PL438719A1 - 1-(1'-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1' hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-onu - Google Patents

1-(1'-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1' hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-onu Download PDF

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Publication number
PL438719A1
PL438719A1 PL438719A PL43871921A PL438719A1 PL 438719 A1 PL438719 A1 PL 438719A1 PL 438719 A PL438719 A PL 438719A PL 43871921 A PL43871921 A PL 43871921A PL 438719 A1 PL438719 A1 PL 438719A1
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Poland
Prior art keywords
nonan
oxabicyclo
hydroxyethyl
formula
obtaining
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PL438719A
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English (en)
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PL243849B1 (pl
Inventor
Marcelina Mazur
Aleksandra Pawlak
Witold Gładkowski
Karolina Przysiężna
Bożena Obmińska-Mrukowicz
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Uniwersytet Przyrodniczy we Wrocławiu
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Priority to PL438719A priority Critical patent/PL243849B1/pl
Publication of PL438719A1 publication Critical patent/PL438719A1/pl
Publication of PL243849B1 publication Critical patent/PL243849B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/65—Absidia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania optycznie czynnego 1-(1'-hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-onu który polega na tym, że 1-(1'-bromoetylo)-9-oksabicyklo[4.3.0]nonan-8-on o wzorze 1 poddaje się mikrobiologicznym przekształceniom w kulturze szczepu Absidia glauca AM177 otrzymując 1-(1'-hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on o wzorze 2, który następnie oczyszcza się metodą chromatografii kolumnowej. 1-(1'-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on o wzorze 2 może znaleźć zastosowanie w farmacji jako związek o działaniu antynowotworowym.
PL438719A 2021-08-10 2021-08-10 1-(1’-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1’-hydroksyetylo)-9-oksabicyklo[4.3.0] nonan-8-onu PL243849B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL438719A PL243849B1 (pl) 2021-08-10 2021-08-10 1-(1’-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1’-hydroksyetylo)-9-oksabicyklo[4.3.0] nonan-8-onu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438719A PL243849B1 (pl) 2021-08-10 2021-08-10 1-(1’-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1’-hydroksyetylo)-9-oksabicyklo[4.3.0] nonan-8-onu

Publications (2)

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PL438719A1 true PL438719A1 (pl) 2023-02-13
PL243849B1 PL243849B1 (pl) 2023-10-23

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PL438719A PL243849B1 (pl) 2021-08-10 2021-08-10 1-(1’-Hydroksyetylo)-9-oksabicyklo[4.3.0]nonan-8-on oraz sposób otrzymywania 1-(1’-hydroksyetylo)-9-oksabicyklo[4.3.0] nonan-8-onu

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Publication number Publication date
PL243849B1 (pl) 2023-10-23

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