PL444517A1 - Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie - Google Patents

Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie

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Publication number
PL444517A1
PL444517A1 PL444517A PL44451723A PL444517A1 PL 444517 A1 PL444517 A1 PL 444517A1 PL 444517 A PL444517 A PL 444517A PL 44451723 A PL44451723 A PL 44451723A PL 444517 A1 PL444517 A1 PL 444517A1
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PL
Poland
Prior art keywords
secretory
preparation
microvesicles
stem cells
producing
Prior art date
Application number
PL444517A
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English (en)
Inventor
Marlena TYNECKA
Andrzej ELJASZEWICZ
Marcin Moniuszko
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Uniwersytet Medyczny W Białymstoku
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Application filed by Uniwersytet Medyczny W Białymstoku filed Critical Uniwersytet Medyczny W Białymstoku
Priority to PL444517A priority Critical patent/PL444517A1/pl
Priority to PCT/IB2024/053826 priority patent/WO2024218730A1/en
Priority to EP24739259.0A priority patent/EP4698633A1/en
Publication of PL444517A1 publication Critical patent/PL444517A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2301—Interleukin-1 (IL-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Wynalazek dotyczy sposobu pozyskiwania preparatu biologicznego złożonego z mikropęcherzyków wydzielniczych (ang. microvesicles, MV) mezenchymalnych komórek macierzystych (ang. mesenchymal stem cells, MSC) w celu ich wykorzystania do leczenia chorób dróg oddechowych, w tym astmy. W kolejnym aspekcie wynalazek dotyczy również preparatu mikropęcherzyków wydzielniczych otrzymanego niniejszym sposobem.
PL444517A 2023-04-21 2023-04-21 Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie PL444517A1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL444517A PL444517A1 (pl) 2023-04-21 2023-04-21 Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie
PCT/IB2024/053826 WO2024218730A1 (en) 2023-04-21 2024-04-19 Method of producing a preparation of secretory microvesicles from stem cells and use of the preparation of the secretory microvesicles produced by this method
EP24739259.0A EP4698633A1 (en) 2023-04-21 2024-04-19 Method of producing a preparation of secretory microvesicles from stem cells and use of the preparation of the secretory microvesicles produced by this method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL444517A PL444517A1 (pl) 2023-04-21 2023-04-21 Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie

Publications (1)

Publication Number Publication Date
PL444517A1 true PL444517A1 (pl) 2024-10-28

Family

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Family Applications (1)

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PL444517A PL444517A1 (pl) 2023-04-21 2023-04-21 Sposób wytwarzania preparatu mikropęcherzyków wydzielniczych z komórek macierzystych oraz preparat mikropęcherzyków wydzielniczych wytworzony tym sposobem i jego zastosowanie

Country Status (3)

Country Link
EP (1) EP4698633A1 (pl)
PL (1) PL444517A1 (pl)
WO (1) WO2024218730A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119530145A (zh) * 2024-12-11 2025-02-28 中国人民解放军总医院第三医学中心 Adsc外泌体在调控il33分泌中的应用

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CN104971383A (zh) * 2015-06-25 2015-10-14 华中科技大学同济医学院附属协和医院 一种微泡复合的再生医用材料的制备方法
EP3414320A1 (en) * 2016-02-12 2018-12-19 Cell Care Therapeutics Adipose tissue derived mesenchymal stromal cell conditioned media and methods of making and using the same
JP2019516771A (ja) * 2016-05-25 2019-06-20 エラスムス ユニバーシティ メディカルセンター ロッテルダムＥｒａｓｍｕｓ Ｕｎｉｖｅｒｓｉｔｙ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Ｒｏｔｔｅｒｄａｍ 間葉系幹細胞およびその一部の使用
IT201600109148A1 (it) * 2016-10-28 2018-04-28 Pharmaexceed Srl Processo per isolare e liofilizzare vescicole extracellulari

Non-Patent Citations (5)

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Title
HAO SUN, TIANYUAN ZHANG, JIANQING GAO: "BioDrugs (2022) 36: 701–715", EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLS: A POTENTIAL BIODRUG FOR ACUTE RESPIRATORY DISTRESS SYNDROME TREATMENT, DOI: https://doi.org/10.1007/s40259-022-00555-5 *
LIGIA LINS DE CASTRO I IN.,: "Stem Cell Research & Therapy (2017) 8:151", HUMAN ADIPOSE TISSUE MESENCHYMAL STROMAL CELLS AND THEIR EXTRACELLULAR VESICLES ACT DIFFERENTIALLY ON LUNG MECHANICS AND INFLAMMATION IN EXPERIMENTAL ALLERGIC ASTHMA, DOI: DOI 10.1186/s13287-017-0600-8 *
LÓPEZ-GARCÍA, L.; CASTRO-MANRREZA, M.E: "Int. J. Mol. Sci. 2021, 22, 9531", TNF-Α AND IFN-Γ PARTICIPATE IN IMPROVING THE IMMUNOREGULATORY CAPACITY OF MESENCHYMAL STEM/STROMAL CELLS: IMPORTANCE OF CELL–CELL CONTACT AND EXTRACELLULAR VESICLES, DOI: https://doi.org/10.3390/ijms22179531; *
MANZOOR, T., SALEEM, A., FAROOQ, N. I IN.: "Inflamm Regener 43, 17 (28.02.2023).", EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLS — A NOVEL THERAPEUTIC TOOL IN INFECTIOUS DISEASES, DOI: https://doi.org/10.1186/s41232-023-00266-6 *
YUKARI WATANABE, TAKAO FUKUDA I IN.: "Scientifc Reports, (2022) 12:13344", EXTRACELLULAR VESICLES DERIVED FROM GMSCS STIMULATED WITH TNF‑Α AND IFN‑Α PROMOTE M2 MACROPHAGE POLARIZATION VIA ENHANCED CD73 AND CD5L EXPRESSION, DOI: https://doi.org/10.1038/s41598-022-17692-0 *

Also Published As

Publication number Publication date
WO2024218730A1 (en) 2024-10-24
EP4698633A1 (en) 2026-02-25

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