PT1141315E - Polipéptidos do envelope (env) de hiv modificados - Google Patents
Polipéptidos do envelope (env) de hiv modificados Download PDFInfo
- Publication number
- PT1141315E PT1141315E PT99968574T PT99968574T PT1141315E PT 1141315 E PT1141315 E PT 1141315E PT 99968574 T PT99968574 T PT 99968574T PT 99968574 T PT99968574 T PT 99968574T PT 1141315 E PT1141315 E PT 1141315E
- Authority
- PT
- Portugal
- Prior art keywords
- hiv env
- env polypeptides
- modified hiv
- polypeptides
- modified
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16061—Methods of inactivation or attenuation
- C12N2740/16062—Methods of inactivation or attenuation by genetic engineering
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11449598P | 1998-12-31 | 1998-12-31 | |
| US15667099P | 1999-09-29 | 1999-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1141315E true PT1141315E (pt) | 2008-05-05 |
Family
ID=26812260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99968574T PT1141315E (pt) | 1998-12-31 | 1999-12-30 | Polipéptidos do envelope (env) de hiv modificados |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6689879B2 (enExample) |
| EP (1) | EP1141315B1 (enExample) |
| JP (1) | JP4776075B2 (enExample) |
| AT (1) | ATE384795T1 (enExample) |
| AU (1) | AU2596600A (enExample) |
| CA (1) | CA2358915C (enExample) |
| CY (1) | CY1107393T1 (enExample) |
| DE (1) | DE69938062T2 (enExample) |
| DK (1) | DK1141315T3 (enExample) |
| ES (1) | ES2299276T3 (enExample) |
| PT (1) | PT1141315E (enExample) |
| WO (1) | WO2000039303A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2360347C (en) | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| JP2003523721A (ja) | 1998-12-31 | 2003-08-12 | カイロン コーポレイション | 抗原性hivc型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用 |
| US6656706B2 (en) | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
| AU2002320314A1 (en) * | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US20030198621A1 (en) | 2001-07-05 | 2003-10-23 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| EP1427806A4 (en) * | 2001-08-31 | 2006-04-26 | Chiron Corp | ANTIGENIC HIV-TYPE B POLYPEPTIDE-CODING POLYNUCLEOTIDES, POLYPEPTIDES, AND USES THEREOF |
| US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| EP1553976B1 (en) | 2002-05-07 | 2013-08-21 | Novartis Vaccines and Diagnostics, Inc. | Hiv envelope-cd4 complexes and hybrids |
| AU2003282498A1 (en) | 2002-10-07 | 2004-05-04 | Chiron Corporation | Hiv vaccine formulations |
| CA2539021A1 (en) * | 2003-09-15 | 2005-03-31 | Chiron Corporation | Combination approaches for generating immune responses |
| US7622125B2 (en) * | 2004-05-05 | 2009-11-24 | Novartis Vaccines And Diagnostics, Inc. | Polycistronic HIV vector constructs |
| EP1784513A4 (en) | 2004-06-08 | 2010-01-06 | Novartis Vaccines & Diagnostic | FUSION PROTEINS WITH CD4 MINIMUM MODULES AND USE METHOD THEREFOR |
| AU2005335203A1 (en) * | 2004-09-08 | 2007-02-15 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Compositions and methods for the detection of HIV-1/HIV-2 infection |
| EP1814583A2 (en) | 2004-11-01 | 2007-08-08 | Novartis Vaccines and Diagnostics, Inc. | Combination approaches for generating immune responses |
| CA2597040A1 (en) | 2005-02-03 | 2006-08-10 | Novartis Vaccines And Diagnostics, Inc. | Hiv tat-cd4 hybrid molecules and methods of use thereof |
| EP2357000A1 (en) | 2005-10-18 | 2011-08-17 | Novartis Vaccines and Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
| CN101591379B (zh) * | 2008-05-27 | 2017-01-18 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于eiav减毒活疫苗的氨基酸突变而构建的抗hiv疫苗 |
