IL26490A - Animal feed additives - Google Patents

Description

feed additives DEUTSCHE ROESSLER Cx 25198 The present invention concerns durable additives to animal food It is known that intensive cattle breeding in the modern sense of this concept is not possible unless the need of the animals for minerals and other biologically active matters is met by a richer supply of these substances than can be achieved by mere feeding on natural this requirement of the animals is met by the use of These concentrates contain in in addition to a fodder of high protein content of vegetable or animal and cereal Premises of various compositions are known which contain antibiotics and other invigorating matters in the case of possibly also veterinary substances for the prevention of diseases as well as minerals and traoe A very essential active material is choline which plays an important role in the lipoid metabolism and is required in particular by growing or organisms subjected to strong A general problem in the preparation of prenixee is the admixture of a relatively small quantity of filler material with valuable active materials in such a that in addition to an adequate a maximum durability Of only such can be used as fillers as are indifferent and pass unchanged through the organism or can be absorbed by the organism without detrimental effect on the Particular difficulties arise when aotive materials are to be used which are readily decomposable durability of e already after relatively short storage unless a large quantity of filler but this renders the use and transport of the premix more for with premixes containing large volumes have to be handled already in the manufacturing and special measures have to be taken of large quantities of beoause of the hygroscopic nature of the active material and its tendency to In many cases even a premix so prepared still not as durable as is for for in It is the object of the present invention to provide durable premixes which have an increased concentration of active material and certain fillers which render the mixture stable even where the active material is readily decomposable and the proportion of filler with a view to making the premixes especially suitable for use in of tropical The invention consists in premixes containing at least one active ingredient in intimate mixture with finely divided synthetic Such silica has a stabilizing effect on the In the context this invention the term finely silica as well as pyrogenic silica having a size of less than 500 preferably from 3 to 40 Such silica has a specific gravity of about and a surface of about to 200 m by the method described S by Emmet and Its bulk density is 40g and after shaking to 65 Such silioa also practically chemically The description chemically pure means products having an content below and an content below while the contents of or are lower than and In mixed oxides whose individual particles consist each of plus or plus or in oxide mixtures or which are formed by the joint coagulation of primary particles of Si02 with o is to A silioa of this quality can be for by pyrogenic decomposition of silicium tetrachloride or silicium or by other thermal in an electrio arc or in a plasma or else by wet use of amorphous silica has been proposed in the past for various Thus has been used as thickener the manufacture of synthetic as a persion agent and emulsion stabilizer in the manufacture of paints and printing in the production of fluorescent tubes for rendering the glass in the production luminescent as sedimentation in the paper in various branches of the chemical industry for making powders in the food industry for preventing caking and preserving the free flowing character of substances which are naturally as a thiokener for and as a tabletting in the pharmaceutical and cosmetic as a filler in the rubber in the mineral oil industry for the production of solid lubricants or for polishing versatility of use of such lead to extensive research into the reasons of the particular properties of this and many explanations were offered for the results of the which showed mainly the existence o and chemical interactions and combinations It difficult to find a uniform explanation of the properties realting from the finely divided state of this material because the uniform reason of the surface phenomena in various systems had not been explored and because the structure and the of the organisms had to be taken into consi present invention is based on the empirioal observation that the surface phenomena whic play a fundamental role in the interactions of the silica have an exponential ship to the polarity of the material serving as ing to the efuatlon where S is the heat of adsorption of the dispersed system and is the the heat of adsorption results from an interreaotion with the silica and is determined solely by surface establishment of the following constants for the above the uni reason of the surface phenomena a function of polarity of the or the this result could be applied to the of fodder was established that amorphous size silica having the above and a suitable polarity towards the active material can enter into interaction with the latter whereby the properties of the latter be modified in a desired It becomes possible readily to active which could be used hitherto in mixture wit a large volume of filler because of their and properties tendency to proved apply particularly in the of choline which is generally used in fodder premixea in the form of choline chloride and as mentioned a very important active Premixea that contain choline can in accordance with the first stage the required quantity of choline chloride is intensively mixed with can be done both materials may be d in common in a suitable solvent upon leads to a mutual dispersion of the highest or the mixing may be done by the course of this stage the finely divided eilioa interacts with the as contrasted to pure choline chloride which in the presence of air immediately and is therefore difficult handle la e second stage of the process the further active ingredients are admixed to the choline After the admixture of the further active ingredients an equilibrium comes into being between the interaction of the choline chloride and further active ingredients whereby the crumbly mixture is transformed a dry power after a short period of In this form the product can easily be transported and The premixes according to the invention are o high centration and are superior to those known Thus for conventional premixes contain for eac kilogram of cho line approximately 9 kg of as little as about kg of silica per kg of choline is required for the premixes according to the invention and the bran content can be reduced to the proportion which effective as a nutritional The interaction between the active ingredients and the results in advantageous properties which could not be expected from past since the physical stability and chemical durability of the premix are increased For a premix according to the invention can be stored at for 10 days without observable while with known premixes containing the same active changes are