PL441126A1 - Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania - Google Patents
Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywaniaInfo
- Publication number
- PL441126A1 PL441126A1 PL441126A PL44112622A PL441126A1 PL 441126 A1 PL441126 A1 PL 441126A1 PL 441126 A PL441126 A PL 441126A PL 44112622 A PL44112622 A PL 44112622A PL 441126 A1 PL441126 A1 PL 441126A1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- formula
- fluorouracil
- conjugates
- preparation
- Prior art date
Links
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 title abstract 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005215 dichloroacetic acid Drugs 0.000 title abstract 2
- 229960002949 fluorouracil Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 abstract 3
- 239000000010 aprotic solvent Substances 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
- 235000009518 sodium iodide Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są koniugaty 5-fluorouracylu i kwasu dichlorooctowego o wzorze ogólnym 1, w którym n oznacza przynajmniej jedną grupę metylenową, korzystnie n oznacza 1-5 grup metylenowych oraz sposób ich otrzymywania, który polega na reakcji związku o wzorze 2 ze związkiem o wzorze 3 prowadzonej wobec aminy alifatycznej w rozpuszczalniku aprotonowym, w wyniku której otrzymuje się związek o wzorze 4, który po rozpuszczeniu w rozpuszczalniku aprotonowym w reakcji ze związkiem o wzorze 5, prowadzonej w obecności jodku sodu daje związek o wzorze ogólnym 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL441126A PL245284B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL441126A PL245284B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL441126A1 true PL441126A1 (pl) | 2023-11-13 |
| PL245284B1 PL245284B1 (pl) | 2024-06-17 |
Family
ID=88789791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL441126A PL245284B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL245284B1 (pl) |
-
2022
- 2022-05-09 PL PL441126A patent/PL245284B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL245284B1 (pl) | 2024-06-17 |
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