PT1146041E - Derivados de heterocicloalquilbenzociclobutano e de heteroarilbenzociclobutano e sua utilizacao como inibidores de recaptura da serotonina e da noradrenalina - Google Patents

Derivados de heterocicloalquilbenzociclobutano e de heteroarilbenzociclobutano e sua utilizacao como inibidores de recaptura da serotonina e da noradrenalina

Info

Publication number
PT1146041E
PT1146041E PT01400940T PT01400940T PT1146041E PT 1146041 E PT1146041 E PT 1146041E PT 01400940 T PT01400940 T PT 01400940T PT 01400940 T PT01400940 T PT 01400940T PT 1146041 E PT1146041 E PT 1146041E
Authority
PT
Portugal
Prior art keywords
heterocycloalquilbenzocyclobutane
heteroarilbenzocyclobutane
noradrenalin
serotonin
derivatives
Prior art date
Application number
PT01400940T
Other languages
English (en)
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT1146041E publication Critical patent/PT1146041E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PT01400940T 2000-04-13 2001-04-12 Derivados de heterocicloalquilbenzociclobutano e de heteroarilbenzociclobutano e sua utilizacao como inibidores de recaptura da serotonina e da noradrenalina PT1146041E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0004742A FR2807753B1 (fr) 2000-04-13 2000-04-13 Nouveaux derives d'heterocycloalkylbenzocyclobutane et d'heteroarylbenzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PT1146041E true PT1146041E (pt) 2004-03-31

Family

ID=8849212

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01400940T PT1146041E (pt) 2000-04-13 2001-04-12 Derivados de heterocicloalquilbenzociclobutano e de heteroarilbenzociclobutano e sua utilizacao como inibidores de recaptura da serotonina e da noradrenalina

Country Status (25)

Country Link
US (1) US6420413B2 (pt)
EP (1) EP1146041B1 (pt)
JP (1) JP3761796B2 (pt)
KR (1) KR100456795B1 (pt)
CN (1) CN1166659C (pt)
AR (1) AR028324A1 (pt)
AT (1) ATE254102T1 (pt)
AU (1) AU777825B2 (pt)
BR (1) BR0101444A (pt)
CA (1) CA2344255C (pt)
DE (1) DE60101177T2 (pt)
DK (1) DK1146041T3 (pt)
EA (1) EA004473B1 (pt)
ES (1) ES2210104T3 (pt)
FR (1) FR2807753B1 (pt)
HK (1) HK1042477B (pt)
HU (1) HUP0101503A3 (pt)
MX (1) MXPA01003553A (pt)
NO (1) NO318158B1 (pt)
NZ (1) NZ511092A (pt)
PL (1) PL347056A1 (pt)
PT (1) PT1146041E (pt)
SI (1) SI1146041T1 (pt)
TR (1) TR200302002T4 (pt)
ZA (1) ZA200103065B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
US7803894B2 (en) * 2003-12-05 2010-09-28 3M Innovatie Properties Company Coating compositions with perfluoropolyetherisocyanate derived silane and alkoxysilanes
CN105541662B (zh) * 2015-12-28 2018-04-17 云南大学 二氢萘类化合物的固相合成方法
CN107445835B (zh) * 2017-07-05 2020-09-22 江苏师范大学 一种1,2-二氢环丁烯并[a]萘衍生物及其前体的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69429895T2 (de) * 1993-06-28 2002-08-29 American Home Products Corp., Madison Neue Behandlungsmethoden durch Verwendung von Phenethylderivaten
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
JPH09512025A (ja) * 1994-04-23 1997-12-02 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 5ht▲下2c▼および5ht▲下2b▼アンタゴニストとしての三環式誘導体
US5506270A (en) * 1995-01-30 1996-04-09 American Home Products Corporation Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women
FR2775687B1 (fr) * 1998-03-04 2000-04-14 Adir Nouveaux composes du benzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AR028324A1 (es) 2003-05-07
JP2001302599A (ja) 2001-10-31
BR0101444A (pt) 2001-12-04
NZ511092A (en) 2002-10-25
FR2807753B1 (fr) 2002-06-07
PL347056A1 (en) 2001-10-22
FR2807753A1 (fr) 2001-10-19
SI1146041T1 (en) 2004-02-29
CN1166659C (zh) 2004-09-15
KR20010098547A (ko) 2001-11-08
HK1042477B (zh) 2005-05-06
NO20011862L (no) 2001-10-15
EA200100343A2 (ru) 2001-10-22
TR200302002T4 (tr) 2004-01-21
CA2344255A1 (fr) 2001-10-13
AU3518701A (en) 2001-10-18
NO20011862D0 (no) 2001-04-11
EP1146041A1 (fr) 2001-10-17
NO318158B1 (no) 2005-02-07
KR100456795B1 (ko) 2004-11-10
HK1042477A1 (en) 2002-08-16
MXPA01003553A (es) 2002-06-04
CA2344255C (fr) 2006-07-11
ES2210104T3 (es) 2004-07-01
CN1323794A (zh) 2001-11-28
HU0101503D0 (en) 2001-06-28
EA004473B1 (ru) 2004-04-29
JP3761796B2 (ja) 2006-03-29
ATE254102T1 (de) 2003-11-15
EP1146041B1 (fr) 2003-11-12
DK1146041T3 (da) 2004-03-22
ZA200103065B (en) 2001-10-18
AU777825B2 (en) 2004-11-04
US20020019380A1 (en) 2002-02-14
EA200100343A3 (ru) 2002-02-28
DE60101177T2 (de) 2004-07-29
HUP0101503A2 (hu) 2002-05-29
HUP0101503A3 (en) 2003-02-28
DE60101177D1 (de) 2003-12-18
US6420413B2 (en) 2002-07-16

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