| US20130052221A1 (en) | 2010-02-26 | 2013-02-28 | The Govt. of the U.S, as represented by The Sec. of The Dept. of Health and Human Services | Dna-protein vaccination protocols |
| EP2780035A1 (en) | 2011-11-14 | 2014-09-24 | Novartis AG | Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof |
| EP3189067B1 (en) * | 2014-09-04 | 2021-05-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Recombinant hiv-1 envelope proteins and their use |
| AU2016359838B2 (en) | 2015-11-24 | 2020-08-06 | Glaxosmithkline Intellectual Property Development Limited | Transient transfection method for retroviral production |
| US11136356B2 (en) | 2017-10-16 | 2021-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant HIV-1 envelope proteins and their use |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364773A (en) | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US4652639A (en) | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US7815916B1 (en) * | 1984-08-22 | 2010-10-19 | The United States Of America As Represented By The Secretary Of Health And Human Services | Cloning and expression of HTLV-III DNA |
| US5032510A (en) | 1984-09-26 | 1991-07-16 | Eli Lilly And Company | Method for expression and secretion in bacillus |
| CA1341423C (en) | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
| WO1986003224A1 (en) | 1984-11-29 | 1986-06-05 | Scripps Clinic And Research Foundation | Polypeptides and antibodies related to deglycosylated viral glycoproteins |
| EP0187041B1 (en) | 1984-12-24 | 1996-05-15 | Genentech, Inc. | Fusions of AIDS-related polypeptides |
| NZ215867A (en) | 1985-04-19 | 1989-10-27 | Hoffmann La Roche | Aids envelope protein, dna vectors and method of production |
| ATE108022T1 (de) | 1985-10-24 | 1994-07-15 | Southwest Found Biomed Res | Synthetische peptide und deren verwendung zur diagnose und impfung für aids und arc. |
| EP0242216A1 (en) | 1986-04-16 | 1987-10-21 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Non-cytopathic clone of Human T-Cell Lymphotropic Virus type III |
| AU7786387A (en) | 1986-07-21 | 1988-02-10 | Southwest Foundation For Biomedical Research | Composition of matter and method of immunizing against viral causative agents of aids and arc |
| US4861707A (en) | 1987-02-02 | 1989-08-29 | E. I. Du Pont De Nemours And Company | Human immunodeficiency virus antigen |
| US5256767A (en) | 1987-06-10 | 1993-10-26 | The Immune Response Corporation | Retroviral antigens |
| ES2167304T3 (es) | 1987-06-22 | 2002-05-16 | Medeva Holdings Bv | Peptido que contiene el antigeno de superficie de la hepatitis b. |
| WO1989001940A1 (en) | 1987-09-04 | 1989-03-09 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins |
| US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
| WO1989002277A2 (en) | 1987-08-28 | 1989-03-23 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
| US5128319A (en) | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
| US5879907A (en) | 1987-09-14 | 1999-03-09 | Skandigen Ab | Artificial gene coding for authentic human serum albumin, use thereof and method |
| NZ226414A (en) | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
| IL87902A0 (en) | 1987-10-08 | 1989-03-31 | Dana Farber Cancer Inst Inc | Soluble human cd4 fragments and applications thereof |
| US5683864A (en) | 1987-11-18 | 1997-11-04 | Chiron Corporation | Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies |
| US5714596A (en) | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
| US5712088A (en) | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
| CA1340748C (en) | 1988-07-13 | 1999-09-14 | Stephen Oroszlan | Synthetic hiv protease gene and method for its expression |
