KR100239682B1 - Additives for livestock feed containing chromium(+3) picolinate and preparation method therdof - Google Patents

Abstract

According to the present invention, there is provided a composition for the addition of animal feed in which chromic picolinate (+3) is homogeneously mixed. According to the present invention, a picolinic acid is prepared by first mixing the picolinate chromium (+3) raw powder with a fine food standard metal oxide as an intermediate diluent to form an intermediate mixture and then mixing it with limestone, zeolite, or bentonite as a carrier. A uniformly dispersed composition can be obtained.

Description

ADDITIVES FOR LIVESTOCK FEED CONTAINING CHROMIUM (+3) PICOLINATE AND PREPARATION METHOD THERDOF}

The present invention relates to a composition for adding animal feed for efficiently supplying chromium (+3), which is an essential trace metal component of living organisms, and a method for preparing the same. In other words, calcium carbonate, zeolite, or bentonite, which is harmless to animals, is used as a carrier to efficiently supply chromium picolinate (+3), which is the most absorbent among chromium compounds, and fine zinc oxide, titanium oxide or The present invention relates to a composition for adding animal feed using a substance which is harmless or beneficial to an animal such as iron oxide, and a method for producing the same.

Chromium (+3) has been found to be essential for the regulation of blood glucose in mammals (K. Schwarz and W. Mertz, Arch. Biochem. Biophys. 85 , 292 (1959)). Increasing insulin activity has been shown to regulate blood glucose levels. (RA Anderson, JH Brantner and MM Polansky, J. Agric. Food. Chem., 26 , 1219 (1978)). In addition, chromium (+3) has recently been known to be involved in protein synthesis (e.g., GW Evans and TD Bowman, J. Inorg. Bioche., 46 , 243 (1992)). 3) Unlike compounds, it is known that not only increases insulin in the body, but also enhances muscle synthesis by increasing sugar and leucine absorption. In addition, studies have shown that adequate amounts of chromium picolinate in humans (GR Kaats, JA Fisher and K. Blum., J. Aging, 34 , 25 (1991)) increase body muscle mass and significantly reduce body fat. Recently, the addition of chromic picolinate to pig feed increased muscle mass by 7% and decreased fat and hypercholesterol cholesterol by 20% and 19%, respectively (TG Page, LL Southern, TL Ward, and DL Thompson, Jr.). J. Anim. Sci., 71 , 656 (1993)) and the addition of about 200 ppb of chromic choline phosphate to pig feed daily improved the quality of pork (MD Lindeman, CM Wood, AF Harper, ET). Kornegay and RA Anderson, J. Anim. Sci., 73 , 457 (1995)). As the physiological effects of chromic picolinate (+3) is revealed, the US FDA recently approved the use of human nutrients as supplementary nutrients, and the amount of animal feed additives such as pigs is rapidly increasing. To date, research suggests a safe and adequate daily intake of chromium picolinate (+3) of approximately 50 to 200 micrograms. (RA Anderson, Agric. Research / October, 14 (1990)).

Accordingly, it is an object of the present invention to provide a composition for the addition of animal feed in which chromic picolinate (+3) is homogeneously blended.

Still another object of the present invention is to provide a method for preparing a composition for adding animal feed, in which chromium picolinate (+3) is homogeneously blended.

In order to consume a small amount of picochromate (+3) daily and safely, it is irrelevant for humans to combine it with a diluent such as sugar and take it in tablet form, but it is not easy for animals to mix a certain amount evenly in a feed. . In other words, chromic picolinate (+3) (Cr (C ₅ H ₄ NCOO) 3 _˙ H ₂ O) is a pink powder with a specific gravity of 0.62 (g / ml), so it is insoluble in a small amount of alcohol and insoluble in any solvent. The only option is to add and blend directly to the feed in powder form.

