PT2229185E - Coadministração de um agente ligado a um péptido de internalização tat com um agente anti-inflamatório - Google Patents
Coadministração de um agente ligado a um péptido de internalização tat com um agente anti-inflamatório Download PDFInfo
- Publication number
- PT2229185E PT2229185E PT88599063T PT08859906T PT2229185E PT 2229185 E PT2229185 E PT 2229185E PT 88599063 T PT88599063 T PT 88599063T PT 08859906 T PT08859906 T PT 08859906T PT 2229185 E PT2229185 E PT 2229185E
- Authority
- PT
- Portugal
- Prior art keywords
- agent
- administration
- internalization peptide
- linked
- tat internalization
- Prior art date
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 238000011260 co-administration Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99267807P | 2007-12-05 | 2007-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2229185E true PT2229185E (pt) | 2016-01-26 |
Family
ID=40756064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT88599063T PT2229185E (pt) | 2007-12-05 | 2008-12-02 | Coadministração de um agente ligado a um péptido de internalização tat com um agente anti-inflamatório |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8080518B2 (enExample) |
| EP (1) | EP2229185B8 (enExample) |
| JP (1) | JP5520230B2 (enExample) |
| CN (1) | CN101970011B (enExample) |
| AU (1) | AU2008335490B2 (enExample) |
| BR (1) | BRPI0820912B1 (enExample) |
| DK (1) | DK2229185T3 (enExample) |
| ES (1) | ES2555524T3 (enExample) |
| HR (1) | HRP20151312T1 (enExample) |
| HU (1) | HUE027216T2 (enExample) |
| PL (1) | PL2229185T3 (enExample) |
| PT (1) | PT2229185E (enExample) |
| SI (1) | SI2229185T1 (enExample) |
| WO (1) | WO2009076105A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7510824B2 (en) | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| CA2657665C (en) * | 2006-07-11 | 2015-06-02 | Arbor Vita Corporation | Method and compositions for treating stroke with fever |
| US8008253B2 (en) * | 2007-07-03 | 2011-08-30 | Andrew Tasker | Treatment for anxiety |
| CN102088990A (zh) * | 2008-05-16 | 2011-06-08 | 阿尔伯维塔公司 | 癫痫的治疗 |
| JP5801197B2 (ja) | 2008-09-03 | 2015-10-28 | ノノ インコーポレイテッド | 痛みの治療に関する薬剤及び方法 |
| PT2440231T (pt) * | 2009-06-10 | 2020-01-08 | Nono Inc | Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos |
| CA2765169C (en) | 2009-06-10 | 2019-06-18 | Nono Inc. | Model systems and treatment regimes for treatment of neurological disease |
| US9301999B2 (en) | 2009-09-28 | 2016-04-05 | Duke University | Peptide, adjuvants, vaccines, and methods of use |
| EP2552472A4 (en) * | 2010-03-29 | 2014-03-12 | Massachusetts Inst Technology | INFLAMMATION INHIBITING FACTORS |
| EP2580233B1 (en) * | 2010-06-10 | 2016-08-10 | Indiana University Research And Technology Corporation | Materials and method for suppressing inflammatory and neuropathic pain |
| US9629892B2 (en) * | 2010-08-12 | 2017-04-25 | Nono Inc. | Treatment of penetrative injury to the brain |
| KR102046830B1 (ko) * | 2011-05-13 | 2019-11-20 | 코벤하븐스 유니버시테트 | 허혈성 뇌 손상에 대한 효과적인 신경보호제이며 통증의 치료를 위한 ｐｓｄ-95의 고-친화성, 이량체 저해제 |
| HRP20220519T1 (hr) | 2011-06-24 | 2022-05-27 | Nono Inc. | Kombinacijska terapija ishemije |
| SG11201406142XA (en) | 2012-03-27 | 2014-10-30 | Univ Duke | Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage |
| TR201905787T4 (tr) * | 2012-11-28 | 2019-05-21 | Nono Inc | Liyofilize TAT-NR2B9C formülasyonu. |
| US10251935B2 (en) | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
| US9783586B2 (en) * | 2013-03-15 | 2017-10-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the linear ubiquitin chain assembly complex (LUBAC) and related methods |
| US20140349944A1 (en) * | 2013-05-23 | 2014-11-27 | Musc Foundation For Research Development | Chaperone-based integrin inhibitors for the treatment of cancer and inflammatory diseases |
| PL2946765T3 (pl) | 2014-05-23 | 2017-08-31 | Ares Trading S.A. | Ciekła kompozycja farmaceutyczna |
| EP2946767B1 (en) | 2014-05-23 | 2016-10-05 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP2946766B1 (en) | 2014-05-23 | 2016-03-02 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2016049280A1 (en) * | 2014-09-24 | 2016-03-31 | Memorial Sloan Kettering Cancer Center | mTORC1 MODULATION |
