PL99653B1 - PRODUCT FOR ANIMAL BREEDING - Google Patents

Description

The subject of the invention is an animal breeding agent that accelerates the growth of non-rotting animals, improves the efficiency of animal feed consumption and reduces the incidence of acute diarrhea. Based on, for example, DE-DE patent specification No. 2,413,222 it is known that some salts diaryliodonium of the general formula R2J. + Z-, in which the two R symbols are the same or different groups, representing phenyl groups, naphthyl, furyl, thienyl or pyridyl optionally substituted with one or more typical substituents and Z ~ is an inorganic or organic anion derived from a non-toxic pharmaceutically acceptable acid which has utility in the breeding of lactating animals such as sheep and cattle. It is believed that feeding ruminants in the dose of an active ingredient containing the above-mentioned diaryliodonium salt as an active ingredient, inhibits the microbial deamination of amino acids and proteins normally occurring in the first stomach. This allows the passage of amino acid units through the destructive environment of their first stomach. absorption in the lower intestine. The amino acids and proteins are thus used by the body and not lost as useless ammonia, which is converted into urea. As a consequence of this use of the diaryl iodonium salt to inhibit microbiological deamination in ruminants, the productivity, daily weight gain and feed efficiency of growing and fattened cattle and lambs increase, and the production of wool in mature sheep and lambs increases. It is known that microbial protein degradation plays a minor role in non-producing animals. Thus, the diaryliodonium salt, which inhibits microbial deamination in the first stomach, cannot be expected to have any beneficial effect on weight gain or the feeding efficiency of non-chewing animals that cannot have microbial deaminations in the first stomach. It is therefore surprising to find, at the heart of the invention, that similar diaryl iodonium salts find use in the rearing of non-chewing animals as they increase growth rate and feed efficiency. It has also been found that administration of such compounds reduces the incidence of acute diarrhea, especially in young pigs. According to the invention, a preparation for breeding non-chewing animals such as, for example, chickens, barbs, ducks, geese, pigs, sheep and milk-fed calves that do not have a functional first stomach, and rabbits, contain an iodine salt of the general formula RWJ. + K-, where R1 and R * are the same or different groups, and not respectively represent a phenyl, naphthyl or thienyl group, optionally substituted with one or more substituents such as nitro, hydroxy and carboxyl, halogen, alkyl, alkoxy and alkanoylamino each with up to 6 carbon atoms, a cycloalkyl group with 3 to 7 carbon atoms, and phenyl iodonium and thienyl iodonium optionally substituted with one or more substituents as defined above, and X- is a physiologically acceptable anion, together with liquid or solid edible and non-toxic with a diluent or carrier. Preferably, R1 and R2 are independently phenyl or thienyl, optionally substituted with the above groups, especially one of these groups is thienyl. It is preferred that R 1 and / or R 2 represent an optionally substituted 2-thienyl group. When the optional substituent in R 1 or R 2 is a halogen atom, it is chlorine, bromine, iodine or fluorine. When the substituent in the R 1 or R 2 group is an alkyl, alkoxy or alkanoylamino group up to 6 carbon atoms, it is preferably a methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl, tert -butyl group. -butyI, pentyl, hexyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, Il-but-butoxy, 111-irz.butoxy, pentyloxy, hexyloxy, acetamide, propionamide