| DE68918867T2 (de) | 1988-09-13 | 1995-02-16 | Chiron Corp | Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. |
| KR900701836A (ko) | 1988-10-03 | 1990-12-04 | 라메쉬 엘. 라탄 | 신규 hiv 단백질 및 aids의 진단, 예방 또는 치료에 유용한 펩티드 |
| CA2003383A1 (en) | 1988-11-23 | 1990-05-23 | Sushil G. Devare | Synthetic dna derived recombinant hiv antigens |
| US5082767A (en) | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
| IL93682A (en) | 1989-03-16 | 1996-06-18 | Yeda Res & Dev | Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them |
| WO1990011359A1 (en) | 1989-03-20 | 1990-10-04 | Whitehead Institute For Biomedical Research | Intracellular method of inhibiting hiv in mammalian cells |
| CA2357538A1 (en) | 1989-03-21 | 1990-10-04 | Wisconsin Alumni Research Foundation | Expression of exogenous polynucleotide sequences in a vertebrate |
| US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
| AU5421090A (en) | 1989-04-05 | 1990-11-05 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | A clone of double-stranded rna virus and applications thereof |
| ES2198400T3 (es) | 1989-06-01 | 2004-02-01 | Applied Biotechnology, Inc. | Vector que codifica particulas virales no autopropagantes, defectuosas, auto-ensambladas. |
| US5130247A (en) | 1989-09-19 | 1992-07-14 | Merck & Co., Inc. | Expression of fusion protein of HIV envelope and HBsAG |
| AU6523590A (en) | 1989-09-22 | 1991-04-18 | Idec Pharmaceuticals Corporation | Novel peptides associated with the cd4 binding region of gp120 and their methods of use |
| EP0424748B1 (en) | 1989-10-23 | 1995-05-10 | F. Hoffmann-La Roche Ag | Synthetic envelope peptides of HTLV-I |
| WO1991006319A1 (en) | 1989-10-27 | 1991-05-16 | Arch Development Corporation | Methods and compositions for promoting immunopotentiation |
| AU6965591A (en) | 1989-11-17 | 1991-06-13 | Amgen, Inc. | A method of detecting htlv-i antibodies in human body fluids |
| HUT60506A (en) | 1989-11-20 | 1992-09-28 | Oncogen | Process for producing non-replicable, recombinant retrovirus particles and antiviral and immunogenic preparations |
| SE468168B (sv) | 1990-02-20 | 1992-11-16 | Replico Medical Ab | Hiv-1, p24 peptider, diagnostiska antigener och foerfarande foer saerskiljande diagnostik av preliminaert hiv-1 positiva serumprov |
| ATE207930T1 (de) | 1990-03-09 | 2001-11-15 | Chiron Corp | Gereinigtes gp120, in dem seine natürliche konformation erhalten bleibt |
| US5876724A (en) | 1990-03-19 | 1999-03-02 | Institut Pasteur | Induction of neutralizing antibody against viral infection by synergy between virus envelope glycoprotein and peptides corresponding to neutralization epitopes of the glycoprotein |
| ATE183235T1 (de) | 1990-03-21 | 1999-08-15 | Wolf Hans Joachim Prof Dr | Für abgeänderte retrovirale gag-polypeptide kodierende dna-sequenzen und diese enthaltende impfstoffe oder aggregate davon |
| EP0527760B1 (en) | 1990-04-03 | 1995-07-19 | Genentech, Inc. | Methods and compositions for vaccination against hiv |
| JPH05506221A (ja) | 1990-04-03 | 1993-09-16 | ジェネンテク,インコーポレイテッド | Hivエンベロープポリペプチド |
| IL97985A0 (en) | 1990-05-07 | 1992-06-21 | North American Vaccine Inc | Improved vaccine compositions |
| AP237A (en) | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
| WO1991019803A1 (en) | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
| SE470074B (sv) | 1990-08-16 | 1993-11-01 | Replico Medical Ab | Förfarande för diagnos av picorna- och/eller flavivirusinfektion, peptider, diagnostiska antigener och vaccinkomposition med dessa peptider |
| EP0551308A4 (en) | 1990-08-29 | 1994-09-14 | Us Health | Novel peptide antigens and immunoassays, test kits and vaccines using the same |
