PT1147114E - Novos aralquilaminas de espirofuropiridinas uteis em terapia. - Google Patents
Novos aralquilaminas de espirofuropiridinas uteis em terapia.Info
- Publication number
- PT1147114E PT1147114E PT99967044T PT99967044T PT1147114E PT 1147114 E PT1147114 E PT 1147114E PT 99967044 T PT99967044 T PT 99967044T PT 99967044 T PT99967044 T PT 99967044T PT 1147114 E PT1147114 E PT 1147114E
- Authority
- PT
- Portugal
- Prior art keywords
- spirofuropyridines
- aralquilamins
- uprising
- therapy
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9900100A SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1147114E true PT1147114E (pt) | 2003-10-31 |
Family
ID=20414101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99967044T PT1147114E (pt) | 1999-01-15 | 1999-12-23 | Novos aralquilaminas de espirofuropiridinas uteis em terapia. |
Country Status (34)
Country | Link |
---|---|
US (2) | US6995167B2 (pt) |
EP (1) | EP1147114B1 (pt) |
JP (1) | JP2002534525A (pt) |
KR (1) | KR100660496B1 (pt) |
CN (1) | CN1132837C (pt) |
AR (1) | AR022283A1 (pt) |
AT (1) | ATE240960T1 (pt) |
AU (1) | AU775433B2 (pt) |
BR (1) | BR9916906A (pt) |
CA (1) | CA2359990A1 (pt) |
CZ (1) | CZ20012554A3 (pt) |
DE (1) | DE69908185T2 (pt) |
DK (1) | DK1147114T3 (pt) |
EE (1) | EE04528B1 (pt) |
ES (1) | ES2200590T3 (pt) |
HK (1) | HK1040517B (pt) |
HU (1) | HUP0200513A3 (pt) |
ID (1) | ID30034A (pt) |
IL (1) | IL144266A0 (pt) |
IS (1) | IS6000A (pt) |
MY (1) | MY118109A (pt) |
NO (1) | NO20013478L (pt) |
NZ (1) | NZ512733A (pt) |
PT (1) | PT1147114E (pt) |
RU (1) | RU2233282C2 (pt) |
SA (1) | SA00200987B1 (pt) |
SE (1) | SE9900100D0 (pt) |
SI (1) | SI1147114T1 (pt) |
SK (1) | SK9932001A3 (pt) |
TR (1) | TR200102042T2 (pt) |
TW (2) | TWI227237B (pt) |
UA (1) | UA71598C2 (pt) |
WO (1) | WO2000042044A1 (pt) |
ZA (1) | ZA200105527B (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
FR2790474B1 (fr) * | 1999-03-05 | 2001-04-06 | Synthelabo | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique |
DK1397366T3 (da) * | 2001-06-01 | 2007-05-07 | Astrazeneca Ab | Hidtil ukendt ligander for nicotinacetylcholinreceptorer egnede i terapi |
US6569865B2 (en) | 2001-06-01 | 2003-05-27 | Astrazeneca Ab | Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine |
IL160884A0 (en) * | 2001-10-02 | 2004-08-31 | Upjohn Co | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
MXPA04010193A (es) * | 2002-04-18 | 2005-02-03 | Astrazeneca Ab | Compuesto de tienilo. |
EP1499616B1 (en) * | 2002-04-18 | 2009-06-17 | AstraZeneca AB | Heterocyclic compounds |
AU2003225456B2 (en) * | 2002-04-18 | 2009-02-05 | Astrazeneca Ab | Furyl compounds |
US7244745B2 (en) | 2002-08-30 | 2007-07-17 | Memory Pharmaceuticals Corp. | Heterocyclic compounds, methods for the preparation thereof, and uses thereof |
SE0202598D0 (sv) * | 2002-09-02 | 2002-09-02 | Astrazeneca Ab | Alpha-7 Nicotinic receptor agonists and statins in combination |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
EP1949901B1 (en) * | 2002-12-06 | 2014-02-12 | The Feinstein Institute for Medical Research | A method for determining a cholinergic agonist selective for an alpha 7 nicotinic receptor |
WO2004063201A1 (ja) * | 2003-01-08 | 2004-07-29 | Mitsubishi Pharma Corporation | 統合失調症治療剤 |
WO2005000250A2 (en) * | 2003-06-24 | 2005-01-06 | Johns Hopkins University | Imaging agents and methods of imaging alpha 7-nicotinic cholinergic receptor |
CN100494202C (zh) * | 2003-10-21 | 2009-06-03 | 阿斯利康(瑞典)有限公司 | 螺呋喃并吡啶芳基衍生物 |
US7045530B2 (en) | 2003-12-22 | 2006-05-16 | Abbott Laboratories | Spirocyclic quinuclidinic ether derivatives |
EP2336128A1 (en) | 2004-03-25 | 2011-06-22 | Memory Pharmaceuticals Corporation | Benzoisothiazoles and preparation and uses thereof |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
RU2448111C2 (ru) * | 2006-08-21 | 2012-04-20 | Дженентек, Инк. | Соединения азабензофуранила и способ их применения |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
CA2728675A1 (en) | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
EP3357495B1 (en) | 2008-11-19 | 2019-12-25 | Axovant Sciences GmbH | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
BRPI1014793A2 (pt) * | 2009-05-11 | 2016-04-05 | Envivo Pharmaceuticals Inc | tratamento de distúrbios de cognição com determinados receptores de ácido alfa-7-nicotínico em combinação com inibidores de acetil-colinesterase |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
