PT2145002E - Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos - Google Patents

Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos Download PDF

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Publication number
PT2145002E
PT2145002E PT88280797T PT08828079T PT2145002E PT 2145002 E PT2145002 E PT 2145002E PT 88280797 T PT88280797 T PT 88280797T PT 08828079 T PT08828079 T PT 08828079T PT 2145002 E PT2145002 E PT 2145002E
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Portugal
Prior art keywords
bacterially
derived
nucleic acid
mammalian cells
vivo delivery
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PT88280797T
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English (en)
Portuguese (pt)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Toby Hulf
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Engeneic Molecular Delivery Pty Ltd
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Publication of PT2145002E publication Critical patent/PT2145002E/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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    • C12Y207/11021—Polo kinase (2.7.11.21)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/141—MicroRNAs, miRNAs
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PT88280797T 2007-03-30 2008-03-26 Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos PT2145002E (pt)

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US90907407P 2007-03-30 2007-03-30

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PT2145002E true PT2145002E (pt) 2015-04-29

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PT88280797T PT2145002E (pt) 2007-03-30 2008-03-26 Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos
PT151501293T PT2865755T (pt) 2007-03-30 2008-03-26 Minicélulas intactas derivadas de bactéria compreendendo arn regulatório

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PT151501293T PT2865755T (pt) 2007-03-30 2008-03-26 Minicélulas intactas derivadas de bactéria compreendendo arn regulatório

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EP (5) EP2145002B1 (https=)
JP (1) JP5167338B2 (https=)
CN (2) CN105854029B (https=)
AU (1) AU2008291833B2 (https=)
CA (3) CA2933978C (https=)
CY (1) CY1119031T1 (https=)
DK (2) DK2145002T3 (https=)
ES (2) ES2534435T3 (https=)
HR (2) HRP20150328T1 (https=)
LT (1) LT2865755T (https=)
MX (1) MX2009010411A (https=)
NZ (1) NZ580487A (https=)
PL (2) PL2145002T3 (https=)
PT (2) PT2145002E (https=)
SG (2) SG10201804257RA (https=)
SI (2) SI2865755T1 (https=)
WO (1) WO2009027830A2 (https=)

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AU2020205040A1 (en) 2019-01-04 2021-08-12 Engeneic Molecular Delivery Pty Ltd Encapsulated glycolipid antigens for treatment of neoplastic diseases
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HRP20150328T1 (hr) * 2007-03-30 2015-05-22 Engeneic Molecular Delivery Pty Ltd. Bakterijski dobivene, intaktne mini-stanice koje obuhvaä†aju funkcionalnu nukleinsku kiselinu, bez plazmida, za in vivo dopremu do stanica sisavaca

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SI2865755T1 (sl) 2017-06-30
SI2145002T1 (sl) 2015-05-29
HRP20150328T1 (hr) 2015-05-22
CN105854029B (zh) 2019-10-18
EP3564372A1 (en) 2019-11-06
CA2933978A1 (en) 2009-03-05
LT2865755T (lt) 2017-07-25
PL2145002T3 (pl) 2015-06-30
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AU2008291833A1 (en) 2009-03-05
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AU2008291833B2 (en) 2012-11-08
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WO2009027830A3 (en) 2009-05-14
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