or butyramide, and when the substituent in the R 1 or R 2 group is a cycloalkyl group having 3 to 7 carbon atoms, i.e., for example, a cyclopentyl or cyclohexyl group. A suitable physiologically acceptable anion X- is, for example, chloride, bromide, iodide, bisulfate , sulphate, nitrate, phosphate, p-toluenesulphonate, acetate, trifluoroacetate, hydrogen succinate, succinate, hydrogen tartrate, tartrate, citrate or maleate. The preferred iodonium salts to be used in the present invention are those in which R1 or R2 is a 4-chlorophenyl or 4-fluorophenyl group iodonium salts which can be used in the composition according to the invention not preferred are the salts of the di (-4-chlorophenyl) -two (4-fluorophenyl) -, di (2-thienyl) -, phenyl (2-thienyl) -, 4- chlorophenyl) (4-tolyl) -, bis (4-chloro-2,5-dimethylphenyl) -, 4-chlorophenyl) (4-fluorophenyl), (4-chlorophenyl) (2,4,5-trimethylphenyl), ( 4-fluorophenyl) -phenyl-, (4-chloro-2,5-dimethylphenyl) phenyl-, (4-chlorophenyl) (4-methoxyphenyl) and (4-fluorophenyl) (4-tolyl) iodonium, especially chlorides and bromides. Suitable liquid diluents or carriers are, for example, drinking water and whole or skim milk. A suitable solid, edible and non-toxic diluent or carrier is, for example, a nutritionally balanced animal feed, such as the standard diet for chickens made of ground grain or cereal by-products, animal proteins with added vitamins and sub-ingredients. minerals, standard commercial pig diets or other conventional animal feed, or an inert solid diluent or carrier with little or no nutritional value, such as: for example kaolin, talcum, calcium carbonate, fuller earth, attapulgite, ground shells oyster, ground limestone, starch or lactose. According to the invention, it can be used in the form of a complete feed for direct feeding of animals and contains from 0.0001 to 0.025% by weight of iodonium salt, preferably 0.0001 to 0.005% of the recommended iodonium salt. - and mixed with typical animal feed or in the form of a concentrated premix intended for supplementing the feed before direct feeding This premix contains from 0.025 to 50% by weight of iodonium salt in a mixture or with a balanced feed, animal or neutral solid diluent, eg ground limestone. Such a premix can be diluted in a conventional way, preferably two or several times, which ensures uniform mixing, a typical animal feed and a supplementary feed suitable for direct feeding of the animals is obtained. No toxic effects are observed at the optimal doses of iodonium salts for promoting growth. The iodonium salts used in the composition according to the invention can be prepared by methods known for the preparation of their chemical analogs. For example, iodonium salts of the formula R1R2J + X-, in where R1 and R2 are the same groups, the compound R1 is obtained by reaction! with iodonyl sulphate, for example sulfuric acid, with an alkali metal iodate, for example sodium or potassium iodate, in acetic anhydride and sulfuric acid, or with iodine trie (C 1-6 alkanecarboxylate), for example iodine triacetate or iodine trifluoroacetate, in the presence of acid. Salts of the above formula, wherein R 1 and R 2 are the same or different groups, can be prepared by reacting R * H with a di-CCi ^ alkanoyloxy iodo compound of the general formula R2J (OR8) 2 in which R8 is an alkanoyl group of 1 - 4 carbon atoms, for example a di (acetoxy) iodine compound. The invention is illustrated by the following examples. 45 Example I. A premix of diluted animal feed is made by introducing 5, 10, 25, 50 or 100 g of di (4-chlorophenyl) iodonium chloride into the standard broiler diet, containing ground corn, 50 red corn and fish flour with addition of lysine, methionine, vitamins and minerals in such amounts that the total weight of the premix is 500 g. Other premixes can be prepared by replacing 55 di (4-chlorophenyl) iodonium chloride with the same amount of di (4 - fluorophenyl) iodonium chloride, chloride di (2-thienyl) iodonium chloride, phenyl (2-thienyl) iodonium chloride, or any other iodonium salt described above. 