observed after 5 It is in particular noteworthy that the biological stability of the product is also increased days instead of 3 4 The presence of silica influences the of ho distribution of the moisture content as well as the wetting properties of the moisture in a premix according to the invention is present in a different energy state which can be proved by the velocity of thermal processes and the changes in the In a premix according to the invention the diffusion capacity of water vapour increases more slowly than in conventional premixes used for even under conditions in an atmosphere saturated with water In addition known advantageous properties of finely divided silica can be flowing velocity 6 7 higher than that of conventional a preferred embodiment of the invention approximately 10 by weight of the finely divided calculated on the amount of choline chloride or any other active ients of corresponding polarity and biological activity is It to use smaller or larger proportions of depending on desired properties of the final the polarity of any additional active their relative proportions and their In general the proportion of silica between by weight of the active As further active numerous biologically important and chemically compatible substances are there may be used vitamins vitamin folic aotive fura amino trace elements and various physiologically desirable sal fish soya bean groundnut The invention is illustrated by the following without being limited Example 1 of crystalline choline chloride was comminuted in a slowly rotating mill down to a mesh She uted choline chloride in several altogether of finely divided pyrogenic silica of 10 to 40 particle size and the mixture is stirred for 20 so that a high degree of dispersion is To dry crumbly material the following furthe aotive ingredients a added with continuous Vitamin A 1 500 000000 Vitamin 1 000 000 Vitamin 200 Vitamin 300 g Vitamin g Vitamin 12 y g 2 000 g Vitamin 1 200 The thus prepared can be used for feeding or After feeding chickens 10 with a of a choline dispersion corresponding to about 100 that contained in the premixes according to the invention no toxic effects or undesired side effects could be indicates that the dispersion does not impair the action of the active ingredients contained in the A examination of premix was carried out with mg of in a derivatograph using a heating velocity of under an air premix sample contained by weight of loss of weight observable with uniform heating proceeded between 70 and in two endothermlc With premixes which do not exothermic one endothermic process could be velocity of flow of the premix was examined in a funnel of cm diameter whose side walls formed with a horizontal line an angle of 100 g the premix were introduced into an which was kept in movement by means of a vibration premix which contained silica showed the value of sec while with the comparison substance which did not the value 1 see although in both samples the diffusion capacity of water vapour and the moisture content practically the 2 g of the premix a glass ampoule were heated at in an air thermostat for 11 Batches from ampoules each were refluxed with 100 ml of ethanol and the extracts were subjected to extinction measurements in Unlearn 500 photometer in layers of 1 cm at a wavelength of 420 in order to detect any chemical difference of the extinction after 11 days was in the case of the premix according to the invention premix was kept in an open vessel in air saturated with water vapour at for comparison a preparation without silica was Mold colonies appeared on the comparison substance already after 3 4 while the premix ing to the invention remained unchanged after 8 to 9 it possessed a greater biological 200 of crystalline choline chloride were admixed at with 35 kg of water with stirring to form a homogeneous Shis mixture was gradually admixed with kg of silica 40 with intensive stirring whereby a geneous dispersion was The crumbly substance was admixed with the further active ingredients enumerated Example stability and effects of the resulting composition were similar to those of the preparation acoording to Example 3 By the same procedure as in Example 1 a premix of the following composition was Choline 50 000 Siliea 5 600 mg Vitamin 350 000 ID Vitamin D 70 000 Vitami 200 mg Vitamin 350 mg Vitamin 3 mg 1 000 mg 500 mg Bthoxymethyl 12 500 mg Oxytetraoyoline 5 000 mg This premix was suitable for feeding pigs of 15 40 kg body Its stability was equally as pared with containing no silic Example 4 200 kg of a mixture of fats were melted in a vessel and with uniform at 70 to with kg of butyl hydrox 18 kg of an emulsifier made from fatty acid ester 200 kg of bentanite content were then added and the mixture was further homogenised in a kneading When the mixture had assumed the state of a gel it was up to 1000 kg by the addition of finely divided prepared silica of particle The stirring was continued until a powderous mixture was care being taken to maintain the temperature of the mixture at The product thus obtained was granulated in a suitable apparatus to a uniform grain The product can be used as enrichment for An energy storage product can be prepared as mixture the following compositions 680 kg of a mixture of were melted in a vessel and admixed with uniform stirring at 70 to with kg of butyl of 200 kg of and kg of choline kg of finely divided precipitated silica content mixture was further homogenised in a kneading When the mixture had assumed the state of a i was made up to 1000 kg by the addition of 100 of pyrogenic silioa of particle The stirring was continued until a mixture was care being taken to maintain the temperature of the mixture at The product thus obtained was granulated in a suitable apparatus to a uniform grain The mixture is eepeoially useful as a chicken Example 6 By the same method as in Example a mixture of the following composition was 1950 g of choline ohloride were intimately mixed with kg of pyrogenic silica of particle Do the thus obtained a mixture of following position by the method of 4 or Pat mixture 60 Lecithin 18 k Butyl hydrox oluene kg Precipitated silica kg Vitamin 5 g Vitamin 7 g Vitamin 40 g Vitamin 50 g Vitamin g Niacin 25 g Ox hydrochloride 125 g Vitamin A Vitamin Ε This mixture can be used for supplementing skim milk as a calf product is stable except for good does not require special measures for insufficientOCRQuality

Claims (1)

1. Durable feed containing at least biologically active ingredient in mixture finely divided synthetic silica herein Premixes according to Claim containing from preferably 10 of the calculated on the total weight of active according to Claim 1 or containing choline chloride as an active Premises according to 2 or containing vitamins prophylactic substances amino acids physiologically desirable trace elements salts as further active Premixes according to any of Claims 1 to wherein the silica used is a product of the pyrogenio decomposition of sillciua tetrachloride or Premixes according to Claim substantially as describe and exemplified Fodder mixes containing premixes according to any 1 to insufficientOCRQuality