PL69747B1 - - Google Patents
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- Publication number
- PL69747B1 PL69747B1 PL1966117285A PL11728566A PL69747B1 PL 69747 B1 PL69747 B1 PL 69747B1 PL 1966117285 A PL1966117285 A PL 1966117285A PL 11728566 A PL11728566 A PL 11728566A PL 69747 B1 PL69747 B1 PL 69747B1
- Authority
- PL
- Poland
- Prior art keywords
- silicon dioxide
- mixed
- active substances
- choline chloride
- biologically active
- Prior art date
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 57
- 238000000034 method Methods 0.000 claims description 29
- 239000000377 silicon dioxide Substances 0.000 claims description 28
- 235000012239 silicon dioxide Nutrition 0.000 claims description 27
- 239000003674 animal food additive Substances 0.000 claims description 18
- 239000013543 active substance Substances 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims description 13
- 235000019743 Choline chloride Nutrition 0.000 claims description 13
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims description 13
- 229960003178 choline chloride Drugs 0.000 claims description 13
- 239000000945 filler Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 5
- 238000005979 thermal decomposition reaction Methods 0.000 claims description 5
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- VXEGSRKPIUDPQT-UHFFFAOYSA-N 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C=CC(N)=CC=2)CC1 VXEGSRKPIUDPQT-UHFFFAOYSA-N 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229910052681 coesite Inorganic materials 0.000 claims description 3
- 229910052906 cristobalite Inorganic materials 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 239000005049 silicon tetrachloride Substances 0.000 claims description 3
- 229910052682 stishovite Inorganic materials 0.000 claims description 3
- 239000011573 trace mineral Substances 0.000 claims description 3
- 235000013619 trace mineral Nutrition 0.000 claims description 3
- 229910052905 tridymite Inorganic materials 0.000 claims description 3
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- KPZGRMZPZLOPBS-UHFFFAOYSA-N 1,3-dichloro-2,2-bis(chloromethyl)propane Chemical compound ClCC(CCl)(CCl)CCl KPZGRMZPZLOPBS-UHFFFAOYSA-N 0.000 claims 1
- 239000000047 product Substances 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 11
- 239000000654 additive Substances 0.000 description 7
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 5
- 229960003512 nicotinic acid Drugs 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- 229940045997 vitamin a Drugs 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229960001231 choline Drugs 0.000 description 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000001968 nicotinic acid Nutrition 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- MJVAVZPDRWSRRC-UHFFFAOYSA-N vitamin K3 Natural products C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 229930003471 Vitamin B2 Natural products 0.000 description 2
- 229930003537 Vitamin B3 Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229910052593 corundum Inorganic materials 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- ABTOQLMXBSRXSM-UHFFFAOYSA-N silicon tetrafluoride Chemical compound F[Si](F)(F)F ABTOQLMXBSRXSM-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000019164 vitamin B2 Nutrition 0.000 description 2
- 239000011716 vitamin B2 Substances 0.000 description 2
- 235000019160 vitamin B3 Nutrition 0.000 description 2
- 239000011708 vitamin B3 Substances 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- 239000011647 vitamin D3 Substances 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 235000012711 vitamin K3 Nutrition 0.000 description 2
- 239000011652 vitamin K3 Substances 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- KLBXMTZIIFLHGJ-UHFFFAOYSA-N 3-ethoxy-2-methylquinoline Chemical compound C1=CC=C2N=C(C)C(OCC)=CC2=C1 KLBXMTZIIFLHGJ-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 238000004438 BET method Methods 0.000 description 1