60 Example II. Premixes suitable for dilution of animal feed can be prepared: as described in example 1 by using ground calcium instead of the standard broiler diet. 65 Example III. Animal feed suitable for direct feeding of poultry is prepared by mixing 500 g of the premix obtained according to example I or II with 4.5 kg of the standard chicken diet, which is then mixed to obtain 995 kg of the standard diet containing, depending on the concentration of iodonium salt in the premix, 5, 10, 25, 50 or 100 g of iodonium salt per tone. Example IV. Groups of 20 day old chickens were housed in small cages lined with wood shavings and provided with automatic water dispensers. Chickens in 16 randomly selected cages were fed for 3 or 6 days a balanced control diet with no growth promoter, and chickens in the remaining 4 cages were fed the same basic diet over the same period to which the amounts of salt indicated in Table 1 were added. iodonium. At the end of the test period, the chickens were weighed and the weight gain of each cage was determined. Based on standard statistical methods, a significant (P <0.05) growth effect of the test compounds was found, as the average weight gain of the chickens fed with these The compound was 30% (and more) higher than the average live weight gain of the control chickens. For each diet, the efficiency of feed conversion was also determined, i.e. the ratio of the amount of food consumed to the live weight gain. The results are given in Table 1.R1 * 4. -tolyl 4-acetamidophenyl ¦ 3-nitrophenyl 2-thienyl 1 4-methoxyphenyl I 4-methyl-2-thienyl-methyl-2-thienyl 2,4-dichlorophenyl 4-fluorophenyl phenyl 4-chlorophenyl 1-naphthyl 4-cyclohexylphenyl 4- ichlorophenyl 4-fluorophenyl 1 4-bromophenyl 4-chlorophenyl phenyl phenyl 4-fluorophenyl phenyl Ta R2 1 ^ 4-tolyl 4-acetamidophenyl 3-nitrophenyl 2-thienyl 4-methoxyphenyl 4-methyl-2-thienyl-methyl-2-thienyl 2 , 4-dichlorophenyl 4-fluorophenyl 2-thienyl 4-chlorophenyl 1-naphthyl 4-cyclohe xylphenyl 2-thienyl 2-thienyl 4-bromophenyl 4-methyl-2-thienyl 4-methyl-2-thienyl-chloro-2-thienyl 4-methyl-2-thienyl-methyl-2-thienyl b 1 X 1 * Cl J Cl *) HS04 Cl Br Br Cl Cl Br J Cl NO3 Cl and HS04 p-toluenesulfonate Br Br Cl Cl Cl HSO4 Cl Cl Cl Cl Cl Soybean soybean synthesis ppm 4 100 50 50 50 50 50 50 50 50 50 50 50 50 50 100 50 50 50 100 50 100 50 50 Percentage Difference in Weight Gains Between Consumers and Controls 57 46 55 44 82 66 42 78 70 49 78 66 76 64 42 86 48 42 60 80 36 54 39 43 47 .54 55 1 41 65 61 34 63 43 Percentage Difference in Phtharma Efficacy between Consumers and Controls 6 53 53 41 38 60 54 31 67 68 45 22 71 44 62 51 42 78 48 56 72 75 32 53 48 45 43 51 55 31 54 55 31 69 4099 653 1 x I 4-nitrophenyl 4-tolyl 3-tolyl 3-chlorophenyl 3-carboxyphenyl 2-chlorophenyl 3-nitrophenyl phenyl 4-bromo-2 -thienyl-bromo-2-thienyl 3-nitrophenyl phenyl 4-tolyl 4-chlorophenyl 4-chloro-3-methylphenyl 4-chlar-2,5-dimethylphen 4-chlorophenyl 4-hydroxyphenyl | 4-fluorophenyl 2 2-thienyl 2-thienyl 2-thienyl 2-thienyl 2-thienyl 2-thienyl 2-thienyl-nitro-2-thienyl 4-bnomo-2-thienyl-bromo-2-thienyl 4-fluorophenyl 4-iodophenyl 4-chlorophenyl 2-chlorophenyl 4-chloro-3-methylphenyl 4- (chloro-2,5-dimethylphenyl 4-fluorophenyl 2-thienyl 4-tolyl 3 Cl Cl Cl Cl Cl Cl Cl Br *) Cl *) Cl Cl ca *) Cl *) Cl *) Cl *) Cl *) Cl *) Cl *) Cl *) ¦ 4 50 50 100 100 50 50 50 50 100 50 50 50 50 50 50 50 50 50 1 5 79 48 78 49 41 75 55 61 43 31 119 106 136 51 61 131 145 205 131 6 63 39 69 41 38 69 51 53 44 19 