Chromium picolinate (+3) The chromium content in the raw material is about 12%. To add about 100 micrograms of daily necessity to the daily feed (2-3 kg) of pigs, feed chromic choline (+3). In fact, it is not easy to evenly dilute picolinate krum (+3) powder in animal feed by 1 million times. The present inventors have studied to solve such a problem and found that it is practical to use chromium picolinate (+3) powder in a suitable proportion once again in an auxiliary carrier which is easy to add to the feed. At this time, the diluent for diluting chromium picolinate (+3) should not contain harmful substances in the animal body and should be homogeneous and easily mixed with animal feed, Mix well and have properties that should not cause chemical reactions even during long-term storage. The most suitable materials for such physical properties include calcium carbonate, which is already used as an animal feed additive, seok hee seok, and zeolite and bentonite minerals composed of alumina and silica. Natural limestone, zeolite or bentonite, in particular, contain no harmful ingredients such as heavy metals and are already used as animal feed supplements because they help metabolism in the body.

When these feed supplements are used as auxiliary carriers of the chromic choline phosphate (+3) of the present invention, the limit of the final dilution ratio for animal feed is about 1000 times. Dilution ratio also has a method of adding to animal feed after diluting about 1000 times, but has the following technical problems.

In other words, chromium picolinate (+3) does not dissolve in all solvents as described above, so it should be added to the feed as a powder phase. If the particle size is large, the absorption is slow in the body and the utilization efficiency is greatly reduced. Therefore, fine powder (less than 10 μm) Supply in the state to maximize the utilization rate. However, chromium picolate (+3) has the property of agglomerating itself as the finer powder, and as mentioned above, the specific gravity of the powder is 0.62. Since the specific gravity is 1.2 to 1.5, it is not easy to dilute the chromic picolinate (+3) powder by 100 times directly to these auxiliary carriers even with a good mixer.

In the present invention, the fine chromium phosphate (+3) powder is not directly diluted in the auxiliary carrier, but as the intermediate diluent, very fine (<1 μm) zinc oxide, titanium oxide, or iron oxide powder of chromium picolinate ( +3) After diluting the powder (<10 μm) by 10 to 100 times, and then diluting the intermediate mixture by 10 to 100 times in the limestone or zeolite as auxiliary carrier, the chromium picolinate is dispersed in a very even and fine particle state. Feed additives were obtained, and this additive composition was very convenient and suitable for addition to most animal feeds. The results of the animal experiments showed that the effect of chromium picolinate (+3) was excellent.

The technical content of the present invention will be described in more detail. After thorough drying of the picolinate chromium (+3) raw material, it is ground in a crusher with fine (<10 μm) powder and then finer (<1 μm) food standard as an intermediate diluent. Is mixed sufficiently with the metal oxide of ie, zinc oxide, titanium oxide or iron oxide powder in a supermixer in a ratio of 1:10 to 100 (about 5 to 10 minutes). At this time, it is very important to check whether the chromium picolinate (+3) powder in the intermediate mixture is uniformly dispersed and mixed with zinc oxide, titanium oxide or iron oxide, which is an intermediate diluent. Since the color of the chromium picolinate (+3) powder is dark pink and the diluent is white in the case of zinc oxide or titanium oxide, the dispersibility of the chromic picolinate (+3) can be visually recognized to some extent. In the case of iron oxide, it is brown or red, and it is impossible to visually distinguish it. In either case, samples should be taken at random to confirm the dispersibility of chromium picolinate (+3) through chromium content analysis. When the intermediate mixture is mixed with limestone, zeolite or bentonite, which is a carrier having a particle size of 50 to 300 mesh, in a powder mixer at a ratio of 1:10 to 100, it is easy to add to animal feed and is easy to add to chromium phosphate (+3). A feed additive composition containing the same can be obtained.