- 241000224483 Coccidia Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004470 DL Methionine Substances 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229910010067 TiC2 Inorganic materials 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- -1 Vitamin K3 Vitamin Bi Vitamin B2 Vitamin Chemical class 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- LGDAGYXJBDILKZ-UHFFFAOYSA-N [2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1$l^{6},2-benzothiazin-4-yl] 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 LGDAGYXJBDILKZ-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
- 229960001625 furazolidone Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 229960004368 oxytetracycline hydrochloride Drugs 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical group 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K30/00—Processes specially adapted for preservation of materials in order to produce animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Description
Uprawniony z patentu: 'Deutsche Gold — und Silber-Scheideanstalt vor- mals Roessler, Frankfurt n/Menem (Niemiecka Republika Federalna) Sposób wytwarzania trwalych dodatków do pasz Przedmiotem wynalazku jeslt sposób wytwarza¬ nia trwalego dodatku do pasz, zawierajacego chlo¬ rek choliny i inne substancje biologicznie czynne oraz wypelniacz.Pasze tresciwe oprócz zasadniczego skladnika odzywczego, (takiego jak bialko roslinne ilub zwie¬ rzece i sruta zbozowa, zawieraja szereg dodatków, takich jak witaminy, antybiotyki, pierwiastki sla¬ dowe itp., jak równiez nosniki. Jednym z wazniej¬ szych dodatków jest cholina, odgrywajaca wazna role w przemianie lipoidów, niezbedna dla orga¬ nizmów rosnacych lub zagrozonych schorzeniami.Ogólnym problemem w produkcji dodatków do pasz jest takie zmieszanie stosunkowo malej ilosci wypelniacza z wartosciowymi srodkami biollogicznie czynnymi, aby zapewnic im obok maksymalnej trwalosci równiez odpowiednia jednorodnosc. W tym cellu mozna stosowac tylko materialy obojetne, prze¬ chodzace bez zmian przez organizm, aJlbo tez przy¬ swajalne przez organizm i nie zawierajajce szkodli¬ wego wplywu. Szczególne trudnosci wystepuja w przypadku stosowania latwo rozkladajacych sie substancji biologicznie czynnych, na przyklad sub¬ stancji hygroskopijnych, które nawet po stosunkowo krótkim skladowaniu zmniejszaja trwalosc dodatku do pasz Chyba, ze zastosuje sie duza ilosc srodków wypelniajacych, co jednak utrudnia transport do¬ datków i ich dawkowanie.Tak np. stosowanie dodatków zawierajacych chlo¬ rek choliny powoduje juz w czasie ich produkcji 10 15 25 30 koniecznosc przerobu duzych ilosci, co zmusza do stosowania specjalnych zabiegów, na przyklad uzy¬ wania duzych lillosci wypelniaczy, takich jak otreby.Pomimo tych zabiegów otrzymany dodatek do pasz, czesto jednak jest niedostatecznie trwaly, na przy¬ klad nie moze byc stosowany w tropikach.Celem wynalazku jeslt opracowanie sposobu wy¬ twarzania trwalych dodatków do pasz o zwiekszo¬ nej zawartosci substancji biollogicznie czynnych.Pasze te w przypadku zawartosci latwo rozklada¬ jacych sie substancji biollogicznie czynnych powin¬ ny byc dostatecznie trwale nawelt przy niewielkim dodatku obojetnego wypelniacza tak, aby mozna je bylo stosowac w warunkach tropikalnych.Sposób wedlug wynalazku polega na tym, ze bez-; wodny krystaliczny chlorek choliny miesza sie z 0,5—30%, korzystnie 10—20% wagowych synte¬ tycznego, silnie rozdrobnionego, bezpostaciowego dwutlenku krzemu o wielkosci czastek mniejszej niz 500 milimikronów i otrzymany produkt miesza sie jedna lub kilkoma znanymi substancjami bio¬ logicznie czynnymi i ewentualnie znanymi dodat¬ kami do pasz, ma przyklad takimi jak witaminy, biologicznie czynne substancje o dzialaniu profi¬ laktycznym, aminokwasy, pierwiastki sladowe i so¬ le. Jako dwutlenek krzemu szczególnie korzystnie stosuje sie produkt otrzymany z czterochlorku lub czterofluorku krzemu na drodze termicznego, roz¬ kladu.Stosowanie dwutlenku krzemu pirzy wyrobie pasz 69 7473 69 747 4 dla zwierzat jest znane na przyklad z polskiego opisu patentowego nr 47831. Wedlug tej publikacji jako substancje nosne dla wstepnych mieszanek paszowych mozna stosowac liczne rozdirobrndone ma¬ terialy pochodzenia mineralnego, takie jak bentonit, zmienia okrzemkowa, mielone muszle ostryg lub dwutlenek krzemu, nia przyklad w positaoi mialu