PL437263A1 - N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie - Google Patents

N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie

Info

Publication number
PL437263A1
PL437263A1 PL437263A PL43726321A PL437263A1 PL 437263 A1 PL437263 A1 PL 437263A1 PL 437263 A PL437263 A PL 437263A PL 43726321 A PL43726321 A PL 43726321A PL 437263 A1 PL437263 A1 PL 437263A1
Authority
PL
Poland
Prior art keywords
preparation
application
aminoethyl
morpholine
rna analogs
Prior art date
Application number
PL437263A
Other languages
English (en)
Inventor
Adam MAMOT
Paweł SIKORSKI
Joanna Kowalska
Jacek Jemielity
Original Assignee
Uniwersytet Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Warszawski filed Critical Uniwersytet Warszawski
Priority to PL437263A priority Critical patent/PL437263A1/pl
Priority to PCT/PL2022/050013 priority patent/WO2022191725A1/en
Priority to US18/281,352 priority patent/US20240182512A1/en
Priority to AU2022234261A priority patent/AU2022234261A1/en
Priority to JP2023555632A priority patent/JP2024510598A/ja
Priority to CA3211579A priority patent/CA3211579A1/en
Priority to EP22728314.0A priority patent/EP4305045A1/en
Priority to KR1020237034358A priority patent/KR20230157386A/ko
Publication of PL437263A1 publication Critical patent/PL437263A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C09B11/245—Phthaleins having both OH and amino substituent(s) on aryl ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Przedmiotem wynalazku są analogi RNA, sposób ich otrzymywania i zastosowanie, między innymi w obserwacjach mikroskopowych, badaniu procesu ekspresji genów oraz monitorowaniu aktywności enzymów.
PL437263A 2021-03-10 2021-03-10 N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie PL437263A1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL437263A PL437263A1 (pl) 2021-03-10 2021-03-10 N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie
PCT/PL2022/050013 WO2022191725A1 (en) 2021-03-10 2022-03-10 N-(2-aminoethyl)morpholine-based rna analogs, method for the preparation and use thereof
US18/281,352 US20240182512A1 (en) 2021-03-10 2022-03-10 N-(2-aminoethyl)morpholine-based rna analogs, method for the preparation and use thereof
AU2022234261A AU2022234261A1 (en) 2021-03-10 2022-03-10 N-(2-aminoethyl)morpholine-based rna analogs, method for the preparation and use thereof
JP2023555632A JP2024510598A (ja) 2021-03-10 2022-03-10 Ｎ－（２－アミノエチル）モルホリンベースのｒｎａ類似体、調製方法、及びそれらの使用
CA3211579A CA3211579A1 (en) 2021-03-10 2022-03-10 N-(2-aminoethyl)morpholine-based rna analogs, method for the preparation and use thereof
EP22728314.0A EP4305045A1 (en) 2021-03-10 2022-03-10 N-(2-aminoethyl)morpholine-based rna analogs, method for the preparation and use thereof
KR1020237034358A KR20230157386A (ko) 2021-03-10 2022-03-10 N-(2-아미노에틸)모르폴린-기반 rna 유사체, 이의 제조 방법 및 용도

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL437263A PL437263A1 (pl) 2021-03-10 2021-03-10 N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie

Publications (1)

Publication Number Publication Date
PL437263A1 true PL437263A1 (pl) 2022-09-12

Family

ID=81940985

Family Applications (1)

Application Number Title Priority Date Filing Date
PL437263A PL437263A1 (pl) 2021-03-10 2021-03-10 N-(2-aminoetylo)morfolinowe analogi RNA, sposób ich otrzymywania i zastosowanie

Country Status (8)

Country Link
US (1) US20240182512A1 (pl)
EP (1) EP4305045A1 (pl)
JP (1) JP2024510598A (pl)
KR (1) KR20230157386A (pl)
AU (1) AU2022234261A1 (pl)
CA (1) CA3211579A1 (pl)
PL (1) PL437263A1 (pl)
WO (1) WO2022191725A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4464713A1 (en) 2023-05-18 2024-11-20 Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii Circular rna analogs, preparation and application thereof
WO2026106497A2 (en) 2024-11-18 2026-05-21 Sieć Badawcza Łukasiewicz – Port Polski Osrodek Rozwoju Technologii Functionalized circular rna and methods and intermediates for their production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
WO2017066789A1 (en) * 2015-10-16 2017-04-20 Modernatx, Inc. Mrna cap analogs with modified sugar
JP2018530587A (ja) * 2015-10-16 2018-10-18 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法
AU2021277407A1 (en) * 2020-05-22 2022-11-17 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof

Also Published As

Publication number Publication date
AU2022234261A9 (en) 2024-01-11
AU2022234261A1 (en) 2023-09-28
KR20230157386A (ko) 2023-11-16
CA3211579A1 (en) 2022-09-15
EP4305045A1 (en) 2024-01-17
JP2024510598A (ja) 2024-03-08
US20240182512A1 (en) 2024-06-06
WO2022191725A1 (en) 2022-09-15

Similar Documents

Publication Publication Date Title
CO2019014682A2 (es) Composiciones y métodos para enzimas de internalización
BR112021023814A2 (pt) Inibidores de proteases de cisteína e métodos de uso das mesmas
EP4211234A4 (en) Base editing enzymes
MX2020013347A (es) Polimerasas, composiciones y metodos de uso.
MX2022009056A (es) Inhibidores de integrina ?v?6.
DOP2024000083A (es) Composiciones y métodos para inhibir la expresión de la proteína angiotensinógeno (agt)
GEAP202416531A (en) Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
EP3574094A4 (en) LOW MOLECULAR WEIGHT ACTIVE VARIANTS OF ANGIOTENSIN II CONVERTING ENZYME (ECA II)
EA201991255A1 (ru) Регулируемая транскрипция
EP4324520A3 (en) Angiotensinogen (agt) irna compositions and methods of use thereof
AR092526A1 (es) Composiciones y procedimientos para controlar nematodos parasitos de plantas
EP4426826A4 (en) BASIC EDITION ENZYMES
BR112022024501A2 (pt) Construtos de rnai para inibir a expressão de hsd17b13 e métodos de uso dos mesmos
EP4069861A4 (en) Methods for cultivating cells, preparation of hydrolysate from cells and applications thereof
MX2022001933A (es) Inhibidores de enzimas.
BR112023026176A2 (pt) Vetores de expressão, vetores livres de sequência bacteriana e métodos de fabricação e uso dos mesmos
MX386601B (es) Disminución de homocisteína mediada por enzimas humanas para el tratamiento de pacientes con hiperhomocisteinemia y homocistinuria.
EP4103691C0 (en) CELL CULTURE SUBSTRATES, METHODS AND USES THEREOF
WO2020005667A8 (en) Compositions and methods for editing an endogenous nac gene in plants
MX2020010932A (es) Enzimas quinureninasa humanas y sus usos.
EP4370594A4 (en) ENZYMES AND THEIR USES
JOP20220206A1 (ar) الخلايا التائية واستخداماتها
CL2023003108A1 (es) Ingeniería de fábricas de proteínas basadas en células b para tratar enfermedades graves
BR112022005608A2 (pt) Inibidores de jak
MX2024002187A (es) Anticuerpos y conjugados de nectina-4.