Thus, compared with the case of using chromium picolinate (+3) as an intermediate diluent, using fine zinc oxide, titanium oxide or iron oxide powder and directly mixing it with limestone, zeolite or bentonite of appropriate particle size as an auxiliary carrier, In addition to the significant difference in the dispersibility of the composition was confirmed a large difference in the stability of the composition. In other words, when chromium picolinate (+3) powder is directly mixed with limestone, zeolite or bentonite, first, the dispersibility of chromium picolinate (+3) is observed under a microscope. It was observed that there were many parts and not evenly distributed on the surface of the adjuvant, and that a large portion of the chromium picolate powder (+3) was separated from the auxiliary carrier when the solution was shaken by dispersing it in an aqueous solution or an organic solvent. On the other hand, the feed additive of the present invention, which was firstly dispersed with zinc oxide, titanium oxide, or iron oxide as a diluent, was first dispersed with chromic picolinate (+3) powder, and was then mixed with limestone, zeolite, or bentonite as an auxiliary carrier. It was observed that the chromium phosphate (+3) powder was finely and uniformly dispersed evenly on the surface of the adjuvant, and chromium phosphate (+3) was completely isolated from the adjuvant even if it was shaken in the powder or liquid phase. It can be observed that it remains in a stable mixture.

The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples.

Example 1

100 g of chromium phosphate (+3) raw material was dried at 100 ° C. for at least 30 minutes, pulverized to 10 μm or less in a crusher, and added to 900 g of zinc oxide powder of fine food standard having a particle size of 0.5 to 1.0 μm. Stir at least 10 minutes to obtain a uniform intermediate mixture. The mixture is added to 29,000 g of limestone with a particle size of 50 to 200 mesh and then mixed until a homogeneous mixture in a powder mixer. At this time, three samples were randomly picked and analyzed for chromium content. The chromium content was very uniform at 0.038 to 0.039%.

Example 2

100 g of chromium picolinate (+3) raw material was dried at 100 ° C. for 30 minutes or more, pulverized to 10 μm or less in a crusher, and then added to 1,400 g of fine iron oxide powder having a particle size of 0.1 to 0.5 μm. Stir at least for minutes to obtain a uniform intermediate mixture. This mixture is added to 28,500 g of limestone having a particle size of 50 to 200 mesh and then mixed until a homogeneous mixture in a powder mixer. At this time, three samples were randomly picked and analyzed for chromium content. The chromium content was very uniform at 0.037 to 0.038%.

Example 3

100 g of chromium picolinate (+3) was dried at 100 ° C. for at least 30 minutes, pulverized to 10 μm or less in a crusher, and added to 2,900 g of titanium oxide powder of fine food standard having a particle size of 0.1 to 0.6 μm. Stir at least 10 minutes to obtain a uniform intermediate mixture. This mixture is added to 87,000 g of limestone with a particle size of 50 to 200 mesh and then mixed until a homogeneous mixture in a powder mixer. At this time, three samples were randomly collected and analyzed for chromium content, thereby obtaining a uniform composition having a chromium content of 0.012 to 0.013%.

Example 4

100 g of chromium picolinate (+3) was dried at 100 ° C. for at least 30 minutes, pulverized to 10 μm or less in a crusher, and then added to 1,400 g of fine iron oxide powder having a particle size of 0.1 to 0.5 μm, and then mixed in a super mixer. Stir at least for minutes to obtain a uniform intermediate mixture. This intermediate mixture is added to 28,500 g of domestic zeolite having a particle size of 50 to 300 mesh and then mixed until a uniform mixture is obtained in a powder mixer. At this time, three samples were randomly collected and the chromium content was analyzed. The chromium content was uniform at 0.039 to 0.040%.

Example 5

100 g of chromium picolinate (+3) was dried at 100 ° C. for at least 30 minutes, pulverized to 10 μm or less in a crusher, and then added to 1,400 g of fine zinc oxide powder having a particle size of 0.1 to 0.6 μm. Stir at least 10 minutes in order to obtain a uniform intermediate mixture. This mixture is added to 28,500 g of bentonite having a particle size of 50 to 300 mesh and then mixed in a powder mixer until a uniform mixture is obtained. At this time, three samples were randomly taken and the chromium content was analyzed. As a result, the chromium content was very uniform (0.038 to 0.039%).