104 93 134 42 60 110 138 185 114 | *) Tested for 6 days and the rest for 3 days. Example 5 103 young piglets with an initial weight of about 15 kg were weighed and divided into 4 experimental groups of 25 or 26 animals. The lambs were fed individually twice a day, with live weight per day, and the feed conversion rate (kg of feed per kg of weight gain). Wipe the mano the following results: Table 2 Diet 1 1 2 3 4 Number of individuals 2 26 26 26 Average live weight gain per day Feed utilization rate kg 3 0.258 0.286 *) 0.266 0.248 standard error kg of feed: kg gain 4 1 5 0.009 0.007 0.010 0.008 3.46 3.15 **) 3.24 *) 3.29 standard error 6 0.06 0.05 0.04 0.08 *) significant at P <0.05 **) significant at P < 0.01 giving them as much food as they could eat in a minute. One group was fed a standard staple diet containing no growth promoter, the other group was fed the same diet with 50 g per ton of di (4-fluorophenyl) iodonium chloride, the third group was fed with 25 g per ton of di (4-fluorophenyl) chloride. ) iodonium, and the fourth - basic diet with the addition of 10 g per ton of nitro-wine (known growth promoter). After 28 days, the piglets were weighed and the mean growth was determined. Example VI. The procedure was as in Example 5 with piglets in groups of 20, which were fed respectively: 1) basic diet, 2) basic diet with the addition of 50 g per ton of di (4-chlorophenyl) iodonium chloride, 3) basic diet with addition of 25 g per ton of di- (4-chlorophenyl) iodonium chloride and 4) basic diet with the addition of 10 g per ton of nitrovin. The results obtained after 23 and 63 test days are summarized in the table below: Table 3 Diet 1 1 2 Average gain in live weight per day kg 2 After 23 days 0.705 0.751 *) standard error 3 0.016 0.014 Feed utilization rate kg feed: kg Increment 4 2.582 2.507 *) Standard error '0.035 0.03599 653 1 1 3 4 1 2 3 4 2 0.730 0.722 After 63 days 0.764 0.804 *) 0.801 *) 0.787 3 0.016 0.017 0.009 0.011 0.014 0.008 4 2.537 2.584 3.068 2.959 *) 2.960 *) 2.966 *) 0.034 0.037 0.047 0.036 0.040 0.044 1 *) significant for P <0.05 Example VII. The procedure was as in Example IV, carrying out tests on young cocks placed in 6 cages with 30 individuals each. The results after 4 weeks of testing are summarized in Tables 4 and 5; Experiment 1 Table 4 Diet 1 1 Basic + 50 ppm of di- (4-fluorophenyl) iodonium chloride Basic + 25 ppm of di- (4-fluo (phenyl) iodonium chloride Basic + 50 ppm of di (2-thienyl) iodonium chloride Basic + 25 ppm of di (2-thienyl) iodonium chloride Basic + 50 ppm of phenyl (2-thienyl) iodonium chloride Basic + 25 ppm of phenyl (2-thienyl) iodonium chloride Basic + 50 ppm of di (4-chlorophenyl) iodonium chloride Basic + 25ppm of di (4-chlorophenyl) iodonium chloride Average live weight gain (g) 2 220.8 251.7 ***) 239.2 **) 228.3 *) 248.0 *) 235.8 *) 236.3 *) 230.2 *) The degree of feed consumption 3 2.17 2.09 2.10 2.18 2.13 2.11 2.12 2.13 *) Significance different than for the control group (diet basic) at the level of P <0.05 **) Significance other than for the control group (basic diet) at the level of P <0.01 ***) Significance other than for the control group (basic diet) at the level of P <0.001 40 55 60 Experiment 2 Table 5 Diet 1 Basic Basic + 10 ppm of nitriovin Basic + 100 ppm of di- (4-chlorophenyl) iodonium chloride Basic + 50 ppm of di (4-chlorophenyl) iodonium chloride Basic + 25 ppm of di- (4-chlorophenyl) iodonium chloride Basic + 50 ppm of di-chloride - (4-fluoro-phenyl) iodonium Basic + 25 ppm of di- (4-fluoro-phenyl) iodonium chloride Average gain in live weight (g) 2 253.2 282.1 ***) 273.3 *) 269.3 *) 263.5 273.1 *) 265.1 Feed utilization rate 3 2.06 1.86 1.98 1.98 1.96 1.93 2.02 Significance as in experiment 1 Example VII. The procedure was as in Example IV, administering