| EP3693001A4 (en) | 2017-09-30 | 2021-07-07 | Biocells (Beijing) Biotech Co., Ltd. | PEPTIDIC COMPOSITION ALLOWING THE TREATMENT OF INJURIES RELATED TO EXCITING NEUROTOXICITY |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2354644A1 (en) * | 1998-12-11 | 2000-06-15 | Biomira, Inc. | Muc-1 antagonists and methods of treating immune disorders |
| US20040226056A1 (en) | 1998-12-22 | 2004-11-11 | Myriad Genetics, Incorporated | Compositions and methods for treating neurological disorders and diseases |
| US20060148711A1 (en) * | 1999-05-14 | 2006-07-06 | Arbor Vita Corporation | Molecular interactions in neurons |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| DE60026313D1 (de) | 1999-07-23 | 2006-04-27 | Uutech Ltd | Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes |
| WO2001013957A2 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| US6864355B1 (en) * | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
| US20020032154A1 (en) * | 2000-06-07 | 2002-03-14 | Peyman John A. | Interferon-suppressing placental lactogen peptides |
| WO2003024389A2 (en) | 2001-07-30 | 2003-03-27 | Immunex Corporation | T. reesei phytase enyzmes, polynucleides encoding the enzymes, vectors and host cells thereof, and methods of using |
| WO2004071531A1 (en) * | 2003-02-13 | 2004-08-26 | Licentia Oy | Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia |
| WO2006029028A2 (en) * | 2004-09-02 | 2006-03-16 | Cognosci, Inc. | Improved apo e analogs and methods for their use |
| US7151084B2 (en) * | 2004-12-27 | 2006-12-19 | Miller Landon C G | Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes |
| WO2009006611A1 (en) * | 2007-07-03 | 2009-01-08 | Arbor Vita Corporation | Small molecule inhibitors of pdz interactions |
| DK2178549T3 (en) * | 2007-07-26 | 2017-01-09 | Revance Therapeutics Inc | Antimicrobial peptide AND COMPOSITIONS THEREOF |
| ES2328776B1 (es) * | 2007-11-19 | 2010-07-06 | Proyecto De Biomedicina Cima S.L. | Peptidos con capacidad para unirse a escurfina y aplicaciones. |
| PT2440231T (pt) | 2009-06-10 | 2020-01-08 | Nono Inc | Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos |
-
2008
- 2008-11-26 US US12/323,915 patent/US8080518B2/en active Active
- 2008-12-02 EP EP08859906.3A patent/EP2229185B8/en active Active
- 2008-12-02 HR HRP20151312TT patent/HRP20151312T1/hr unknown
- 2008-12-02 WO PCT/US2008/085280 patent/WO2009076105A2/en not_active Ceased
- 2008-12-02 PL PL08859906T patent/PL2229185T3/pl unknown
- 2008-12-02 DK DK08859906.3T patent/DK2229185T3/en active
- 2008-12-02 BR BRPI0820912-0A patent/BRPI0820912B1/pt not_active IP Right Cessation
- 2008-12-02 CN CN2008801261196A patent/CN101970011B/zh not_active Expired - Fee Related
- 2008-12-02 PT PT88599063T patent/PT2229185E/pt unknown
- 2008-12-02 ES ES08859906.3T patent/ES2555524T3/es active Active
- 2008-12-02 SI SI200831555T patent/SI2229185T1/sl unknown
- 2008-12-02 JP JP2010537016A patent/JP5520230B2/ja not_active Expired - Fee Related
- 2008-12-02 AU AU2008335490A patent/AU2008335490B2/en not_active Ceased
- 2008-12-02 HU HUE08859906A patent/HUE027216T2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0820912B1 (pt) | 2022-05-24 |
| AU2008335490B2 (en) | 2013-08-22 |
| WO2009076105A3 (en) | 2010-01-07 |
| JP2011506328A (ja) | 2011-03-03 |
| PL2229185T3 (pl) | 2016-03-31 |
| US20090176713A1 (en) | 2009-07-09 |
| US8080518B2 (en) | 2011-12-20 |
| JP5520230B2 (ja) | 2014-06-11 |
| WO2009076105A2 (en) | 2009-06-18 |
| HRP20151312T1 (hr) | 2016-03-11 |
| DK2229185T3 (en) | 2016-01-11 |
| EP2229185A2 (en) | 2010-09-22 |
| CN101970011A (zh) | 2011-02-09 |
| HUE027216T2 (en) | 2016-08-29 |
| EP2229185B8 (en) | 2016-12-21 |
| EP2229185B1 (en) | 2015-10-07 |
| CN101970011B (zh) | 2013-04-24 |
| ES2555524T3 (es) | 2016-01-04 |
| AU2008335490A1 (en) | 2009-06-18 |
| BRPI0820912A2 (pt) | 2018-07-17 |
| EP2229185A4 (en) | 2011-11-23 |
| SI2229185T1 (sl) | 2016-02-29 |
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