kwarcowego.W procesie prowadzonym sposobem wedlug wy¬ nalazku dwutlenek krzemu nie stanowi jednak nosnika, ;lecz sltanowi istotny skladnik paszy, ma¬ jacy zasadniczy wplyw na jej trwalosc. Mianowicie w pierwszym stadium procesu ustala sie stan rów¬ nowagi pomiedzy adsorbentem i substancja adsor- bowana, przy czym iten stan równowagi, bedacy niezbednym wairuinkiem do otrzymania wstepnie utrwalonego produktu, usitafla sie tyflko wtedy gdy na oba mieszane skladniki nie oddzialywuja inne skladniki paszowe i gdy sftosuje sie dwutlenek krze¬ mu rozdrobniony w sposób wyzej opisany. Produkt otrzymany w pierwszym stadium procesu jest w pewnym stopniu trwaly i ma konsystencje syp¬ ka. Produkt iten miesza sie w drugiej fazie procesu z innymi aktywnymi skladnikami dodatku do pasz, przy czym i w tym przypadku usitala sie stan rów¬ nowagi, tym razem pomiedzy produktem wstepnie utrwalonym i skladnikami dodanymi w drugiej fa¬ zie procesu, które ulegaja adsorpcji. Ostateczna postac, trwalosc chemiczna i fizyczna produkt uzyskuje dopiero po przeprowadzeniu drugiej fazy procesu przy czym produkt taki nie ulega zmianom chemicznym i biologicznym nawet przy przecho¬ waniu go w ciagu dluzszego okresu czasu w wa¬ runkach atmosferycznych, a nawet w temperaturze dosc wysokiej. Stwierdzono na przyklad, ze spo¬ sobem wedlug wynalazku mozna wytwarzac do¬ datki do pasz, które przechowywane w tempera¬ turze 50°C w ciagu 10 dni nie wykazuja zmian zawartych w mim substancji czynnych, podczas gdy dodatki zawierajace podobne skladniki ale wytwo¬ rzone znanymi sposobami, ulegaja zmianom juz po uplywie 5 dni.Sposób wedlug wynalazku umozliwia wytwarza¬ nie dodatków do pasz o wysokim stezeniu. Tak na przyklad w znanych dodatkach do pasz na 1 kg choliny trzeba stosowac okolo 9 kg otrab, natomiast przy stosowaniu sposobu wedlug wynalazku na 1 kg choliny wystarcza 0,11 kg dwutlenku krzemu, zas dodatek otrab mozna ograniczyc do ilosci takiej, jaka stanowi niezbedny' czynny skladnik paszy.W procesie prowadzonym sposobem wedlug wyna¬ lazku korzystnie stosuje sie HO—20% dwutlenku krzemu o duzym rozdrobnieniu w przeliczeniu na chlorek choliny, albo inne srodki o odpowiedniej biegunowosci i aktywnosci biologicznej. W zalez¬ nosci od osiagnietych wlasciwosci produktów kon¬ cowych, allbo tez biegunowosci innych substancji czynnych oraz ich ilosci i wlasciwosci fizyko-che¬ micznych, mozna stosowac niniejsze lub wieksze iflosci dwutlenku krzemu.Zasadnicze znaczenie posiada jakosc dwutlenku krzemu, przy czym najodpowiedniejszy jest prak¬ tycznie chemicznie czysty dwutlenek krzemu w po¬ staci proszku o wielkosci czastek 3—40 mpi, o cie- 20 zarze wlasciwym, okolo 2, o powierzchni 150— 200 m2/g (oznaczenie metoda BET), o ciezarze na¬ sypowym 40 g/litr. i o ciezarze po utrzesieniu 60—65 g/liitr. Jako praktycznie chemicznie czysty 5 nalezy uwazac taki produkt, którego zawartosc HC1 wynosi mniej niz 0,03%, zawartosc Fe203 wynosi ponizej 0,003%, zawartosc A1^03 wynosi ponizej 0,05%, a zawartosc Ti02 mniej niz 0,03%- Zawartosc tlenków mieszanych, których kazda 10 czastka pierwotna sklada sie z Si02 i z AI2O3 lub TiC2, albo tez mieszanin tlenków, które uzyskuje sie przez koagulacje poszczególnych czastek pier¬ wotnych z Si02 i 'A1203 ilub Ti02, jako tak zwane wtórne koaguilaty tych tlenków, moze wynosic okolo 15 0,3—1,0%.Dwutlenek krzemu tej jakosci mozna korzystnie wytwarzac z czterochlorku lub czteroflluorku krze¬ mu na drodze rozkladu termicznego w plomieniu.Mozna stosowac równiez krzemionki otrzymane na drodze innych procesów termicznych, na przyklad w luku elektrycznym albo pafliniku plazmowym, albo na drodze mokrej, w szczególnosci przez stra¬ canie.Jako inne dodatki mozna stosowac liczne sub¬ stancje biologicznie czynne i zapewniajace wzajem¬ na chemiczna zgodnosc, na przyklad witamine A, D3, E, K, Bi, B2, B3, Bi2, B6, C, niacyne kwas folio¬ wy itd. srodki biologicznie czynne o dzialaniu pro¬ filaktycznym na przyklad antybiotyki, pochodne furanu, srodki przeciwultleniajaoe, srodki kokcydio- statyczne, srodki przeciwczerwiowe itd, aminokwa¬ sy, pierwiastki sladowe, na przyklad zelazo, man¬ gan, miedz, cynk, jod, kobalt oraz rózne soile.Dodatki do pasz wytworzone