| US5840313A (en) | 1990-09-27 | 1998-11-24 | Syntello Vaccine Development Kb | Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus |
| EP0550516A1 (en) | 1990-09-28 | 1993-07-14 | Hospital For Joint Diseases | Method for inhibiting the infectivity of human immunodeficiency virus |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| IE920366A1 (en) | 1991-02-04 | 1992-08-12 | Univ Saskatchewan | Vp6 encapsulated drug delivery |
| CA2104958A1 (en) | 1991-03-07 | 1992-09-08 | Jean C. Nichols | Use of cell surface receptor targeted molecules for the treatment of viral diseases |
| WO1993002102A1 (en) | 1991-07-23 | 1993-02-04 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Novel peptide antigens and immunoassays, test kits and vaccines using the same |
| US5558865A (en) | 1991-08-22 | 1996-09-24 | Nissin Shokuhin Kabushiki Kaisha | HIV immunotherapeutics |
| EP0554446B1 (en) | 1991-08-22 | 1998-11-04 | Nissin Shokuhin Kabushiki Kaisha | Monoclonal antibodies useful in therapy of HIV-1 infection |
| EP0608261B1 (en) | 1991-09-13 | 2002-11-27 | Chiron Corporation | Immunoreactive hepatitis c virus polypeptide compositions |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| US5665720A (en) | 1992-08-07 | 1997-09-09 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| DE4228458A1 (de) | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| US6004763A (en) | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| CA2105629A1 (en) | 1992-09-14 | 1994-03-15 | Robert S. Becker | Potentiation of immunogenic response |
| US5686078A (en) | 1992-09-14 | 1997-11-11 | Connaught Laboratories, Inc. | Primary and secondary immunization with different physio-chemical forms of antigen |
| US5304472A (en) | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| DK0679187T4 (da) | 1993-01-16 | 2001-09-17 | Manfred Schawaller | Fremgangsmåde til udvinding af native, oligomere, glycosylerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIV |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5869624A (en) * | 1993-03-26 | 1999-02-09 | Progenics Pharmaceuticals, Inc. | HIV-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses thereof |
| AU686616B2 (en) | 1993-03-26 | 1998-02-12 | Gen-Probe Incorporated | Detection of human immunodeficiency virus type 1 |
| US5419900A (en) | 1993-05-19 | 1995-05-30 | The United States Of America As Represented By The Department Of Of Health And Human Services | Immunologic enhancement with intermittent interleukin-2 therapy |
| US5864027A (en) | 1993-06-07 | 1999-01-26 | Genentech, Inc. | HIV envelope polypeptides |
| BR9406821A (pt) | 1993-06-09 | 1996-03-26 | Connaught Lab | Peptideo sintético composiçao imunogenica kit de diagnostico útil para dectar anticorpos especificos de hiv em amostra de teste kit de diagnostico para detectar antigenos de hiv em amostra de teste codificaçao de molécula de ácido nucléico e anticorpo |
| US5614413A (en) | 1993-07-01 | 1997-03-25 | The Uab Research Foundation | Encapsidated recombinant poliovirus nucleic acid and methods of making and using same |
| US5955342A (en) | 1994-08-15 | 1999-09-21 | Connaught Laboratories Limited | Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region |
| US6291157B1 (en) | 1998-02-23 | 2001-09-18 | Connaught Laboratories Limited | Antigenically-marked non-infectious retrovirus-like particles |
| US6080408A (en) | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| US5550280A (en) | 1994-11-30 | 1996-08-27 | Uniroyal Chemical Ltd./ Uniroyal Chemical Ltee | Hindered aromatic ester compounds useful as anti-viral agents |
