PT1476192E - Métodos e composições para tratar condições hierproliferativas - Google Patents
Métodos e composições para tratar condições hierproliferativas Download PDFInfo
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- PT1476192E PT1476192E PT03702642T PT03702642T PT1476192E PT 1476192 E PT1476192 E PT 1476192E PT 03702642 T PT03702642 T PT 03702642T PT 03702642 T PT03702642 T PT 03702642T PT 1476192 E PT1476192 E PT 1476192E
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- Prior art keywords
- phenyl
- pyrimidin
- benzyloxy
- growth factor
- pyrrolo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35691202P | 2002-02-14 | 2002-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1476192E true PT1476192E (pt) | 2007-07-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03702642T PT1476192E (pt) | 2002-02-14 | 2003-02-14 | Métodos e composições para tratar condições hierproliferativas |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1476192B1 (https=) |
| JP (1) | JP5053503B2 (https=) |
| CN (1) | CN100591355C (https=) |
| AT (1) | ATE360442T1 (https=) |
| AU (1) | AU2003205768A1 (https=) |
| BR (1) | BR0307629A (https=) |
| CA (1) | CA2476000A1 (https=) |
| DE (1) | DE60313434T2 (https=) |
| ES (1) | ES2283744T3 (https=) |
| PT (1) | PT1476192E (https=) |
| WO (1) | WO2003068265A1 (https=) |
Families Citing this family (20)
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| AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| ATE514434T1 (de) * | 2004-02-25 | 2011-07-15 | Dana Farber Cancer Inst Inc | Hemmer des insulinartigen wachstumsfaktor- rezeptors-1 zur hemmung von tumorzellwachstum |
| TWI378934B (en) | 2004-04-02 | 2012-12-11 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| US7329495B2 (en) | 2004-06-09 | 2008-02-12 | Board Of Regents, The University Of Texas System | Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors |
| TW200613306A (en) | 2004-07-20 | 2006-05-01 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| AU2006292278B2 (en) | 2005-09-20 | 2012-03-08 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| AR057960A1 (es) | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
| WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
| US20110171124A1 (en) | 2009-02-26 | 2011-07-14 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the EMT status of tumor cells in vivo |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| EP2401614A1 (en) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| CA2783656A1 (en) | 2010-03-03 | 2011-09-09 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| CA2783665A1 (en) | 2010-03-03 | 2011-09-09 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| EP2544672A1 (en) | 2010-03-09 | 2013-01-16 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US20120214830A1 (en) | 2011-02-22 | 2012-08-23 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| JP6255038B2 (ja) | 2013-02-26 | 2017-12-27 | トリアクト セラピューティクス，インク． | 癌治療 |
| US9381246B2 (en) | 2013-09-09 | 2016-07-05 | Triact Therapeutics, Inc. | Cancer therapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ226799A (en) * | 1987-11-06 | 1991-08-27 | Oncogen | Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor |
| DE4129533A1 (de) * | 1991-09-05 | 1993-03-11 | Max Planck Gesellschaft | Mutierter wachstumsfaktorrezeptor als arzneimittel und seine verwendung zur behandlung von krebs |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| CN1117097C (zh) * | 1998-05-29 | 2003-08-06 | 北京金赛狮生物制药技术开发有限责任公司 | 类胰岛素生长因子受体基因的反义核酸的抑癌作用 |
-
2003
- 2003-02-14 ES ES03702642T patent/ES2283744T3/es not_active Expired - Lifetime
- 2003-02-14 CA CA002476000A patent/CA2476000A1/en not_active Abandoned
- 2003-02-14 JP JP2003567445A patent/JP5053503B2/ja not_active Expired - Fee Related
- 2003-02-14 AU AU2003205768A patent/AU2003205768A1/en not_active Abandoned
- 2003-02-14 AT AT03702642T patent/ATE360442T1/de active
- 2003-02-14 DE DE60313434T patent/DE60313434T2/de not_active Expired - Lifetime
- 2003-02-14 CN CN03803734A patent/CN100591355C/zh not_active Expired - Fee Related
- 2003-02-14 PT PT03702642T patent/PT1476192E/pt unknown
- 2003-02-14 EP EP03702642A patent/EP1476192B1/en not_active Expired - Lifetime
- 2003-02-14 WO PCT/EP2003/001507 patent/WO2003068265A1/en not_active Ceased
- 2003-02-14 BR BR0307629-6A patent/BR0307629A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313434T2 (de) | 2008-01-10 |
| CN100591355C (zh) | 2010-02-24 |
| CA2476000A1 (en) | 2003-08-21 |
| DE60313434D1 (de) | 2007-06-06 |
| JP2005517040A (ja) | 2005-06-09 |
| ES2283744T3 (es) | 2007-11-01 |
| WO2003068265A1 (en) | 2003-08-21 |
| CN1630534A (zh) | 2005-06-22 |
| JP5053503B2 (ja) | 2012-10-17 |
| ATE360442T1 (de) | 2007-05-15 |
| EP1476192B1 (en) | 2007-04-25 |
| BR0307629A (pt) | 2005-01-11 |
| AU2003205768A1 (en) | 2003-09-04 |
| EP1476192A1 (en) | 2004-11-17 |
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