sposobem wedlug wynalazku miesza sie bezposrednio przed uzyciem z takimi znanymi dodatkami do pasz jak maczka rybna, sruta sojowa, sruta z orzeszków ziemnych, drozdze, melasa itd i bezposrednio skarmia lub rozciencza innymi skladnikami paszowymi.Przyklad I. 200 kg krystalicznego chlorku choliny rozdrabnia sie w wollnoobrotowym mlynie do wielkosci czastek tworzacych nadziarno na sicie nr 16 (wymiar oczka 1,5 mm). Potem wstepnie roz¬ drobniony chlorek choliny miesza sie w ciagu 20 mi¬ nut porcjami z 22,22 kg dwutlenku krzemu, o wiel¬ kosci czastek 10—40 millimikronów, otrzymanego na drodze termicznego rozkladu, osiagajac przy tym duzy stopien rozproszenia. Do suchego gruzelkowa- tego materialu dodaje sie nastepnie mieszajac na¬ stepujace substancje biologicznie czynne: 35 45 Witamina A Witamina D3 Witamina E 55 Witamina K3 Witamina Bi Witamina B2 Witamina Bi2 Niacyna 60 Witamina B3 Efcoksymetylochinolina 1 500 000 000 jednostek 300 000 000 jednostek 1 000 000 jednostek 200 g 300 g 500 g 5 g 2 000 g 1200 g 12 500 g Otrzymamy dodatek do pasz mozna stosowac w paszy do tuczenia gesi, albo kur. Po 10-tygodnio- wym podawaniu kurom 100-krotnej dawki miesza- 65 nliny chlorku choliny i dwutlenku krzemu, zawartej5 69 747 6 w dodatku do paszy, nie isitwieirdzono zadnych dzia¬ lan toksycznych, albo 'niekorzystnych dzialan ubocz¬ nych. Swiadczy to o tym, ze rozproszone substancje sa chemicznie obojetne i nie wplywaja na dziala/nie zawartych w dodatkach do pasz srodków biologicz¬ nie .czynnych.Tarmoanalityczne bacbainlia preparatu przeprowa¬ dzono za pomoca derywaitografu Paiuilik-tPauflik- -Erdey'a (Z. AnaL Chem. 660. 241/1958) przy pred¬ kosci podgrzewania 3°C na 1 minute, w atmos¬ ferze powietrza na próbce o wadze 300—400 mg.Derywatogram produktu podano na rysunku, na którym uwidoczniono, ze badany produkt zawiera 9,1% wody. Zmiany na wadze zaobserwowane przy równomiernym ogrzewaniu w temperaturze 70— —110°C przebiegaly w dwóch procesach, entoder- micznych (w przypadku preparatów nie zawiera¬ jacych dwutlenku krzemu mozna bylo zaobserwo¬ wac jeden proces egzotermiczny i jeden endoter- miczny).Predkosc nasypywania preparatu badano w lej¬ ku o srednicy 0,8 cm, którego boki tworzyly z pozio¬ mem kat 60°. 100 g preparatu umieszczono w apa¬ racie, który utrzymywano w ruchu przy uzyciu mieszadla wibracyjnego. Preparat zawierajacy dwutlenek krzemu wykazal wartosc 7,4 (± 0,05) g • cm-2 • sek-1, natomiast dla substancji porównaw¬ czej wartosc ta wyniosla 1,4 (± 0,2) g • cm-2 • sek-1, chodiaz w obu przypadkach dyfuzyjmosc pary wod¬ nej i zawartosci wilgoci byly praktycznie te same. 2,00 g preparatu umieszczono w zamknietej gu¬ mowym korkiem ampulce szklanej i trzymano w temperaturze 50°C w termostacie powietrznym w ciagu 11 dni. Szesc równoleglych próbek za¬ wierajacych po 100, 0 ml 96% etanolu ogrzewano do wrzenia pod chlodnica zwrotna, po czym otrzy¬ mane wyciagi badano w warstwach grubosci 1 om, plrzy uzyciu fotometru Unicam S.P.500, przy dlu¬ gosci fali 420 miliimiikronów w celu stworzenia zmian chemicznych. Róznica wygasania wynosila dla preparatu otrzymanego sposobem wedlug wy¬ nalazku po 11 dniach 0,il20±0,075, a dla substancji porównawczej 0,284+0,026.Preparat trzymano w naczyniu otwartym, w po- wiietrzu nasyconym wilgocia, w temperaturze 20qC, stosujac jako substancje porównawcza preparat bez dwutlenku krzemu. Na powierzchni substancji porównawczej pojawily sie juz po 3—4 dniach ko¬ lonie plesnie natomiast preparat zawierajacy dwu¬ tlenek krzemu byl jeszcze po 8—9 dniach bez zmian, wykazal wiec zwiekszona trwalosc biolo¬ giczna.Przyklad II. 200 kg krystalicznego chlorku chdliny mliesza sie w temperaturze 50°C z 35 kg wody, otrzymujac jednorodna mieszanine po czym* dodaje stqpniowo 32,22 kg dwutlenku krzemu (10—40 millimikronów), mieszajac intensywnie, aby otrzymac równomierne rozproszenie mieszaniny. Do gruzelkowatej substancji dodaje sie, mieszajac srodkli biologiczne czynne z przykladu I.Trwalosc i dzialanie otrzymanego preparatu Od¬ powiada wlasciwosciom . preparatu otrzymanego sposobem opisanym w przykladzie I.Przyklad III. Jak w przykladzie I wytworzo¬ no dodatek do paszy o nastepujacym skladzie: Chlorek choliny 50 