| CU22559A1 (es) | 1996-01-17 | 1999-05-03 | Ct Ingenieria Genetica Biotech | Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión |
| US5741492A (en) | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
| US6087486A (en) | 1996-01-29 | 2000-07-11 | The Trustees Of The University Of Pennsylvania | Nucleotide sequences encoding vpr receptor protein |
| US6060587A (en) | 1996-01-29 | 2000-05-09 | The Trustees Of The University Of Pennsylvania | Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle |
| US5951975A (en) | 1996-06-28 | 1999-09-14 | University Of Pittsburgh | Induction of CTLs specific for natural antigens by cross priming immunization |
| US6093800A (en) | 1996-09-06 | 2000-07-25 | The Regents Of The University Of California | E25a protein, methods for production and use thereof |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| US6139833A (en) | 1997-08-08 | 2000-10-31 | Lexicon Genetics Incorporated | Targeted gene discovery |
| US5858675A (en) | 1997-05-13 | 1999-01-12 | Incyte Pharmaceuticals, Inc. | Double-stranded RNA-binding protein |
| US6099847A (en) | 1997-05-15 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric Gag pseudovirions |
| US5932442A (en) | 1997-09-23 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human regulatory molecules |
| US5932445A (en) | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| EP1078052A2 (en) | 1998-04-14 | 2001-02-28 | Chiron Corporation | Noncloning technique for expressing a gene of interest |
| US6090388A (en) | 1998-06-20 | 2000-07-18 | United Biomedical Inc. | Peptide composition for prevention and treatment of HIV infection and immune disorders |
| US6316253B1 (en) | 1999-11-01 | 2001-11-13 | Chiron Corporation | Expression vectors, transfection systems, and method of use thereof |
-
1999
- 1999-12-30 WO PCT/US1999/031272 patent/WO2000039303A2/en not_active Ceased
- 1999-12-30 JP JP2000591194A patent/JP4776075B2/ja not_active Expired - Fee Related
- 1999-12-30 DE DE69938062T patent/DE69938062T2/de not_active Expired - Lifetime
- 1999-12-30 AT AT99968574T patent/ATE384795T1/de active
- 1999-12-30 US US09/476,242 patent/US6689879B2/en not_active Expired - Fee Related
- 1999-12-30 PT PT99968574T patent/PT1141315E/pt unknown
- 1999-12-30 DK DK99968574T patent/DK1141315T3/da active
- 1999-12-30 AU AU25966/00A patent/AU2596600A/en not_active Abandoned
- 1999-12-30 EP EP99968574A patent/EP1141315B1/en not_active Expired - Lifetime
- 1999-12-30 CA CA2358915A patent/CA2358915C/en not_active Expired - Fee Related
- 1999-12-30 ES ES99968574T patent/ES2299276T3/es not_active Expired - Lifetime
-
2003
- 2003-07-25 US US10/452,018 patent/US7662916B2/en not_active Expired - Fee Related
-
2008
- 2008-04-15 CY CY20081100418T patent/CY1107393T1/el unknown
-
2009
- 2009-11-19 US US12/621,992 patent/US20100092502A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1141315A2 (en) | 2001-10-10 |
| US7662916B2 (en) | 2010-02-16 |
| ES2299276T3 (es) | 2008-05-16 |
| DK1141315T3 (da) | 2008-05-19 |
| US6689879B2 (en) | 2004-02-10 |
| JP4776075B2 (ja) | 2011-09-21 |
| US20100092502A1 (en) | 2010-04-15 |
| DE69938062T2 (de) | 2009-01-15 |
| CY1107393T1 (el) | 2012-12-19 |
| US20090304740A1 (en) | 2009-12-10 |
| JP2002533125A (ja) | 2002-10-08 |
| AU2596600A (en) | 2000-07-31 |
| US20020146683A1 (en) | 2002-10-10 |
| ATE384795T1 (de) | 2008-02-15 |
| WO2000039303A2 (en) | 2000-07-06 |
| CA2358915A1 (en) | 2000-07-06 |
| EP1141315B1 (en) | 2008-01-23 |
| WO2000039303A3 (en) | 2000-09-21 |
| CA2358915C (en) | 2010-06-01 |
| DE69938062D1 (de) | 2008-03-13 |
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