compounds at a dose of 50 to 50 ppm for 6 days. The results are given in Table 7. Example IX. Groups of 20 randomly selected day-old chickens were placed in small cages lined with wood chips and provided with automatic water supplies. Chickens in 16 randomly selected cages were fed for 6 days with a balanced control diet without growth promoter. The chickens in the 4 remaining cages were fed over the same period of the same basic diet to which an iodonium compound was added. The chickens were then weighed and the cumulative live weight gain of individuals in each cage and the average value for each cage for each diet were determined. The results are given in Table 8.99 653 11 12 Table 7 R1 4-bromo-2,5-dimethylphenyl 4-methoxy-3-nitrophenyl phenyl 4-chlorophenyl 4-chlorophenyl 4-chlorophenyl 4-chlorophenyl 4-fluorophenyl 4-chlorophenyl 4-chlorophenyl 3 , 4-dichlorophenyl 4-chlorophenyl 4-cyclohexylphenyl 4-chlorophenyl 2,4,6-trichlorophenyl R * 4-bromo-2,5-dimethylphenyl 4-methoxy-3-nitrophenyl mesityl 4-methoxy-3-nitrophenyl1 4-s- butylphenyl 2,4-xylyl phenyl phenyl mesethyl and 2,3,4-trimethylphenyl phenyl 4-bromophenyl phenyl 2,4-dimethoxyphenyl phenyl X Cl Cl hso4 Br Cl Cl Br Br Br Br Br Cl Cl Br Br Cl Percentage difference in increments weights between drug and control groups 84 129 96 72 125 129 223 212 214 260 ^ 190 91 90 115 89 65 Percentage difference in feed efficiency between groups consuming and control 97 108 82 56 106 117 200 185 190 230 175 91 92 103 88 77 Table 8 1 R1 4-iodophenyl 4-iodophenyl 2-thienyl 4-phenoxyphenyl 4-chlorophenyl 4-tolyl phenyl 4-chlorophenyl phenyl phenyl phenyl 4-chlorophyll enyl 2-thienyl 4-chlorophenyl 4-methoxyphenyl 2-thienyl R2 phenyl phenyl 4-phenoxyphenyl 4-phenoxyphenyl 4-chlorio-2,5-dimethylphenyl 4-cyclohexylphenyl 4-chloro-2,5-dimethylphenyl 4-methoxyphenyl 4-acetamidophenyl 4 -bromophenyl 4-bromophenyl 4- (4-chlorophenyliodonio) phenyl 4- (2-thienyliodonio) -phenyl 4-acetamidophenyl 3- (4-methoxyphenyliodonio) phenyl 3- (2-thienyliodonyl) phenyl X Br Cl Cl Cl Cl Br Cl Cl Br Cl Br 2C1 2CF3C02 Cl 2C1 2C1 Weight difference, 8, 9 7.5, 4 6.2 4.6, 6 12.6 7.0 7.3 3.5 6.0, 3 9.3 6, 6 2.9 Table 9 Additive (Jo diet di- / 4-chlorophenyl-iodonium chloride 50 g / tone + 1 + 1 + 1 + 1 nitrovin g / tone ++ 11 ++ 11 copper 100 g / tone + + + + 1 1 1 1 Average gain in live weight per day g 684 720 712 737 716 743 715 755 Food utilization level 111III! I99 653 13 U The difference in weight, given in the last column, is the difference between the weight of the tested group A and the weight of the control group B, expressed as a percentage of the weight of the control group, i.e. 100 B Example X. 72 piglets with initial weight According to their drink and live weight, 30-35 kg were placed in 8 groups of 9 piglets each. Each group was fed a random diet selected from the 8 diets indicated in Table 9. All individuals were fed individually twice a day with an accurately weighed amount of diet consistent with the body weight feeding scale and adjusted weekly. The study was completed after 48 days and the mean live weight gain and utilization rate were determined for each group. karma (expressed as in example V). The results are presented in Table 9. PL

Claims (38)