000 mg Dwutlenek krzemu (10—40 iti\i) 5 600 mg 5 Witamina A (octan, stabilizowana) 350 000 jednostek Wlitamina D3 (stabilizowania) 70 000 jednostek WitaminaBi 200 mg WitamfiinaB2 350 mg io WitaminaBi2 3 mg niacyna 1 000 mg dl-pantoteniian wapnia 500 mg dl-metionina 5 000 mg Furazolidon 10 000 mg 15 Etoksymetylochinolina 12 500 mg Oksytetracyklina 3 000 mg Preparat ten nadaje sie do tuczenia swin o wa¬ dze 15—40 kg. Trwalosc preparatu jest równiez 20 zwiekszona w porównaniu z substancjami nie za¬ wierajacymi dwutlenku krzemu.Przyklad IV. Podobnie jak w przykladzie 1 wytwarza sie mieszanline o nastepujacym skladzie: 1 950 g chlorku 'choliny zarabia sie, z 200 kg dwu- 25 tlenku krzemu (10—40 mjx) otrzymanego na dro¬ dze rozkladu termiczniego. Otrzymany produkt do¬ daje sie do mieszaniny o podanym skladzie: 600 kg mieszaniny tluszczów; 18 kg lecytyny; 2,5 kg buty- lohydroksytofluenu; 170 kg straconego dwutlenku 30 krzemu; 5 g witaminy K3; 7 g witaminy Bi; 40 g witaminy B2; 50 g witaminy B3; 0,25 g witaminy B12; 25 g nliacyny; 125 g chlorowodorku oksytetra¬ cykliny; 250 000 000 j. witaminy A; 50 000000 j. wi¬ taminy D oraz 75 000 jednostek witaminy E. 35 Mieszanine te mozna stosowac do karmienia cielat, w celu uzupelnienia chudego mleka. Produkt ten jest 'trwaly i nie wymaga specjalnego ubezpie¬ czenia przy przechowywaniu. 40 PL PLThe holder of the patent: 'Deutsche Gold - und Silber-Scheideanstalt vormals Roessler, Frankfurt am Main (German Federal Republic). Method of producing stable feed additives. The subject of the invention is a method of producing a stable feed additive containing choline chloride and other biologically active substances and filler. Content besides the essential nutrient (such as vegetable or animal proteins and grains) contain a number of additives such as vitamins, antibiotics, nutrients, etc., as well as carriers. The most important additives is choline, which plays an important role in the metabolism of lipoids, necessary for organisms growing or at risk of disease. A general problem in the production of feed additives is to mix a relatively small amount of filler with valuable bioactive agents to provide them with a maximum shelf life. also adequate homogeneity In this cell, only matter may be used They are neutral, pass through the body unchanged, or are absorbed by the body and do not contain any harmful effects. Particular difficulties arise with the use of easily decomposing biologically active substances, for example hygroscopic substances, which, even after relatively short storage, reduce the shelf life of the feed additive unless a large amount of filler is used, which, however, hinders the transport of additives and their additives. For example, the use of additives containing choline chloride causes the need to process large amounts already during their production, which necessitates the use of special procedures, for example the use of large fillers, such as bran, despite these treatments. The obtained feed additive, however, is often insufficiently stable, for example, it cannot be used in the tropics. The aim of the invention is to develop a method of producing stable feed additives with an increased content of bioactive substances. These feeds, in the case of their content, can be easily decomposed Active substances should be present be sufficiently permanently lubricated with little addition of inert filler so that they can be used in tropical conditions. The method according to the invention is that without-; the aqueous crystalline choline chloride is mixed with 0.5-30%, preferably 10-20% by weight of synthetic, finely divided, amorphous silicon dioxide with a particle size of less than 500 millimicrons and the obtained product is mixed with one or more biologically known substances. active and possibly known feed additives, for example vitamins, biologically active substances with a prophylactic effect, amino acids, trace elements and salts. As silicon dioxide, it is particularly preferred to use a product obtained from silicon tetrachloride or tetrafluoride by thermal decomposition. The use of silicon dioxide in feed products 69 7473 69 747 4 for animals is