PT2272863E - Derivados de phl p 5a com alergenicidade reduzida e reatividade da célula t retida - Google Patents
Derivados de phl p 5a com alergenicidade reduzida e reatividade da célula t retidaInfo
- Publication number
- PT2272863E PT2272863E PT100098557T PT10009855T PT2272863E PT 2272863 E PT2272863 E PT 2272863E PT 100098557 T PT100098557 T PT 100098557T PT 10009855 T PT10009855 T PT 10009855T PT 2272863 E PT2272863 E PT 2272863E
- Authority
- PT
- Portugal
- Prior art keywords
- poa
- conserved
- derivatives
- reactivity
- cell reactivity
- Prior art date
Links
- 230000009257 reactivity Effects 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 abstract 3
- 239000013566 allergen Substances 0.000 abstract 2
- 230000003266 anti-allergic effect Effects 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 241001330029 Pooideae Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10325508 | 2003-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2272863E true PT2272863E (pt) | 2013-01-30 |
Family
ID=33494849
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT100098557T PT2272863E (pt) | 2003-06-04 | 2004-05-06 | Derivados de phl p 5a com alergenicidade reduzida e reatividade da célula t retida |
| PT04739147T PT1629006E (pt) | 2003-06-04 | 2004-05-06 | Derivados do phl p 5a com uma alergenicidade reduzida e uma reactividade mantida com as células t |
| PT100098565T PT2287180E (pt) | 2003-06-04 | 2004-05-06 | Derivados de lol p 5 com alergenicidade reduzida e reatividade mantida com as células t |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04739147T PT1629006E (pt) | 2003-06-04 | 2004-05-06 | Derivados do phl p 5a com uma alergenicidade reduzida e uma reactividade mantida com as células t |
| PT100098565T PT2287180E (pt) | 2003-06-04 | 2004-05-06 | Derivados de lol p 5 com alergenicidade reduzida e reatividade mantida com as células t |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8628946B2 (https=) |
| EP (3) | EP2287180B9 (https=) |
| JP (2) | JP4782671B2 (https=) |
| CN (1) | CN1798763B (https=) |
| AT (1) | ATE513848T1 (https=) |
| AU (1) | AU2004245184B2 (https=) |
| BR (1) | BRPI0410908A (https=) |
| CA (1) | CA2528053C (https=) |
| ES (3) | ES2434720T3 (https=) |
| PL (2) | PL2287180T3 (https=) |
| PT (3) | PT2272863E (https=) |
| RU (1) | RU2368620C2 (https=) |
| WO (1) | WO2004108758A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR779201A0 (en) | 2001-09-20 | 2001-10-11 | University Of Melbourne, The | Immunotherapeutic and immunoprophylactic reagents |
| ATE513848T1 (de) * | 2003-06-04 | 2011-07-15 | Merck Patent Gmbh | Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| JP5871819B2 (ja) * | 2010-01-14 | 2016-03-01 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プロリン残基の突然変異誘発により低減したアレルゲン性を有するイネ科のグループ５アレルゲンの変異体 |
| WO2023039598A1 (en) | 2021-09-13 | 2023-03-16 | Life Technologies Corporation | Gene editing tools |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736362A (en) * | 1990-10-26 | 1998-04-07 | The University Of Melbourne | Ryegrass pollen allergen |
| DE19713001A1 (de) * | 1997-03-27 | 1998-10-01 | Merck Patent Gmbh | Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung |
| DE19918682A1 (de) | 1999-04-23 | 2000-10-26 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens |
| IT1318692B1 (it) | 2000-09-12 | 2003-08-27 | Consiglio Nazionale Ricerche | Varianti di proteine allergeniche di phleum pratense. |
| CN100577804C (zh) * | 2000-11-16 | 2010-01-06 | 阿尔克-阿贝洛有限公司 | 新型变态反应原突变体 |
| AUPR779201A0 (en) * | 2001-09-20 | 2001-10-11 | University Of Melbourne, The | Immunotherapeutic and immunoprophylactic reagents |
| ATE513848T1 (de) * | 2003-06-04 | 2011-07-15 | Merck Patent Gmbh | Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität |
-
2004
- 2004-05-06 AT AT04739147T patent/ATE513848T1/de active
- 2004-05-06 WO PCT/EP2004/004848 patent/WO2004108758A1/de not_active Ceased
- 2004-05-06 EP EP10009856.5A patent/EP2287180B9/de not_active Expired - Lifetime
- 2004-05-06 ES ES10009856T patent/ES2434720T3/es not_active Expired - Lifetime
- 2004-05-06 ES ES04739147T patent/ES2367633T3/es not_active Expired - Lifetime
- 2004-05-06 JP JP2006508164A patent/JP4782671B2/ja not_active Expired - Fee Related
- 2004-05-06 PL PL10009856T patent/PL2287180T3/pl unknown
- 2004-05-06 CN CN200480015311XA patent/CN1798763B/zh not_active Expired - Fee Related
- 2004-05-06 PL PL10009855T patent/PL2272863T3/pl unknown
- 2004-05-06 ES ES10009855T patent/ES2397778T3/es not_active Expired - Lifetime
- 2004-05-06 PT PT100098557T patent/PT2272863E/pt unknown
- 2004-05-06 AU AU2004245184A patent/AU2004245184B2/en not_active Ceased
- 2004-05-06 RU RU2005141524/13A patent/RU2368620C2/ru not_active IP Right Cessation
- 2004-05-06 CA CA2528053A patent/CA2528053C/en not_active Expired - Fee Related
- 2004-05-06 PT PT04739147T patent/PT1629006E/pt unknown
- 2004-05-06 EP EP10009855A patent/EP2272863B1/de not_active Expired - Lifetime
- 2004-05-06 US US10/559,272 patent/US8628946B2/en not_active Expired - Fee Related
- 2004-05-06 BR BRPI0410908-2A patent/BRPI0410908A/pt not_active IP Right Cessation
- 2004-05-06 EP EP04739147A patent/EP1629006B1/de not_active Expired - Lifetime
- 2004-05-06 PT PT100098565T patent/PT2287180E/pt unknown
-
2010
- 2010-09-16 JP JP2010207438A patent/JP5363441B2/ja not_active Expired - Fee Related
-
2014
- 2014-01-02 US US14/146,364 patent/US9522938B2/en not_active Expired - Fee Related
-
2016
- 2016-04-05 US US15/090,935 patent/US20160207967A1/en not_active Abandoned
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