Claims 1. A preparation for breeding non-fasting animals, characterized in that it comprises an iodonium salt of formula RWJ. + K-. wherein R 1 and R * are the same or different groups and are independently phenyl, naphthyl or thienyl. optionally substituted with one or more substituents such as nitro, halogen, alkyl, alkoxy, alkanoylamino each with up to 6 carbon atoms, and a cycloalkyl group of 3-7 carbon atoms, and X- is physiologically an acceptable anion, together with a liquid or solid, edible and non-toxic diluent or carrier. 2. The measure according to claim The process of claim 1, wherein the liquid, edible and non-toxic diluent or carrier is drinking water, or whole or skim milk. The agent according to claim 1, characterized in that the edible solid and non-toxic diluent or carrier is animal kairme. 4. The measure according to claim A method as claimed in claim 1, characterized in that it comprises a standard broiler diet comprising ground cereal grains and cereal by-products, animal proteins supplemented with vitamins and minerals, a typical pig fattening and final diet or other conventional animal feed. 5. The measure according to claim 3. The method according to claim 3 or 4, characterized in that it is a feed for direct feeding of animals, containing from 0.0001 to 0.025% by weight of an iodonium salt of the above formula. 6. The measure according to claim 2. The process of claim 1, wherein it is a feed for direct feeding of animals, containing from 0.0001 to 0.005% by weight of an iodonium salt of the above formula, wherein R1 is 4-chlorophenyl or 4-fluorophenyl and R * has the meaning given above. 7. a measure according to claim A food according to claim 1, characterized in that it is a feed for direct feeding of animals, containing from 0.0001 to 0.00% by weight of the di-chlorophenyl) -, di- (4-fluorophenyl) -, di- (2-thienyl) - salt, phenyl (2-thienyl) -, (4-chlorophenyl) (4-tolyl, di (4-ch] Oro-2,5-dimethylphenyl) -, (4-chlorophenyl) (4-fluorophenyl) -, ( 4-chlorophenyl) v (2,4,5-trimethylphenyl) -, (4-fluorophenyl) phenyl-, (4-chloro-2,5-dimethylphenyl) phenyl-, (4-chlorophenyl) - (4-methoxyphenyl) ) - or (4-fluorophenyl) (4-tolyl) - 5-iodonium. 8. The measure according to claim The process according to claim 6 or 7, characterized in that the iodonium salt is in the form of chloride or bromide. 9. The measure according to claim The method of claim 1, wherein the io comprises a solid, inert, non-nutrient diluent or carrier. 10. - The measure according to claim The process of claim 9, comprising kaolin, talc, calcium carbonate, Fuller's earth, attapulgite, ground oyster shells, ground limes, starches or lactose. 11. The measure according to claim The process of claim 1, wherein it is a concentrated masterbatch containing from 0.025 to 50% by weight of the iodonium salt. 12. The measure according to claim The composition of claim 1, wherein the iodonium salt is of the above formula, wherein R 1 is an optionally substituted 2-thienyl group and R 8 is as defined above. 13. The measure according to claim 3. The compound of claim 1, wherein the iodonium salt of the above-defined formula, wherein R1 and R * are the same or different groups and represent a phenyl, naphthyl or thienyl group optionally substituted with one or more substituents such as a nitro group. 30 wa, chlorine, bromine, iodine and fluorine, methyl, ethyl, n-propyl, isopropyl, n-butyl, tertiary butyl, tertiary, butyl, pentyl groups, hexyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, tert-butoxy, tertiary-35-butoxy, pentyloxy, hexyloxy, aceitamide, propionamide, butyramide, cyclopentyl and cyclohexyl, and X- is chloride, bromide, iodide, bisulfate, sulfate, nitrate, phosphate, p-toluenesulfonate, acetate, trifluoroacetate, hydrogen succinate, succinate, bitartrate, tartrate, citrate or maleate. 