known, for example, from Polish patent specification No. 47831. According to this publication, Carriers for the premix feed can be made of many minerals such as bentonite, which changes diatomaceous, ground oyster shells or silicon dioxide, such as in a silica meal, but in the process of the invention silicon dioxide is not carrier, but is an essential component of the feed, which is essential for its stability. Namely, in the first stage of the process, the state of equilibrium between the adsorbent and the adsorbed substance is established, and this equilibrium state, which is a necessary varuin to obtain a pre-fixed product, settles only when the two mixed components are not affected by other feed components and when Silicon dioxide particulate is used as described above. The product obtained in the first stage of the process is somewhat stable and has a free flowing consistency. This product is mixed in the second stage of the process with the other active ingredients of the feed additive, and in this case a state of equilibrium is established, this time between the pre-fixed product and the ingredients added in the second stage of the process which are adsorbed. The final form, chemical and physical stability of the product is obtained only after the second phase of the process, and the product does not undergo any chemical and biological changes, even when stored for a longer period of time in atmospheric conditions, and even at quite high temperatures. For example, it has been found that the method according to the invention can produce feed additives which, if stored at 50 ° C for 10 days, show no change in their active substances, while additives containing similar ingredients but produced According to the known methods, they change after 5 days. The method according to the invention makes it possible to produce high concentration feed additives. For example, in known feed additives, about 9 kg of bran are needed per 1 kg of choline, while when using the method according to the invention, 0.11 kg of silicon dioxide is sufficient for 1 kg of choline, and the addition of bran may be limited to the amount necessary ' active ingredient of the feed. In the process according to the invention, preferably HO to 20% finely divided silicon dioxide based on choline chloride or other agents of appropriate polarity and biological activity are used. Depending on the properties of the end products achieved, or the polarity of the other active substances and their quantity and physico-chemical properties, one or more values of silicon dioxide may be used. The quality of silicon dioxide is essential, with the most suitable method being Chemically pure silicon dioxide in the form of a powder with a particle size of 3 to 40 mpi, with a specific gravity of about 2, with an area of 150-200 m2 / g (BET method determination), with a bulk density of 40 g /liter. and an equalization weight of 60-65 g / liter. A product with a HCl content of less than 0.03%, a Fe2O3 content of less than 0.003%, an Al ^ 03 content of less than 0.05% and a TiO2 content of less than 0.03% should be considered as practically chemically pure. mixed oxides, the primary part of which consists of SiO2 and Al2O3 or TiC2, or mixtures of oxides which are obtained by coagulation of individual primary particles with SiO2 and 'Al2O3 or TiO2, as so-called secondary coaguilates of these oxides, can be about 0.3-1.0%. Silicon dioxide of this quality can be advantageously produced from silicon tetrachloride or tetrafluoride by thermal decomposition in a flame. Silicas obtained by other thermal processes, for example in an electric arc or paflinic, may also be used. by plasma or wet, in particular by losing. As other additives, numerous biologically active substances may be used and chemically compatible with each other, for example ad vitamin A, D3, E, K, Bi, B2, B3, Bi2, B6, C, niacin, folate, etc., biologically active agents with a prophylactic effect, for example, antibiotics, furan derivatives, antioxidants, coccidia agents static, anti-redness agents, etc., amino acids, trace elements, for example iron, manganese, copper, zinc, iodine, cobalt and various