PT1140023E - Formulacoes cocleares integrativas de proteina-adn e metodos de transformacao celular - Google Patents
Formulacoes cocleares integrativas de proteina-adn e metodos de transformacao celularInfo
- Publication number
- PT1140023E PT1140023E PT99966144T PT99966144T PT1140023E PT 1140023 E PT1140023 E PT 1140023E PT 99966144 T PT99966144 T PT 99966144T PT 99966144 T PT99966144 T PT 99966144T PT 1140023 E PT1140023 E PT 1140023E
- Authority
- PT
- Portugal
- Prior art keywords
- dna
- proteins
- coclear
- integrating
- formulations
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/210,578 US6340591B1 (en) | 1998-12-14 | 1998-12-14 | Integrative protein-DNA cochleate formulations and methods for transforming cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1140023E true PT1140023E (pt) | 2005-03-31 |
Family
ID=22783444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99966144T PT1140023E (pt) | 1998-12-14 | 1999-12-13 | Formulacoes cocleares integrativas de proteina-adn e metodos de transformacao celular |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6340591B1 (pt) |
| EP (2) | EP1140023B1 (pt) |
| AT (1) | ATE283035T1 (pt) |
| AU (1) | AU759178B2 (pt) |
| CA (1) | CA2354527A1 (pt) |
| DE (1) | DE69922248T2 (pt) |
| ES (1) | ES2233097T3 (pt) |
| PT (1) | PT1140023E (pt) |
| WO (1) | WO2000035421A2 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60013479T2 (de) * | 1999-12-13 | 2005-09-01 | Lipoxen Technologies Ltd. | Liposomen enthaltend einen komplex aus polyanion und calciumphosphat |
| WO2004012709A1 (en) * | 2002-08-06 | 2004-02-12 | Tuo Jin | Cochleates without metal cations as the bridging agents |
| US20050013854A1 (en) * | 2003-04-09 | 2005-01-20 | Mannino Raphael J. | Novel encochleation methods, cochleates and methods of use |
| EP1631669A2 (en) | 2003-04-09 | 2006-03-08 | Biodelivery Sciences International, Inc. | Cochleate compositions directed against expression of proteins |
| US20060029656A1 (en) * | 2004-02-03 | 2006-02-09 | Biodelivery Sciences International, Inc. | Replacement enzyme cochleates |
| AU2005244262A1 (en) * | 2004-04-09 | 2005-11-24 | Biodelivery Sciences International, Inc. | Nucleotide-cochleate compositions and methods of use |
| US20100178325A1 (en) * | 2006-08-23 | 2010-07-15 | Biodelivery Sciences International, Inc. | Amphiphilic nucleotide cochleate compositions and methods of using the same |
| CA2672338C (en) | 2006-12-15 | 2017-06-06 | National Research Council Of Canada | Archaeal polar lipid aggregates for administration to animals |
| US20220226465A1 (en) | 2021-01-18 | 2022-07-21 | ConserV Bioscience | Coronavirus Immunogenic Compositions, Methods and Uses Thereof |
| WO2024038407A1 (en) * | 2022-08-19 | 2024-02-22 | Seqirus Inc. | Lipid nanoparticle comprising a dna-binding protein |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0646178A1 (en) * | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| US5840707A (en) | 1993-10-04 | 1998-11-24 | Albany Medical College | Stabilizing and delivery means of biological molecules |
| US5994318A (en) * | 1993-10-04 | 1999-11-30 | Albany Medical College | Cochleate delivery vehicles |
| US6342390B1 (en) * | 1994-11-23 | 2002-01-29 | The United States Of America As Represented By The Secretary Of Health And Human Services | Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy |
| US5843742A (en) | 1994-12-16 | 1998-12-01 | Avigen Incorporated | Adeno-associated derived vector systems for gene delivery and integration into target cells |
| US5972899A (en) * | 1996-01-25 | 1999-10-26 | New York University | Apoptosis induced by Shigella IpaB |
| WO1997030725A1 (en) | 1996-02-22 | 1997-08-28 | Raphael James Mannino | Cochleat delivery vehicles |
-
1998
- 1998-12-14 US US09/210,578 patent/US6340591B1/en not_active Expired - Fee Related
-
1999
- 1999-12-13 WO PCT/US1999/029446 patent/WO2000035421A2/en active IP Right Grant
- 1999-12-13 EP EP99966144A patent/EP1140023B1/en not_active Expired - Lifetime
- 1999-12-13 CA CA002354527A patent/CA2354527A1/en not_active Abandoned
- 1999-12-13 AU AU21756/00A patent/AU759178B2/en not_active Ceased
- 1999-12-13 DE DE69922248T patent/DE69922248T2/de not_active Expired - Fee Related
- 1999-12-13 EP EP04027647A patent/EP1525881A2/en not_active Withdrawn
- 1999-12-13 AT AT99966144T patent/ATE283035T1/de not_active IP Right Cessation
- 1999-12-13 ES ES99966144T patent/ES2233097T3/es not_active Expired - Lifetime
- 1999-12-13 PT PT99966144T patent/PT1140023E/pt unknown
-
2001
- 2001-09-21 US US09/957,031 patent/US20020034822A1/en not_active Abandoned
-
2005
- 2005-01-24 US US11/042,598 patent/US20050129661A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020034822A1 (en) | 2002-03-21 |
| US6340591B1 (en) | 2002-01-22 |
| WO2000035421A2 (en) | 2000-06-22 |
| DE69922248T2 (de) | 2005-11-03 |
| CA2354527A1 (en) | 2000-06-22 |
| EP1525881A2 (en) | 2005-04-27 |
| EP1140023B1 (en) | 2004-11-24 |
| WO2000035421A3 (en) | 2000-11-09 |
| US20050129661A1 (en) | 2005-06-16 |
| ATE283035T1 (de) | 2004-12-15 |
| AU759178B2 (en) | 2003-04-10 |
| ES2233097T3 (es) | 2005-06-01 |
| EP1140023A2 (en) | 2001-10-10 |
| AU2175600A (en) | 2000-07-03 |
| DE69922248D1 (de) | 2004-12-30 |
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