14. The measure according to claim The process as claimed in claim 11, characterized in that the iodonium salt is of the above-defined formula, wherein R 1 is 4-chlorophenyl or 4-fluorophenyl and R * has the meaning given above. ' 15. A non-fasting animal breeding agent comprising an iodonium salt of formula R1RIJ + X-, wherein R1 is a phenyl, naphthyl or thienyl group, optionally substituted with one or more substituents such as a nitro group, halogen, alkyl, alkoxy, alkanoylamino, each with up to 6 carbon atoms, cycloalkyl 55 with 3 to 7 carbon atoms, and phenyl iodonium or thienyl iodonium groups, optionally substituted with one or more of the substituents specified above, R s is phenyl, naphthyl or thienyl, optionally substituted with one or more substituents such as phenyl iodonium and thienyl iodonium, each optionally substituted with the above-specified substituents, and X- being a physiologically acceptable anion, together with a liquid or solid edible and a non-toxic diluent or carrier.15 99 653 16 16. The measure according to claim The process of claim 15, wherein the liquid, edible and non-toxic diluent or carrier is drinking water, or whole or skim milk. 17. The measure according to claim The process of claim 15, wherein the solid, edible and non-toxic diluent or carrier is animal food. 18. The measure according to claim A method as claimed in claim 15, comprising a standard broiler diet including ground cereal grains and cereal by-products, animal proteins supplemented with vitamins and minerals, conventional commercial pig fattening and finishing diets or other conventional animal feed. 19. The measure according to claim A food according to claim 17 or 18, characterized in that it is a feed for direct feeding of animals, containing from 0.0001 to 0.025% by weight of an iodonium salt of the formula above. 20. The measure according to claim 15, characterized in that the feed for direct feeding of animals contains from 0.0001 to 0.005% by weight of an iodonium salt of the above-defined formula, in which R1 is 4-chlorophenyl or 4-fluorophenyl and R2 is as defined above. importance. 21. The measure according to claim 15, characterized by. that is a feed for direct feeding of animals, containing from 0.0001 to 0.005% by weight of di- (4-chlorophenyl) -, di- (4-fluorophenyl) -, di- (2-thienyl) -, phenyl (2-thienyl) salt ) -, (4-chlorophenyl) (4-tolyl) -, di- (4-chloro-2,5-dimethylphenyl) -, (4-chlorophenyl) (4-fluorophenyl) -, (4-chlorophenyl) ( 2,4,5-trimethylphenyl) -, (4-fluoro-phenyl) phenyl-, (4-chloro-2,5-dimethylphenyl) phenyl-, (4-chlorophenyl-, (4-chlorophenyl) - (4- methoxyphenyl) - or (4-fluorophenyl) (4-tolyl) iodonium. 22. The measure according to claim The process of claim 15, wherein the iodonium salt is chloride or bromide. 23. The measure according to claim The process of claim 17, characterized in that it is a concentrated masterbatch containing from 0.025 to 50% by weight of iodonium salt. 24. The measure according to claim The process of claim 15, wherein the iodonium salt is of the above-defined formula, in which R1 is an optionally substituted 2-thienyl group and R2 has the meaning given above. 25. The measure according to claim 15. The method of claim 15, wherein the iodonium salt of the above formula, in which R1 and R2 are the same or different groups, represent a phenyl, naphthyl or thienyl group optionally substituted with one or more substituents such as nitro, chlorine, bromine. , iodine and fluorine, methyl, n-propyl, isopropyl, n-butyl, second-tertiary butyl, tertiary-butyl, pentyl, hexyl, methoxy, ethoxy, n-propoxy, isopropox - sy, n-butoxy, tert-butoxy, tert-butoxy, pentyloxy, hexyloxy, acetamide, propionamide, butyramide, cyclopentyl and cyclohexyl, and X- is chloride, bromide, iodide , hydrogen sulfate, nitrate, phosphate, p-tolenesulfonate, acetate, trifluoroacetate, hydrosuccinate, succinate, hydrogen tartrate, tartrate, citrate or maleate. 26. The measure according to claim 15. The method of claim 15, wherein the iodonium salt is of the above formula, wherein R 1 is 4-chlorophenyl or 4-fluorophenyl and Rz has the meaning given above. 