Example of animal experiment

16 to 21 domestic mixed pigs (Yorxia × Land Race × Durolock) with an initial average weight of 69 kg were fixed in a group, and the daily chromium (+3) content was fixed at 200 ppb in normal feed and chromium picolinate (+3 ) In the form of a feed additive composition as in the embodiment of the present invention when the feed was raised, chromium picoline was added to the feed without any addition to normal feed (control 1), and picoline The acid chromium (+3) raw powder was mixed with limestone as a carrier without using an intermediate diluent, and then added to the feed and reared (control 2). The breeding period is about 40 days until the final average weight of the pig reaches 114 kg, comparing the growth rate of the pig with the carcass grade and the backfat thickness (backfat thickness of the tenth rib) of the slaughtered pig. As a result, there was no difference in the growth rate of the pigs in the case of no supply of chromium (+3) or the addition of 200 ppb of chromium (+3) every day. One difference was observed. In other words, as shown in the following Table 1, 200 ppb daily was more excellent in back fat thickness and meat quality than chromium (+3) was not added to the pig feed (control 1). It can be seen that when the intermediate diluent is not used (control) added to the feed using the intermediate diluent as in the embodiment of the present invention, the back fat thickness and meat quality are better.

Breeding Results of Pigs by Addition of Chromium Picolinate (+3) Sample Type Daily chromium (Ⅲ) content (ppb) Back fat thickness (mm) Meat quality A B C D Control 1 0 23.00 0 One 5 One Control 2 ^* 200 21.86 0 One 6 0 Example 1 200 17.71 0 4 3 0 Example 2 200 20.57 0 4 3 0 Example 4 200 18.71 4 0 2 One Example 5 200 20.29 0 3 4 0 * When chromic picolinate powder is directly added to pig feed

According to the present invention there is provided a feed additive composition is uniformly dispersed chromic choline (+3) that could not be achieved in the prior art. Another great advantage of the additive composition of the present invention is that it is an intermediate diluent of chromium picolinate (+3) to increase the dispersing effect by using fine zinc oxide, titanium oxide or iron oxide to increase the particle size of the carrier limestone, zeolite or bentonite. It can be greatly increased to ˜300 mesh, so that powder is not blown at all during the manufacturing process of the composition for feed addition of the present invention, as well as during packaging, transportation, and addition to the feed, so that the environment of the workplace can be kept clean and the hygiene of workers Safety can also be ensured in management. In addition, as a result of animal experiments using the feed additive composition, it was found that the physiological effect of picolinate chromium (+3) was superior to that of no intermediate diluent.

Claims (4)

50-300 mesh feed granules with an intermediate mixture containing a chromium phosphate (+3) raw material with a particle size of 10 μm or less and a food-grade metal oxide having a particle size of 1 μm or less in a weight ratio of 1:10 to 100 as an intermediate diluent. A composition for the addition of animal feed, in which chromic picolinate (+3) is uniformly dispersed, comprising a carrier in a weight ratio of 1:10 to 100. The composition of claim 1, wherein the intermediate diluent is iron oxide, zinc oxide or titanium oxide. The composition for adding animal feed according to claim 1 or 2, wherein the granular carrier is limestone, zeolite or bentonite. The chromium picolinate (+3) powder is completely dried and finely pulverized to a particle size of 10 μm or less, and then applied to a food standard intermediate diluent selected from zinc oxide, titanium oxide, and iron oxide fine powder having a particle size of 1 μm or less. After dispersing at a weight ratio of 100 to form an intermediate mixture, after analyzing the chromium content in the intermediate mixture to determine the dispersibility of chromium picolinate (+3), the intermediate mixture is selected from limestone, zeolite and bentonite. A method for producing a composition for adding animal feed, in which chromic picolinate (+3) is uniformly dispersed in a granular carrier of 300 mesh and mixed until a uniform mixture in a weight ratio of 1:10 to 100.