PT1572614E - Processo para a preparação de 1,5-bis(4-hidroxi-3-metoxifenil)- penta-1,4-dien-3-ona - Google Patents

Processo para a preparação de 1,5-bis(4-hidroxi-3-metoxifenil)- penta-1,4-dien-3-ona Download PDF

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Publication number
PT1572614E
PT1572614E PT37733649T PT03773364T PT1572614E PT 1572614 E PT1572614 E PT 1572614E PT 37733649 T PT37733649 T PT 37733649T PT 03773364 T PT03773364 T PT 03773364T PT 1572614 E PT1572614 E PT 1572614E
Authority
PT
Portugal
Prior art keywords
metoxy
dien
penta
bis
hydroxy
Prior art date
Application number
PT37733649T
Other languages
English (en)
Inventor
José Agustin Quincoces Suarez
Klaus Peseke
Marcus Kordian
Joao Ernesto Carvalho
Luciana Konecny Kohn
Márcia Aparecida Antonio
Heloiza Brunhari
Original Assignee
Fundaçao De Amparo Pesquisa Do Estado De Sao Paulo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundaçao De Amparo Pesquisa Do Estado De Sao Paulo filed Critical Fundaçao De Amparo Pesquisa Do Estado De Sao Paulo
Publication of PT1572614E publication Critical patent/PT1572614E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
PT37733649T 2002-11-28 2003-11-28 Processo para a preparação de 1,5-bis(4-hidroxi-3-metoxifenil)- penta-1,4-dien-3-ona PT1572614E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR0207141-0 BRPI0207141B8 (pt) 2002-11-28 2002-11-28 processo para preparar compostos, uso de compostos, composição farmacêutica e método para tratamento de câncer

Publications (1)

Publication Number Publication Date
PT1572614E true PT1572614E (pt) 2014-04-03

Family

ID=67251474

Family Applications (1)

Application Number Title Priority Date Filing Date
PT37733649T PT1572614E (pt) 2002-11-28 2003-11-28 Processo para a preparação de 1,5-bis(4-hidroxi-3-metoxifenil)- penta-1,4-dien-3-ona

Country Status (8)

Country Link
US (1) US7432401B2 (pt)
EP (1) EP1572614B1 (pt)
JP (1) JP2006508149A (pt)
AU (1) AU2003283092A1 (pt)
BR (1) BRPI0207141B8 (pt)
ES (1) ES2464268T3 (pt)
PT (1) PT1572614E (pt)
WO (1) WO2004047716A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
BRPI0602640B8 (pt) * 2006-07-06 2021-05-25 Anhanguera Educacional Ltda métodos de obtenção de penta-1,4-dien-3-onas e de cicloexanonas substituídas e derivados com propriedades antitumorais e antiparasitárias, processo para preparar 1,5-bis-(aril)-penta-1,4-dien-3-onas alquiladas e aciladas, processo para preparar 4-nitro-3,5-diaril-cicloexanonas substituídas, processo para preparar 2,6-dibenzilideno-4-nitro-3,5-diaril-cicloexanonas substituídas, processo para preparar uma mistura formada por quantidades determinadas dos compostos (1,5-bis(4-hidróxi-3-metóxi-fenil)penta-1,4-dien-3-ona) e (1,5-bis(3-metóxi-4-acetóxi-fenil)penta-1,4-dien-3-ona), compostos e seus usos, composição farmacêutica, método terapêutico para tratamento dos cânceres e composição sinérgica
CN103922911A (zh) * 2014-04-17 2014-07-16 上海应用技术学院 一种(1e,4e)-1,5-二(邻溴间甲氧基苯基)-1,4-戊二烯酮化合物及合成方法
CN114478256B (zh) * 2022-01-26 2024-02-23 安徽理工大学环境友好材料与职业健康研究院(芜湖) 一种新型姜黄素衍生物的制备方法及其抗肝癌的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521629A (en) * 1984-06-29 1985-06-04 American Cyanamid Company Method for the preparation of 1,5-bis-aryl-1,4-pentadien-3-ones
DE69028136T2 (de) * 1989-05-17 1997-01-23 Shionogi Seiyaku Kk Alkoxyiminoacetamid-Derivate und ihre Verwendung als pilztötendes Mittel
JP2856838B2 (ja) * 1990-04-30 1999-02-10 株式会社クラレ ステロイド誘導体の製造方法
JP2921104B2 (ja) * 1990-11-15 1999-07-19 東亞合成株式会社 β，γ―不飽和アルケニル基置換フェノール類の製造方法
JPH07215957A (ja) * 1994-02-03 1995-08-15 Takeda Chem Ind Ltd グリシジルエーテル類の製造法及びそのための連続製造装置
US6852248B1 (en) * 1999-04-02 2005-02-08 Hrl Laboratories, Llc Dopants for liquid-crystal devices
US6664272B2 (en) * 1999-12-03 2003-12-16 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties

Also Published As

Publication number Publication date
ES2464268T3 (es) 2014-06-02
AU2003283092A1 (en) 2004-06-18
BRPI0207141B8 (pt) 2021-05-25
BRPI0207141B1 (pt) 2019-04-16
EP1572614B1 (en) 2013-12-25
BR0207141A (pt) 2004-06-29
JP2006508149A (ja) 2006-03-09
WO2004047716A2 (en) 2004-06-10
US7432401B2 (en) 2008-10-07
AU2003283092A8 (en) 2004-06-18
WO2004047716A3 (en) 2004-08-19
EP1572614A2 (en) 2005-09-14
US20060128997A1 (en) 2006-06-15

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