soils. The feed additives of the invention are mixed with such known feed additives immediately prior to use. such as fish meal, soybean meal, peanut meal, yeast, molasses, etc. and directly fed or diluted with other feed ingredients. Example I. 200 kg of crystalline choline chloride is crushed in a low-speed mill to the size of particles forming the grain on a sieve No. 16 (mesh size 1.5 mm). The pre-crushed choline chloride is then mixed for 20 minutes with 22.22 kg of silicon dioxide having a particle size of 10 to 40 millimicrons, obtained by thermal decomposition, while achieving a high degree of dispersion. The following biologically active substances are then added to the dry granulated material: 35 45 Vitamin A Vitamin D3 Vitamin E 55 Vitamin K3 Vitamin Bi Vitamin B2 Vitamin Bi2 Niacin 60 Vitamin B3 Efcoxymethylquinoline 1,500,000,000 units 300,000,000 units 1,000 000 units 200 g 300 g 500 g 5 g 2,000 g 1,200 g 12,500 g The resulting feed additive can be used in feed for fattening goose or chickens. After 10 weeks of administering to chickens a 100-fold dose of a mixture of choline chloride and silicon dioxide, contained in the feed supplement, no toxic effects or adverse side effects were observed. This proves that the dispersed substances are chemically inert and do not affect the activity of biologically active agents not contained in feed additives. The tarmoanalytical bacbainlia of the preparation was carried out using the Paiuilik-tPauflik-Erdey derivative (Z. AnaL Chem. 660, 241/1958) at a heating speed of 3 ° C for 1 minute, in air on a sample weighing 300-400 mg. The product's derivatogram is given in the figure, which shows that the tested product contains 9 , 1% water. The changes in weight observed with uniform heating at the temperature of 70-110 ° C took place in two processes, entodermic (in the case of preparations containing no silicon dioxide, one exothermic and one endothermic process could be observed). The preparation was tested in a funnel 0.8 cm in diameter, the sides of which formed an angle of 60 °. 100 g of the formulation were placed in an apparatus which was kept in motion by a vibrating mixer. The preparation containing silicon dioxide showed a value of 7.4 (± 0.05) g · cm-2 · sec-1, while for the reference substance, the value was 1.4 (± 0.2) g · cm-2 · sec. -1, although in both cases the water vapor diffusivity and the moisture content were practically the same. 2.00 g of the formulation was placed in a glass ampoule closed with a rubber stopper and kept at 50 ° C. in an air thermostat for 11 days. Six parallel samples, each containing 100.0 ml of 96% ethanol, were boiled under a reflux condenser, and the resulting extracts were tested in 1 ohm layers, using a Unicam SP500 photometer at a wavelength of 420 milli microns to creating chemical changes. The extinction difference for the preparation obtained by the method according to the invention after 11 days was 0.120 ± 0.075, and for the comparative substance 0.284 + 0.026. The preparation was kept in an open vessel, in air saturated with moisture, at a temperature of 20 ° C, using the preparation as reference substance. without silicon dioxide. Mild colts appeared on the surface of the comparative substance after 3-4 days, while the preparation containing silicon dioxide was still after 8-9 days unchanged, so it showed an increased biological stability. Example II. 200 kg of crystalline choline chloride are mixed at 50 ° C with 35 kg of water to form a homogeneous mixture, and then 32.22 kg of silicon dioxide (10-40 millimicrons) are added gradually, stirring vigorously to obtain a uniform dispersion of the mixture. The biological active substances of Example 1 are added to the lumpy substance by mixing. Stability and performance of the preparation obtained corresponds to the properties. of the preparation obtained by the method described in example I. Example III. As in example 1, a feed additive was prepared with the following composition: Choline chloride 50,000 mg Silicon dioxide (10-40 µl) 5,600 mg 5 Vitamin A (acetate, stabilized) 350,000 units Vitamin D3 (stabilized) 70,000 units VitaminBi 200 mg VitaminB2 350 mg