US8445696B2 (en) * | 2009-10-14 | 2013-05-21 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
CN102946859B (zh) | 2010-02-26 | 2016-03-02 | 泽农医药公司 | 用于局部给药的螺-羟吲哚化合物的药物组合物及其作为治疗剂的用途 |
CA2989633A1 (en) | 2010-05-17 | 2011-11-24 | Forum Pharmaceuticals Inc. | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
EP2838902B1 (en) | 2012-04-12 | 2018-12-05 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
US9593106B2 (en) | 2013-02-07 | 2017-03-14 | Heptares Therapeutics Limited | Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists |
JP6401254B2 (ja) | 2013-06-21 | 2018-10-10 | 武田薬品工業株式会社 | プロキネシチン受容体のモジュレータとしての1−スルホニルピペリジン誘導体 |
GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
US10100060B2 (en) | 2016-06-16 | 2018-10-16 | Xenon Pharmaceuticals Inc. | Asymmetric synthesis of funapide |
GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE122353T1 (de) * | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Heterozyklische spiroverbindungen und ihre herstellung. |
JPH0195922A (ja) | 1987-10-08 | 1989-04-14 | Mazda Motor Corp | 車両のサスペンション制御装置 |
SK282366B6 (sk) * | 1994-08-24 | 2002-01-07 | Astra Aktiebolag | Spiro-azabicyklická zlúčenina, farmaceutický prípravok s jej obsahom, spôsob prípravy, medziprodukty tohto spôsobu a jej použitie v medicíne |
ES2156998T3 (es) * | 1995-07-28 | 2001-08-01 | Abbott Lab | Compuestos de furopiridina, tienopiridina, pirrolopiridina y de pirimidina, piridazina y triazina relacionados utiles para controlar la transmision sinaptica quimica. |
US6156783A (en) | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
AR013184A1 (es) * | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
-
1999
- 1999-01-15 SE SE9900100A patent/SE9900100D0/xx unknown
- 1999-12-23 SK SK993-2001A patent/SK9932001A3/sk unknown
- 1999-12-23 CN CN998164224A patent/CN1132837C/zh not_active Expired - Fee Related
- 1999-12-23 KR KR1020017008939A patent/KR100660496B1/ko not_active IP Right Cessation
- 1999-12-23 ID IDW00200101529A patent/ID30034A/id unknown
- 1999-12-23 NZ NZ512733A patent/NZ512733A/en unknown
- 1999-12-23 DE DE69908185T patent/DE69908185T2/de not_active Expired - Fee Related
- 1999-12-23 UA UA2001085777A patent/UA71598C2/uk unknown
- 1999-12-23 RU RU2001122812/04A patent/RU2233282C2/ru not_active IP Right Cessation
- 1999-12-23 CA CA002359990A patent/CA2359990A1/en not_active Abandoned
- 1999-12-23 EE EEP200100370A patent/EE04528B1/xx not_active IP Right Cessation
- 1999-12-23 AU AU23343/00A patent/AU775433B2/en not_active Ceased
- 1999-12-23 US US09/529,654 patent/US6995167B2/en not_active Expired - Fee Related
- 1999-12-23 WO PCT/SE1999/002478 patent/WO2000042044A1/en active IP Right Grant
- 1999-12-23 ES ES99967044T patent/ES2200590T3/es not_active Expired - Lifetime
- 1999-12-23 TR TR2001/02042T patent/TR200102042T2/xx unknown
- 1999-12-23 JP JP2000593611A patent/JP2002534525A/ja active Pending
- 1999-12-23 EP EP99967044A patent/EP1147114B1/en not_active Expired - Lifetime
- 1999-12-23 AT AT99967044T patent/ATE240960T1/de not_active IP Right Cessation
- 1999-12-23 SI SI9930375T patent/SI1147114T1/xx unknown
- 1999-12-23 CZ CZ20012554A patent/CZ20012554A3/cs unknown
- 1999-12-23 PT PT99967044T patent/PT1147114E/pt unknown
- 1999-12-23 HU HU0200513A patent/HUP0200513A3/hu unknown
- 1999-12-23 DK DK99967044T patent/DK1147114T3/da active
- 1999-12-23 BR BR9916906-1A patent/BR9916906A/pt not_active Application Discontinuation
- 1999-12-23 IL IL14426699A patent/IL144266A0/xx unknown
-
2000
- 2000-01-13 AR ARP000100156A patent/AR022283A1/es not_active Application Discontinuation
- 2000-01-13 MY MYPI20000100A patent/MY118109A/en unknown
- 2000-01-21 TW TW089100989A patent/TWI227237B/zh not_active IP Right Cessation
- 2000-01-21 TW TW093106537A patent/TW200413387A/zh unknown
- 2000-02-21 SA SA00200987A patent/SA00200987B1/ar unknown
-
2001
- 2001-07-04 ZA ZA200105527A patent/ZA200105527B/en unknown
- 2001-07-12 IS IS6000A patent/IS6000A/is unknown
- 2001-07-13 NO NO20013478A patent/NO20013478L/no not_active Application Discontinuation
-
2002
- 2002-03-21 HK HK02102161.7A patent/HK1040517B/zh not_active IP Right Cessation
-
2005
- 2005-07-14 US US11/181,098 patent/US7196096B2/en not_active Expired - Fee Related
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