737070A1 (en) * | 2011-07-27 | 2014-06-04 | GBiotech SARL | Production of recombinant protein in insect cells using a baculovirus expression system |
| FR2978456B1 (fr) * | 2011-07-27 | 2015-02-20 | Genethon | Systeme baculoviral pour l'expression d'un vecteur de therapie genique |
| TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒（ａａｖ）ｓｆｌｔ-１治療老年性黃斑部退化（ａｍｄ） |
| RU2619161C2 (ru) * | 2012-06-12 | 2017-05-12 | Альтернативе Гене Экспрессион С.Л. | Элементы рекомбинантной днк для экспрессии рекомбинантных белков в клетке-хозяине |
| ES3042252T3 (en) | 2014-03-17 | 2025-11-19 | Adverum Biotechnologies Inc | Compositions and methods for enhanced gene expression in cone cells |
| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| CN112553229A (zh) | 2014-11-05 | 2021-03-26 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| MX2017006217A (es) | 2014-11-14 | 2018-05-02 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| RU2020108189A (ru) | 2014-11-14 | 2020-03-11 | Вояджер Терапьютикс, Инк. | Композиции и способы лечения бокового амиотрофического склероза (als) |
| EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| CN114480502A (zh) | 2015-03-02 | 2022-05-13 | 阿德夫拉姆生物技术股份有限公司 | 用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法 |
| JP7064214B2 (ja) | 2015-09-28 | 2022-05-10 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 抗体回避性ウイルスベクターのための方法および組成物 |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| AU2017267665C1 (en) | 2016-05-18 | 2023-10-05 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| BR112018073472A2 (pt) | 2016-05-18 | 2019-08-27 | Voyager Therapeutics, Inc. | composições e métodos de tratamento da doença de huntington |
| CN109477111B (zh) * | 2016-06-07 | 2023-12-15 | 塞弗德公司 | 热稳定聚合酶抑制剂组合物和方法 |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| CN111108198A (zh) | 2017-05-05 | 2020-05-05 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
| CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CN111132626B (zh) | 2017-07-17 | 2024-01-30 | 沃雅戈治疗公司 | 轨迹阵列引导系统 |
| WO2019028306A2 (en) | 2017-08-03 | 2019-02-07 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR ADMINISTRATION OF ADENO-ASSOCIATED VIRUSES |
| TWI904068B (zh) | 2017-08-09 | 2025-11-11 | 美商生物化學醫療公司 | 核酸分子及其用途 |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| CN111479924B (zh) | 2017-10-16 | 2024-06-14 | 沃雅戈治疗公司 | 肌萎缩性侧索硬化症(als)的治疗 |
| US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| JP7425738B2 (ja) | 2018-04-03 | 2024-01-31 | ギンコ バイオワークス インコーポレイテッド | 眼組織を標的とするウイルスベクター |
| US12091435B2 (en) | 2018-04-03 | 2024-09-17 | Ginkgo Bioworks, Inc. | Antibody-evading virus vectors |
| MX2020010464A (es) | 2018-04-03 | 2021-01-29 | Vectores de virus que evitan anticuerpos. | |
| AU2019268330A1 (en) | 2018-05-15 | 2020-11-26 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of Parkinson's disease |
| WO2019237376A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | TXGP1基因定点整合至Raji细胞的方法及其应用 |
| WO2019237377A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 一种将SLEB2基因定点整合至Jurkat细胞的方法及其应用 |
| WO2019237374A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | Mtabc3基因定点整合至a375细胞的方法及其应用 |
| CN108823176B (zh) * | 2018-07-20 | 2021-09-28 | 山西大学 | 一种重组杆状病毒及其构建方法和应用 |
