PT101047A - Agentes anti-helmiticos de benzimidazole e processo para a sua preparacao - Google Patents
Agentes anti-helmiticos de benzimidazole e processo para a sua preparacaoInfo
- Publication number
- PT101047A PT101047A PT101047A PT10104792A PT101047A PT 101047 A PT101047 A PT 101047A PT 101047 A PT101047 A PT 101047A PT 10104792 A PT10104792 A PT 10104792A PT 101047 A PT101047 A PT 101047A
- Authority
- PT
- Portugal
- Prior art keywords
- c4alkoxy
- pct
- heteroaryl
- aryl
- date
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 229940124339 anthelmintic agent Drugs 0.000 abstract 2
- 239000000921 anthelmintic agent Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 1
- JYZIHLWOWKMNNX-UHFFFAOYSA-N benzimidazole Chemical compound C1=C[CH]C2=NC=NC2=C1 JYZIHLWOWKMNNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000004540 pour-on Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000004544 spot-on Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919124002A GB9124002D0 (en) | 1991-11-12 | 1991-11-12 | Benzimidazole anthelmintic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT101047A true PT101047A (pt) | 1994-02-28 |
| PT101047B PT101047B (pt) | 1999-08-31 |
Family
ID=10704487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT101047A PT101047B (pt) | 1991-11-12 | 1992-11-10 | Agentes anti-helmiticos de benzimidazole e processo para a sua preparacao |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5475005A (pt) |
| EP (1) | EP0613469B1 (pt) |
| JP (1) | JP2818030B2 (pt) |
| AT (1) | ATE141594T1 (pt) |
| AU (1) | AU681047B2 (pt) |
| BR (1) | BR9206731A (pt) |
| CA (1) | CA2120616C (pt) |
| DE (1) | DE69213021T2 (pt) |
| DK (1) | DK0613469T3 (pt) |
| ES (1) | ES2090701T3 (pt) |
| GB (1) | GB9124002D0 (pt) |
| GR (1) | GR3021344T3 (pt) |
| NZ (1) | NZ245089A (pt) |
| PT (1) | PT101047B (pt) |
| WO (1) | WO1993010101A1 (pt) |
| ZA (1) | ZA928684B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU662580B2 (en) * | 1991-12-26 | 1995-09-07 | Microsules Argentina S.A. De Servicios C.I.I.A. | Subcutaneous or intramuscular injectable compositions containing benzimidazole as active agent for the treatment of gastrointestinal helminthiasis and method for their preparation |
| WO2006050148A2 (en) * | 2004-10-29 | 2006-05-11 | Teva Pharmaceutical Industries, Ltd. | Propargyl trifluoromethoxy aminobenzimidazole derivatives |
| US20140296068A1 (en) * | 2011-10-26 | 2014-10-02 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2933502A (en) * | 1958-02-12 | 1960-04-19 | Du Pont | Benzimidazolone derivatives |
| US3010698A (en) * | 1960-04-14 | 1961-11-28 | Stanray Corp | Lift jack |
| BE666795A (pt) * | 1964-08-04 | 1966-01-13 | ||
| US3427388A (en) * | 1966-05-06 | 1969-02-11 | Du Pont | Esters of benzimidazolecarbamic acid as mite ovicides |
| FR2046114A5 (en) * | 1970-01-30 | 1971-03-05 | Dynachim Sarl | Benzimidazole derivs anthelmintic, antifung - al bactericidal, aericidal, insecticidal, nema |
| US4002640A (en) * | 1972-12-29 | 1977-01-11 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| HU169503B (pt) * | 1974-02-05 | 1976-12-28 | ||
| DE2425704A1 (de) * | 1974-05-28 | 1975-12-18 | Hoechst Ag | Substituierte phenylmercapto-benzimidazole |
| US3915986A (en) * | 1974-06-19 | 1975-10-28 | Smithkline Corp | Methyl 5-propylthio-2-benzimidazolecarbamate |
| US4032536A (en) * | 1976-07-22 | 1977-06-28 | Janssen Pharmaceutica N.V. | (1h-benzimidazol-2-yl)carbamates |
| IN149762B (pt) * | 1978-06-16 | 1982-04-10 | Ciba Geigy India Ltd | |
| DE2840927A1 (de) * | 1978-09-20 | 1980-04-10 | Bayer Ag | 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4512998A (en) * | 1980-10-20 | 1985-04-23 | Schering Corporation | Anthelmintic benzimidazole carbamates |
| US4435418A (en) * | 1982-12-13 | 1984-03-06 | Smithkline Beckman Corporation | 5-Phenylethenylbenzimidazoles |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4826841A (en) * | 1985-04-05 | 1989-05-02 | Eli Lilly And Company | Alkanoyl anilides as pesticides |
| NZ232785A (en) * | 1989-03-15 | 1991-03-26 | Janssen Pharmaceutica Nv | 5-(1,2 benzisoxazol-, benzimidazol and benzisothiazol-3- yl)-1h-benzimadazol-2-yl carbamic acid ester derivatives preparatory processes, intermediates and anthelmintic compositions |
-
1991
- 1991-11-12 GB GB919124002A patent/GB9124002D0/en active Pending
-
1992
- 1992-11-04 DK DK92923126.4T patent/DK0613469T3/da active