io VitaminBi2 3 mg niacin 1,000 mg dl-calcium panthotheate 500 mg dl-methionine 5,000 mg Furazolidone 10,000 mg 15 Ethoxymethylquinoline 12,500 mg Oxytetracycline 3,000 mg This preparation is suitable for fattening pigs by weight between 15 and 40 kg. The stability of the formulation is also increased compared to substances which do not contain silicon dioxide. Example IV. As in example 1, a mixture is prepared with the following composition: 1,950 g of choline chloride is prepared from 200 kg of silicon dioxide (10-40 m 3) obtained by thermal decomposition. The product obtained is added to the mixture of the following composition: 600 kg of the fat mixture; 18 kg of lecithin; 2.5 kg of butylhydroxytofluene; 170 kg of silicon dioxide lost; 5 g of vitamin K3; 7 g of vitamin Bi; 40 g of vitamin B2; 50 g of vitamin B3; 0.25 g of vitamin B12; 25 g of nliacin; 125 g of oxytetracycline hydrochloride; 250,000,000 units of vitamin A; 50,000,000 units of vitamin D and 75,000 units of vitamin E. This mixture can be used to feed calves to supplement skim milk. This product is stable and requires no special storage protection. 40 PL PL
Claims (4)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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HUPE000578 | 1965-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL69747B1 true PL69747B1 (en) | 1973-08-31 |
Family
ID=11000411
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1966117285A PL69747B1 (en) | 1965-11-10 | 1966-11-09 | |
PL1966158466A PL82392B1 (en) | 1965-11-10 | 1966-11-09 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1966158466A PL82392B1 (en) | 1965-11-10 | 1966-11-09 |
Country Status (13)
Country | Link |
---|---|
AT (1) | AT295307B (en) |
BE (1) | BE689457A (en) |
BR (1) | BR6684409D0 (en) |
CH (1) | CH502068A (en) |
DE (1) | DE1692417B1 (en) |
DK (1) | DK121277B (en) |
ES (1) | ES332802A1 (en) |
FI (1) | FI46019C (en) |
FR (2) | FR1549173A (en) |
GB (1) | GB1163596A (en) |
IL (1) | IL26490A (en) |
NL (1) | NL6614640A (en) |
PL (2) | PL69747B1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2483189A1 (en) * | 1980-05-28 | 1981-12-04 | Luzenac Sa Talcs | Prepn. of flavoured finely divided food, esp. for animals - by fixing the flavouring using talc and/or chlorite |
DE3409063A1 (en) * | 1984-03-13 | 1985-09-19 | Basf Ag, 6700 Ludwigshafen | METHOD FOR PRODUCING FLOWABLE CHOLIN CHLORIDE-SILICONE POWDER |
ES2036910B1 (en) * | 1990-10-11 | 1994-01-16 | Quimica Mobi S A | CORRECTOR ADDITIVE FOR FEED BASED ON CHOLINE CHLORIDE. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1734234U (en) * | 1955-05-23 | 1956-11-22 | M Franz Micheler Fa | THINNING AGENT CARRIER. |
-
1966
- 1966-04-07 DE DE19661692417 patent/DE1692417B1/en active Pending
- 1966-09-09 IL IL26490A patent/IL26490A/en unknown
- 1966-09-13 CH CH1321866A patent/CH502068A/en not_active IP Right Cessation
- 1966-10-11 FI FI662667A patent/FI46019C/en active
- 1966-10-17 AT AT968566A patent/AT295307B/en not_active IP Right Cessation
- 1966-10-18 NL NL6614640A patent/NL6614640A/xx unknown
- 1966-10-21 FR FR1549173D patent/FR1549173A/fr not_active Expired
- 1966-10-27 ES ES332802A patent/ES332802A1/en not_active Expired
- 1966-11-02 GB GB49195/66A patent/GB1163596A/en not_active Expired
- 1966-11-08 BE BE689457D patent/BE689457A/xx not_active IP Right Cessation
- 1966-11-09 PL PL1966117285A patent/PL69747B1/pl unknown
- 1966-11-09 PL PL1966158466A patent/PL82392B1/pl unknown
- 1966-11-09 BR BR184409/66A patent/BR6684409D0/en unknown
- 1966-11-09 DK DK581866AA patent/DK121277B/en unknown
-
1967
- 1967-09-15 FR FR121246A patent/FR94816E/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH502068A (en) | 1971-01-31 |
IL26490A (en) | 1970-10-30 |
ES332802A1 (en) | 1968-03-16 |
DK121277B (en) | 1971-09-27 |
AT295307B (en) | 1971-12-27 |
BE689457A (en) | 1967-04-14 |
FI46019B (en) | 1972-08-31 |
FR1549173A (en) | 1968-12-13 |
BR6684409D0 (en) | 1973-12-04 |
FI46019C (en) | 1972-12-11 |
GB1163596A (en) | 1969-09-10 |
PL82392B1 (en) | 1975-10-31 |
DE1692417B1 (en) | 1972-01-13 |
FR94816E (en) | 1969-11-28 |
NL6614640A (en) | 1967-05-11 |
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