| WO2020033863A1 (en) | 2018-08-09 | 2020-02-13 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| CN108998455B (zh) * | 2018-08-13 | 2021-03-16 | 西南大学 | 家蚕核型多角体病毒诱导型39k启动子及其重组载体和应用 |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN111434774B (zh) * | 2019-01-11 | 2023-06-23 | 陕西杆粒生物科技有限公司 | 一种解除高滴度抑制的杆状病毒表达载体 |
| JP7698583B2 (ja) | 2019-03-21 | 2025-06-25 | ギンコ バイオワークス インコーポレイテッド | 組換えアデノ随伴ウイルスベクター |
| SG11202110607WA (en) | 2019-04-01 | 2021-10-28 | Tenaya Therapeutics Inc | Adeno-associated virus with engineered capsid |
| AU2020302861A1 (en) * | 2019-06-26 | 2022-02-24 | Virovek, Inc. | Baculovirus expression system |
| IL292297A (en) | 2019-10-17 | 2022-06-01 | Stridebio Inc | Adeno-associated viral vectors for treatment of niemann-pick disease type c |
| CN110940807A (zh) * | 2019-11-08 | 2020-03-31 | 江苏科技大学 | 研究家蚕基因抑制BmNPV DNA复制相关基因的表达的方法 |
| CA3189878A1 (en) | 2020-08-19 | 2022-02-24 | Colin O'BANION | Adeno-associated virus vectors for treatment of rett syndrome |
| BR112023002395A2 (pt) * | 2020-08-23 | 2023-03-21 | Bioverativ Therapeutics Inc | Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna) |
| CN115698304A (zh) | 2020-10-09 | 2023-02-03 | 特纳亚治疗股份有限公司 | 亲斑蛋白-2基因疗法的方法和组合物 |
| CN115491377B (zh) * | 2021-06-18 | 2025-09-16 | 北京三诺佳邑生物技术有限责任公司 | 一种诱导rna干扰和降低并清除细胞中病毒污染的核苷酸序列及应用 |
| CN115491436A (zh) * | 2021-06-18 | 2022-12-20 | 舒泰神（北京）生物制药股份有限公司 | 一种用于检测杆状病毒残留dna的引物、探针及方法 |
| CA3229668A1 (en) * | 2021-08-23 | 2023-03-02 | Bioverativ Therapeutics Inc. | Baculovirus expression system |
| CN114058598B (zh) * | 2021-11-04 | 2023-04-28 | 中国科学院精密测量科学与技术创新研究院 | 新的重组杆状病毒基因组插入位点及其应用 |
| EP4508062A1 (en) | 2022-04-11 | 2025-02-19 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| CN118956967A (zh) * | 2024-04-17 | 2024-11-15 | 和元生物技术（上海）股份有限公司 | 核酸分子、包含其的重组杆状病毒及其应用 |
| CN120137918B (zh) * | 2025-05-12 | 2025-09-02 | 中国林业科学研究院高原林业研究所 | 重组dsRNA-杆状病毒及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| EP0127839B1 (en) | 1983-05-27 | 1992-07-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Method for producing a recombinant baculovirus expression vector |
| ZA848495B (en) | 1984-01-31 | 1985-09-25 | Idaho Res Found | Production of polypeptides in insect cells |
| CN1062601C (zh) * | 1992-03-24 | 2001-02-28 | 剑桥药物研究有限公司 | 病毒疫苗 |
| FR2756297B1 (fr) * | 1996-11-22 | 1999-01-08 | Centre Nat Rech Scient | Procede de production de virus recombinants |
| GB9919409D0 (en) * | 1999-08-18 | 1999-10-20 | Univ Oxford Brookes | Baculovirus expression system |
| US20040219516A1 (en) * | 2002-07-18 | 2004-11-04 | Invitrogen Corporation | Viral vectors containing recombination sites |
| WO2005072364A2 (en) * | 2004-01-27 | 2005-08-11 | University Of Florida | A modified baculovirus expression system for production of pseudotyped raav vector |
| EP2292781A1 (en) * | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
-
2009
- 2009-08-17 EP EP09305761A patent/EP2292781A1/en not_active Withdrawn
-
2010
- 2010-08-05 EP EP10743083.7A patent/EP2467489B1/en not_active Not-in-force
- 2010-08-05 ES ES10743083.7T patent/ES2542740T3/es active Active
- 2010-08-05 US US13/390,806 patent/US8993317B2/en not_active Expired - Fee Related
