PT1116721E - Processo para a reducao de pterinas - Google Patents

Processo para a reducao de pterinas

Info

Publication number
PT1116721E
PT1116721E PT00100504T PT00100504T PT1116721E PT 1116721 E PT1116721 E PT 1116721E PT 00100504 T PT00100504 T PT 00100504T PT 00100504 T PT00100504 T PT 00100504T PT 1116721 E PT1116721 E PT 1116721E
Authority
PT
Portugal
Prior art keywords
pterins
reduction
dihydroxypropyl
alkyl
formula
Prior art date
Application number
PT00100504T
Other languages
English (en)
Inventor
Nando Toderi
Marazza Dr Fabrizio
Original Assignee
Cerbios Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerbios Pharma Sa filed Critical Cerbios Pharma Sa
Publication of PT1116721E publication Critical patent/PT1116721E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT00100504T 1999-05-07 2000-01-12 Processo para a reducao de pterinas PT1116721E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/306,996 US6162914A (en) 1998-04-24 1999-05-07 Process for the reduction of pterins
EP00100504A EP1116721B1 (de) 1999-05-07 2000-01-12 Verfahren zur Reduktion von Pterinen

Publications (1)

Publication Number Publication Date
PT1116721E true PT1116721E (pt) 2003-07-31

Family

ID=26070419

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00100504T PT1116721E (pt) 1999-05-07 2000-01-12 Processo para a reducao de pterinas

Country Status (7)

Country Link
US (1) US6162914A (pt)
EP (1) EP1116721B1 (pt)
AT (1) ATE234303T1 (pt)
DE (1) DE50001434D1 (pt)
DK (1) DK1116721T3 (pt)
ES (1) ES2193012T3 (pt)
PT (1) PT1116721E (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ES2596827T3 (es) 2003-11-17 2017-01-12 Biomarin Pharmaceutical Inc. Tratamiento de la fenilcetonuria con BH4
CN101132776A (zh) 2004-11-17 2008-02-27 生物马林药物股份有限公司 稳定的四氢生物喋呤片剂制剂
CN102329318B (zh) * 2011-10-20 2013-07-10 浙江圣达药业有限公司 一种高纯度四氢叶酸的制备方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2790802A (en) * 1954-05-06 1957-04-30 American Cyanamid Co Substituted tetrahydropteridines and method of preparing the same
US2927113A (en) * 1957-10-14 1960-03-01 Lepetit Spa Leucovorin purification
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
US4206307A (en) * 1977-08-22 1980-06-03 United States Of America Preparation of tetrahydrofolic acid from folic acid
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS5976086A (ja) * 1982-09-20 1984-04-28 ザ　ウエルカム　フアウンデ−シヨン　リミテツド プテリジン化合物
GB8318833D0 (en) * 1983-07-12 1983-08-10 Wellcome Found Chemical compounds
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
DE69227561T2 (de) * 1991-08-21 1999-06-02 Eisai Co Ltd Kondensierte Pyrimidinderivate als Antitumorverbindungen
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
CA2084556C (en) * 1991-12-06 1996-12-24 So Tanaka Method for manufacturing an artificial grain boundary type josephson junction device

Also Published As

Publication number Publication date
AU7230700A (en) 2001-07-19
ES2193012T3 (es) 2003-11-01
DK1116721T3 (da) 2003-07-14
AU744296B2 (en) 2002-02-21
EP1116721A1 (de) 2001-07-18
US6162914A (en) 2000-12-19
EP1116721B1 (de) 2003-03-12
DE50001434D1 (de) 2003-04-17
ATE234303T1 (de) 2003-03-15

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