PT110063A - Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral - Google Patents

Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral

Info

Publication number
PT110063A
PT110063A PT110063A PT11006317A PT110063A PT 110063 A PT110063 A PT 110063A PT 110063 A PT110063 A PT 110063A PT 11006317 A PT11006317 A PT 11006317A PT 110063 A PT110063 A PT 110063A
Authority
PT
Portugal
Prior art keywords
aryl
triazole
methyl
group
hydroxy
Prior art date
Application number
PT110063A
Other languages
English (en)
Inventor
Burke Anthony
Silva Marques Carolina
Gaudio Eugenio
Busto Vásquez Natalia
Bertoni Francesco
Original Assignee
Univ Evora
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Evora filed Critical Univ Evora
Priority to PT110063A priority Critical patent/PT110063A/pt
Priority to EP18169956.2A priority patent/EP3400938B1/en
Priority to PT181699562T priority patent/PT3400938T/pt
Publication of PT110063A publication Critical patent/PT110063A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENÇÃO DIZ RESPEITO À UTILIZAÇÃO DE NOVOS DERIVADOS DE N-(1,2,3-TRIAZOLE-METILO)ISATINA E N-(1,2,3-TRIAZOLEMETILO)-3-HIDROXI-3-ARILO-OXINDOLES COM ACTIVIDADE CITOTÓXICA E ANTI-TUMORAL E COMO POTENTES INIBIDORES DE CERTAS LINHAS CELULARES TUMORAIS. OS COMPOSTOS N-(1,2,3-TRIAZOLE-METILO)-3-HIDROXI-3-ARILOOXINDOLES QUIRAIS DE FÓRMULA (I), SÃO OBTIDOS NUM ESTADO ENANTIOMÉRICAMENTE RICOS OU PUROS A PARTIR DE PRECURSORES DE FÓRMULA (II) ATRAVÉS DE UM PROCESSO EFICIENTE DE ARILAÇÃO UTILIZANDO REAGENTES DE ARILO-BORO E SEUS DERIVADOS E UM CATALISADOR QUIRAL DE METAL DE TRANSIÇÃO, SOB CONDIÇÕES REACCIONAIS SUAVES, ONDE R, R1, R2 E R3 REPRESENTAM H, ALQUILO, ARILO, VINILO, ALILO, ALCÓXILO, HALOGÉNIO, OH, CN, CHO E CO2H; R4 REPRESENTA UM GRUPO LINEAR ALQUILO COM 1-6 CARBONOS, UM GRUPO CICLOHETEROALQUILO, UM GRUPO ARILO OU HETEROARILO, QUE INCLUI UM GRUPO FENILO SUBSTITUÍDO CONTENDO ALCÓXILO, HALOGÉNIO, OH, CN, CHO, CO2H, 2- E 4-PIRIDINA, PIRIMIDINA, PIRIDAZINA, TIOFENO, FURANO, PIRANO, BENZOILO, PIRROLE, UM GRUPO BENZILO OU DERIVADO; R5 REPRESENTA UM GRUPO ARILO.
PT110063A 2017-05-08 2017-05-08 Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral PT110063A (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PT110063A PT110063A (pt) 2017-05-08 2017-05-08 Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral
EP18169956.2A EP3400938B1 (en) 2017-05-08 2018-04-27 Novel n-(1,2,3-triazolmethyl)isatin and n-(1,2,3-triazolmethyl)-3-hydroxy-3-aryloxindoles with cytotoxic and anti-tumor activity
PT181699562T PT3400938T (pt) 2017-05-08 2018-04-27 Novos derivados n-(1,2,3-triazole-metilo)isatina e n- (1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT110063A PT110063A (pt) 2017-05-08 2017-05-08 Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral

Publications (1)

Publication Number Publication Date
PT110063A true PT110063A (pt) 2018-11-08

Family

ID=62089688

Family Applications (2)

Application Number Title Priority Date Filing Date
PT110063A PT110063A (pt) 2017-05-08 2017-05-08 Novos derivados n-(1,2,3-triazole-metilo)isatina e n-(1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral
PT181699562T PT3400938T (pt) 2017-05-08 2018-04-27 Novos derivados n-(1,2,3-triazole-metilo)isatina e n- (1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT181699562T PT3400938T (pt) 2017-05-08 2018-04-27 Novos derivados n-(1,2,3-triazole-metilo)isatina e n- (1,2,3-triazole-metilo)-3-hidroxi-3-arilo-oxindoles com actividade citotóxica e anti-tumoral

Country Status (2)

Country Link
EP (1) EP3400938B1 (pt)
PT (2) PT110063A (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115043849B (zh) * 2022-05-20 2023-08-15 贵州大学 环内酯骨架拼接茚二酮双螺环类化合物及其制备方法及应用
CN116621767B (zh) * 2023-02-23 2024-05-31 中山大学 一种靛红衍生物及其制备方法和应用

Also Published As

Publication number Publication date
PT3400938T (pt) 2020-12-16
EP3400938B1 (en) 2020-09-09
EP3400938A1 (en) 2018-11-14

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Effective date: 20180730