27. A non-fasting animal breeding agent comprising an iodonium salt of formula R1R2J + X-, wherein R1 is phenyl, naphthyl or thienyl groups, optionally substituted with one or more substituents such as a nitro group. , hydroxy, carboxyl, halogen, alkyl, alkoxy, alkanoylamino, each containing up to 6 carbon atoms, cycloalkyl groups of 3-7 carbon atoms, and phenyl iodonium or thienyl iodine groups, optionally substituted with one or more 28. R2 is a phenyl, naphthyl or thienyl group, optionally substituted with one or more substituents such as hydroxyl and carboxyl, and X- is a physiologically acceptable anion, together with a liquid or solid. an edible and non-toxic diluent or carrier. 25 28. The measure according to claim The process of claim 27, wherein the liquid, edible and non-toxic diluent or carrier is drinking water, or whole or skim milk. 29. The measure according to claim The process of claim 27, wherein the solid, edible and non-toxic diluent or carrier is a balanced animal food. 30. The measure according to claim The method of claim 27, characterized in that it comprises a standard broiler diet including ground cereal grains and cereal by-products, animal proteins supplemented with vitamins and minerals, a typical commercial pig and finishing diet for pigs or other conventional animal feed. 40 31. The measure according to claim 27. A method according to claim 27, characterized in that it is a feed for direct feeding of animals, containing from 0.0001 to 0.025% by weight of iodonium soybean of the above-defined formula. 32. Sirodek according to claim 27, characterized in that it is a feed for direct feeding of animals containing from 0.0001 to 0.005% by weight of an iodonium salt of the above formula, in which R1 is a 4-chlorophenyl or 4-fluorophenyl group, and R2 has the meaning given above. 33. The measure according to claim 28, characterized in that it is a feed for direct feeding of animals, containing from 0.0001 to 0.005% by weight of di- (4-chlorophenyl) -, di- (4-fluorophenyl) -, di- (2-thienyl) salt -, phenyl (2-thienyl) -, (4-chlorophenyl) 55 (4-tolyl) -, di- (4-chloro-2,5-dimethylphenyl) -, (4-chlorophenyl) (4-fluorophenyl) - , (4-chlorophenyl) (2,4,5-trimethylphenyl) -, (4-fluorophenyl) phenyl-, (4-chloro-2,5-dimethylphenyl) phenyl-, (4-chlorophenyl) - (4 - -methoxyphenyl) - or (4-fluorophenyl) (4-tolyl) -iodinium. 34. The measure according to claim A compound according to claim 32 or 33, characterized in that the iodonium salt is in the form of chloride or bromide, 65 35. The agent according to claim 29, wherein the agent is a concentrated masterbatch containing from 0.025 to 50% by weight of iodonium salt. 36. The measure according to the provisions. 27. The method of claim 27, wherein the iodonium salt is of the above-defined formula, in which R1 is an optionally substituted 2-thienyl group and R2 is as defined above. 37. The measure according to claim 27, characterized in that it contains an iodonium salt of the above-defined formula, in which R1 and R2 are the same or different groups and represent a phenyl, naphthyl or thienyl group optionally substituted with one or more substituents such as a nitro group, hydroxy and carboxyl, chlorine, bromine, iodine and fluorine, methyl, ethyl, n-propyl, isopropyl, n-butyl, tertiary butyl, tertiary butyl, pentyl, hexyl, methoxy , ethoxy, n-propoxy, isopropoxy, n-butoxy 5, tert-butoxy, tert-butoxy, pentyloxy, hexyloxy, acetamide, propionamide, butyamide, cyclopentyl and cyclohexyl, and X- is chloride, bromide, iodide, bisulfate, sulfate, nitrate, phosphate, p-toluenesulfonate, acetate, and ° trifluoroacetate, hydrogen succinate, succinate, bitartrate, tartrate, citrate or maleate. 38. The measure according to claim 15. The process of claim 35, characterized in that it contains an iodonium salt of the formula as above, wherein R1 is 4-chlorophenyl or is 4-fluorophenyl and R2 is as defined above. «R PL