PT1054018E - Bibliotecas de fragmentos fab e métodos para a sua utilização - Google Patents

Bibliotecas de fragmentos fab e métodos para a sua utilização Download PDF

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Publication number
PT1054018E
PT1054018E PT99201558T PT99201558T PT1054018E PT 1054018 E PT1054018 E PT 1054018E PT 99201558 T PT99201558 T PT 99201558T PT 99201558 T PT99201558 T PT 99201558T PT 1054018 E PT1054018 E PT 1054018E
Authority
PT
Portugal
Prior art keywords
methods
fab fragment
fragment libraries
fab
libraries
Prior art date
Application number
PT99201558T
Other languages
English (en)
Inventor
Hendricus Renerus J Hoogenboom
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of PT1054018E publication Critical patent/PT1054018E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
PT99201558T 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização PT1054018E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201558A EP1054018B1 (en) 1999-05-18 1999-05-18 Fab fragment libraries and methods for their use

Publications (1)

Publication Number Publication Date
PT1054018E true PT1054018E (pt) 2009-02-16

Family

ID=8240210

Family Applications (2)

Application Number Title Priority Date Filing Date
PT91512335T PT2067788E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização
PT99201558T PT1054018E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT91512335T PT2067788E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização

Country Status (11)

Country Link
EP (2) EP2067788B1 (pt)
JP (3) JP4741086B2 (pt)
AT (1) ATE421976T1 (pt)
AU (1) AU780145B2 (pt)
CA (1) CA2372582C (pt)
DE (1) DE69940364D1 (pt)
DK (2) DK2067788T3 (pt)
ES (2) ES2549440T3 (pt)
HK (1) HK1134303A1 (pt)
PT (2) PT2067788E (pt)
WO (1) WO2000070023A1 (pt)

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WO2003095492A1 (en) 2002-05-06 2003-11-20 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Identification of novel broadly cross-reactive hiv-1 neutralizing human monoclonal antibodies
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US7157562B1 (en) * 2003-04-14 2007-01-02 The United States Of America As Represented By The Secretary Of The Army Bioprocess for the production of recombinant anti-botulinum toxin antibody
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
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AU2005207003C1 (en) 2004-01-20 2013-06-13 Humanigen, Inc. Antibody specificity transfer using minimal essential binding determinants
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ES2387809T3 (es) 2004-03-19 2012-10-02 Imclone Llc Anticuerpo frente al receptor del factor de crecimiento epidérmico humano
MY146381A (en) * 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP1707628B1 (en) * 2005-03-30 2009-11-11 Sekisui Chemical Co., Ltd. Methods for producing recombinant polyclonal immunoglobulins
EP2069558B1 (en) * 2006-10-02 2013-05-01 Sea Lane Biotechnologies,llc. Design and construction of diverse synthetic peptide and polypeptide libraries
CN101126760B (zh) * 2007-01-17 2011-11-16 江苏省人民医院 全人源抗卵泡刺激素β单链抗体筛选方法及其用途
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WO2012142662A1 (en) 2011-04-21 2012-10-26 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
DK2761006T3 (en) 2011-09-28 2017-03-27 Zera Intein Protein Solutions S L Cleft inteins and uses thereof
MX360109B (es) 2012-04-20 2018-10-23 Merus Nv Metodos y medios para la produccion de moleculas de tipo ig.
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
EP2883883A1 (en) 2013-12-16 2015-06-17 Cardio3 Biosciences S.A. Therapeutic targets and agents useful in treating ischemia reperfusion injury
MX2017012679A (es) 2015-04-06 2018-02-09 Subdomain Llc Polipeptidos que contienen dominios de union de novo y usos de los mismos.
PT3440208T (pt) 2016-04-06 2020-12-04 Zumutor Biologics Inc Vetores para clonagem e expressão de proteínas, métodos e suas aplicações
CA3028002A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
WO2018192974A1 (en) 2017-04-18 2018-10-25 Université Libre de Bruxelles Biomarkers and targets for proliferative diseases
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
JP7285267B2 (ja) 2017-11-14 2023-06-01 アーセルクス インコーポレイテッド Ｄドメイン含有ポリペプチドおよびその使用
CN112384527B (zh) 2018-03-23 2023-06-27 布鲁塞尔自由大学 Wnt信号传递激动剂分子
JP7332691B2 (ja) 2018-07-08 2023-08-23 スペシフィカ インコーポレイティド 抗体の開発可能性が最大化された抗体ライブラリー

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Also Published As

Publication number Publication date
EP2067788B1 (en) 2015-07-22
ATE421976T1 (de) 2009-02-15
ES2321568T3 (es) 2009-06-08
JP5159841B2 (ja) 2013-03-13
ES2549440T3 (es) 2015-10-28
EP1054018A1 (en) 2000-11-22
DK2067788T3 (da) 2015-10-19
DK1054018T3 (da) 2009-05-18
WO2000070023A9 (en) 2002-01-17
JP2013078315A (ja) 2013-05-02
AU5142200A (en) 2000-12-05
JP4741086B2 (ja) 2011-08-03
JP2010273689A (ja) 2010-12-09
HK1134303A1 (en) 2010-04-23
EP1054018B1 (en) 2009-01-28
DE69940364D1 (de) 2009-03-19
AU780145B2 (en) 2005-03-03
EP2067788A3 (en) 2010-04-21
WO2000070023A1 (en) 2000-11-23
PT2067788E (pt) 2015-10-29
CA2372582A1 (en) 2000-11-23
JP2002543830A (ja) 2002-12-24
EP2067788A2 (en) 2009-06-10
CA2372582C (en) 2013-08-13

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