- 1992-11-04 US US08/240,652 patent/US5475005A/en not_active Expired - Fee Related
- 1992-11-04 JP JP5508941A patent/JP2818030B2/ja not_active Expired - Lifetime
- 1992-11-04 WO PCT/EP1992/002564 patent/WO1993010101A1/en not_active Ceased
- 1992-11-04 BR BR9206731A patent/BR9206731A/pt not_active Application Discontinuation
- 1992-11-04 EP EP92923126A patent/EP0613469B1/en not_active Expired - Lifetime
- 1992-11-04 DE DE69213021T patent/DE69213021T2/de not_active Expired - Fee Related
- 1992-11-04 ES ES92923126T patent/ES2090701T3/es not_active Expired - Lifetime
- 1992-11-04 CA CA002120616A patent/CA2120616C/en not_active Expired - Fee Related
- 1992-11-04 AT AT92923126T patent/ATE141594T1/de not_active IP Right Cessation
- 1992-11-10 PT PT101047A patent/PT101047B/pt not_active IP Right Cessation
- 1992-11-11 ZA ZA928684A patent/ZA928684B/xx unknown
- 1992-11-11 NZ NZ245089A patent/NZ245089A/en unknown
-
1995
- 1995-09-22 AU AU32831/95A patent/AU681047B2/en not_active Ceased
-
1996
- 1996-10-16 GR GR960402717T patent/GR3021344T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2120616C (en) | 1998-09-22 |
| JPH07501326A (ja) | 1995-02-09 |
| DE69213021D1 (de) | 1996-09-26 |
| WO1993010101A1 (en) | 1993-05-27 |
| EP0613469A1 (en) | 1994-09-07 |
| GR3021344T3 (en) | 1997-01-31 |
| PT101047B (pt) | 1999-08-31 |
| ES2090701T3 (es) | 1996-10-16 |
| JP2818030B2 (ja) | 1998-10-30 |
| EP0613469B1 (en) | 1996-08-21 |
| NZ245089A (en) | 1995-04-27 |
| AU681047B2 (en) | 1997-08-14 |
| ATE141594T1 (de) | 1996-09-15 |
| ZA928684B (en) | 1994-05-11 |
| AU2912592A (en) | 1993-06-15 |
| AU660338B2 (en) | 1995-06-22 |
| DE69213021T2 (de) | 1996-12-19 |
| CA2120616A1 (en) | 1993-05-27 |
| DK0613469T3 (da) | 1996-09-09 |
| BR9206731A (pt) | 1995-10-31 |
| US5475005A (en) | 1995-12-12 |
| AU3283195A (en) | 1996-04-04 |
| GB9124002D0 (en) | 1992-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY129408A (en) | Disubstituted bicyclic, heterocycles, the preparation and the use thereof as pharmaceutical compositions | |
| EA199901014A1 (ru) | C-4"-замещенные макролидные производные | |
| YU56492A (sh) | Derivati hinuklidina | |
| AR029383A1 (es) | Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes | |
| DK0597088T3 (da) | Nye imidazolderivater, deres fremstilling og terapeutiske anvendelser | |
| DE69622031D1 (de) | INDOLDERIVATE ALS cGMP-PDE INHIBITOREN | |
| BG60032B2 (bg) | Метод за получаване на триазолни производни | |
| AR038955A1 (es) | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso | |
| RU94022743A (ru) | Амидо- или карбамидо-производные, обладающие антигиперхолестериновой активностью, и фармацевтическая композиция на их основе | |
| LV10435A (lv) | Azola atvasinajumi to iegusanas panemiens un pielietojums | |
| CA2337825A1 (en) | Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions | |
| BG105111A (bg) | Бензимидазоли, тяхното получаване и употребата имкато лекарствени средства | |
| YU33401A (sh) | 13-točlani azalidi i njihova primena kao antibiotičkih sredstava | |
| BR0015195A (pt) | Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma condição associada com a transmissão reduzida de nicotina para o tratamento ou profilaxia de distúrbios psicóticos ou distúrbios de deterioração intelectual e para o tratamento ou profilaxia de doenças ou condições humanas | |
| ATE199549T1 (de) | Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung | |
| MD1560G2 (ro) | Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri | |
| PT101047A (pt) | Agentes anti-helmiticos de benzimidazole e processo para a sua preparacao | |
| ATE161837T1 (de) | Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält | |
| ES2094545T3 (es) | Derivados n-substituidos del 3-azabiciclo(3.2.0)heptano, como neurolepticos etc.. | |
| RU94022663A (ru) | Производные 2-меркаптобензимидазола, обладающие селективной анксиолитической активностью | |
| ATE236133T1 (de) | Benzimidazolderivate | |
| BR9610175A (pt) | Composto processo de preparação do composto composição farmacêutica e utilização do composto | |
| FR2756562B1 (fr) | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique | |
| ATE200277T1 (de) | Substituierte phenylamidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung | |
| KR910002818A (ko) | 4,5,6,7-사치환된 벤즈옥사졸론 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19930713 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990526 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20001130 |