PT1981515E - Tratamento com mapc de lesões e doenças cerebrais - Google Patents
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- PT1981515E PT1981515E PT77624575T PT07762457T PT1981515E PT 1981515 E PT1981515 E PT 1981515E PT 77624575 T PT77624575 T PT 77624575T PT 07762457 T PT07762457 T PT 07762457T PT 1981515 E PT1981515 E PT 1981515E
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Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2581752Y2 (ja) | 1993-11-11 | 1998-09-24 | 株式会社三東工業社 | 二重薬液案内路を有する伸縮式掘削作業ロッド |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| ZA200200049B (en) | 2001-01-25 | 2002-07-16 | Nippon Catalytic Chem Ind | Fixed-bed shell-and-tube reactor and its usage. |
| US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| DK2471904T3 (en) | 2005-12-29 | 2019-02-18 | Celularity Inc | Placenta stem cell populations |
| US11992507B2 (en) | 2006-01-23 | 2024-05-28 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
| CA2850793A1 (en) | 2006-10-23 | 2008-05-02 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| HRP20130765T1 (hr) | 2007-02-12 | 2013-10-25 | Anthrogenesis Corporation | Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice |
| US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| CA2712496C (en) | 2008-01-18 | 2021-01-12 | Wei-Shou Hu | Stem cell aggregates and methods for making and using |
| MX339624B (es) * | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
| EP2331109B1 (en) * | 2008-08-22 | 2013-05-29 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CN107095883A (zh) * | 2008-09-04 | 2017-08-29 | Abt控股公司 | 干细胞预防神经元顶梢枯死的用途 |
| CA2743566C (en) | 2008-11-19 | 2021-11-09 | Anthrogenesis Corporation | Amnion derived adherent cells |
| AU2013231210B2 (en) * | 2009-07-21 | 2014-11-20 | Healios K.K. | Use of stem cells to reduce leukocyte extravasation |
| SG10201404281YA (en) * | 2009-07-21 | 2014-09-26 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| AU2010276201B2 (en) * | 2009-07-21 | 2013-10-17 | Healios K.K. | Use of stem cells to reduce leukocyte extravasation |
| AU2013237687B2 (en) * | 2009-07-21 | 2014-11-20 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| RU2424004C1 (ru) * | 2009-11-12 | 2011-07-20 | Государственное образовательное учреждение дополнительного профессионального образования Санкт-Петербургская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию | Способ лечения перинатального поражения головного мозга гипоксически-ишемического генеза у детей первого года жизни |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| WO2011106476A1 (en) * | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation of microglia activation |
| BR112012021451B8 (pt) * | 2010-02-25 | 2021-05-25 | Abt Holding Co | uso de células que apresentam uma eficiência desejada para a expressão e/ou secreção dos fatores pró-angiogênicos vegf, cxcl5 e il8, métodos para construir um banco de células, para desenvolver fármaco, e para aumentar a expressão de um ou mais fatores pró-angiogênicos em uma célula realizado in vitro, e, composição |
| TW201703777A (zh) | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
| NZ602798A (en) | 2010-04-08 | 2014-10-31 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
| SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| WO2011143411A1 (en) * | 2010-05-12 | 2011-11-17 | Abt Holding Company | Modulation of splenocytes in cell therapy for traumatic brain injury |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| CN104220081A (zh) | 2011-06-01 | 2014-12-17 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
| WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
| AU2014250761B2 (en) | 2013-04-12 | 2019-02-28 | Robert J. Deans | Improving organs for transplantation |
| US20160326494A1 (en) * | 2015-05-05 | 2016-11-10 | Katholieke Universiteit Leuven | Methods for Pancreatic Islet Transplantation |
| HK1256413A1 (zh) | 2016-01-21 | 2019-09-20 | Abt Holding Company | 用於伤口癒合的干细胞 |
| RU2753508C2 (ru) | 2017-03-17 | 2021-08-17 | Мицубиси Кемикал Корпорейшн | Способ каталитического окисления и способ получения сопряженного диена |
| US20200246390A1 (en) * | 2019-02-01 | 2020-08-06 | Abt Holding Company | Multipotent adult projenitor cells for treatment of ich |
| TWI825446B (zh) * | 2020-08-14 | 2023-12-11 | 中國醫藥大學 | 醫藥組合物治療組織缺血狀況之用途 |
| WO2022196233A1 (ja) | 2021-03-16 | 2022-09-22 | 日本碍子株式会社 | ガスセンサ素子及びガスセンサ |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4749620A (en) | 1984-02-15 | 1988-06-07 | Massachusetts Institute Of Technology | Encapsulated active material system |
| US4744933A (en) | 1984-02-15 | 1988-05-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system |
| JPH0628570B2 (ja) | 1986-02-13 | 1994-04-20 | 雪印乳業株式会社 | カプセル体の製造方法及び装置 |
| EP0301777A1 (en) | 1987-07-28 | 1989-02-01 | Queen's University At Kingston | Multiple membrane microencapsulation |
| US5089272A (en) | 1989-03-29 | 1992-02-18 | Snow Brand Milk Products Co., Ltd. | Process for producing capsules having a permeability-controllable membrane |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| GB2244058B (en) | 1990-05-01 | 1993-03-24 | Courtaulds Films & Packaging | Packaging materials |
| US5578442A (en) | 1992-03-23 | 1996-11-26 | Vivorx, Inc. | Graft copolymers of polycationic species and water-soluble polymers, and use therefor |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| CA2169292C (en) * | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| IN184685B (enExample) | 1996-02-14 | 2000-09-23 | Nat Inst Immunology | |
