PT1290012E - Derivados amida do acido 2-amino-3-hidroxi-4-tert-leucil-amino-5-fenil-pentanoico - Google Patents
Derivados amida do acido 2-amino-3-hidroxi-4-tert-leucil-amino-5-fenil-pentanoicoInfo
- Publication number
- PT1290012E PT1290012E PT01943442T PT01943442T PT1290012E PT 1290012 E PT1290012 E PT 1290012E PT 01943442 T PT01943442 T PT 01943442T PT 01943442 T PT01943442 T PT 01943442T PT 1290012 E PT1290012 E PT 1290012E
- Authority
- PT
- Portugal
- Prior art keywords
- amino
- leucyl
- tert
- hydroxy
- phenyl
- Prior art date
Links
- GDCNWEJCGIGPPQ-HRDQMINSSA-N (6S)-2,2,6-triamino-4-benzyl-3-hydroxy-7,7-dimethyl-5-oxooctanamide Chemical compound CC(C)(C)[C@H](N)C(=O)C(C(O)C(N)(N)C(N)=O)CC1=CC=CC=C1 GDCNWEJCGIGPPQ-HRDQMINSSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0012795.1A GB0012795D0 (en) | 2000-05-25 | 2000-05-25 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1290012E true PT1290012E (pt) | 2006-09-29 |
Family
ID=9892401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01943442T PT1290012E (pt) | 2000-05-25 | 2001-05-23 | Derivados amida do acido 2-amino-3-hidroxi-4-tert-leucil-amino-5-fenil-pentanoico |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20030166572A1 (https=) |
| EP (1) | EP1290012B1 (https=) |
| JP (1) | JP2003533541A (https=) |
| AT (1) | ATE325809T1 (https=) |
| AU (1) | AU2001266019A1 (https=) |
| CA (1) | CA2405871A1 (https=) |
| DE (1) | DE60119514T2 (https=) |
| ES (1) | ES2261422T3 (https=) |
| GB (1) | GB0012795D0 (https=) |
| PT (1) | PT1290012E (https=) |
| WO (1) | WO2001089282A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351738B2 (en) * | 2002-11-27 | 2008-04-01 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| GB0504950D0 (en) * | 2005-03-10 | 2005-04-20 | Novartis Ag | Organic compositions |
| CA2604133C (en) | 2005-04-07 | 2015-12-01 | Centre National De La Recherche Scientifique | Compounds useful as modulators of the proteasome activity |
| BRPI0907805A2 (pt) * | 2008-02-28 | 2015-07-14 | Novartis Ag | Combinações para tratar dor associada à hiv |
| WO2010096574A1 (en) | 2009-02-20 | 2010-08-26 | Lisanti Michael P | A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm |
| GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
| WO2014172627A1 (en) | 2013-04-19 | 2014-10-23 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| CN112867706B (zh) * | 2018-05-29 | 2024-11-15 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
| EP0982317A1 (en) * | 1998-08-26 | 2000-03-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bivalent inhibitors of the proteasome |
| BR0010134A (pt) * | 1999-04-27 | 2002-01-15 | Novartis Ag | Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma |
-
2000
- 2000-05-25 GB GBGB0012795.1A patent/GB0012795D0/en not_active Ceased
-
2001
- 2001-05-23 PT PT01943442T patent/PT1290012E/pt unknown
- 2001-05-23 WO PCT/EP2001/005952 patent/WO2001089282A2/en not_active Ceased
- 2001-05-23 US US10/258,901 patent/US20030166572A1/en not_active Abandoned
- 2001-05-23 AU AU2001266019A patent/AU2001266019A1/en not_active Abandoned
- 2001-05-23 ES ES01943442T patent/ES2261422T3/es not_active Expired - Lifetime
- 2001-05-23 CA CA002405871A patent/CA2405871A1/en not_active Abandoned
- 2001-05-23 DE DE60119514T patent/DE60119514T2/de not_active Expired - Fee Related
- 2001-05-23 EP EP01943442A patent/EP1290012B1/en not_active Expired - Lifetime
- 2001-05-23 JP JP2001585538A patent/JP2003533541A/ja active Pending
- 2001-05-23 AT AT01943442T patent/ATE325809T1/de not_active IP Right Cessation
-
2006
- 2006-05-15 US US11/434,398 patent/US20060205673A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060205673A1 (en) | 2006-09-14 |
| ES2261422T3 (es) | 2006-11-16 |
| DE60119514D1 (de) | 2006-06-14 |
| CA2405871A1 (en) | 2001-11-29 |
| WO2001089282A3 (en) | 2002-05-10 |
| GB0012795D0 (en) | 2000-07-19 |
| US20030166572A1 (en) | 2003-09-04 |
| AU2001266019A1 (en) | 2001-12-03 |
| EP1290012A2 (en) | 2003-03-12 |
| JP2003533541A (ja) | 2003-11-11 |
| ATE325809T1 (de) | 2006-06-15 |
| EP1290012B1 (en) | 2006-05-10 |
| DE60119514T2 (de) | 2006-10-05 |
| WO2001089282A2 (en) | 2001-11-29 |
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