- 2010-08-05 EP EP16205440.7A patent/EP3187589B1/en active Active
- 2010-08-05 DK DK16205440.7T patent/DK3187589T3/da active
- 2010-08-05 HU HUE10743083A patent/HUE025056T2/en unknown
- 2010-08-05 ES ES15168775.3T patent/ES2627744T3/es active Active
- 2010-08-05 PT PT107430837T patent/PT2467489E/pt unknown
- 2010-08-05 PL PL10743083T patent/PL2467489T3/pl unknown
- 2010-08-05 DK DK15168775.3T patent/DK2933336T3/en active
- 2010-08-05 WO PCT/EP2010/061456 patent/WO2011020710A2/en not_active Ceased
- 2010-08-05 PT PT151687753T patent/PT2933336T/pt unknown
- 2010-08-05 CN CN2010800456298A patent/CN102686732A/zh active Pending
- 2010-08-05 PT PT162054407T patent/PT3187589T/pt unknown
- 2010-08-05 ES ES16205440T patent/ES2787706T3/es active Active
- 2010-08-05 PL PL16205440T patent/PL3187589T3/pl unknown
- 2010-08-05 EP EP15168775.3A patent/EP2933336B1/en not_active Not-in-force
- 2010-08-05 DK DK10743083.7T patent/DK2467489T3/en active
- 2010-08-05 CA CA3050271A patent/CA3050271A1/en not_active Abandoned
- 2010-08-05 CA CA2771250A patent/CA2771250C/en not_active Expired - Fee Related
-
2015
- 2015-03-27 US US14/670,459 patent/US9862934B2/en not_active Expired - Fee Related
-
2017
- 2017-12-14 US US15/841,359 patent/US10428315B2/en not_active Expired - Fee Related
-
2019
- 2019-08-27 US US16/551,787 patent/US11236307B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2933336T (pt) | Produção biofármacos com base em baculovírus isentos de viriões baculovíricos contaminantes | |
| PL2289864T3 (pl) | Proces otrzymywania związków fluorowych | |
| SI2496562T1 (sl) | Postopek priprave kalkobutrola | |
| PL2604268T3 (pl) | Sposób wytwarzania pochodnych tiazolu | |
| PT2913337T (pt) | Processo para a produção de sofosbuvir | |
| IL220170A0 (en) | New process for the preparation of dronedarone | |
| IL216322A0 (en) | Process for the production of dronedarone intermediates | |
| IL216942A0 (en) | Process for the manufacture of alkenones | |
| IL214906A (en) | A process for making Iwan | |
| ZA201105709B (en) | Process for the synthesis of cleistanthin | |
| EP2397438A4 (en) | METHOD FOR PRODUCING A FLUOR COMPOUND | |
| EP2464584A4 (en) | SHIPPING OF LIQUIDS | |
| IL217139A0 (en) | Process for the preparation of arylpyridinyl compounds | |
| IL219111A0 (en) | Process for the manufacture of organic compounds | |
| ZA201107259B (en) | Process for the synthesis of a propargylic alcohol | |
| ZA201106175B (en) | Chemical process for the production of haloalkenone ethers | |
| EP2423212A4 (en) | PROCESS FOR PREPARING A 2-AZAADAMANTAN COMPOUND FROM A BICYCLOCARBAMATE COMPOUND | |
| EP2393786A4 (en) | NEW POLYMORPHIC FROM LOPINAVIR | |
| IL215022A0 (en) | Novel process for the preparation of enaminocarbonyl compounds | |
| FI20095142L (fi) | Laitteisto lasimateriaalin valmistamiseksi | |
| IL217460A0 (en) | Novel process for the preparation of 4-aminobut-2-enolides | |
| IL217402A0 (en) | Continuous flow process for the preparation of sulphoxide compounds | |
| GB0905895D0 (en) | Process for the preparation of chalcogenone compounds | |
| SI2387557T1 (sl) | Postopek za pripravo N-(5-(3-dimetilamino-akriloil)-2-fluorofenil)-N-metil-acetamida | |
| GB0915850D0 (en) | Inspection of glazing components |