| US5839275A (en) | 1996-08-20 | 1998-11-24 | Toyota Jidosha Kabushiki Kaisha | Fuel injection control device for a direct injection type engine |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| DK1007631T4 (da) | 1997-07-14 | 2009-04-27 | Osiris Therapeutics Inc | Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller |
| US20030103951A1 (en) | 1997-07-14 | 2003-06-05 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| AU1508899A (en) | 1997-12-02 | 1999-06-16 | Chong Kun Dang Corporation | Pharmaceutical composition comprising cyclosporin solid-state microemulsion |
| EP1062321B1 (en) | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| CA2320040C (en) | 1998-03-18 | 2007-05-22 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US6797269B2 (en) | 1998-04-03 | 2004-09-28 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| WO2005113748A2 (en) | 2004-04-21 | 2005-12-01 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| DK1226233T3 (da) * | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US20030044843A1 (en) | 2001-01-09 | 2003-03-06 | Mitsubishi Pharma Corporation | Novel proteome analysis method and devices therefor |
| CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| JP4628618B2 (ja) | 2001-09-26 | 2011-02-09 | 富士フイルム株式会社 | 撮像光学系 |
| AU2003209259A1 (en) * | 2002-01-14 | 2003-07-30 | The Board Of Trustees Of The University Of Illinois | Novel mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof |
| KR100667746B1 (ko) | 2002-07-15 | 2007-01-11 | 삼성전자주식회사 | 드라이브 정보가 기록된 정보저장 매체 및 그 기록 방법 |
| US20040037811A1 (en) * | 2002-08-22 | 2004-02-26 | The Cleveland Clinic Foundation | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
| WO2004069172A2 (en) | 2003-01-30 | 2004-08-19 | The Government of the United States of America as represented by the Department of Veterans Affairs | Multilineage-inducible cells and uses thereof |
| WO2004099395A2 (en) * | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for the generation of neural progenitor cells |
| WO2004099394A2 (en) | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for efficient transfer of human blastocyst-derived stem cells (hbs cells) from a feeder-supported to a feeder-free culture system |
| ATE414144T1 (de) | 2003-05-09 | 2008-11-15 | Crucell Holland Bv | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| JP2007513188A (ja) * | 2003-12-04 | 2007-05-24 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | リソソーム蓄積症の処置のための組成物および方法 |
| AU2005331559B2 (en) | 2005-05-05 | 2012-04-19 | Regents Of The University Of Minnesota | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
| US20080311084A1 (en) | 2005-05-05 | 2008-12-18 | Verfaillie Catherine M | Mapc Engraftment in the Hematopoietic System |
| TW200726474A (en) * | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
| EP2368973A1 (en) | 2005-10-13 | 2011-09-28 | Anthrogenesis Corporation | Production Of Oligodendrocytes From Placenta-Derived Stem Cells |
| US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| US11992507B2 (en) | 2006-01-23 | 2024-05-28 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| HRP20130765T1 (hr) | 2007-02-12 | 2013-10-25 | Anthrogenesis Corporation | Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice |
| US20120121545A1 (en) | 2009-01-15 | 2012-05-17 | Corestem Co., Ltd. | Pharmaceutical Composition For Bone Disease Treatment Or Countering Inflammation, Comprising Cartilage Stem Cells As An Active Principle |
| EP2241617A1 (en) | 2009-04-06 | 2010-10-20 | Rijksuniversiteit Groningen | Multipotent cells derived from blood and methods and uses related thereto |
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- 2007-01-23 CN CN201510271093.6A patent/CN105560284A/zh active Pending
- 2007-01-23 NZ NZ570616A patent/NZ570616A/en not_active IP Right Cessation
- 2007-01-23 CA CA3155196A patent/CA3155196A1/en active Pending
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2013
- 2013-07-19 JP JP2013150313A patent/JP6338331B2/ja active Active
- 2013-07-19 JP JP2013150338A patent/JP6344892B2/ja active Active
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2015
- 2015-03-04 HK HK15102179.2A patent/HK1201481A1/xx unknown
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2016
- 2016-10-13 JP JP2016201854A patent/JP6509795B2/ja active Active
- 2016-10-13 JP JP2016201847A patent/JP6502301B2/ja active Active
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2017
- 2017-12-20 US US15/849,181 patent/US11351202B2/en not_active Expired - Lifetime
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2018
- 2018-07-31 HK HK18109888.6A patent/HK1250478A1/en unknown
- 2018-12-19 JP JP2018237463A patent/JP6871899B2/ja not_active Expired - Fee Related
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2019
- 2019-01-17 JP JP2019006297A patent/JP2019056015A/ja not_active Withdrawn
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2020
- 2020-05-28 JP JP2020093132A patent/JP2020128427A/ja not_active Withdrawn
- 2020-12-18 JP JP2020209942A patent/JP2021042258A/ja not_active Withdrawn
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2021
- 2021-06-10 US US17/344,205 patent/US20210299185A1/en not_active Abandoned
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2022
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2023
- 2023-08-25 JP JP2023137277A patent/JP2023153391A/ja active Pending
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